SAIL: Structure-Aware Interpretable Learning for Anatomy-Aligned Post-hoc Explanations in OCT

Optical coherence tomography (OCT), a commonly used retinal imaging modality, plays a central role in retinal disease diagnosis by providing high-resolution visualization of retinal layers. While deep learning (DL) has achieved expert-level accuracy in OCT-based retinal disease detection, its "black box" nature poses challenges for clinical adoption, where explainability is essential for clinical trust and regulatory approval. Existing post-hoc explainable AI (XAI) methods often struggle to delineate fine-grained lesion structures, respect anatomical boundaries, or suppress noise, limiting the trustworthiness of their explanations. To bridge these gaps, we propose a Structure-Aware Interpretable Learning (SAIL) framework that integrates retinal anatomical priors at the representation level and couples them with semantic features via a fusion design. Without modifying standard post-hoc explainability methods, this representation yields sharper and more anatomically aligned attribution maps. Comprehensive experiments on diverse OCT datasets demonstrate that our structure-aware method consistently enhances interpretability, producing clinically meaningful and anatomy-aware explanations. Ablation studies further show that strong interpretability requires both structural priors and semantic features, and that properly fusing the two is critical to achieve the best explanation quality. Together, these results highlight structure-aware representations as a key step toward reliable explainability in OCT.

OphMAE: Bridging Volumetric and Planar Imaging with a Foundation Model for Adaptive Ophthalmological Diagnosis

The advent of foundation models has heralded a new era in medical artificial intelligence (AI), enabling the extraction of generalizable representations from large-scale unlabeled datasets. However, current ophthalmic AI paradigms are predominantly constrained to single-modality inference, thereby creating a dissonance with clinical practice where diagnosis relies on the synthesis of complementary imaging modalities. Furthermore, the deployment of high-performance AI in resource-limited settings is frequently impeded by the unavailability of advanced three-dimensional imaging hardware. Here, we present the Ophthalmic multimodal Masked Autoencoder (OphMAE), a multi-imaging foundation model engineered to synergize the volumetric depth of 3D Optical Coherence Tomography (OCT) with the planar context of 2D en face OCT. By implementing a novel cross-modal fusion architecture and a unique adaptive inference mechanism, OphMAE was pre-trained on a massive dataset with of 183,875 paired OCT images derived from 32,765 patients. In a rigorous benchmark encompassing 17 diverse diagnostic tasks with 48,340 paired OCT images from 8,191 patients, the model demonstrated state-of-the-art performance, achieving an Area Under the Curve (AUC) of 96.9% for Age-related Macular Degeneration (AMD) and 97.2% for Diabetic Macular Edema (DME), consistently surpassing existing single-modal and multimodal foundation models. Crucially, OphMAE exhibits robust engineering adaptability: it maintains high diagnostic accuracy, such as 93.7\% AUC for AMD, even when restricted to single-modality 2D inputs, and demonstrates exceptional data efficiency by retaining 95.7% AUC with as few as 500 labeled samples. This work establishes a scalable and adaptable framework for ophthalmic AI, ensuring robust performance across different tasks.

Cerebra: A Multidisciplinary AI Board for Multimodal Dementia Characterization and Risk Assessment

Modern clinical practice increasingly depends on reasoning over heterogeneous, evolving, and incomplete patient data. Although recent advances in multimodal foundation models have improved performance on various clinical tasks, most existing models remain static, opaque, and poorly aligned with real-world clinical workflows. We present Cerebra, an interactive multi-agent AI team that coordinates specialized agents for EHR, clinical notes, and medical imaging analysis. These outputs are synthesized into a clinician-facing dashboard that combines visual analytics with a conversational interface, enabling clinicians to interrogate predictions and contextualize risk at the point of care. Cerebra supports privacy-preserving deployment by operating on structured representations and remains robust when modalities are incomplete. We evaluated Cerebra using a massive multi-institutional dataset spanning 3 million patients from four independent healthcare systems. Cerebra consistently outperformed both state-of-the-art single-modality models and large multimodal language model baselines. In dementia risk prediction, it achieved AUROCs up to 0.80, compared with 0.74 for the strongest single-modality model and 0.68 for language model baselines. For dementia diagnosis, it achieved an AUROC of 0.86, and for survival prediction, a C-index of 0.81. In a reader study with experienced physicians, Cerebra significantly improved expert performance, increasing accuracy by 17.5 percentage points in prospective dementia risk estimation. These results demonstrate Cerebra's potential for interpretable, robust decision support in clinical care.

A Multidisciplinary AI Board for Multimodal Dementia Characterization and Risk Assessment

Modern clinical practice increasingly depends on reasoning over heterogeneous, evolving, and incomplete patient data. Although recent advances in multimodal foundation models have improved performance on various clinical tasks, most existing models remain static, opaque, and poorly aligned with real-world clinical workflows. We present Cerebra, an interactive multi-agent AI team that coordinates specialized agents for EHR, clinical notes, and medical imaging analysis. These outputs are synthesized into a clinician-facing dashboard that combines visual analytics with a conversational interface, enabling clinicians to interrogate predictions and contextualize risk at the point of care. Cerebra supports privacy-preserving deployment by operating on structured representations and remains robust when modalities are incomplete. We evaluated Cerebra using a massive multi-institutional dataset spanning 3 million patients from four independent healthcare systems. Cerebra consistently outperformed both state-of-the-art single-modality models and large multimodal language model baselines. In dementia risk prediction, it achieved AUROCs up to 0.80, compared with 0.74 for the strongest single-modality model and 0.68 for language model baselines. For dementia diagnosis, it achieved an AUROC of 0.86, and for survival prediction, a C-index of 0.81. In a reader study with experienced physicians, Cerebra significantly improved expert performance, increasing accuracy by 17.5 percentage points in prospective dementia risk estimation. These results demonstrate Cerebra's potential for interpretable, robust decision support in clinical care.

AndroTMem: From Interaction Trajectories to Anchored Memory in Long-Horizon GUI Agents

Long-horizon GUI agents are a key step toward real-world deployment, yet effective interaction memory under prevailing paradigms remains under-explored. Replaying full interaction sequences is redundant and amplifies noise, while summaries often erase dependency-critical information and traceability. We present AndroTMem, a diagnostic framework for anchored memory in long-horizon Android GUI agents. Its core benchmark, AndroTMem-Bench, comprises 1,069 tasks with 34,473 interaction steps (avg. 32.1 per task, max. 65). We evaluate agents with TCR (Task Complete Rate), focusing on tasks whose completion requires carrying forward critical intermediate state; AndroTMem-Bench is designed to enforce strong step-to-step causal dependencies, making sparse yet essential intermediate states decisive for downstream actions and centering interaction memory in evaluation. Across open- and closed-source GUI agents, we observe a consistent pattern: as interaction sequences grow longer, performance drops are driven mainly by within-task memory failures, not isolated perception errors or local action mistakes. Guided by this diagnosis, we propose Anchored State Memory (ASM), which represents interaction sequences as a compact set of causally linked intermediate-state anchors to enable subgoal-targeted retrieval and attribution-aware decision making. Across multiple settings and 12 evaluated GUI agents, ASM consistently outperforms full-sequence replay and summary-based baselines, improving TCR by 5%-30.16% and AMS by 4.93%-24.66%, indicating that anchored, structured memory effectively mitigates the interaction-memory bottleneck in long-horizon GUI tasks. The code, benchmark, and related resources are publicly available at [https://github.com/CVC2233/AndroTMem](https://github.com/CVC2233/AndroTMem).

On the Learnability of Offline Model-Based Optimization: A Ranking Perspective

Offline model-based optimization (MBO) seeks to discover high-performing designs using only a fixed dataset of past evaluations. Most existing methods rely on learning a surrogate model via regression and implicitly assume that good predictive accuracy leads to good optimization performance. In this work, we challenge this assumption and study offline MBO from a learnability perspective. We argue that offline optimization is fundamentally a problem of ranking high-quality designs rather than accurate value prediction. Specifically, we introduce an optimization-oriented risk based on ranking between near-optimal and suboptimal designs, and develop a unified theoretical framework that connects surrogate learning to final optimization. We prove the theoretical advantages of ranking over regression, and identify distributional mismatch between the training data and near-optimal designs as the dominant error. Inspired by this, we design a distribution-aware ranking method to reduce this mismatch. Empirical results across various tasks show that our approach outperforms twenty existing methods, validating our theoretical findings. Additionally, both theoretical and empirical results reveal intrinsic limitations in offline MBO, showing a regime in which no offline method can avoid over-optimistic extrapolation.

Beyond the Grid: Layout-Informed Multi-Vector Retrieval with Parsed Visual Document Representations

Harnessing the full potential of visually-rich documents requires retrieval systems that understand not just text, but intricate layouts, a core challenge in Visual Document Retrieval (VDR). The prevailing multi-vector architectures, while powerful, face a crucial storage bottleneck that current optimization strategies, such as embedding merging, pruning, or using abstract tokens, fail to resolve without compromising performance or ignoring vital layout cues. To address this, we introduce ColParse, a novel paradigm that leverages a document parsing model to generate a small set of layout-informed sub-image embeddings, which are then fused with a global page-level vector to create a compact and structurally-aware multi-vector representation. Extensive experiments demonstrate that our method reduces storage requirements by over 95% while simultaneously yielding significant performance gains across numerous benchmarks and base models. ColParse thus bridges the critical gap between the fine-grained accuracy of multi-vector retrieval and the practical demands of large-scale deployment, offering a new path towards efficient and interpretable multimodal information systems.

DenoiseFlow: Uncertainty-Aware Denoising for Reliable LLM Agentic Workflows

Autonomous agents are increasingly entrusted with complex, long-horizon tasks, ranging from mathematical reasoning to software generation. While agentic workflows facilitate these tasks by decomposing them into multi-step reasoning chains, reliability degrades significantly as the sequence lengthens. Specifically, minor interpretation errors in natural-language instructions tend to compound silently across steps. We term this failure mode accumulated semantic ambiguity. Existing approaches to mitigate this often lack runtime adaptivity, relying instead on static exploration budgets, reactive error recovery, or single-path execution that ignores uncertainty entirely. We formalize the multi-step reasoning process as a Noisy MDP and propose DenoiseFlow, a closed-loop framework that performs progressive denoising through three coordinated stages: (1)Sensing estimates per-step semantic uncertainty; (2)Regulating adaptively allocates computation by routing between fast single-path execution and parallel exploration based on estimated risk; and (3)Correcting performs targeted recovery via influence-based root-cause localization. Online self-calibration continuously aligns decision boundaries with verifier feedback, requiring no ground-truth labels. Experiments on six benchmarks spanning mathematical reasoning, code generation, and multi-hop QA show that DenoiseFlow achieves the highest accuracy on every benchmark (83.3% average, +1.3% over the strongest baseline) while reducing cost by 40--56% through adaptive branching. Detailed ablation studies further confirm framework-level's robustness and generality. Code is available at https://anonymous.4open.science/r/DenoiseFlow-21D3/.

EyeLayer: Integrating Human Attention Patterns into LLM-Based Code Summarization

Code summarization is the task of generating natural language descriptions of source code, which is critical for software comprehension and maintenance. While large language models (LLMs) have achieved remarkable progress on this task, an open question remains: can human expertise in code understanding further guide and enhance these models? We propose EyeLayer, a lightweight attention-augmentation module that incorporates human eye-gaze patterns, as a proxy of human expertise, into LLM-based code summarization. EyeLayer models human attention during code reading via a Multimodal Gaussian Mixture, redistributing token embeddings based on learned parameters (μ_i, σ_i^2) that capture where and how intensively developers focus. This design enables learning generalizable attention priors from eye-tracking data and incorporating them into LLMs seamlessly, without disturbing existing representations. We evaluate EyeLayer across diverse model families (i.e., LLaMA-3.2, Qwen3, and CodeBERT) covering different scales and architectures. EyeLayer consistently outperforms strong fine-tuning baselines across standard metrics, achieving gains of up to 13.17% on BLEU-4. These results demonstrate that human gaze patterns encode complementary attention signals that enhance the semantic focus of LLMs and transfer effectively across diverse models for code summarization.

Unlocking Multimodal Document Intelligence: From Current Triumphs to Future Frontiers of Visual Document Retrieval

With the rapid proliferation of multimodal information, Visual Document Retrieval (VDR) has emerged as a critical frontier in bridging the gap between unstructured visually rich data and precise information acquisition. Unlike traditional natural image retrieval, visual documents exhibit unique characteristics defined by dense textual content, intricate layouts, and fine-grained semantic dependencies. This paper presents the first comprehensive survey of the VDR landscape, specifically through the lens of the Multimodal Large Language Model (MLLM) era. We begin by examining the benchmark landscape, and subsequently dive into the methodological evolution, categorizing approaches into three primary aspects: multimodal embedding models, multimodal reranker models, and the integration of Retrieval-Augmented Generation (RAG) and Agentic systems for complex document intelligence. Finally, we identify persistent challenges and outline promising future directions, aiming to provide a clear roadmap for future multimodal document intelligence.