ProteinZero: Self-Improving Protein Generation via Online Reinforcement Learning

Protein generative models have shown remarkable promise in protein design but still face limitations in success rate, due to the scarcity of high-quality protein datasets for supervised pretraining. We present ProteinZero, a novel framework that enables scalable, automated, and continuous self-improvement of the inverse folding model through online reinforcement learning. To achieve computationally tractable online feedback, we introduce efficient proxy reward models based on ESM-fold and a novel rapid ddG predictor that significantly accelerates evaluation speed. ProteinZero employs a general RL framework balancing multi-reward maximization, KL-divergence from a reference model, and a novel protein-embedding level diversity regularization that prevents mode collapse while promoting higher sequence diversity. Through extensive experiments, we demonstrate that ProteinZero substantially outperforms existing methods across every key metric in protein design, achieving significant improvements in structural accuracy, designability, thermodynamic stability, and sequence diversity. Most impressively, ProteinZero reduces design failure rates by approximately 36% - 48% compared to widely-used methods like ProteinMPNN, ESM-IF and InstructPLM, consistently achieving success rates exceeding 90% across diverse and complex protein folds. Notably, the entire RL run on CATH-4.3 can be done with a single 8 X GPU node in under 3 days, including reward computation. Our work establishes a new paradigm for protein design where models evolve continuously from their own generated outputs, opening new possibilities for exploring the vast protein design space.

Variational Supervised Contrastive Learning

Contrastive learning has proven to be highly efficient and adaptable in shaping representation spaces across diverse modalities by pulling similar samples together and pushing dissimilar ones apart. However, two key limitations persist: (1) Without explicit regulation of the embedding distribution, semantically related instances can inadvertently be pushed apart unless complementary signals guide pair selection, and (2) excessive reliance on large in-batch negatives and tailored augmentations hinders generalization. To address these limitations, we propose Variational Supervised Contrastive Learning (VarCon), which reformulates supervised contrastive learning as variational inference over latent class variables and maximizes a posterior-weighted evidence lower bound (ELBO) that replaces exhaustive pair-wise comparisons for efficient class-aware matching and grants fine-grained control over intra-class dispersion in the embedding space. Trained exclusively on image data, our experiments on CIFAR-10, CIFAR-100, ImageNet-100, and ImageNet-1K show that VarCon (1) achieves state-of-the-art performance for contrastive learning frameworks, reaching 79.36% Top-1 accuracy on ImageNet-1K and 78.29% on CIFAR-100 with a ResNet-50 encoder while converging in just 200 epochs; (2) yields substantially clearer decision boundaries and semantic organization in the embedding space, as evidenced by KNN classification, hierarchical clustering results, and transfer-learning assessments; and (3) demonstrates superior performance in few-shot learning than supervised baseline and superior robustness across various augmentation strategies.

Atomic Reasoning for Scientific Table Claim Verification

Scientific texts often convey authority due to their technical language and complex data. However, this complexity can sometimes lead to the spread of misinformation. Non-experts are particularly susceptible to misleading claims based on scientific tables due to their high information density and perceived credibility. Existing table claim verification models, including state-of-the-art large language models (LLMs), often struggle with precise fine-grained reasoning, resulting in errors and a lack of precision in verifying scientific claims. Inspired by Cognitive Load Theory, we propose that enhancing a model's ability to interpret table-based claims involves reducing cognitive load by developing modular, reusable reasoning components (i.e., atomic skills). We introduce a skill-chaining schema that dynamically composes these skills to facilitate more accurate and generalizable reasoning with a reduced cognitive load. To evaluate this, we create SciAtomicBench, a cross-domain benchmark with fine-grained reasoning annotations. With only 350 fine-tuning examples, our model trained by atomic reasoning outperforms GPT-4o's chain-of-thought method, achieving state-of-the-art results with far less training data.

DecisionFlow: Advancing Large Language Model as Principled Decision Maker

In high-stakes domains such as healthcare and finance, effective decision-making demands not just accurate outcomes but transparent and explainable reasoning. However, current language models often lack the structured deliberation needed for such tasks, instead generating decisions and justifications in a disconnected, post-hoc manner. To address this, we propose DecisionFlow, a novel decision modeling framework that guides models to reason over structured representations of actions, attributes, and constraints. Rather than predicting answers directly from prompts, DecisionFlow builds a semantically grounded decision space and infers a latent utility function to evaluate trade-offs in a transparent, utility-driven manner. This process produces decisions tightly coupled with interpretable rationales reflecting the model's reasoning. Empirical results on two high-stakes benchmarks show that DecisionFlow not only achieves up to 30% accuracy gains over strong prompting baselines but also enhances alignment in outcomes. Our work is a critical step toward integrating symbolic reasoning with LLMs, enabling more accountable, explainable, and reliable LLM decision support systems. We release the data and code at https://github.com/xiusic/DecisionFlow.

PARTONOMY: Large Multimodal Models with Part-Level Visual Understanding

Real-world objects are composed of distinctive, object-specific parts. Identifying these parts is key to performing fine-grained, compositional reasoning-yet, large multimodal models (LMMs) struggle to perform this seemingly straightforward task. In this work, we introduce PARTONOMY, an LMM benchmark designed for pixel-level part grounding. We construct PARTONOMY from existing part datasets and our own rigorously annotated set of images, encompassing 862 part labels and 534 object labels for evaluation. Unlike existing datasets that simply ask models to identify generic parts, PARTONOMY uses specialized concepts (e.g., agricultural airplane), and challenges models to compare objects' parts, consider part-whole relationships, and justify textual predictions with visual segmentations. Our experiments demonstrate significant limitations in state-of-the-art LMMs (e.g., LISA-13B achieves only 5.9% gIoU), highlighting a critical gap in their part grounding abilities. We note that existing segmentation-enabled LMMs (segmenting LMMs) have two key architectural shortcomings: they use special [SEG] tokens not seen during pretraining which induce distribution shift, and they discard predicted segmentations instead of using past predictions to guide future ones. To address these deficiencies, we train several part-centric LMMs and propose PLUM, a novel segmenting LMM that uses span tagging instead of segmentation tokens and that conditions on prior predictions in a feedback loop. We find that pretrained PLUM outperforms existing segmenting LMMs on reasoning segmentation, VQA, and visual hallucination benchmarks. In addition, PLUM finetuned on our proposed Explanatory Part Segmentation task is competitive with segmenting LMMs trained on significantly more segmentation data. Our work opens up new avenues towards enabling fine-grained, grounded visual understanding in LMMs.

Community Moderation and the New Epistemology of Fact Checking on Social Media

Social media platforms have traditionally relied on internal moderation teams and partnerships with independent fact-checking organizations to identify and flag misleading content. Recently, however, platforms including X (formerly Twitter) and Meta have shifted towards community-driven content moderation by launching their own versions of crowd-sourced fact-checking -- Community Notes. If effectively scaled and governed, such crowd-checking initiatives have the potential to combat misinformation with increased scale and speed as successfully as community-driven efforts once did with spam. Nevertheless, general content moderation, especially for misinformation, is inherently more complex. Public perceptions of truth are often shaped by personal biases, political leanings, and cultural contexts, complicating consensus on what constitutes misleading content. This suggests that community efforts, while valuable, cannot replace the indispensable role of professional fact-checkers. Here we systemically examine the current approaches to misinformation detection across major platforms, explore the emerging role of community-driven moderation, and critically evaluate both the promises and challenges of crowd-checking at scale.

ModelingAgent: Bridging LLMs and Mathematical Modeling for Real-World Challenges

Recent progress in large language models (LLMs) has enabled substantial advances in solving mathematical problems. However, existing benchmarks often fail to reflect the complexity of real-world problems, which demand open-ended, interdisciplinary reasoning and integration of computational tools. To address this gap, we introduce ModelingBench, a novel benchmark featuring real-world-inspired, open-ended problems from math modeling competitions across diverse domains, ranging from urban traffic optimization to ecosystem resource planning. These tasks require translating natural language into formal mathematical formulations, applying appropriate tools, and producing structured, defensible reports. ModelingBench also supports multiple valid solutions, capturing the ambiguity and creativity of practical modeling. We also present ModelingAgent, a multi-agent framework that coordinates tool use, supports structured workflows, and enables iterative self-refinement to generate well-grounded, creative solutions. To evaluate outputs, we further propose ModelingJudge, an expert-in-the-loop system leveraging LLMs as domain-specialized judges assessing solutions from multiple expert perspectives. Empirical results show that ModelingAgent substantially outperforms strong baselines and often produces solutions indistinguishable from those of human experts. Together, our work provides a comprehensive framework for evaluating and advancing real-world problem-solving in open-ended, interdisciplinary modeling challenges.

mCLM: A Function-Infused and Synthesis-Friendly Modular Chemical Language Model

Despite their ability to understand chemical knowledge and accurately generate sequential representations, large language models (LLMs) remain limited in their capacity to propose novel molecules with drug-like properties. In addition, the molecules that LLMs propose can often be challenging to make in the lab. To more effectively enable the discovery of functional small molecules, LLMs need to learn a molecular language. However, LLMs are currently limited by encoding molecules from atoms. In this paper, we argue that just like tokenizing texts into (sub-)word tokens instead of characters, molecules should be decomposed and reassembled at the level of functional building blocks, i.e., parts of molecules that bring unique functions and serve as effective building blocks for real-world automated laboratory synthesis. This motivates us to propose mCLM, a modular Chemical-Language Model tokenizing molecules into building blocks and learning a bilingual language model of both natural language descriptions of functions and molecule building blocks. By reasoning on such functional building blocks, mCLM guarantees to generate efficiently synthesizable molecules thanks to recent progress in block-based chemistry, while also improving the functions of molecules in a principled manner. In experiments on 430 FDA-approved drugs, we find mCLM capable of significantly improving 5 out of 6 chemical functions critical to determining drug potentials. More importantly, mCLM can reason on multiple functions and improve the FDA-rejected drugs (``fallen angels'') over multiple iterations to greatly improve their shortcomings.

Prioritizing Image-Related Tokens Enhances Vision-Language Pre-Training

In standard large vision-language models (LVLMs) pre-training, the model typically maximizes the joint probability of the caption conditioned on the image via next-token prediction (NTP); however, since only a small subset of caption tokens directly relates to the visual content, this naive NTP unintentionally fits the model to noise and increases the risk of hallucination. We present PRIOR, a simple vision-language pre-training approach that addresses this issue by prioritizing image-related tokens through differential weighting in the NTP loss, drawing from the importance sampling framework. PRIOR introduces a reference model-a text-only large language model (LLM) trained on the captions without image inputs, to weight each token based on its probability for LVLMs training. Intuitively, tokens that are directly related to the visual inputs are harder to predict without the image and thus receive lower probabilities from the text-only reference LLM. During training, we implement a token-specific re-weighting term based on the importance scores to adjust each token's loss. We implement PRIOR in two distinct settings: LVLMs with visual encoders and LVLMs without visual encoders. We observe 19% and 8% average relative improvement, respectively, on several vision-language benchmarks compared to NTP. In addition, PRIOR exhibits superior scaling properties, as demonstrated by significantly higher scaling coefficients, indicating greater potential for performance gains compared to NTP given increasing compute and data.

Must Read: A Systematic Survey of Computational Persuasion

Persuasion is a fundamental aspect of communication, influencing decision-making across diverse contexts, from everyday conversations to high-stakes scenarios such as politics, marketing, and law. The rise of conversational AI systems has significantly expanded the scope of persuasion, introducing both opportunities and risks. AI-driven persuasion can be leveraged for beneficial applications, but also poses threats through manipulation and unethical influence. Moreover, AI systems are not only persuaders, but also susceptible to persuasion, making them vulnerable to adversarial attacks and bias reinforcement. Despite rapid advancements in AI-generated persuasive content, our understanding of what makes persuasion effective remains limited due to its inherently subjective and context-dependent nature. In this survey, we provide a comprehensive overview of computational persuasion, structured around three key perspectives: (1) AI as a Persuader, which explores AI-generated persuasive content and its applications; (2) AI as a Persuadee, which examines AI's susceptibility to influence and manipulation; and (3) AI as a Persuasion Judge, which analyzes AI's role in evaluating persuasive strategies, detecting manipulation, and ensuring ethical persuasion. We introduce a taxonomy for computational persuasion research and discuss key challenges, including evaluating persuasiveness, mitigating manipulative persuasion, and developing responsible AI-driven persuasive systems. Our survey outlines future research directions to enhance the safety, fairness, and effectiveness of AI-powered persuasion while addressing the risks posed by increasingly capable language models.