Medical Model Synthesis Architectures: A Case Study

Medicine is rife with high-stakes uncertainty. Doctors routinely make clinical judgments and decisions that juggle many fundamental unknowns, like predictions about what might be causing a patients' symptoms or decisions about what treatment to try next. Despite increasing interest in developing AI systems that aid or even replace doctors in clinical settings, current systems struggle with calibrated reasoning under uncertainty, and are often deeply opaque about their reasoning. We propose a framework for AI systems that can make practically useful but formally transparent clinical predictions under uncertainty. Given a clinical situation, our framework (MedMSA) uses language models to retrieve relevant prior knowledge, but constructs a formal probabilistic model to support calibrated and verifiable inferences under uncertainty. We show how an initial proof-of-concept of this framework can be used for differential diagnosis, producing an uncertainty-weighted list of potential diagnoses that could explain a patients' symptoms, and discuss future applications and directions for applying this framework more generally for safe clinical collaborations.

Improving the Efficiency of Language Agent Teams with Adaptive Task Graphs

Large language models (LLMs) are increasingly deployed in teams, yet existing coordination approaches often occupy two extremes. Highly structured methods rely on fixed roles, pipelines, or task decompositions assigned a priori. In contrast, fully unstructured teams enable adaptability and exploration but suffer from inefficiencies such as error propagation, inter-agent conflicts, and wasted resources (measured in time, tokens, or file operations). We introduce Language Agent Teams for Task Evolution (LATTE), a framework for coordinating LLM teams inspired by distributed systems, where processors must operate under partial observability and communication constraints. In LATTE, a team of agents collaboratively construct and maintain a shared, evolving coordination graph which encodes sub-task dependencies, individual agent assignment, and the current state of sub-task progress. This protocol maintains consistency while empowering agents to dynamically allocate work, adapt coordination, and discover new tasks. Across multiple collaborative tasks and a variety of base models, we demonstrate how LATTE reduces token usage, wall-clock time, communication, and coordination failures (e.g. file conflicts and redundant outputs) while matching or exceeding the accuracy of standard designs including MetaGPT, decentralized teams, top-down Leader-Worker hierarchies, and static decompositions.

Under the Influence: Quantifying Persuasion and Vigilance in Large Language Models

With increasing integration of Large Language Models (LLMs) into areas of high-stakes human decision-making, it is important to understand the risks they introduce as advisors. To be useful advisors, LLMs must sift through large amounts of content, written with both benevolent and malicious intent, and then use this information to convince a user to take a specific action. This involves two social capacities: vigilance (the ability to determine which information to use, and which to discard) and persuasion (synthesizing the available evidence to make a convincing argument). While existing work has investigated these capacities in isolation, there has been little prior investigation of how these capacities may be linked. Here, we use a simple multi-turn puzzle-solving game, Sokoban, to study LLMs' abilities to persuade and be rationally vigilant towards other LLM agents. We find that puzzle-solving performance, persuasive capability, and vigilance are dissociable capacities in LLMs. Performing well on the game does not automatically mean a model can detect when it is being misled, even if the possibility of deception is explicitly mentioned. However, LLMs do consistently modulate their token use, using fewer tokens to reason when advice is benevolent and more when it is malicious, even if they are still persuaded to take actions leading them to failure. To our knowledge, our work presents the first investigation of the relationship between persuasion, vigilance, and task performance in LLMs, and suggests that monitoring all three independently will be critical for future work in AI safety.

AI Gamestore: Scalable, Open-Ended Evaluation of Machine General Intelligence with Human Games

Rigorously evaluating machine intelligence against the broad spectrum of human general intelligence has become increasingly important and challenging in this era of rapid technological advance. Conventional AI benchmarks typically assess only narrow capabilities in a limited range of human activity. Most are also static, quickly saturating as developers explicitly or implicitly optimize for them. We propose that a more promising way to evaluate human-like general intelligence in AI systems is through a particularly strong form of general game playing: studying how and how well they play and learn to play \textbf{all conceivable human games}, in comparison to human players with the same level of experience, time, or other resources. We define a "human game" to be a game designed by humans for humans, and argue for the evaluative suitability of this space of all such games people can imagine and enjoy -- the "Multiverse of Human Games". Taking a first step towards this vision, we introduce the AI GameStore, a scalable and open-ended platform that uses LLMs with humans-in-the-loop to synthesize new representative human games, by automatically sourcing and adapting standardized and containerized variants of game environments from popular human digital gaming platforms. As a proof of concept, we generated 100 such games based on the top charts of Apple App Store and Steam, and evaluated seven frontier vision-language models (VLMs) on short episodes of play. The best models achieved less than 10\% of the human average score on the majority of the games, and especially struggled with games that challenge world-model learning, memory and planning. We conclude with a set of next steps for building out the AI GameStore as a practical way to measure and drive progress toward human-like general intelligence in machines.

A Matter of Interest: Understanding Interestingness of Math Problems in Humans and Language Models

The evolution of mathematics has been guided in part by interestingness. From researchers choosing which problems to tackle next, to students deciding which ones to engage with, people's choices are often guided by judgments about how interesting or challenging problems are likely to be. As AI systems, such as LLMs, increasingly participate in mathematics with people -- whether for advanced research or education -- it becomes important to understand how well their judgments align with human ones. Our work examines this alignment through two empirical studies of human and LLM assessment of mathematical interestingness and difficulty, spanning a range of mathematical experience. We study two groups: participants from a crowdsourcing platform and International Math Olympiad competitors. We show that while many LLMs appear to broadly agree with human notions of interestingness, they mostly do not capture the distribution observed in human judgments. Moreover, most LLMs only somewhat align with why humans find certain math problems interesting, showing weak correlation with human-selected interestingness rationales. Together, our findings highlight both the promises and limitations of current LLMs in capturing human interestingness judgments for mathematical AI thought partnerships.

What's in the Box? Reasoning about Unseen Objects from Multimodal Cues

People regularly make inferences about objects in the world that they cannot see by flexibly integrating information from multiple sources: auditory and visual cues, language, and our prior beliefs and knowledge about the scene. How are we able to so flexibly integrate many sources of information to make sense of the world around us, even if we have no direct knowledge? In this work, we propose a neurosymbolic model that uses neural networks to parse open-ended multimodal inputs and then applies a Bayesian model to integrate different sources of information to evaluate different hypotheses. We evaluate our model with a novel object guessing game called ``What's in the Box?'' where humans and models watch a video clip of an experimenter shaking boxes and then try to guess the objects inside the boxes. Through a human experiment, we show that our model correlates strongly with human judgments, whereas unimodal ablated models and large multimodal neural model baselines show poor correlation.

Identifying, Evaluating, and Mitigating Risks of AI Thought Partnerships

Artificial Intelligence (AI) systems have historically been used as tools that execute narrowly defined tasks. Yet recent advances in AI have unlocked possibilities for a new class of models that genuinely collaborate with humans in complex reasoning, from conceptualizing problems to brainstorming solutions. Such AI thought partners enable novel forms of collaboration and extended cognition, yet they also pose major risks-including and beyond risks of typical AI tools and agents. In this commentary, we systematically identify risks of AI thought partners through a novel framework that identifies risks at multiple levels of analysis, including Real-time, Individual, and Societal risks arising from collaborative cognition (RISc). We leverage this framework to propose concrete metrics for risk evaluation, and finally suggest specific mitigation strategies for developers and policymakers. As AI thought partners continue to proliferate, these strategies can help prevent major harms and ensure that humans actively benefit from productive thought partnerships.

When Should We Orchestrate Multiple Agents?

Strategies for orchestrating the interactions between multiple agents, both human and artificial, can wildly overestimate performance and underestimate the cost of orchestration. We design a framework to orchestrate agents under realistic conditions, such as inference costs or availability constraints. We show theoretically that orchestration is only effective if there are performance or cost differentials between agents. We then empirically demonstrate how orchestration between multiple agents can be helpful for selecting agents in a simulated environment, picking a learning strategy in the infamous Rogers' Paradox from social science, and outsourcing tasks to other agents during a question-answer task in a user study.

General Scales Unlock AI Evaluation with Explanatory and Predictive Power

Ensuring safe and effective use of AI requires understanding and anticipating its performance on novel tasks, from advanced scientific challenges to transformed workplace activities. So far, benchmarking has guided progress in AI, but it has offered limited explanatory and predictive power for general-purpose AI systems, given the low transferability across diverse tasks. In this paper, we introduce general scales for AI evaluation that can explain what common AI benchmarks really measure, extract ability profiles of AI systems, and predict their performance for new task instances, in- and out-of-distribution. Our fully-automated methodology builds on 18 newly-crafted rubrics that place instance demands on general scales that do not saturate. Illustrated for 15 large language models and 63 tasks, high explanatory power is unleashed from inspecting the demand and ability profiles, bringing insights on the sensitivity and specificity exhibited by different benchmarks, and how knowledge, metacognition and reasoning are affected by model size, chain-of-thought and distillation. Surprisingly, high predictive power at the instance level becomes possible using these demand levels, providing superior estimates over black-box baseline predictors based on embeddings or finetuning, especially in out-of-distribution settings (new tasks and new benchmarks). The scales, rubrics, battery, techniques and results presented here represent a major step for AI evaluation, underpinning the reliable deployment of AI in the years ahead.

On Benchmarking Human-Like Intelligence in Machines

Recent benchmark studies have claimed that AI has approached or even surpassed human-level performances on various cognitive tasks. However, this position paper argues that current AI evaluation paradigms are insufficient for assessing human-like cognitive capabilities. We identify a set of key shortcomings: a lack of human-validated labels, inadequate representation of human response variability and uncertainty, and reliance on simplified and ecologically-invalid tasks. We support our claims by conducting a human evaluation study on ten existing AI benchmarks, suggesting significant biases and flaws in task and label designs. To address these limitations, we propose five concrete recommendations for developing future benchmarks that will enable more rigorous and meaningful evaluations of human-like cognitive capacities in AI with various implications for such AI applications.