CADA: Multi-scale Collaborative Adversarial Domain Adaptation for Unsupervised Optic Disc and Cup Segmentation

The diversity of retinal imaging devices poses a significant challenge: domain shift, which leads to performance degradation when applying the deep learning models trained on one domain to new testing domains. In this paper, we propose a multi-scale input along with multiple domain adaptors applied hierarchically in both feature and output spaces. The proposed training strategy and novel unsupervised domain adaptation framework, called Collaborative Adversarial Domain Adaptation (CADA), can effectively overcome the challenge. Multi-scale inputs can reduce the information loss due to the pooling layers used in the network for feature extraction, while our proposed CADA is an interactive paradigm that presents an exquisite collaborative adaptation through both adversarial learning and ensembling weights at different network layers. In particular, to produce a better prediction for the unlabeled target domain data, we simultaneously achieve domain invariance and model generalizability via adversarial learning at multi-scale outputs from different levels of network layers and maintaining an exponential moving average (EMA) of the historical weights during training. Without annotating any sample from the target domain, multiple adversarial losses in encoder and decoder layers guide the extraction of domain-invariant features to confuse the domain classifier. Meanwhile, the ensembling of weights via EMA reduces the uncertainty of adapting multiple discriminator learning. Comprehensive experimental results demonstrate that our CADA model incorporating multi-scale input training can overcome performance degradation and outperform state-of-the-art domain adaptation methods in segmenting retinal optic disc and cup from fundus images stemming from the REFUGE, Drishti-GS, and Rim-One-r3 datasets.

Towards Better Data Augmentation using Wasserstein Distance in Variational Auto-encoder

VAE, or variational auto-encoder, compresses data into latent attributes, and generates new data of different varieties. VAE based on KL divergence has been considered as an effective technique for data augmentation. In this paper, we propose the use of Wasserstein distance as a measure of distributional similarity for the latent attributes, and show its superior theoretical lower bound (ELBO) compared with that of KL divergence under mild conditions. Using multiple experiments, we demonstrate that the new loss function exhibits better convergence property and generates artificial images that could better aid the image classification tasks.

Exploration in Deep Reinforcement Learning: A Comprehensive Survey

Deep Reinforcement Learning (DRL) and Deep Multi-agent Reinforcement Learning (MARL) have achieved significant success across a wide range of domains, such as game AI, autonomous vehicles, robotics and finance. However, DRL and deep MARL agents are widely known to be sample-inefficient and millions of interactions are usually needed even for relatively simple game settings, thus preventing the wide application in real-industry scenarios. One bottleneck challenge behind is the well-known exploration problem, i.e., how to efficiently explore the unknown environments and collect informative experiences that could benefit the policy learning most. In this paper, we conduct a comprehensive survey on existing exploration methods in DRL and deep MARL for the purpose of providing understandings and insights on the critical problems and solutions. We first identify several key challenges to achieve efficient exploration, which most of the exploration methods aim at addressing. Then we provide a systematic survey of existing approaches by classifying them into two major categories: uncertainty-oriented exploration and intrinsic motivation-oriented exploration. The essence of uncertainty-oriented exploration is to leverage the quantification of the epistemic and aleatoric uncertainty to derive efficient exploration. By contrast, intrinsic motivation-oriented exploration methods usually incorporate different reward agnostic information for intrinsic exploration guidance. Beyond the above two main branches, we also conclude other exploration methods which adopt sophisticated techniques but are difficult to be classified into the above two categories. In addition, we provide a comprehensive empirical comparison of exploration methods for DRL on a set of commonly used benchmarks. Finally, we summarize the open problems of exploration in DRL and deep MARL and point out a few future directions.

Circuit design and integration feasibility of a high-resolution broadband on-chip spectral monitor

Up-to-date network telemetry is the key enabler for resource optimization by a variety of means including capacity scaling, fault recovery, network reconfiguration. Reliable optical performance monitoring in general and specifically the monitoring of the spectral profile of WDM signals in fixed- and flex-grid architecture across the entire C-band remains challenging. This article describes a spectrometer circuit architecture along with an original data processing algorithm that combined can measure the spectrum quantitatively across the entire C-band aiming at 1 GHz resolution bandwidth. The circuit is composed of a scanning ring resonator followed by a parallel arrangement of AWGs with interlaced channel spectra. The comb of ring resonances provides the high resolution and the algorithm creates a virtual tuneable AWG that isolates individual resonances of the comb within the flat pass-band of its synthesized channels. The parallel arrangement of AWGs may be replaced by a time multiplexed multi-input port AWG. The feasibility of a ring resonator functioning over whole C-band is experimentally validated. Full tuning of the comb of resonances over a free spectral range is achieved with a high-resolution bandwidth of 1.30 GHz. Due to its maturity and low loss, CMOS compatible silicon nitride is chosen for integration. Additionally, the whole system demonstration is presented using industry standard simulation tool. The architecture is robust to fabrication process variations owing to its data processing approach.

An explainable two-dimensional single model deep learning approach for Alzheimer's disease diagnosis and brain atrophy localization

Early and accurate diagnosis of Alzheimer's disease (AD) and its prodromal period mild cognitive impairment (MCI) is essential for the delayed disease progression and the improved quality of patients'life. The emerging computer-aided diagnostic methods that combine deep learning with structural magnetic resonance imaging (sMRI) have achieved encouraging results, but some of them are limit of issues such as data leakage and unexplainable diagnosis. In this research, we propose a novel end-to-end deep learning approach for automated diagnosis of AD and localization of important brain regions related to the disease from sMRI data. This approach is based on a 2D single model strategy and has the following differences from the current approaches: 1) Convolutional Neural Network (CNN) models of different structures and capacities are evaluated systemically and the most suitable model is adopted for AD diagnosis; 2) a data augmentation strategy named Two-stage Random RandAugment (TRRA) is proposed to alleviate the overfitting issue caused by limited training data and to improve the classification performance in AD diagnosis; 3) an explainable method of Grad-CAM++ is introduced to generate the visually explainable heatmaps that localize and highlight the brain regions that our model focuses on and to make our model more transparent. Our approach has been evaluated on two publicly accessible datasets for two classification tasks of AD vs. cognitively normal (CN) and progressive MCI (pMCI) vs. stable MCI (sMCI). The experimental results indicate that our approach outperforms the state-of-the-art approaches, including those using multi-model and 3D CNN methods. The resultant localization heatmaps from our approach also highlight the lateral ventricle and some disease-relevant regions of cortex, coincident with the commonly affected regions during the development of AD.

Feature-Filter: Detecting Adversarial Examples through Filtering off Recessive Features

Deep neural networks (DNNs) are under threat from adversarial example attacks. The adversary can easily change the outputs of DNNs by adding small well-designed perturbations to inputs. Adversarial example detection is a fundamental work for robust DNNs-based service. Adversarial examples show the difference between humans and DNNs in image recognition. From a human-centric perspective, image features could be divided into dominant features that are comprehensible to humans, and recessive features that are incomprehensible to humans, yet are exploited by DNNs. In this paper, we reveal that imperceptible adversarial examples are the product of recessive features misleading neural networks, and an adversarial attack is essentially a kind of method to enrich these recessive features in the image. The imperceptibility of the adversarial examples indicates that the perturbations enrich recessive features, yet hardly affect dominant features. Therefore, adversarial examples are sensitive to filtering off recessive features, while benign examples are immune to such operation. Inspired by this idea, we propose a label-only adversarial detection approach that is referred to as feature-filter. Feature-filter utilizes discrete cosine transform to approximately separate recessive features from dominant features, and gets a mutant image that is filtered off recessive features. By only comparing DNN's prediction labels on the input and its mutant, feature-filter can real-time detect imperceptible adversarial examples at high accuracy and few false positives.

DiffSinger: Singing Voice Synthesis via Shallow Diffusion Mechanism

Singing voice synthesis (SVS) system is built to synthesize high-quality and expressive singing voice, in which the acoustic model generates the acoustic features (e.g., mel-spectrogram) given a music score. Previous singing acoustic models adopt simple loss (e.g., L1 and L2) or generative adversarial network (GAN) to reconstruct the acoustic features, while they suffer from over-smoothing and unstable training issues respectively, which hinder the naturalness of synthesized singing. In this work, we propose DiffSinger, an acoustic model for SVS based on the diffusion probabilistic model. DiffSinger is a parameterized Markov chain which iteratively converts the noise into mel-spectrogram conditioned on the music score. By implicitly optimizing variational bound, DiffSinger can be stably trained and generates realistic outputs. To further improve the voice quality and speed up inference, we introduce a shallow diffusion mechanism to make better use of the prior knowledge learned by the simple loss. Specifically, DiffSinger starts generation at a shallow step smaller than the total number of diffusion steps, according to the intersection of the diffusion trajectories of the ground-truth mel-spectrogram and the one predicted by a simple mel-spectrogram decoder. Besides, we train a boundary prediction network to locate the intersection and determine the shallow step adaptively. The evaluations conducted on the Chinese singing dataset demonstrate that DiffSinger outperforms state-of-the-art SVS work. Our extensional experiments also prove the generalization of DiffSinger on text-to-speech task.

Importance Weighted Adversarial Discriminative Transfer for Anomaly Detection

Previous transfer methods for anomaly detection generally assume the availability of labeled data in source or target domains. However, such an assumption is not valid in most real applications where large-scale labeled data are too expensive. Therefore, this paper proposes an importance weighted adversarial autoencoder-based method to transfer anomaly detection knowledge in an unsupervised manner, particularly for a rarely studied scenario where a target domain has no labeled normal/abnormal data while only normal data from a related source domain exist. Specifically, the method learns to align the distributions of normal data in both source and target domains, but leave the distribution of abnormal data in the target domain unchanged. In this way, an obvious gap can be produced between the distributions of normal and abnormal data in the target domain, therefore enabling the anomaly detection in the domain. Extensive experiments on multiple synthetic datasets and the UCSD benchmark demonstrate the effectiveness of our approach.

Principled Exploration via Optimistic Bootstrapping and Backward Induction

One principled approach for provably efficient exploration is incorporating the upper confidence bound (UCB) into the value function as a bonus. However, UCB is specified to deal with linear and tabular settings and is incompatible with Deep Reinforcement Learning (DRL). In this paper, we propose a principled exploration method for DRL through Optimistic Bootstrapping and Backward Induction (OB2I). OB2I constructs a general-purpose UCB-bonus through non-parametric bootstrap in DRL. The UCB-bonus estimates the epistemic uncertainty of state-action pairs for optimistic exploration. We build theoretical connections between the proposed UCB-bonus and the LSVI-UCB in a linear setting. We propagate future uncertainty in a time-consistent manner through episodic backward update, which exploits the theoretical advantage and empirically improves the sample-efficiency. Our experiments in the MNIST maze and Atari suite suggest that OB2I outperforms several state-of-the-art exploration approaches.