VMambaMorph: a Multi-Modality Deformable Image Registration Framework based on Visual State Space Model with Cross-Scan Module

Image registration, a critical process in medical imaging, involves aligning different sets of medical imaging data into a single unified coordinate system. Deep learning networks, such as the Convolutional Neural Network (CNN)-based VoxelMorph, Vision Transformer (ViT)-based TransMorph, and State Space Model (SSM)-based MambaMorph, have demonstrated effective performance in this domain. The recent Visual State Space Model (VMamba), which incorporates a cross-scan module with SSM, has exhibited promising improvements in modeling global-range dependencies with efficient computational cost in computer vision tasks. This paper hereby introduces an exploration of VMamba with image registration, named VMambaMorph. This novel hybrid VMamba-CNN network is designed specifically for 3D image registration. Utilizing a U-shaped network architecture, VMambaMorph computes the deformation field based on target and source volumes. The VMamba-based block with 2D cross-scan module is redesigned for 3D volumetric feature processing. To overcome the complex motion and structure on multi-modality images, we further propose a fine-tune recursive registration framework. We validate VMambaMorph using a public benchmark brain MR-CT registration dataset, comparing its performance against current state-of-the-art methods. The results indicate that VMambaMorph achieves competitive registration quality. The code for VMambaMorph with all baseline methods is available on GitHub.

VMambaMorph: a Visual Mamba-based Framework with Cross-Scan Module for Deformable 3D Image Registration

Image registration, a critical process in medical imaging, involves aligning different sets of medical imaging data into a single unified coordinate system. Deep learning networks, such as the Convolutional Neural Network (CNN)-based VoxelMorph, Vision Transformer (ViT)-based TransMorph, and State Space Model (SSM)-based MambaMorph, have demonstrated effective performance in this domain. The recent Visual State Space Model (VMamba), which incorporates a cross-scan module with SSM, has exhibited promising improvements in modeling global-range dependencies with efficient computational cost in computer vision tasks. This paper hereby introduces an exploration of VMamba with image registration, named VMambaMorph. This novel hybrid VMamba-CNN network is designed specifically for 3D image registration. Utilizing a U-shaped network architecture, VMambaMorph computes the deformation field based on target and source volumes. The VMamba-based block with 2D cross-scan module is redesigned for 3D volumetric feature processing, and a fine-grained feature extraction module is proposed for high-dimensional feature learning. We validate VMambaMorph using a public benchmark brain MR-CT registration dataset, comparing its performance against current state-of-the-art methods. The results indicate that VMambaMorph achieves competitive registration quality. The code for VMambaMorph is available on GitHub.

MambaMorph: a Mamba-based Backbone with Contrastive Feature Learning for Deformable MR-CT Registration

Deformable image registration is an essential approach for medical image analysis.This paper introduces MambaMorph, an innovative multi-modality deformable registration network, specifically designed for Magnetic Resonance (MR) and Computed Tomography (CT) image alignment. MambaMorph stands out with its Mamba-based registration module and a contrastive feature learning approach, addressing the prevalent challenges in multi-modality registration. The network leverages Mamba blocks for efficient long-range modeling and high-dimensional data processing, coupled with a feature extractor that learns fine-grained features for enhanced registration accuracy. Experimental results showcase MambaMorph's superior performance over existing methods in MR-CT registration, underlining its potential in clinical applications. This work underscores the significance of feature learning in multi-modality registration and positions MambaMorph as a trailblazing solution in this field. The code for MambaMorph is available at: https://github.com/Guo-Stone/MambaMorph.

1DFormer: Learning 1D Landmark Representations via Transformer for Facial Landmark Tracking

Recently, heatmap regression methods based on 1D landmark representations have shown prominent performance on locating facial landmarks. However, previous methods ignored to make deep explorations on the good potentials of 1D landmark representations for sequential and structural modeling of multiple landmarks to track facial landmarks. To address this limitation, we propose a Transformer architecture, namely 1DFormer, which learns informative 1D landmark representations by capturing the dynamic and the geometric patterns of landmarks via token communications in both temporal and spatial dimensions for facial landmark tracking. For temporal modeling, we propose a recurrent token mixing mechanism, an axis-landmark-positional embedding mechanism, as well as a confidence-enhanced multi-head attention mechanism to adaptively and robustly embed long-term landmark dynamics into their 1D representations; for structure modeling, we design intra-group and inter-group structure modeling mechanisms to encode the component-level as well as global-level facial structure patterns as a refinement for the 1D representations of landmarks through token communications in the spatial dimension via 1D convolutional layers. Experimental results on the 300VW and the TF databases show that 1DFormer successfully models the long-range sequential patterns as well as the inherent facial structures to learn informative 1D representations of landmark sequences, and achieves state-of-the-art performance on facial landmark tracking.

PromptFL: Let Federated Participants Cooperatively Learn Prompts Instead of Models -- Federated Learning in Age of Foundation Model

Quick global aggregation of effective distributed parameters is crucial to federated learning (FL), which requires adequate bandwidth for parameters communication and sufficient user data for local training. Otherwise, FL may cost excessive training time for convergence and produce inaccurate models. In this paper, we propose a brand-new FL framework, PromptFL, that replaces the federated model training with the federated prompt training, i.e., let federated participants train prompts instead of a shared model, to simultaneously achieve the efficient global aggregation and local training on insufficient data by exploiting the power of foundation models (FM) in a distributed way. PromptFL ships an off-the-shelf FM, i.e., CLIP, to distributed clients who would cooperatively train shared soft prompts based on very few local data. Since PromptFL only needs to update the prompts instead of the whole model, both the local training and the global aggregation can be significantly accelerated. And FM trained over large scale data can provide strong adaptation capability to distributed users tasks with the trained soft prompts. We empirically analyze the PromptFL via extensive experiments, and show its superiority in terms of system feasibility, user privacy, and performance.

Vertical Machine Unlearning: Selectively Removing Sensitive Information From Latent Feature Space

Recently, the enactment of privacy regulations has promoted the rise of machine unlearning paradigm. Most existing studies mainly focus on removing unwanted data samples from a learnt model. Yet we argue that they remove overmuch information of data samples from latent feature space, which is far beyond the sensitive feature scope that genuinely needs to be unlearned. In this paper, we investigate a vertical unlearning mode, aiming at removing only sensitive information from latent feature space. First, we introduce intuitive and formal definitions for this unlearning and show its orthogonal relationship with existing horizontal unlearning. Secondly, given the fact of lacking general solutions to vertical unlearning, we introduce a ground-breaking solution based on representation detachment, where the task-related information is encouraged to retain while the sensitive information is progressively forgotten. Thirdly, observing that some computation results during representation detachment are hard to obtain in practice, we propose an approximation with an upper bound to estimate it, with rigorous theoretical analysis. We validate our method by spanning several datasets and models with prevailing performance. We envision this work as a necessity for future machine unlearning system and an essential component of the latest privacy-related legislation.

DialogueBERT: A Self-Supervised Learning based Dialogue Pre-training Encoder

With the rapid development of artificial intelligence, conversational bots have became prevalent in mainstream E-commerce platforms, which can provide convenient customer service timely. To satisfy the user, the conversational bots need to understand the user's intention, detect the user's emotion, and extract the key entities from the conversational utterances. However, understanding dialogues is regarded as a very challenging task. Different from common language understanding, utterances in dialogues appear alternately from different roles and are usually organized as hierarchical structures. To facilitate the understanding of dialogues, in this paper, we propose a novel contextual dialogue encoder (i.e. DialogueBERT) based on the popular pre-trained language model BERT. Five self-supervised learning pre-training tasks are devised for learning the particularity of dialouge utterances. Four different input embeddings are integrated to catch the relationship between utterances, including turn embedding, role embedding, token embedding and position embedding. DialogueBERT was pre-trained with 70 million dialogues in real scenario, and then fine-tuned in three different downstream dialogue understanding tasks. Experimental results show that DialogueBERT achieves exciting results with 88.63% accuracy for intent recognition, 94.25% accuracy for emotion recognition and 97.04% F1 score for named entity recognition, which outperforms several strong baselines by a large margin.

A generative adversarial approach to facilitate archival-quality histopathologic diagnoses from frozen tissue sections

In clinical diagnostics and research involving histopathology, formalin fixed paraffin embedded (FFPE) tissue is almost universally favored for its superb image quality. However, tissue processing time (more than 24 hours) can slow decision-making. In contrast, fresh frozen (FF) processing (less than 1 hour) can yield rapid information but diagnostic accuracy is suboptimal due to lack of clearing, morphologic deformation and more frequent artifacts. Here, we bridge this gap using artificial intelligence. We synthesize FFPE-like images ,virtual FFPE, from FF images using a generative adversarial network (GAN) from 98 paired kidney samples derived from 40 patients. Five board-certified pathologists evaluated the results in a blinded test. Image quality of the virtual FFPE data was assessed to be high and showed a close resemblance to real FFPE images. Clinical assessments of disease on the virtual FFPE images showed a higher inter-observer agreement compared to FF images. The nearly instantaneously generated virtual FFPE images can not only reduce time to information but can facilitate more precise diagnosis from routine FF images without extraneous costs and effort.

Adaptive Affinity Propagation Clustering

Affinity propagation clustering (AP) has two limitations: it is hard to know what value of parameter 'preference' can yield an optimal clustering solution, and oscillations cannot be eliminated automatically if occur. The adaptive AP method is proposed to overcome these limitations, including adaptive scanning of preferences to search space of the number of clusters for finding the optimal clustering solution, adaptive adjustment of damping factors to eliminate oscillations, and adaptive escaping from oscillations when the damping adjustment technique fails. Experimental results on simulated and real data sets show that the adaptive AP is effective and can outperform AP in quality of clustering results.