Prediction of Post-Operative Renal and Pulmonary Complications Using Transformers

Postoperative complications pose a significant challenge in the healthcare industry, resulting in elevated healthcare expenses and prolonged hospital stays, and in rare instances, patient mortality. To improve patient outcomes and reduce healthcare costs, healthcare providers rely on various perioperative risk scores to guide clinical decisions and prioritize care. In recent years, machine learning techniques have shown promise in predicting postoperative complications and fatality, with deep learning models achieving remarkable success in healthcare applications. However, research on the application of deep learning models to intra-operative anesthesia management data is limited. In this paper, we evaluate the performance of transformer-based models in predicting postoperative acute renal failure, postoperative pulmonary complications, and postoperative in-hospital mortality. We compare our method's performance with state-of-the-art tabular data prediction models, including gradient boosting trees and sequential attention models, on a clinical dataset. Our results demonstrate that transformer-based models can achieve superior performance in predicting postoperative complications and outperform traditional machine learning models. This work highlights the potential of deep learning techniques, specifically transformer-based models, in revolutionizing the healthcare industry's approach to postoperative care.

InstructZero: Efficient Instruction Optimization for Black-Box Large Language Models

Large language models~(LLMs) are instruction followers, but it can be challenging to find the best instruction for different situations, especially for black-box LLMs on which backpropagation is forbidden. Instead of directly optimizing the discrete instruction, we optimize a low-dimensional soft prompt applied to an open-source LLM to generate the instruction for the black-box LLM. On each iteration of the proposed method, which we call InstructZero, a soft prompt is converted into an instruction using the open-source LLM, which is then submitted to the black-box LLM for zero-shot evaluation, and the performance is sent to Bayesian optimization to produce new soft prompts improving the zero-shot performance. We evaluate InstructZero on different combinations of open-source LLMs and APIs including Vicuna and ChatGPT. Our results show that InstructZero outperforms SOTA auto-instruction methods across a variety of downstream tasks. Our code and data are publicly available at https://github.com/Lichang-Chen/InstructZero.

Incomplete Multimodal Learning for Complex Brain Disorders Prediction

Recent advancements in the acquisition of various brain data sources have created new opportunities for integrating multimodal brain data to assist in early detection of complex brain disorders. However, current data integration approaches typically need a complete set of biomedical data modalities, which may not always be feasible, as some modalities are only available in large-scale research cohorts and are prohibitive to collect in routine clinical practice. Especially in studies of brain diseases, research cohorts may include both neuroimaging data and genetic data, but for practical clinical diagnosis, we often need to make disease predictions only based on neuroimages. As a result, it is desired to design machine learning models which can use all available data (different data could provide complementary information) during training but conduct inference using only the most common data modality. We propose a new incomplete multimodal data integration approach that employs transformers and generative adversarial networks to effectively exploit auxiliary modalities available during training in order to improve the performance of a unimodal model at inference. We apply our new method to predict cognitive degeneration and disease outcomes using the multimodal imaging genetic data from Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Experimental results demonstrate that our approach outperforms the related machine learning and deep learning methods by a significant margin.

Prompting Language-Informed Distribution for Compositional Zero-Shot Learning

The compositional zero-shot learning (CZSL) task aims to recognize unseen compositional visual concepts (i.e., sliced tomatoes), where the models are learned only from the seen compositions (i.e., sliced potatoes and red tomatoes). Thanks to the prompt tuning on large pre-trained visual language models such as CLIP, recent literature shows impressively better CZSL performance than traditional vision-based methods. However, the key aspects that impact the generalization to unseen compositions, including the diversity and informativeness of class context, and the entanglement between visual primitives (i.e., states and objects), are not properly addressed in existing CLIP-based CZSL literature. In this paper, we propose a model by prompting the language-informed distribution, aka., PLID, for the CZSL task. Specifically, the PLID leverages pre-trained large language models (LLM) to 1) formulate the language-informed class distribution, and 2) enhance the compositionality of the softly prompted class embedding. Moreover, a stochastic logit mixup strategy is proposed to dynamically fuse the decisions from the predictions in the compositional and the primitive logit space. Orthogonal to the existing literature of soft, hard, or distributional prompts, our method advocates prompting the LLM-supported class distribution that leads to a better compositional zero-shot generalization. Experimental results on MIT-States, UT-Zappos, and C-GQA datasets show the superior performance of the PLID to the prior arts. The code and models will be publicly released.

Backdoor Learning on Sequence to Sequence Models

Backdoor learning has become an emerging research area towards building a trustworthy machine learning system. While a lot of works have studied the hidden danger of backdoor attacks in image or text classification, there is a limited understanding of the model's robustness on backdoor attacks when the output space is infinite and discrete. In this paper, we study a much more challenging problem of testing whether sequence-to-sequence (seq2seq) models are vulnerable to backdoor attacks. Specifically, we find by only injecting 0.2\% samples of the dataset, we can cause the seq2seq model to generate the designated keyword and even the whole sentence. Furthermore, we utilize Byte Pair Encoding (BPE) to create multiple new triggers, which brings new challenges to backdoor detection since these backdoors are not static. Extensive experiments on machine translation and text summarization have been conducted to show our proposed methods could achieve over 90\% attack success rate on multiple datasets and models.

PTP: Boosting Stability and Performance of Prompt Tuning with Perturbation-Based Regularizer

Recent studies show that prompt tuning can better leverage the power of large language models than fine-tuning on downstream natural language understanding tasks. However, the existing prompt tuning methods have training instability issues, as the variance of scores under different random seeds is quite large. To address this critical problem, we first investigate and find that the loss landscape of vanilla prompt tuning is precipitous when it is visualized, where a slight change of input data can cause a big fluctuation in the loss landscape. This is an essential factor that leads to the instability of prompt tuning. Based on this observation, we introduce perturbation-based regularizers, which can smooth the loss landscape, into prompt tuning. We propose a new algorithm, called Prompt Tuning with Perturbation-based regularizer~(PTP), which can not only alleviate training instability dramatically but also boost the performance of prompt tuning. We design two kinds of perturbation-based regularizers, including random-noise-based and adversarial-based. In particular, our proposed perturbations are flexible on both text space and embedding space. Extensive experiments show the effectiveness of our proposed methods in stabilizing the training. Our new algorithms improve the state-of-the-art prompt tuning methods by 1.94\% and 2.34\% on SuperGLUE and FewGLUE benchmarks, respectively.

When do you need Chain-of-Thought Prompting for ChatGPT?

Chain-of-Thought (CoT) prompting can effectively elicit complex multi-step reasoning from Large Language Models~(LLMs). For example, by simply adding CoT instruction ``Let's think step-by-step'' to each input query of MultiArith dataset, GPT-3's accuracy can be improved from 17.7\% to 78.7\%. However, it is not clear whether CoT is still effective on more recent instruction finetuned (IFT) LLMs such as ChatGPT. Surprisingly, on ChatGPT, CoT is no longer effective for certain tasks such as arithmetic reasoning while still keeping effective on other reasoning tasks. Moreover, on the former tasks, ChatGPT usually achieves the best performance and can generate CoT even without being instructed to do so. Hence, it is plausible that ChatGPT has already been trained on these tasks with CoT and thus memorized the instruction so it implicitly follows such an instruction when applied to the same queries, even without CoT. Our analysis reflects a potential risk of overfitting/bias toward instructions introduced in IFT, which becomes more common in training LLMs. In addition, it indicates possible leakage of the pretraining recipe, e.g., one can verify whether a dataset and instruction were used in training ChatGPT. Our experiments report new baseline results of ChatGPT on a variety of reasoning tasks and shed novel insights into LLM's profiling, instruction memorization, and pretraining dataset leakage.

Dynamic Voxel Grid Optimization for High-Fidelity RGB-D Supervised Surface Reconstruction

Direct optimization of interpolated features on multi-resolution voxel grids has emerged as a more efficient alternative to MLP-like modules. However, this approach is constrained by higher memory expenses and limited representation capabilities. In this paper, we introduce a novel dynamic grid optimization method for high-fidelity 3D surface reconstruction that incorporates both RGB and depth observations. Rather than treating each voxel equally, we optimize the process by dynamically modifying the grid and assigning more finer-scale voxels to regions with higher complexity, allowing us to capture more intricate details. Furthermore, we develop a scheme to quantify the dynamic subdivision of voxel grid during optimization without requiring any priors. The proposed approach is able to generate high-quality 3D reconstructions with fine details on both synthetic and real-world data, while maintaining computational efficiency, which is substantially faster than the baseline method NeuralRGBD.

Decentralized Riemannian Algorithm for Nonconvex Minimax Problems

The minimax optimization over Riemannian manifolds (possibly nonconvex constraints) has been actively applied to solve many problems, such as robust dimensionality reduction and deep neural networks with orthogonal weights (Stiefel manifold). Although many optimization algorithms for minimax problems have been developed in the Euclidean setting, it is difficult to convert them into Riemannian cases, and algorithms for nonconvex minimax problems with nonconvex constraints are even rare. On the other hand, to address the big data challenges, decentralized (serverless) training techniques have recently been emerging since they can reduce communications overhead and avoid the bottleneck problem on the server node. Nonetheless, the algorithm for decentralized Riemannian minimax problems has not been studied. In this paper, we study the distributed nonconvex-strongly-concave minimax optimization problem over the Stiefel manifold and propose both deterministic and stochastic minimax methods. The Steifel manifold is a non-convex set. The global function is represented as the finite sum of local functions. For the deterministic setting, we propose DRGDA and prove that our deterministic method achieves a gradient complexity of $O( \epsilon^{-2})$ under mild conditions. For the stochastic setting, we propose DRSGDA and prove that our stochastic method achieves a gradient complexity of $O(\epsilon^{-4})$. The DRGDA and DRSGDA are the first algorithms for distributed minimax optimization with nonconvex constraints with exact convergence. Extensive experimental results on the Deep Neural Networks (DNNs) training over the Stiefel manifold demonstrate the efficiency of our algorithms.