The diagnosis and prognosis of cancer are typically based on multi-modal clinical data, including histology images and genomic data, due to the complex pathogenesis and high heterogeneity. Despite the advancements in digital pathology and high-throughput genome sequencing, establishing effective multi-modal fusion models for survival prediction and revealing the potential association between histopathology and transcriptomics remains challenging. In this paper, we propose Pathology-Genome Heterogeneous Graph (PGHG) that integrates whole slide images (WSI) and bulk RNA-Seq expression data with heterogeneous graph neural network for cancer survival analysis. The PGHG consists of biological knowledge-guided representation learning network and pathology-genome heterogeneous graph. The representation learning network utilizes the biological prior knowledge of intra-modal and inter-modal data associations to guide the feature extraction. The node features of each modality are updated through attention-based graph learning strategy. Unimodal features and bi-modal fused features are extracted via attention pooling module and then used for survival prediction. We evaluate the model on low-grade gliomas, glioblastoma, and kidney renal papillary cell carcinoma datasets from the Cancer Genome Atlas (TCGA) and the First Affiliated Hospital of Zhengzhou University (FAHZU). Extensive experimental results demonstrate that the proposed method outperforms both unimodal and other multi-modal fusion models. For demonstrating the model interpretability, we also visualize the attention heatmap of pathological images and utilize integrated gradient algorithm to identify important tissue structure, biological pathways and key genes.
In this paper, we propose a physics-inspired contrastive learning paradigm for low-light enhancement, called PIE. PIE primarily addresses three issues: (i) To resolve the problem of existing learning-based methods often training a LLE model with strict pixel-correspondence image pairs, we eliminate the need for pixel-correspondence paired training data and instead train with unpaired images. (ii) To address the disregard for negative samples and the inadequacy of their generation in existing methods, we incorporate physics-inspired contrastive learning for LLE and design the Bag of Curves (BoC) method to generate more reasonable negative samples that closely adhere to the underlying physical imaging principle. (iii) To overcome the reliance on semantic ground truths in existing methods, we propose an unsupervised regional segmentation module, ensuring regional brightness consistency while eliminating the dependency on semantic ground truths. Overall, the proposed PIE can effectively learn from unpaired positive/negative samples and smoothly realize non-semantic regional enhancement, which is clearly different from existing LLE efforts. Besides the novel architecture of PIE, we explore the gain of PIE on downstream tasks such as semantic segmentation and face detection. Training on readily available open data and extensive experiments demonstrate that our method surpasses the state-of-the-art LLE models over six independent cross-scenes datasets. PIE runs fast with reasonable GFLOPs in test time, making it easy to use on mobile devices.
Image denoising is a fundamental task in computer vision. While prevailing deep learning-based supervised and self-supervised methods have excelled in eliminating in-distribution noise, their susceptibility to out-of-distribution (OOD) noise remains a significant challenge. The recent emergence of contrastive language-image pre-training (CLIP) model has showcased exceptional capabilities in open-world image recognition and segmentation. Yet, the potential for leveraging CLIP to enhance the robustness of low-level tasks remains largely unexplored. This paper uncovers that certain dense features extracted from the frozen ResNet image encoder of CLIP exhibit distortion-invariant and content-related properties, which are highly desirable for generalizable denoising. Leveraging these properties, we devise an asymmetrical encoder-decoder denoising network, which incorporates dense features including the noisy image and its multi-scale features from the frozen ResNet encoder of CLIP into a learnable image decoder to achieve generalizable denoising. The progressive feature augmentation strategy is further proposed to mitigate feature overfitting and improve the robustness of the learnable decoder. Extensive experiments and comparisons conducted across diverse OOD noises, including synthetic noise, real-world sRGB noise, and low-dose CT image noise, demonstrate the superior generalization ability of our method.
Positron Emission Tomography and Magnetic Resonance Imaging (PET-MRI) systems can obtain functional and anatomical scans. PET suffers from a low signal-to-noise ratio. Meanwhile, the k-space data acquisition process in MRI is time-consuming. The study aims to accelerate MRI and enhance PET image quality. Conventional approaches involve the separate reconstruction of each modality within PET-MRI systems. However, there exists complementary information among multi-modal images. The complementary information can contribute to image reconstruction. In this study, we propose a novel PET-MRI joint reconstruction model employing a mutual consistency-driven diffusion mode, namely MC-Diffusion. MC-Diffusion learns the joint probability distribution of PET and MRI for utilizing complementary information. We conducted a series of contrast experiments about LPLS, Joint ISAT-net and MC-Diffusion by the ADNI dataset. The results underscore the qualitative and quantitative improvements achieved by MC-Diffusion, surpassing the state-of-the-art method.
Effective user representations are pivotal in personalized advertising. However, stringent constraints on training throughput, serving latency, and memory, often limit the complexity and input feature set of online ads ranking models. This challenge is magnified in extensive systems like Meta's, which encompass hundreds of models with diverse specifications, rendering the tailoring of user representation learning for each model impractical. To address these challenges, we present Scaling User Modeling (SUM), a framework widely deployed in Meta's ads ranking system, designed to facilitate efficient and scalable sharing of online user representation across hundreds of ads models. SUM leverages a few designated upstream user models to synthesize user embeddings from massive amounts of user features with advanced modeling techniques. These embeddings then serve as inputs to downstream online ads ranking models, promoting efficient representation sharing. To adapt to the dynamic nature of user features and ensure embedding freshness, we designed SUM Online Asynchronous Platform (SOAP), a latency free online serving system complemented with model freshness and embedding stabilization, which enables frequent user model updates and online inference of user embeddings upon each user request. We share our hands-on deployment experiences for the SUM framework and validate its superiority through comprehensive experiments. To date, SUM has been launched to hundreds of ads ranking models in Meta, processing hundreds of billions of user requests daily, yielding significant online metric gains and infrastructure cost savings.
Accurate detection and segmentation of brain tumors is critical for medical diagnosis. However, current supervised learning methods require extensively annotated images and the state-of-the-art generative models used in unsupervised methods often have limitations in covering the whole data distribution. In this paper, we propose a novel framework Two-Stage Generative Model (TSGM) that combines Cycle Generative Adversarial Network (CycleGAN) and Variance Exploding stochastic differential equation using joint probability (VE-JP) to improve brain tumor detection and segmentation. The CycleGAN is trained on unpaired data to generate abnormal images from healthy images as data prior. Then VE-JP is implemented to reconstruct healthy images using synthetic paired abnormal images as a guide, which alters only pathological regions but not regions of healthy. Notably, our method directly learned the joint probability distribution for conditional generation. The residual between input and reconstructed images suggests the abnormalities and a thresholding method is subsequently applied to obtain segmentation results. Furthermore, the multimodal results are weighted with different weights to improve the segmentation accuracy further. We validated our method on three datasets, and compared with other unsupervised methods for anomaly detection and segmentation. The DSC score of 0.8590 in BraTs2020 dataset, 0.6226 in ITCS dataset and 0.7403 in In-house dataset show that our method achieves better segmentation performance and has better generalization.
Most current gait recognition methods suffer from poor interpretability and high computational cost. To improve interpretability, we investigate gait features in the embedding space based on Koopman operator theory. The transition matrix in this space captures complex kinematic features of gait cycles, namely the Koopman operator. The diagonal elements of the operator matrix can represent the overall motion trend, providing a physically meaningful descriptor. To reduce the computational cost of our algorithm, we use a reversible autoencoder to reduce the model size and eliminate convolutional layers to compress its depth, resulting in fewer floating-point operations. Experimental results on multiple datasets show that our method reduces computational cost to 1% compared to state-of-the-art methods while achieving competitive recognition accuracy 98% on non-occlusion datasets.
Recently, regularization model-driven deep learning (DL) has gained significant attention due to its ability to leverage the potent representational capabilities of DL while retaining the theoretical guarantees of regularization models. However, most of these methods are tailored for supervised learning scenarios that necessitate fully sampled labels, which can pose challenges in practical MRI applications. To tackle this challenge, we propose a self-supervised DL approach for accelerated MRI that is theoretically guaranteed and does not rely on fully sampled labels. Specifically, we achieve neural network structure regularization by exploiting the inherent structural low-rankness of the $k$-space data. Simultaneously, we constrain the network structure to resemble a nonexpansive mapping, ensuring the network's convergence to a fixed point. Thanks to this well-defined network structure, this fixed point can completely reconstruct the missing $k$-space data based on matrix completion theory, even in situations where full-sampled labels are unavailable. Experiments validate the effectiveness of our proposed method and demonstrate its superiority over existing self-supervised approaches and traditional regularization methods, achieving performance comparable to that of supervised learning methods in certain scenarios.
Recently, data-driven techniques have demonstrated remarkable effectiveness in addressing challenges related to MR imaging inverse problems. However, these methods still exhibit certain limitations in terms of interpretability and robustness. In response, we introduce Convex Latent-Optimized Adversarial Regularizers (CLEAR), a novel and interpretable data-driven paradigm. CLEAR represents a fusion of deep learning (DL) and variational regularization. Specifically, we employ a latent optimization technique to adversarially train an input convex neural network, and its set of minima can fully represent the real data manifold. We utilize it as a convex regularizer to formulate a CLEAR-informed variational regularization model that guides the solution of the imaging inverse problem on the real data manifold. Leveraging its inherent convexity, we have established the convergence of the projected subgradient descent algorithm for the CLEAR-informed regularization model. This convergence guarantees the attainment of a unique solution to the imaging inverse problem, subject to certain assumptions. Furthermore, we have demonstrated the robustness of our CLEAR-informed model, explicitly showcasing its capacity to achieve stable reconstruction even in the presence of measurement interference. Finally, we illustrate the superiority of our approach using MRI reconstruction as an example. Our method consistently outperforms conventional data-driven techniques and traditional regularization approaches, excelling in both reconstruction quality and robustness.
Most existing MRI reconstruction methods perform tar-geted reconstruction of the entire MR image without tak-ing specific tissue regions into consideration. This may fail to emphasize the reconstruction accuracy on im-portant tissues for diagnosis. In this study, leveraging a combination of the properties of k-space data and the diffusion process, our novel scheme focuses on mining the multi-frequency prior with different strategies to pre-serve fine texture details in the reconstructed image. In addition, a diffusion process can converge more quickly if its target distribution closely resembles the noise distri-bution in the process. This can be accomplished through various high-frequency prior extractors. The finding further solidifies the effectiveness of the score-based gen-erative model. On top of all the advantages, our method improves the accuracy of MRI reconstruction and accel-erates sampling process. Experimental results verify that the proposed method successfully obtains more accurate reconstruction and outperforms state-of-the-art methods.