MixSearch: Searching for Domain Generalized Medical Image Segmentation Architectures

Considering the scarcity of medical data, most datasets in medical image analysis are an order of magnitude smaller than those of natural images. However, most Network Architecture Search (NAS) approaches in medical images focused on specific datasets and did not take into account the generalization ability of the learned architectures on unseen datasets as well as different domains. In this paper, we address this point by proposing to search for generalizable U-shape architectures on a composited dataset that mixes medical images from multiple segmentation tasks and domains creatively, which is named MixSearch. Specifically, we propose a novel approach to mix multiple small-scale datasets from multiple domains and segmentation tasks to produce a large-scale dataset. Then, a novel weaved encoder-decoder structure is designed to search for a generalized segmentation network in both cell-level and network-level. The network produced by the proposed MixSearch framework achieves state-of-the-art results compared with advanced encoder-decoder networks across various datasets.

AniGAN: Style-Guided Generative Adversarial Networks for Unsupervised Anime Face Generation

In this paper, we propose a novel framework to translate a portrait photo-face into an anime appearance. Our aim is to synthesize anime-faces which are style-consistent with a given reference anime-face. However, unlike typical translation tasks, such anime-face translation is challenging due to complex variations of appearances among anime-faces. Existing methods often fail to transfer the styles of reference anime-faces, or introduce noticeable artifacts/distortions in the local shapes of their generated faces. We propose Ani- GAN, a novel GAN-based translator that synthesizes highquality anime-faces. Specifically, a new generator architecture is proposed to simultaneously transfer color/texture styles and transform local facial shapes into anime-like counterparts based on the style of a reference anime-face, while preserving the global structure of the source photoface. We propose a double-branch discriminator to learn both domain-specific distributions and domain-shared distributions, helping generate visually pleasing anime-faces and effectively mitigate artifacts. Extensive experiments qualitatively and quantitatively demonstrate the superiority of our method over state-of-the-art methods.

GuidedStyle: Attribute Knowledge Guided Style Manipulation for Semantic Face Editing

Although significant progress has been made in synthesizing high-quality and visually realistic face images by unconditional Generative Adversarial Networks (GANs), there still lacks of control over the generation process in order to achieve semantic face editing. In addition, it remains very challenging to maintain other face information untouched while editing the target attributes. In this paper, we propose a novel learning framework, called GuidedStyle, to achieve semantic face editing on StyleGAN by guiding the image generation process with a knowledge network. Furthermore, we allow an attention mechanism in StyleGAN generator to adaptively select a single layer for style manipulation. As a result, our method is able to perform disentangled and controllable edits along various attributes, including smiling, eyeglasses, gender, mustache and hair color. Both qualitative and quantitative results demonstrate the superiority of our method over other competing methods for semantic face editing. Moreover, we show that our model can be also applied to different types of real and artistic face editing, demonstrating strong generalization ability.

HI-Net: Hyperdense Inception 3D UNet for Brain Tumor Segmentation

The brain tumor segmentation task aims to classify tissue into the whole tumor (WT), tumor core (TC), and enhancing tumor (ET) classes using multimodel MRI images. Quantitative analysis of brain tumors is critical for clinical decision making. While manual segmentation is tedious, time-consuming, and subjective, this task is at the same time very challenging to automatic segmentation methods. Thanks to the powerful learning ability, convolutional neural networks (CNNs), mainly fully convolutional networks, have shown promising brain tumor segmentation. This paper further boosts the performance of brain tumor segmentation by proposing hyperdense inception 3D UNet (HI-Net), which captures multi-scale information by stacking factorization of 3D weighted convolutional layers in the residual inception block. We use hyper dense connections among factorized convolutional layers to extract more contexual information, with the help of features reusability. We use a dice loss function to cope with class imbalances. We validate the proposed architecture on the multi-modal brain tumor segmentation challenges (BRATS) 2020 testing dataset. Preliminary results on the BRATS 2020 testing set show that achieved by our proposed approach, the dice (DSC) scores of ET, WT, and TC are 0.79457, 0.87494, and 0.83712, respectively.

Robust Facial Landmark Detection by Cross-order Cross-semantic Deep Network

Recently, convolutional neural networks (CNNs)-based facial landmark detection methods have achieved great success. However, most of existing CNN-based facial landmark detection methods have not attempted to activate multiple correlated facial parts and learn different semantic features from them that they can not accurately model the relationships among the local details and can not fully explore more discriminative and fine semantic features, thus they suffer from partial occlusions and large pose variations. To address these problems, we propose a cross-order cross-semantic deep network (CCDN) to boost the semantic features learning for robust facial landmark detection. Specifically, a cross-order two-squeeze multi-excitation (CTM) module is proposed to introduce the cross-order channel correlations for more discriminative representations learning and multiple attention-specific part activation. Moreover, a novel cross-order cross-semantic (COCS) regularizer is designed to drive the network to learn cross-order cross-semantic features from different activation for facial landmark detection. It is interesting to show that by integrating the CTM module and COCS regularizer, the proposed CCDN can effectively activate and learn more fine and complementary cross-order cross-semantic features to improve the accuracy of facial landmark detection under extremely challenging scenarios. Experimental results on challenging benchmark datasets demonstrate the superiority of our CCDN over state-of-the-art facial landmark detection methods.

Context Aware 3D UNet for Brain Tumor Segmentation

Deep convolutional neural network (CNN) achieves remarkable performance for medical image analysis. UNet is the primary source in the performance of 3D CNN architectures for medical imaging tasks, including brain tumor segmentation. The skip connection in the UNet architecture concatenates features from both encoder and decoder paths to extract multi-contexual information from image data. The multi-scaled features play an essential role in brain tumor segmentation. However, the limited use of features can degrade the performance of the UNet approach for segmentation. In this paper, we propose a modified UNet architecture for brain tumor segmentation. In the proposed architecture, we used densely connected blocks in both encoder and decoder paths to extract multi-contexual information from the concept of feature reusability. The proposed residual inception blocks (RIB) are used to extract local and global information by merging features of different kernel sizes. We validate the proposed architecture on the multimodal brain tumor segmentation challenges (BRATS) 2020 testing dataset. The dice (DSC) scores of the whole tumor (WT), tumor core (TC), and enhancement tumor (ET) are 89.12%, 84.74%, and 79.12%, respectively. Our proposed work is in the top ten methods based on the dice scores of the testing dataset.

Think about boundary: Fusing multi-level boundary information for landmark heatmap regression

Although current face alignment algorithms have obtained pretty good performances at predicting the location of facial landmarks, huge challenges remain for faces with severe occlusion and large pose variations, etc. On the contrary, semantic location of facial boundary is more likely to be reserved and estimated on these scenes. Therefore, we study a two-stage but end-to-end approach for exploring the relationship between the facial boundary and landmarks to get boundary-aware landmark predictions, which consists of two modules: the self-calibrated boundary estimation (SCBE) module and the boundary-aware landmark transform (BALT) module. In the SCBE module, we modify the stem layers and employ intermediate supervision to help generate high-quality facial boundary heatmaps. Boundary-aware features inherited from the SCBE module are integrated into the BALT module in a multi-scale fusion framework to better model the transformation from boundary to landmark heatmap. Experimental results conducted on the challenging benchmark datasets demonstrate that our approach outperforms state-of-the-art methods in the literature.

MI^2GAN: Generative Adversarial Network for Medical Image Domain Adaptation using Mutual Information Constraint

Domain shift between medical images from multicentres is still an open question for the community, which degrades the generalization performance of deep learning models. Generative adversarial network (GAN), which synthesize plausible images, is one of the potential solutions to address the problem. However, the existing GAN-based approaches are prone to fail at preserving image-objects in image-to-image (I2I) translation, which reduces their practicality on domain adaptation tasks. In this paper, we propose a novel GAN (namely MI$^2$GAN) to maintain image-contents during cross-domain I2I translation. Particularly, we disentangle the content features from domain information for both the source and translated images, and then maximize the mutual information between the disentangled content features to preserve the image-objects. The proposed MI$^2$GAN is evaluated on two tasks---polyp segmentation using colonoscopic images and the segmentation of optic disc and cup in fundus images. The experimental results demonstrate that the proposed MI$^2$GAN can not only generate elegant translated images, but also significantly improve the generalization performance of widely used deep learning networks (e.g., U-Net).

TR-GAN: Topology Ranking GAN with Triplet Loss for Retinal Artery/Vein Classification

Retinal artery/vein (A/V) classification lays the foundation for the quantitative analysis of retinal vessels, which is associated with potential risks of various cardiovascular and cerebral diseases. The topological connection relationship, which has been proved effective in improving the A/V classification performance for the conventional graph based method, has not been exploited by the deep learning based method. In this paper, we propose a Topology Ranking Generative Adversarial Network (TR-GAN) to improve the topology connectivity of the segmented arteries and veins, and further to boost the A/V classification performance. A topology ranking discriminator based on ordinal regression is proposed to rank the topological connectivity level of the ground-truth, the generated A/V mask and the intentionally shuffled mask. The ranking loss is further back-propagated to the generator to generate better connected A/V masks. In addition, a topology preserving module with triplet loss is also proposed to extract the high-level topological features and further to narrow the feature distance between the predicted A/V mask and the ground-truth. The proposed framework effectively increases the topological connectivity of the predicted A/V masks and achieves state-of-the-art A/V classification performance on the publicly available AV-DRIVE dataset.

Translate the Facial Regions You Like Using Region-Wise Normalization

Though GAN (Generative Adversarial Networks) based technique has greatly advanced the performance of image synthesis and face translation, only few works available in literature provide region based style encoding and translation. We propose in this paper a region-wise normalization framework, for region level face translation. While per-region style is encoded using available approach, we build a so called RIN (region-wise normalization) block to individually inject the styles into per-region feature maps and then fuse them for following convolution and upsampling. Both shape and texture of different regions can thus be translated to various target styles. A region matching loss has also been proposed to significantly reduce the inference between regions during the translation process. Extensive experiments on three publicly available datasets, i.e. Morph, RaFD and CelebAMask-HQ, suggest that our approach demonstrate a large improvement over state-of-the-art methods like StarGAN, SEAN and FUNIT. Our approach has further advantages in precise control of the regions to be translated. As a result, region level expression changes and step by step make up can be achieved. The video demo is available at https://youtu.be/ceRqsbzXAfk.