Antigen-specific Antibody Multi-modal Foundation Model for Functional Antibody Design

Antibodies are essential proteins that play a central role in immune recognition by binding specific antigen molecules. Although recent protein language models have enabled progress in single-chain protein modeling and generation, they often fall short in antigen-specific antibody design, where effective modeling requires explicit pairing between antibody and antigen, particularly at the epitope level. To address these limitations, we introduce AAMFM, an Antigen-specific Antibody Multimodal Foundation Model that learns unified representations of antibody sequences and structures conditioned on antigen context. AAMFM incorporates rich antigen information including geometric interfaces and epitope annotations via a cross-modal adapter, enabling joint modeling of antibody-antigen interactions in a shared latent space. To further guide the model toward functional relevance, we fine-tune AAMFM using Calibrated Direct Preference Optimization (Cal-DPO), leveraging preference signals extracted from a strong structural prior to align learning with binding-specific objectives. Extensive experiments demonstrate that AAMFM achieves state-of-the-art performance in functional antibody design, revealing its potential for antigen-specific antibody engineering. Our code is available at https://github.com/XL-S224/AAMFM.

Online KL-Regularized Reinforcement Learning with Function Approximation under Misspecification

We study KL-regularized contextual bandits and episodic reinforcement learning (RL) under general function approximation with model misspecification. Existing guarantees rely on realizability and therefore do not extend to misspecified models, where classical regret bounds may fail. This work introduces KL misspecification formulations for contextual bandits and episodic RL and analyzes regression-based algorithms with Gibbs policy updates. High-probability KL-regret guarantees with explicit misspecification terms are established, recovering the standard realizable KL-regularized setting as a special case.

Proof-Refactor: Refactoring Generated Formal Proofs into Modular Artifacts

While Large Language Models (LLMs) have shown strong performance in generating formal proofs, their outputs often remain less readable, modular, maintainable, and reusable than proofs in mature formal mathematics libraries. We argue that this gap stems in part from the compile-first objective implicit in most proof-generation pipelines, which encourages monolithic or ad hoc proof scripts rather than library-quality artifacts. Existing approaches to proof-quality improvement often rely on explicit, computable optimization objectives. In practice, however, the most tractable and experimentally validated objectives are largely length-based, while higher-level qualities such as readability, modularity, maintainability, and reusability are difficult to reduce to reliable automatic metrics. Instead of optimizing proof improvement against a single proxy metric, we take a process-guided approach inspired by human proof-refactoring workflows. We propose an agentic framework $\textbf{Proof-Refactor}$ that decomposes proof refactoring into four phases: extracting candidate proof fragments, designing helper declarations, formally proving the extracted and designed components, and repairing the original proof using the verified components. On generated Lean proofs from PutnamBench and Putnam2025, Proof-Refactor improves rubric-based refactoring scores over a strong Claude Code refactoring baseline, with the largest gains in signature quality and human readability. These results suggest that process-guided refactoring can improve proof structure without treating proof length as the primary objective.

Automated Conjecture Resolution with Formal Verification

Recent advances in large language models have significantly improved their ability to perform mathematical reasoning, extending from elementary problem solving to increasingly capable performance on research-level problems. However, reliably solving and verifying such problems remains challenging due to the inherent ambiguity of natural language reasoning. In this paper, we propose an automated framework for tackling research-level mathematical problems that integrates natural language reasoning with formal verification, enabling end-to-end problem solving with minimal human intervention. Our framework consists of two components: an informal reasoning agent, Rethlas, and a formal verification agent, Archon. Rethlas mimics the workflow of human mathematicians by combining reasoning primitives with our theorem search engine, Matlas, to explore solution strategies and construct candidate proofs. Archon, equipped with our formal theorem search engine LeanSearch, translates informal arguments into formalized Lean 4 projects through structured task decomposition, iterative refinement, and automated proof synthesis, ensuring machine-checkable correctness. Using this framework, we automatically resolve an open problem in commutative algebra and formally verify the resulting proof in Lean 4 with essentially no human involvement. Our experiments demonstrate that strong theorem retrieval tools enable the discovery and application of cross-domain mathematical techniques, while the formal agent is capable of autonomously filling nontrivial gaps in informal arguments. More broadly, our work illustrates a promising paradigm for mathematical research in which informal and formal reasoning systems, equipped with theorem retrieval tools, operate in tandem to produce verifiable results, substantially reduce human effort, and offer a concrete instantiation of human-AI collaborative mathematical research.

M2F: Automated Formalization of Mathematical Literature at Scale

Automated formalization of mathematics enables mechanical verification but remains limited to isolated theorems and short snippets. Scaling to textbooks and research papers is largely unaddressed, as it requires managing cross-file dependencies, resolving imports, and ensuring that entire projects compile end-to-end. We present M2F (Math-to-Formal), the first agentic framework for end-to-end, project-scale autoformalization in Lean. The framework operates in two stages. The statement compilation stage splits the document into atomic blocks, orders them via inferred dependencies, and repairs declaration skeletons until the project compiles, allowing placeholders in proofs. The proof repair stage closes these holes under fixed signatures using goal-conditioned local edits. Throughout both stages, M2F keeps the verifier in the loop, committing edits only when toolchain feedback confirms improvement. In approximately three weeks, M2F converts long-form mathematical sources into a project-scale Lean library of 153,853 lines from 479 pages textbooks on real analysis and convex analysis, fully formalized as Lean declarations with accompanying proofs. This represents textbook-scale formalization at a pace that would typically require months or years of expert effort. On FATE-H, we achieve $96\%$ proof success (vs.\ $80\%$ for a strong baseline). Together, these results demonstrate that practical, large-scale automated formalization of mathematical literature is within reach. The full generated Lean code from our runs is available at https://github.com/optsuite/ReasBook.git.

PKI: Prior Knowledge-Infused Neural Network for Few-Shot Class-Incremental Learning

Few-shot class-incremental learning (FSCIL) aims to continually adapt a model on a limited number of new-class examples, facing two well-known challenges: catastrophic forgetting and overfitting to new classes. Existing methods tend to freeze more parts of network components and finetune others with an extra memory during incremental sessions. These methods emphasize preserving prior knowledge to ensure proficiency in recognizing old classes, thereby mitigating catastrophic forgetting. Meanwhile, constraining fewer parameters can help in overcoming overfitting with the assistance of prior knowledge. Following previous methods, we retain more prior knowledge and propose a prior knowledge-infused neural network (PKI) to facilitate FSCIL. PKI consists of a backbone, an ensemble of projectors, a classifier, and an extra memory. In each incremental session, we build a new projector and add it to the ensemble. Subsequently, we finetune the new projector and the classifier jointly with other frozen network components, ensuring the rich prior knowledge is utilized effectively. By cascading projectors, PKI integrates prior knowledge accumulated from previous sessions and learns new knowledge flexibly, which helps to recognize old classes and efficiently learn new classes. Further, to reduce the resource consumption associated with keeping many projectors, we design two variants of the prior knowledge-infused neural network (PKIV-1 and PKIV-2) to trade off a balance between resource consumption and performance by reducing the number of projectors. Extensive experiments on three popular benchmarks demonstrate that our approach outperforms state-of-the-art methods.

Computational Mapping of Reactive Stroma in Prostate Cancer Yields Interpretable, Prognostic Biomarkers

Current histopathological grading of prostate cancer relies primarily on glandular architecture, largely overlooking the tumor microenvironment. Here, we present PROTAS, a deep learning framework that quantifies reactive stroma (RS) in routine hematoxylin and eosin (H&E) slides and links stromal morphology to underlying biology. PROTAS-defined RS is characterized by nuclear enlargement, collagen disorganization, and transcriptomic enrichment of contractile pathways. PROTAS detects RS robustly in the external Prostate, Lung, Colorectal, and Ovarian (PLCO) dataset and, using domain-adversarial training, generalizes to diagnostic biopsies. In head-to-head comparisons, PROTAS outperforms pathologists for RS detection, and spatial RS features predict biochemical recurrence independently of established prognostic variables (c-index 0.80). By capturing subtle stromal phenotypes associated with tumor progression, PROTAS provides an interpretable, scalable biomarker to refine risk stratification.

MoE3D: A Mixture-of-Experts Module for 3D Reconstruction

MoE3D is a mixture-of-experts module designed to sharpen depth boundaries and mitigate flying-point artifacts (highlighted in red) of existing feed-forward 3D reconstruction models (left side). MoE3D predicts multiple candidate depth maps and fuses them via dynamic weighting (visualized by MoE weights on the right side). When integrated with a pre-trained 3D reconstruction backbone such as VGGT, it substantially enhances reconstruction quality with minimal additional computational overhead. Best viewed digitally.

SITA: A Framework for Structure-to-Instance Theorem Autoformalization

While large language models (LLMs) have shown progress in mathematical reasoning, they still face challenges in formalizing theorems that arise from instantiating abstract structures in concrete settings. With the goal of auto-formalizing mathematical results at the research level, we develop a framework for structure-to-instance theorem autoformalization (SITA), which systematically bridges the gap between abstract mathematical theories and their concrete applications in Lean proof assistant. Formalized abstract structures are treated as modular templates that contain definitions, assumptions, operations, and theorems. These templates serve as reusable guides for the formalization of concrete instances. Given a specific instantiation, we generate corresponding Lean definitions and instance declarations, integrate them using Lean's typeclass mechanism, and construct verified theorems by checking structural assumptions. We incorporate LLM-based generation with feedback-guided refinement to ensure both automation and formal correctness. Experiments on a dataset of optimization problems demonstrate that SITA effectively formalizes diverse instances grounded in abstract structures.

DreamSwapV: Mask-guided Subject Swapping for Any Customized Video Editing

With the rapid progress of video generation, demand for customized video editing is surging, where subject swapping constitutes a key component yet remains under-explored. Prevailing swapping approaches either specialize in narrow domains--such as human-body animation or hand-object interaction--or rely on some indirect editing paradigm or ambiguous text prompts that compromise final fidelity. In this paper, we propose DreamSwapV, a mask-guided, subject-agnostic, end-to-end framework that swaps any subject in any video for customization with a user-specified mask and reference image. To inject fine-grained guidance, we introduce multiple conditions and a dedicated condition fusion module that integrates them efficiently. In addition, an adaptive mask strategy is designed to accommodate subjects of varying scales and attributes, further improving interactions between the swapped subject and its surrounding context. Through our elaborate two-phase dataset construction and training scheme, our DreamSwapV outperforms existing methods, as validated by comprehensive experiments on VBench indicators and our first introduced DreamSwapV-Benchmark.