Breast tumor classification based on self-supervised contrastive learning from ultrasound videos

Background: Breast ultrasound is prominently used in diagnosing breast tumors. At present, many automatic systems based on deep learning have been developed to help radiologists in diagnosis. However, training such systems remains challenging because they are usually data-hungry and demand amounts of labeled data, which need professional knowledge and are expensive. Methods: We adopted a triplet network and a self-supervised contrastive learning technique to learn representations from unlabeled breast ultrasound video clips. We further designed a new hard triplet loss to to learn representations that particularly discriminate positive and negative image pairs that are hard to recognize. We also constructed a pretraining dataset from breast ultrasound videos (1,360 videos from 200 patients), which includes an anchor sample dataset with 11,805 images, a positive sample dataset with 188,880 images, and a negative sample dataset dynamically generated from video clips. Further, we constructed a finetuning dataset, including 400 images from 66 patients. We transferred the pretrained network to a downstream benign/malignant classification task and compared the performance with other state-of-the-art models, including three models pretrained on ImageNet and a previous contrastive learning model retrained on our datasets. Results and conclusion: Experiments revealed that our model achieved an area under the receiver operating characteristic curve (AUC) of 0.952, which is significantly higher than the others. Further, we assessed the dependence of our pretrained model on the number of labeled data and revealed that <100 samples were required to achieve an AUC of 0.901. The proposed framework greatly reduces the demand for labeled data and holds potential for use in automatic breast ultrasound image diagnosis.

PatchFinder: A Two-Phase Approach to Security Patch Tracing for Disclosed Vulnerabilities in Open-Source Software

Open-source software (OSS) vulnerabilities are increasingly prevalent, emphasizing the importance of security patches. However, in widely used security platforms like NVD, a substantial number of CVE records still lack trace links to patches. Although rank-based approaches have been proposed for security patch tracing, they heavily rely on handcrafted features in a single-step framework, which limits their effectiveness. In this paper, we propose PatchFinder, a two-phase framework with end-to-end correlation learning for better-tracing security patches. In the **initial retrieval** phase, we employ a hybrid patch retriever to account for both lexical and semantic matching based on the code changes and the description of a CVE, to narrow down the search space by extracting those commits as candidates that are similar to the CVE descriptions. Afterwards, in the **re-ranking** phase, we design an end-to-end architecture under the supervised fine-tuning paradigm for learning the semantic correlations between CVE descriptions and commits. In this way, we can automatically rank the candidates based on their correlation scores while maintaining low computation overhead. We evaluated our system against 4,789 CVEs from 532 OSS projects. The results are highly promising: PatchFinder achieves a Recall@10 of 80.63% and a Mean Reciprocal Rank (MRR) of 0.7951. Moreover, the Manual Effort@10 required is curtailed to 2.77, marking a 1.94 times improvement over current leading methods. When applying PatchFinder in practice, we initially identified 533 patch commits and submitted them to the official, 482 of which have been confirmed by CVE Numbering Authorities.

Learn to Preserve and Diversify: Parameter-Efficient Group with Orthogonal Regularization for Domain Generalization

Domain generalization (DG) aims to avoid the performance degradation of the model when the distribution shift between the limited training data and unseen test data occurs. Recently, foundation models with enormous parameters have been pre-trained with huge datasets, demonstrating strong generalization ability and showing promising direction for solving the DG problem. However, fully Fine-Tuning (FT) the foundation models results in unsatisfactory out-of-distribution accuracy due to the destroyed pre-trained generalized features. Recently, Parameter-Efficient Fine-Tuning (PEFT) alleviates the above problem by fine-tuning a small portion of the model parameters while keeping the rest frozen, which achieves better generalization performance compared to FT. Nevertheless, PEFT still suffers from the issue of overfitting to the training domains. To address the above issue, we propose Parameter-Efficient Group with Orthogonal regularization (PEGO) for vision transformers, which effectively preserves the generalization ability of the pre-trained network and learns more diverse knowledge compared with conventional PEFT. Specifically, we inject a group of trainable Low-Rank Adaptation (LoRA) modules into the pre-trained model and propose an orthogonal regularization loss to enhance the generalization ability of the model. Our framework achieves SOTA performance on five DG benchmarks, while only requiring training a small number of parameters without adding additional testing cost.

The Devil is in the Statistics: Mitigating and Exploiting Statistics Difference for Generalizable Semi-supervised Medical Image Segmentation

Despite the recent success of domain generalization in medical image segmentation, voxel-wise annotation for all source domains remains a huge burden. Semi-supervised domain generalization has been proposed very recently to combat this challenge by leveraging limited labeled data along with abundant unlabeled data collected from multiple medical institutions, depending on precisely harnessing unlabeled data while improving generalization simultaneously. In this work, we observe that domain shifts between medical institutions cause disparate feature statistics, which significantly deteriorates pseudo-label quality due to an unexpected normalization process. Nevertheless, this phenomenon could be exploited to facilitate unseen domain generalization. Therefore, we propose 1) multiple statistics-individual branches to mitigate the impact of domain shifts for reliable pseudo-labels and 2) one statistics-aggregated branch for domain-invariant feature learning. Furthermore, to simulate unseen domains with statistics difference, we approach this from two aspects, i.e., a perturbation with histogram matching at image level and a random batch normalization selection strategy at feature level, producing diverse statistics to expand the training distribution. Evaluation results on three medical image datasets demonstrate the effectiveness of our method compared with recent SOTA methods. The code is available at https://github.com/qiumuyang/SIAB.

Retrieval Augmented Instruction Tuning for Open NER with Large Language Models

The strong capability of large language models (LLMs) has been applied to information extraction (IE) through either retrieval augmented prompting or instruction tuning (IT). However, the best way to incorporate information with LLMs for IE remains an open question. In this paper, we explore Retrieval Augmented Instruction Tuning (RA-IT) for IE, focusing on the task of open named entity recognition (NER). Specifically, for each training sample, we retrieve semantically similar examples from the training dataset as the context and prepend them to the input of the original instruction. To evaluate our RA-IT approach more thoroughly, we construct a Chinese IT dataset for open NER and evaluate RA-IT in both English and Chinese scenarios. Experimental results verify the effectiveness of RA-IT across various data sizes and in both English and Chinese scenarios. We also conduct thorough studies to explore the impacts of various retrieval strategies in the proposed RA-IT framework. Code and data are available at: https://github.com/Emma1066/Retrieval-Augmented-IT-OpenNER

Self-reconfigurable Multifunctional Memristive Nociceptor for Intelligent Robotics

Artificial nociceptors, mimicking human-like stimuli perception, are of significance for intelligent robotics to work in hazardous and dynamic scenarios. One of the most essential characteristics of the human nociceptor is its self-adjustable attribute, which indicates that the threshold of determination of a potentially hazardous stimulus relies on environmental knowledge. This critical attribute has been currently omitted, but it is highly desired for artificial nociceptors. Inspired by these shortcomings, this article presents, for the first time, a Self-Directed Channel (SDC) memristor-based self-reconfigurable nociceptor, capable of perceiving hazardous pressure stimuli under different temperatures and demonstrates key features of tactile nociceptors, including 'threshold,' 'no-adaptation,' and 'sensitization.' The maximum amplification of hazardous external stimuli is 1000%, and its response characteristics dynamically adapt to current temperature conditions by automatically altering the generated modulation schemes for the memristor. The maximum difference ratio of the response of memristors at different temperatures is 500%, and this adaptability closely mimics the functions of biological tactile nociceptors, resulting in accurate danger perception in various conditions. Beyond temperature adaptation, this memristor-based nociceptor has the potential to integrate different sensory modalities by applying various sensors, thereby achieving human-like perception capabilities in real-world environments.

GraphStorm: all-in-one graph machine learning framework for industry applications

Graph machine learning (GML) is effective in many business applications. However, making GML easy to use and applicable to industry applications with massive datasets remain challenging. We developed GraphStorm, which provides an end-to-end solution for scalable graph construction, graph model training and inference. GraphStorm has the following desirable properties: (a) Easy to use: it can perform graph construction and model training and inference with just a single command; (b) Expert-friendly: GraphStorm contains many advanced GML modeling techniques to handle complex graph data and improve model performance; (c) Scalable: every component in GraphStorm can operate on graphs with billions of nodes and can scale model training and inference to different hardware without changing any code. GraphStorm has been used and deployed for over a dozen billion-scale industry applications after its release in May 2023. It is open-sourced in Github: https://github.com/awslabs/graphstorm.

OpenGaussian: Towards Point-Level 3D Gaussian-based Open Vocabulary Understanding

This paper introduces OpenGaussian, a method based on 3D Gaussian Splatting (3DGS) capable of 3D point-level open vocabulary understanding. Our primary motivation stems from observing that existing 3DGS-based open vocabulary methods mainly focus on 2D pixel-level parsing. These methods struggle with 3D point-level tasks due to weak feature expressiveness and inaccurate 2D-3D feature associations. To ensure robust feature presentation and 3D point-level understanding, we first employ SAM masks without cross-frame associations to train instance features with 3D consistency. These features exhibit both intra-object consistency and inter-object distinction. Then, we propose a two-stage codebook to discretize these features from coarse to fine levels. At the coarse level, we consider the positional information of 3D points to achieve location-based clustering, which is then refined at the fine level. Finally, we introduce an instance-level 3D-2D feature association method that links 3D points to 2D masks, which are further associated with 2D CLIP features. Extensive experiments, including open vocabulary-based 3D object selection, 3D point cloud understanding, click-based 3D object selection, and ablation studies, demonstrate the effectiveness of our proposed method. Project page: https://3d-aigc.github.io/OpenGaussian

Real-Time State Modulation and Acquisition Circuit in Neuromorphic Memristive Systems

Memristive neuromorphic systems are designed to emulate human perception and cognition, where the memristor states represent essential historical information to perform both low-level and high-level tasks. However, current systems face challenges with the separation of state modulation and acquisition, leading to undesired time delays that impact real-time performance. To overcome this issue, we introduce a dual-function circuit that concurrently modulates and acquires memristor state information. This is achieved through two key features: 1) a feedback operational amplifier (op-amp) based circuit that ensures precise voltage application on the memristor while converting the passing current into a voltage signal; 2) a division calculation circuit that acquires state information from the modulation voltage and the converted voltage, improving stability by leveraging the intrinsic threshold characteristics of memristors. This circuit has been evaluated in a memristor-based nociceptor and a memristor crossbar, demonstrating exceptional performance. For instance, it achieves mean absolute acquisition errors below 1 {\Omega} during the modulation process in the nociceptor application. These results demonstrate that the proposed circuit can operate at different scales, holding the potential to enhance a wide range of neuromorphic applications.

Fourier123: One Image to High-Quality 3D Object Generation with Hybrid Fourier Score Distillation

Single image-to-3D generation is pivotal for crafting controllable 3D assets. Given its underconstrained nature, we leverage geometric priors from a 3D novel view generation diffusion model and appearance priors from a 2D image generation method to guide the optimization process. We note that a disparity exists between the training datasets of 2D and 3D diffusion models, leading to their outputs showing marked differences in appearance. Specifically, 2D models tend to deliver more detailed visuals, whereas 3D models produce consistent yet over-smooth results across different views. Hence, we optimize a set of 3D Gaussians using 3D priors in spatial domain to ensure geometric consistency, while exploiting 2D priors in the frequency domain through Fourier transform for higher visual quality. This 2D-3D hybrid Fourier Score Distillation objective function (dubbed hy-FSD), can be integrated into existing 3D generation methods, yielding significant performance improvements. With this technique, we further develop an image-to-3D generation pipeline to create high-quality 3D objects within one minute, named Fourier123. Extensive experiments demonstrate that Fourier123 excels in efficient generation with rapid convergence speed and visual-friendly generation results.