AutoMedBench: Towards Medical AutoResearch with Agentic AI Models

Autonomous agents are increasingly expected to support end-to-end medical-AI research workflows, moving beyond isolated prediction tasks or short-form clinical question answering. However, existing medical agent benchmarks primarily evaluate final outputs, providing limited visibility into agent behavior within the research process. To address this gap, we present AutoMedBench, a workflow-aware benchmark for autonomous medical-AI research across diverse medical imaging and multimodal inference tasks, organizing agent execution into a unified five-stage workflow (S1-S5): Plan, Setup, Validate, Inference, and Submit. It comprises long-horizon tasks with each run averaging 33 agent turns, spanning five research tracks: segmentation, image enhancement, visual question answering (VQA), report generation, and lesion detection. Each task is evaluated under two difficulty tiers, Lite and Standard, which use the same data and metrics but differ in the amount of task-brief scaffolding, and each run is scored using both final task performance and S1-S5 stage scores, enabling stage-level analysis from the initial task brief to the final submitted artifact. Across thousands of recorded runs, stage-level scoring reveals that Validate is the weakest workflow stage on average, whereas Setup is the strongest, suggesting that current agents are better at making pipelines executable than at verifying their reliability. Post-run error analysis further shows that verification and submission failures dominate tagged errors, accounting for 37.7% and 38.1% of fired codes respectively, whereas task-understanding errors are rare at 0.9%, and runs with one fired error code have a 48% lower overall score than runs with no error code on average.

Automated Formal Proofs of Combinatorial Identities via Wilf-Zeilberger Guidance and LLMs

Automating formal proofs of combinatorial identities is challenging for LLM-based provers, as long-horizon proof planning is required and unconstrained search quickly explodes. Symbolic methods such as the Wilf-Zeilberger (WZ) method can achieve a mechanized proof of combinatorial identities by constructing special auxiliary functions and demonstrating that they satisfy specific recurrence relations. We propose WZ-LLM, a neuro-symbolic framework that turns WZ proof plans into executable proof sketches in Lean 4 and uses an LLM-based prover to discharge the resulting machine-checkable subgoals. We also train a dedicated WZ-Prover via a Lean-kernel-verified bootstrapping loop with expert-verified iteration, followed by DAPO-based refinement. Experiments show that WZ-LLM achieves a 34% proof success rate on LCI-Test (100 classic combinatorial identities), outperforming strong baselines such as DeepSeek-V3 and Goedel-Prover-V2, and delivering consistent gains on CombiBench and PutnamBench-Comb. These results indicate that our framework provides two complementary strengths: improved direct proving for identities beyond the scope of WZ, and substantially higher end-to-end success when WZ sketches guide a specialized prover.

RMGS-SLAM: Real-time Multi-sensor Gaussian Splatting SLAM

Real-time 3D Gaussian splatting (3DGS)-based Simultaneous Localization and Mapping (SLAM) in large-scale real-world environments remains challenging, as existing methods often struggle to jointly achieve low-latency pose estimation, 3D Gaussian reconstruction in step with incoming sensor streams, and long-term global consistency. In this paper, we present a tightly coupled LiDAR-Inertial-Visual (LIV) 3DGS-based SLAM framework for real-time pose estimation and photorealistic mapping in large-scale real-world scenes. The system executes state estimation and 3D Gaussian primitive initialization in parallel with global Gaussian optimization, thereby enabling continuous dense mapping. To improve Gaussian initialization quality and accelerate optimization convergence, we introduce a cascaded strategy that combines feed-forward predictions with voxel-based principal component analysis (voxel-PCA) geometric priors. To enhance global consistency in large scenes, we further perform loop closure directly on the optimized global Gaussian map by estimating loop constraints through Gaussian-based Generalized Iterative Closest Point (GICP) registration, followed by pose-graph optimization. In addition, we collected challenging large-scale looped outdoor SLAM sequences with hardware-synchronized LiDAR-camera-IMU and ground-truth trajectories to support realistic and comprehensive evaluation. Extensive experiments on both public datasets and our dataset demonstrate that the proposed method achieves a strong balance among real-time efficiency, localization accuracy, and rendering quality across diverse and challenging real-world scenes.

Multi-task Just Recognizable Difference for Video Coding for Machines: Database, Model, and Coding Application

Just Recognizable Difference (JRD) boosts coding efficiency for machine vision through visibility threshold modeling, but is currently limited to a single-task scenario. To address this issue, we propose a Multi-Task JRD (MT-JRD) dataset and an Attribute-assisted MT-JRD (AMT-JRD) model for Video Coding for Machines (VCM), enhancing both prediction accuracy and coding efficiency. First, we construct a dataset comprising 27,264 JRD annotations from machines, supporting three representative tasks including object detection, instance segmentation, and keypoint detection. Secondly, we propose the AMT-JRD prediction model, which integrates Generalized Feature Extraction Module (GFEM) and Specialized Feature Extraction Module (SFEM) to facilitate joint learning across multiple tasks. Thirdly, we innovatively incorporate object attribute information into object-wise JRD prediction through the Attribute Feature Fusion Module (AFFM), which introduces prior knowledge about object size and location. This design effectively compensates for the limitations of relying solely on image features and enhances the model's capacity to represent the perceptual mechanisms of machine vision. Finally, we apply the AMT-JRD model to VCM, where the accurately predicted JRDs are applied to reduce the coding bit rate while preserving accuracy across multiple machine vision tasks. Extensive experimental results demonstrate that AMT-JRD achieves precise and robust multi-task prediction with a mean absolute error of 3.781 and error variance of 5.332 across three tasks, outperforming the state-of-the-art single-task prediction model by 6.7% and 6.3%, respectively. Coding experiments further reveal that compared to the baseline VVC and JPEG, the AMT-JRD-based VCM improves an average of 3.861% and 7.886% Bjontegaard Delta-mean Average Precision (BD-mAP), respectively.

Distilling Photon-Counting CT into Routine Chest CT through Clinically Validated Degradation Modeling

Photon-counting CT (PCCT) provides superior image quality with higher spatial resolution and lower noise compared to conventional energy-integrating CT (EICT), but its limited clinical availability restricts large-scale research and clinical deployment. To bridge this gap, we propose SUMI, a simulated degradation-to-enhancement method that learns to reverse realistic acquisition artifacts in low-quality EICT by leveraging high-quality PCCT as reference. Our central insight is to explicitly model realistic acquisition degradations, transforming PCCT into clinically plausible lower-quality counterparts and learning to invert this process. The simulated degradations were validated for clinical realism by board-certified radiologists, enabling faithful supervision without requiring paired acquisitions at scale. As outcomes of this technical contribution, we: (1) train a latent diffusion model on 1,046 PCCTs, using an autoencoder first pre-trained on both these PCCTs and 405,379 EICTs from 145 hospitals to extract general CT latent features that we release for reuse in other generative medical imaging tasks; (2) construct a large-scale dataset of over 17,316 publicly available EICTs enhanced to PCCT-like quality, with radiologist-validated voxel-wise annotations of airway trees, arteries, veins, lungs, and lobes; and (3) demonstrate substantial improvements: across external data, SUMI outperforms state-of-the-art image translation methods by 15% in SSIM and 20% in PSNR, improves radiologist-rated clinical utility in reader studies, and enhances downstream top-ranking lesion detection performance, increasing sensitivity by up to 15% and F1 score by up to 10%. Our results suggest that emerging imaging advances can be systematically distilled into routine EICT using limited high-quality scans as reference.

Mechanic: Sorrifier-Driven Formal Decomposition Workflow for Automated Theorem Proving

Recent advances in large language models (LLMs) and LLM-based agents have substantially improved the capabilities of automated theorem proving. However, for problems requiring complex mathematical reasoning, current systems rarely succeed on the first try and must repeatedly modify their proof strategies. Existing approaches for handling failed attempts typically either discard the entire proof and regenerate it from scratch or iteratively fix errors within the proof. The former is inefficient, as it may abandon mostly correct reasoning due to localized errors, while the latter, although preserving prior progress, leads to progressively longer contexts which progressively degrades the model's ability to attend to the remaining unresolved subproblems. To address this dilemma, we propose Mechanic, a novel agent system that employs a sorry-driven formal decomposition strategy. By leveraging the sorry placeholder in Lean to precisely isolate unresolved subgoals while preserving the surrounding verified proof structure, Mechanic extracts each failed subproblem into a clean, self-contained context and resolves it independently. This avoids both the waste of full regeneration and the excessive context length induced by repeated repairs. Experimental results on challenging mathematical competition benchmarks, including IMO 2025 and Putnam 2025, demonstrate that our agent achieves significant advantages in proving efficiency.

Atomic Trajectory Modeling with State Space Models for Biomolecular Dynamics

Understanding the dynamic behavior of biomolecules is fundamental to elucidating biological function and facilitating drug discovery. While Molecular Dynamics (MD) simulations provide a rigorous physical basis for studying these dynamics, they remain computationally expensive for long timescales. Conversely, recent deep generative models accelerate conformation generation but are typically either failing to model temporal relationship or built only for monomeric proteins. To bridge this gap, we introduce ATMOS, a novel generative framework based on State Space Models (SSM) designed to generate atom-level MD trajectories for biomolecular systems. ATMOS integrates a Pairformer-based state transition mechanism to capture long-range temporal dependencies, with a diffusion-based module to decode trajectory frames in an autoregressive manner. ATMOS is trained across crystal structures from PDB and conformation trajectory from large-scale MD simulation datasets including mdCATH and MISATO. We demonstrate that ATMOS achieves state-of-the-art performance in generating conformation trajectories for both protein monomers and complex protein-ligand systems. By enabling efficient inference of atomic trajectory of motions, this work establishes a promising foundation for modeling biomolecular dynamics.

Tele-Omni: a Unified Multimodal Framework for Video Generation and Editing

Recent advances in diffusion-based video generation have substantially improved visual fidelity and temporal coherence. However, most existing approaches remain task-specific and rely primarily on textual instructions, limiting their ability to handle multimodal inputs, contextual references, and diverse video generation and editing scenarios within a unified framework. Moreover, many video editing methods depend on carefully engineered pipelines tailored to individual operations, which hinders scalability and composability. In this paper, we propose Tele-Omni, a unified multimodal framework for video generation and editing that follows multimodal instructions, including text, images, and reference videos, within a single model. Tele-Omni leverages pretrained multimodal large language models to parse heterogeneous instructions and infer structured generation or editing intents, while diffusion-based generators perform high-quality video synthesis conditioned on these structured signals. To enable joint training across heterogeneous video tasks, we introduce a task-aware data processing pipeline that unifies multimodal inputs into a structured instruction format while preserving task-specific constraints. Tele-Omni supports a wide range of video-centric tasks, including text-to-video generation, image-to-video generation, first-last-frame video generation, in-context video generation, and in-context video editing. By decoupling instruction parsing from video synthesis and combining it with task-aware data design, Tele-Omni achieves flexible multimodal control while maintaining strong temporal coherence and visual consistency. Experimental results demonstrate that Tele-Omni achieves competitive performance across multiple tasks.

Numina-Lean-Agent: An Open and General Agentic Reasoning System for Formal Mathematics

Agentic systems have recently become the dominant paradigm for formal theorem proving, achieving strong performance by coordinating multiple models and tools. However, existing approaches often rely on task-specific pipelines and trained formal provers, limiting their flexibility and reproducibility. In this paper, we propose the paradigm that directly uses a general coding agent as a formal math reasoner. This paradigm is motivated by (1) A general coding agent provides a natural interface for diverse reasoning tasks beyond proving, (2) Performance can be improved by simply replacing the underlying base model, without training, and (3) MCP enables flexible extension and autonomous calling of specialized tools, avoiding complex design. Based on this paradigm, we introduce Numina-Lean-Agent, which combines Claude Code with Numina-Lean-MCP to enable autonomous interaction with Lean, retrieval of relevant theorems, informal proving and auxiliary reasoning tools. Using Claude Opus 4.5 as the base model, Numina-Lean-Agent solves all problems in Putnam 2025 (12 / 12), matching the best closed-source system. Beyond benchmark evaluation, we further demonstrate its generality by interacting with mathematicians to successfully formalize the Brascamp-Lieb theorem. We release Numina-Lean-Agent and all solutions at https://github.com/project-numina/numina-lean-agent.

TeleWorld: Towards Dynamic Multimodal Synthesis with a 4D World Model

World models aim to endow AI systems with the ability to represent, generate, and interact with dynamic environments in a coherent and temporally consistent manner. While recent video generation models have demonstrated impressive visual quality, they remain limited in real-time interaction, long-horizon consistency, and persistent memory of dynamic scenes, hindering their evolution into practical world models. In this report, we present TeleWorld, a real-time multimodal 4D world modeling framework that unifies video generation, dynamic scene reconstruction, and long-term world memory within a closed-loop system. TeleWorld introduces a novel generation-reconstruction-guidance paradigm, where generated video streams are continuously reconstructed into a dynamic 4D spatio-temporal representation, which in turn guides subsequent generation to maintain spatial, temporal, and physical consistency. To support long-horizon generation with low latency, we employ an autoregressive diffusion-based video model enhanced with Macro-from-Micro Planning (MMPL)--a hierarchical planning method that reduces error accumulation from frame-level to segment-level-alongside efficient Distribution Matching Distillation (DMD), enabling real-time synthesis under practical computational budgets. Our approach achieves seamless integration of dynamic object modeling and static scene representation within a unified 4D framework, advancing world models toward practical, interactive, and computationally accessible systems. Extensive experiments demonstrate that TeleWorld achieves strong performance in both static and dynamic world understanding, long-term consistency, and real-time generation efficiency, positioning it as a practical step toward interactive, memory-enabled world models for multimodal generation and embodied intelligence.