Demystify Protein Generation with Hierarchical Conditional Diffusion Models

Generating novel and functional protein sequences is critical to a wide range of applications in biology. Recent advancements in conditional diffusion models have shown impressive empirical performance in protein generation tasks. However, reliable generations of protein remain an open research question in de novo protein design, especially when it comes to conditional diffusion models. Considering the biological function of a protein is determined by multi-level structures, we propose a novel multi-level conditional diffusion model that integrates both sequence-based and structure-based information for efficient end-to-end protein design guided by specified functions. By generating representations at different levels simultaneously, our framework can effectively model the inherent hierarchical relations between different levels, resulting in an informative and discriminative representation of the generated protein. We also propose a Protein-MMD, a new reliable evaluation metric, to evaluate the quality of generated protein with conditional diffusion models. Our new metric is able to capture both distributional and functional similarities between real and generated protein sequences while ensuring conditional consistency. We experiment with the benchmark datasets, and the results on conditional protein generation tasks demonstrate the efficacy of the proposed generation framework and evaluation metric.

Sculpting Memory: Multi-Concept Forgetting in Diffusion Models via Dynamic Mask and Concept-Aware Optimization

Text-to-image (T2I) diffusion models have achieved remarkable success in generating high-quality images from textual prompts. However, their ability to store vast amounts of knowledge raises concerns in scenarios where selective forgetting is necessary, such as removing copyrighted content, reducing biases, or eliminating harmful concepts. While existing unlearning methods can remove certain concepts, they struggle with multi-concept forgetting due to instability, residual knowledge persistence, and generation quality degradation. To address these challenges, we propose \textbf{Dynamic Mask coupled with Concept-Aware Loss}, a novel unlearning framework designed for multi-concept forgetting in diffusion models. Our \textbf{Dynamic Mask} mechanism adaptively updates gradient masks based on current optimization states, allowing selective weight modifications that prevent interference with unrelated knowledge. Additionally, our \textbf{Concept-Aware Loss} explicitly guides the unlearning process by enforcing semantic consistency through superclass alignment, while a regularization loss based on knowledge distillation ensures that previously unlearned concepts remain forgotten during sequential unlearning. We conduct extensive experiments to evaluate our approach. Results demonstrate that our method outperforms existing unlearning techniques in forgetting effectiveness, output fidelity, and semantic coherence, particularly in multi-concept scenarios. Our work provides a principled and flexible framework for stable and high-fidelity unlearning in generative models. The code will be released publicly.

Towards Distributed Backdoor Attacks with Network Detection in Decentralized Federated Learning

Distributed backdoor attacks (DBA) have shown a higher attack success rate than centralized attacks in centralized federated learning (FL). However, it has not been investigated in the decentralized FL. In this paper, we experimentally demonstrate that, while directly applying DBA to decentralized FL, the attack success rate depends on the distribution of attackers in the network architecture. Considering that the attackers can not decide their location, this paper aims to achieve a high attack success rate regardless of the attackers' location distribution. Specifically, we first design a method to detect the network by predicting the distance between any two attackers on the network. Then, based on the distance, we organize the attackers in different clusters. Lastly, we propose an algorithm to \textit{dynamically} embed local patterns decomposed from a global pattern into the different attackers in each cluster. We conduct a thorough empirical investigation and find that our method can, in benchmark datasets, outperform both centralized attacks and naive DBA in different decentralized frameworks.

Efficient Large-Scale Traffic Forecasting with Transformers: A Spatial Data Management Perspective

Road traffic forecasting is crucial in real-world intelligent transportation scenarios like traffic dispatching and path planning in city management and personal traveling. Spatio-temporal graph neural networks (STGNNs) stand out as the mainstream solution in this task. Nevertheless, the quadratic complexity of remarkable dynamic spatial modeling-based STGNNs has become the bottleneck over large-scale traffic data. From the spatial data management perspective, we present a novel Transformer framework called PatchSTG to efficiently and dynamically model spatial dependencies for large-scale traffic forecasting with interpretability and fidelity. Specifically, we design a novel irregular spatial patching to reduce the number of points involved in the dynamic calculation of Transformer. The irregular spatial patching first utilizes the leaf K-dimensional tree (KDTree) to recursively partition irregularly distributed traffic points into leaf nodes with a small capacity, and then merges leaf nodes belonging to the same subtree into occupancy-equaled and non-overlapped patches through padding and backtracking. Based on the patched data, depth and breadth attention are used interchangeably in the encoder to dynamically learn local and global spatial knowledge from points in a patch and points with the same index of patches. Experimental results on four real world large-scale traffic datasets show that our PatchSTG achieves train speed and memory utilization improvements up to $10\times$ and $4\times$ with the state-of-the-art performance.

Weak-to-Strong Generalization beyond Accuracy: a Pilot Study in Safety, Toxicity, and Legal Reasoning

As large language models (LLMs) continue to advance, ensuring their alignment with human values becomes increasingly critical. Traditional alignment methods heavily rely on human feedback to fine-tune models. With the emergence of superhuman models whose outputs may surpass human understanding, evaluating and aligning these models using human judgments poses significant challenges. To address the challenges, recent works use weak supervisors to elicit knowledge from much stronger models. However, there are important disanalogies between the empirical setup in the existing works and the genuine goal of alignment. We remark that existing works investigate the phenomenon of weak-to-strong generation in analogous setup (i.e., binary classification), rather than practical alignment-relevant tasks (e.g., safety). In this paper, we bridge this gap by extending weak-to-strong generation to the context of practical alignment. We empirically demonstrate the widespread phenomenon of weak-to-strong generation in three complicated alignment tasks: safety, toxicity, and legal reasoning}. Furthermore, we explore efficient strategies for improving alignment performance to enhance the quality of model outcomes. Lastly, we summarize and analyze the challenges and potential solutions in regard to specific alignment tasks, which we hope to catalyze the research progress on the topic of weak-to-strong generalization. Our code is released at https://github.com/yeruimeng/WTS.git.

PLeak: Prompt Leaking Attacks against Large Language Model Applications

Large Language Models (LLMs) enable a new ecosystem with many downstream applications, called LLM applications, with different natural language processing tasks. The functionality and performance of an LLM application highly depend on its system prompt, which instructs the backend LLM on what task to perform. Therefore, an LLM application developer often keeps a system prompt confidential to protect its intellectual property. As a result, a natural attack, called prompt leaking, is to steal the system prompt from an LLM application, which compromises the developer's intellectual property. Existing prompt leaking attacks primarily rely on manually crafted queries, and thus achieve limited effectiveness. In this paper, we design a novel, closed-box prompt leaking attack framework, called PLeak, to optimize an adversarial query such that when the attacker sends it to a target LLM application, its response reveals its own system prompt. We formulate finding such an adversarial query as an optimization problem and solve it with a gradient-based method approximately. Our key idea is to break down the optimization goal by optimizing adversary queries for system prompts incrementally, i.e., starting from the first few tokens of each system prompt step by step until the entire length of the system prompt. We evaluate PLeak in both offline settings and for real-world LLM applications, e.g., those on Poe, a popular platform hosting such applications. Our results show that PLeak can effectively leak system prompts and significantly outperforms not only baselines that manually curate queries but also baselines with optimized queries that are modified and adapted from existing jailbreaking attacks. We responsibly reported the issues to Poe and are still waiting for their response. Our implementation is available at this repository: https://github.com/BHui97/PLeak.

A Survey of Lottery Ticket Hypothesis

The Lottery Ticket Hypothesis (LTH) states that a dense neural network model contains a highly sparse subnetwork (i.e., winning tickets) that can achieve even better performance than the original model when trained in isolation. While LTH has been proved both empirically and theoretically in many works, there still are some open issues, such as efficiency and scalability, to be addressed. Also, the lack of open-source frameworks and consensual experimental setting poses a challenge to future research on LTH. We, for the first time, examine previous research and studies on LTH from different perspectives. We also discuss issues in existing works and list potential directions for further exploration. This survey aims to provide an in-depth look at the state of LTH and develop a duly maintained platform to conduct experiments and compare with the most updated baselines.

Successfully Applying Lottery Ticket Hypothesis to Diffusion Model

Despite the success of diffusion models, the training and inference of diffusion models are notoriously expensive due to the long chain of the reverse process. In parallel, the Lottery Ticket Hypothesis (LTH) claims that there exists winning tickets (i.e., aproperly pruned sub-network together with original weight initialization) that can achieve performance competitive to the original dense neural network when trained in isolation. In this work, we for the first time apply LTH to diffusion models. We empirically find subnetworks at sparsity 90%-99% without compromising performance for denoising diffusion probabilistic models on benchmarks (CIFAR-10, CIFAR-100, MNIST). Moreover, existing LTH works identify the subnetworks with a unified sparsity along different layers. We observe that the similarity between two winning tickets of a model varies from block to block. Specifically, the upstream layers from two winning tickets for a model tend to be more similar than the downstream layers. Therefore, we propose to find the winning ticket with varying sparsity along different layers in the model. Experimental results demonstrate that our method can find sparser sub-models that require less memory for storage and reduce the necessary number of FLOPs. Codes are available at https://github.com/osier0524/Lottery-Ticket-to-DDPM.

SneakyPrompt: Jailbreaking Text-to-image Generative Models

Text-to-image generative models such as Stable Diffusion and DALL$\cdot$E 2 have attracted much attention since their publication due to their wide application in the real world. One challenging problem of text-to-image generative models is the generation of Not-Safe-for-Work (NSFW) content, e.g., those related to violence and adult. Therefore, a common practice is to deploy a so-called safety filter, which blocks NSFW content based on either text or image features. Prior works have studied the possible bypass of such safety filters. However, existing works are largely manual and specific to Stable Diffusion's official safety filter. Moreover, the bypass ratio of Stable Diffusion's safety filter is as low as 23.51% based on our evaluation. In this paper, we propose the first automated attack framework, called SneakyPrompt, to evaluate the robustness of real-world safety filters in state-of-the-art text-to-image generative models. Our key insight is to search for alternative tokens in a prompt that generates NSFW images so that the generated prompt (called an adversarial prompt) bypasses existing safety filters. Specifically, SneakyPrompt utilizes reinforcement learning (RL) to guide an agent with positive rewards on semantic similarity and bypass success. Our evaluation shows that SneakyPrompt successfully generated NSFW content using an online model DALL$\cdot$E 2 with its default, closed-box safety filter enabled. At the same time, we also deploy several open-source state-of-the-art safety filters on a Stable Diffusion model and show that SneakyPrompt not only successfully generates NSFW content, but also outperforms existing adversarial attacks in terms of the number of queries and image qualities.

Rethinking Graph Lottery Tickets: Graph Sparsity Matters

Lottery Ticket Hypothesis (LTH) claims the existence of a winning ticket (i.e., a properly pruned sub-network together with original weight initialization) that can achieve competitive performance to the original dense network. A recent work, called UGS, extended LTH to prune graph neural networks (GNNs) for effectively accelerating GNN inference. UGS simultaneously prunes the graph adjacency matrix and the model weights using the same masking mechanism, but since the roles of the graph adjacency matrix and the weight matrices are very different, we find that their sparsifications lead to different performance characteristics. Specifically, we find that the performance of a sparsified GNN degrades significantly when the graph sparsity goes beyond a certain extent. Therefore, we propose two techniques to improve GNN performance when the graph sparsity is high. First, UGS prunes the adjacency matrix using a loss formulation which, however, does not properly involve all elements of the adjacency matrix; in contrast, we add a new auxiliary loss head to better guide the edge pruning by involving the entire adjacency matrix. Second, by regarding unfavorable graph sparsification as adversarial data perturbations, we formulate the pruning process as a min-max optimization problem to gain the robustness of lottery tickets when the graph sparsity is high. We further investigate the question: Can the "retrainable" winning ticket of a GNN be also effective for graph transferring learning? We call it the transferable graph lottery ticket (GLT) hypothesis. Extensive experiments were conducted which demonstrate the superiority of our proposed sparsification method over UGS, and which empirically verified our transferable GLT hypothesis.