Can LLM Agents Generate Real-World Evidence? Evaluating Observational Studies in Medical Databases

Observational studies can yield clinically actionable evidence at scale, but executing them on real-world databases is open-ended and requires coherent decisions across cohort construction, analysis, and reporting. Prior evaluations of LLM agents emphasize isolated steps or single answers, missing the integrity and internal structure of the resulting evidence bundle. To address this gap, we introduce RWE-bench, a benchmark grounded in MIMIC-IV and derived from peer-reviewed observational studies. Each task provides the corresponding study protocol as the reference standard, requiring agents to execute experiments in a real database and iteratively generate tree-structured evidence bundles. We evaluate six LLMs (three open-source, three closed-source) under three agent scaffolds using both question-level correctness and end-to-end task metrics. Across 162 tasks, task success is low: the best agent reaches 39.9%, and the best open-source model reaches 30.4%. Agent scaffolds also matter substantially, causing over 30% variation in performance metrics. Furthermore, we implement an automated cohort evaluation method to rapidly localize errors and identify agent failure modes. Overall, the results highlight persistent limitations in agents' ability to produce end-to-end evidence bundles, and efficient validation remains an important direction for future work. Code and data are available at https://github.com/somewordstoolate/RWE-bench.

TimeWeaver: Age-Consistent Reference-Based Face Restoration with Identity Preservation

Recent progress in face restoration has shifted from visual fidelity to identity fidelity, driving a transition from reference-free to reference-based paradigms that condition restoration on reference images of the same person. However, these methods assume the reference and degraded input are age-aligned. When only cross-age references are available, as in historical restoration or missing-person retrieval, they fail to maintain age fidelity. To address this limitation, we propose TimeWeaver, the first reference-based face restoration framework supporting cross-age references. Given arbitrary reference images and a target-age prompt, TimeWeaver produces restorations with both identity fidelity and age consistency. Specifically, we decouple identity and age conditioning across training and inference. During training, the model learns an age-robust identity representation by fusing a global identity embedding with age-suppressed facial tokens via a transformer-based ID-Fusion module. During inference, two training-free techniques, Age-Aware Gradient Guidance and Token-Targeted Attention Boost, steer sampling toward desired age semantics, enabling precise adherence to the target-age prompt. Extensive experiments show that TimeWeaver surpasses existing methods in visual quality, identity preservation, and age consistency.

MeInTime: Bridging Age Gap in Identity-Preserving Face Restoration

To better preserve an individual's identity, face restoration has evolved from reference-free to reference-based approaches, which leverage high-quality reference images of the same identity to enhance identity fidelity in the restored outputs. However, most existing methods implicitly assume that the reference and degraded input are age-aligned, limiting their effectiveness in real-world scenarios where only cross-age references are available, such as historical photo restoration. This paper proposes MeInTime, a diffusion-based face restoration method that extends reference-based restoration from same-age to cross-age settings. Given one or few reference images along with an age prompt corresponding to the degraded input, MeInTime achieves faithful restoration with both identity fidelity and age consistency. Specifically, we decouple the modeling of identity and age conditions. During training, we focus solely on effectively injecting identity features through a newly introduced attention mechanism and introduce Gated Residual Fusion modules to facilitate the integration between degraded features and identity representations. At inference, we propose Age-Aware Gradient Guidance, a training-free sampling strategy, using an age-driven direction to iteratively nudge the identity-aware denoising latent toward the desired age semantic manifold. Extensive experiments demonstrate that MeInTime outperforms existing face restoration methods in both identity preservation and age consistency. Our code is available at: https://github.com/teer4/MeInTime

VLA-Thinker: Boosting Vision-Language-Action Models through Thinking-with-Image Reasoning

Vision-Language-Action (VLA) models have shown promising capabilities for embodied intelligence, but most existing approaches rely on text-based chain-of-thought reasoning where visual inputs are treated as static context. This limits the ability of the model to actively revisit the environment and resolve ambiguities during long-horizon tasks. We propose VLA-Thinker, a thinking-with-image reasoning framework that models perception as a dynamically invocable reasoning action. To train such a system, we introduce a two-stage training pipeline consisting of (1) an SFT cold-start phase with curated visual Chain-of-Thought data to activate structured reasoning and tool-use behaviors, and (2) GRPO-based reinforcement learning to align complete reasoning-action trajectories with task-level success. Extensive experiments on LIBERO and RoboTwin 2.0 benchmarks demonstrate that VLA-Thinker significantly improves manipulation performance, achieving 97.5% success rate on LIBERO and strong gains across long-horizon robotic tasks. Project and Codes: https://cywang735.github.io/VLA-Thinker/ .

Vision-Language Semantic Grounding for Multi-Domain Crop-Weed Segmentation

Fine-grained crop-weed segmentation is essential for enabling targeted herbicide application in precision agriculture. However, existing deep learning models struggle to generalize across heterogeneous agricultural environments due to reliance on dataset-specific visual features. We propose Vision-Language Weed Segmentation (VL-WS), a novel framework that addresses this limitation by grounding pixel-level segmentation in semantically aligned, domain-invariant representations. Our architecture employs a dual-encoder design, where frozen Contrastive Language-Image Pretraining (CLIP) embeddings and task-specific spatial features are fused and modulated via Feature-wise Linear Modulation (FiLM) layers conditioned on natural language captions. This design enables image level textual descriptions to guide channel-wise feature refinement while preserving fine-grained spatial localization. Unlike prior works restricted to training and evaluation on single-source datasets, VL-WS is trained on a unified corpus that includes close-range ground imagery (robotic platforms) and high-altitude UAV imagery, covering diverse crop types, weed species, growth stages, and sensing conditions. Experimental results across four benchmark datasets demonstrate the effectiveness of our framework, with VL-WS achieving a mean Dice score of 91.64% and outperforming the CNN baseline by 4.98%. The largest gains occur on the most challenging weed class, where VL-WS attains 80.45% Dice score compared to 65.03% for the best baseline, representing a 15.42% improvement. VL-WS further maintains stable weed segmentation performance under limited target-domain supervision, indicating improved generalization and data efficiency. These findings highlight the potential of vision-language alignment to enable scalable, label-efficient segmentation models deployable across diverse real-world agricultural domains.

RF-GPT: Teaching AI to See the Wireless World

Large language models (LLMs) and multimodal models have become powerful general-purpose reasoning systems. However, radio-frequency (RF) signals, which underpin wireless systems, are still not natively supported by these models. Existing LLM-based approaches for telecom focus mainly on text and structured data, while conventional RF deep-learning models are built separately for specific signal-processing tasks, highlighting a clear gap between RF perception and high-level reasoning. To bridge this gap, we introduce RF-GPT, a radio-frequency language model (RFLM) that utilizes the visual encoders of multimodal LLMs to process and understand RF spectrograms. In this framework, complex in-phase/quadrature (IQ) waveforms are mapped to time-frequency spectrograms and then passed to pretrained visual encoders. The resulting representations are injected as RF tokens into a decoder-only LLM, which generates RF-grounded answers, explanations, and structured outputs. To train RF-GPT, we perform supervised instruction fine-tuning of a pretrained multimodal LLM using a fully synthetic RF corpus. Standards-compliant waveform generators produce wideband scenes for six wireless technologies, from which we derive time-frequency spectrograms, exact configuration metadata, and dense captions. A text-only LLM then converts these captions into RF-grounded instruction-answer pairs, yielding roughly 12,000 RF scenes and 0.625 million instruction examples without any manual labeling. Across benchmarks for wideband modulation classification, overlap analysis, wireless-technology recognition, WLAN user counting, and 5G NR information extraction, RF-GPT achieves strong multi-task performance, whereas general-purpose VLMs with no RF grounding largely fail.

Dynamic Modeling, Parameter Identification and Numerical Analysis of Flexible Cables in Flexibly Connected Dual-AUV Systems

This research presents a dynamic modeling framework and parameter identification methods for describing the highly nonlinear behaviors of flexibly connected dual-AUV systems. The modeling framework is established based on the lumped mass method, integrating axial elasticity, bending stiffness, added mass and hydrodynamic forces, thereby accurately capturing the time-varying response of the forces and cable configurations. To address the difficulty of directly measuring material-related and hydrodynamic coefficients, this research proposes a parameter identification method that combines the physical model with experimental data. High-precision inversion of the equivalent Youngs modulus and hydrodynamic coefficients is performed through tension experiments under multiple configurations, effectively demonstrating that the identified model maintains predictive consistency in various operational conditions. Further numerical analysis indicates that the dynamic properties of flexible cable exhibit significant nonlinear characteristics, which are highly dependent on material property variations and AUV motion conditions. This nonlinear dynamic behavior results in two typical response states, slack and taut, which are jointly determined by boundary conditions and hydrodynamic effects, significantly affecting the cable configuration and endpoint loads. In this research, the dynamics of flexible cables under complex boundary conditions is revealed, providing a theoretical foundation for the design, optimization and further control research of similar systems.

Cognitively Diverse Multiple-Choice Question Generation: A Hybrid Multi-Agent Framework with Large Language Models

Recent advances in large language models (LLMs) have made automated multiple-choice question (MCQ) generation increasingly feasible; however, reliably producing items that satisfy controlled cognitive demands remains a challenge. To address this gap, we introduce ReQUESTA, a hybrid, multi-agent framework for generating cognitively diverse MCQs that systematically target text-based, inferential, and main idea comprehension. ReQUESTA decomposes MCQ authoring into specialized subtasks and coordinates LLM-powered agents with rule-based components to support planning, controlled generation, iterative evaluation, and post-processing. We evaluated the framework in a large-scale reading comprehension study using academic expository texts, comparing ReQUESTA-generated MCQs with those produced by a single-pass GPT-5 zero-shot baseline. Psychometric analyses of learner responses assessed item difficulty and discrimination, while expert raters evaluated question quality across multiple dimensions, including topic relevance and distractor quality. Results showed that ReQUESTA-generated items were consistently more challenging, more discriminative, and more strongly aligned with overall reading comprehension performance. Expert evaluations further indicated stronger alignment with central concepts and superior distractor linguistic consistency and semantic plausibility, particularly for inferential questions. These findings demonstrate that hybrid, agentic orchestration can systematically improve the reliability and controllability of LLM-based generation, highlighting workflow design as a key lever for structured artifact generation beyond single-pass prompting.

Composable Visual Tokenizers with Generator-Free Diagnostics of Learnability

We introduce CompTok, a training framework for learning visual tokenizers whose tokens are enhanced for compositionality. CompTok uses a token-conditioned diffusion decoder. By employing an InfoGAN-style objective, where we train a recognition model to predict the tokens used to condition the diffusion decoder using the decoded images, we enforce the decoder to not ignore any of the tokens. To promote compositional control, besides the original images, CompTok also trains on tokens formed by swapping token subsets between images, enabling more compositional control of the token over the decoder. As the swapped tokens between images do not have ground truth image targets, we apply a manifold constraint via an adversarial flow regularizer to keep unpaired swap generations on the natural-image distribution. The resulting tokenizer not only achieves state-of-the-art performance on image class-conditioned generation, but also demonstrates properties such as swapping tokens between images to achieve high level semantic editing of an image. Additionally, we propose two metrics that measures the landscape of the token space that can be useful to describe not only the compositionality of the tokens, but also how easy to learn the landscape is for a generator to be trained on this space. We show in experiments that CompTok can improve on both of the metrics as well as supporting state-of-the-art generators for class conditioned generation.

Beyond Dense States: Elevating Sparse Transcoders to Active Operators for Latent Reasoning

Latent reasoning compresses the chain-of-thought (CoT) into continuous hidden states, yet existing methods rely on dense latent transitions that remain difficult to interpret and control. Meanwhile, sparse representation models uncover human-interpretable semantic features but remain largely confined to post-hoc analysis. We reconcile this tension by proposing LSTR (Latent Sparse Transcoder Reasoning), a latent reasoning framework that elevates functional sparse transcoders into active reasoning operators to perform multi-step computation through sparse semantic transitions. At its core, LSTR employs a Latent Transition Transcoder (LTT) with a residual skip architecture that decouples linear manifold transport from sparse semantic updates, enabling controllable semantic resolution via explicit sparsity constraints. Extensive experiments show that LSTR preserves reasoning accuracy and compression efficiency while substantially improving interpretability over dense latent baselines. Causal interventions and trajectory analyses further demonstrate that these sparse features act as both interpretable and causally effective operators in the reasoning process.