BRIGHT: A Collaborative Generalist-Specialist Foundation Model for Breast Pathology

Generalist pathology foundation models (PFMs), pretrained on large-scale multi-organ datasets, have demonstrated remarkable predictive capabilities across diverse clinical applications. However, their proficiency on the full spectrum of clinically essential tasks within a specific organ system remains an open question due to the lack of large-scale validation cohorts for a single organ as well as the absence of a tailored training paradigm that can effectively translate broad histomorphological knowledge into the organ-specific expertise required for specialist-level interpretation. In this study, we propose BRIGHT, the first PFM specifically designed for breast pathology, trained on approximately 210 million histopathology tiles from over 51,000 breast whole-slide images derived from a cohort of over 40,000 patients across 19 hospitals. BRIGHT employs a collaborative generalist-specialist framework to capture both universal and organ-specific features. To comprehensively evaluate the performance of PFMs on breast oncology, we curate the largest multi-institutional cohorts to date for downstream task development and evaluation, comprising over 25,000 WSIs across 10 hospitals. The validation cohorts cover the full spectrum of breast pathology across 24 distinct clinical tasks spanning diagnosis, biomarker prediction, treatment response and survival prediction. Extensive experiments demonstrate that BRIGHT outperforms three leading generalist PFMs, achieving state-of-the-art (SOTA) performance in 21 of 24 internal validation tasks and in 5 of 10 external validation tasks with excellent heatmap interpretability. By evaluating on large-scale validation cohorts, this study not only demonstrates BRIGHT's clinical utility in breast oncology but also validates a collaborative generalist-specialist paradigm, providing a scalable template for developing PFMs on a specific organ system.

Unpaired Image-to-Image Translation via a Self-Supervised Semantic Bridge

Adversarial diffusion and diffusion-inversion methods have advanced unpaired image-to-image translation, but each faces key limitations. Adversarial approaches require target-domain adversarial loss during training, which can limit generalization to unseen data, while diffusion-inversion methods often produce low-fidelity translations due to imperfect inversion into noise-latent representations. In this work, we propose the Self-Supervised Semantic Bridge (SSB), a versatile framework that integrates external semantic priors into diffusion bridge models to enable spatially faithful translation without cross-domain supervision. Our key idea is to leverage self-supervised visual encoders to learn representations that are invariant to appearance changes but capture geometric structure, forming a shared latent space that conditions the diffusion bridges. Extensive experiments show that SSB outperforms strong prior methods for challenging medical image synthesis in both in-domain and out-of-domain settings, and extends easily to high-quality text-guided editing.

Pushing the Limits of Inverse Lithography with Generative Reinforcement Learning

Inverse lithography (ILT) is critical for modern semiconductor manufacturing but suffers from highly non-convex objectives that often trap optimization in poor local minima. Generative AI has been explored to warm-start ILT, yet most approaches train deterministic image-to-image translators to mimic sub-optimal datasets, providing limited guidance for escaping non-convex traps during refinement. We reformulate mask synthesis as conditional sampling: a generator learns a distribution over masks conditioned on the design and proposes multiple candidates. The generator is first pretrained with WGAN plus a reconstruction loss, then fine-tuned using Group Relative Policy Optimization (GRPO) with an ILT-guided imitation loss. At inference, we sample a small batch of masks, run fast batched ILT refinement, evaluate lithography metrics (e.g., EPE, process window), and select the best candidate. On \texttt{LithoBench} dataset, the proposed hybrid framework reduces EPE violations under a 3\,nm tolerance and roughly doubles throughput versus a strong numerical ILT baseline, while improving final mask quality. We also present over 20\% EPE improvement on \texttt{ICCAD13} contest cases with 3$\times$ speedup over the SOTA numerical ILT solver. By learning to propose ILT-friendly initializations, our approach mitigates non-convexity and advances beyond what traditional solvers or GenAI can achieve.

Semantic Bridging Domains: Pseudo-Source as Test-Time Connector

Distribution shifts between training and testing data are a critical bottleneck limiting the practical utility of models, especially in real-world test-time scenarios. To adapt models when the source domain is unknown and the target domain is unlabeled, previous works constructed pseudo-source domains via data generation and translation, then aligned the target domain with them. However, significant discrepancies exist between the pseudo-source and the original source domain, leading to potential divergence when correcting the target directly. From this perspective, we propose a Stepwise Semantic Alignment (SSA) method, viewing the pseudo-source as a semantic bridge connecting the source and target, rather than a direct substitute for the source. Specifically, we leverage easily accessible universal semantics to rectify the semantic features of the pseudo-source, and then align the target domain using the corrected pseudo-source semantics. Additionally, we introduce a Hierarchical Feature Aggregation (HFA) module and a Confidence-Aware Complementary Learning (CACL) strategy to enhance the semantic quality of the SSA process in the absence of source and ground truth of target domains. We evaluated our approach on tasks like semantic segmentation and image classification, achieving a 5.2% performance boost on GTA2Cityscapes over the state-of-the-art.

ArthroCut: Autonomous Policy Learning for Robotic Bone Resection in Knee Arthroplasty

Despite rapid commercialization of surgical robots, their autonomy and real-time decision-making remain limited in practice. To address this gap, we propose ArthroCut, an autonomous policy learning framework that upgrades knee arthroplasty robots from assistive execution to context-aware action generation. ArthroCut fine-tunes a Qwen--VL backbone on a self-built, time-synchronized multimodal dataset from 21 complete cases (23,205 RGB--D pairs), integrating preoperative CT/MR, intraoperative NDI tracking of bones and end effector, RGB--D surgical video, robot state, and textual intent. The method operates on two complementary token families -- Preoperative Imaging Tokens (PIT) to encode patient-specific anatomy and planned resection planes, and Time-Aligned Surgical Tokens (TAST) to fuse real-time visual, geometric, and kinematic evidence -- and emits an interpretable action grammar under grammar/safety-constrained decoding. In bench-top experiments on a knee prosthesis across seven trials, ArthroCut achieves an average success rate of 86% over the six standard resections, significantly outperforming strong baselines trained under the same protocol. Ablations show that TAST is the principal driver of reliability while PIT provides essential anatomical grounding, and their combination yields the most stable multi-plane execution. These results indicate that aligning preoperative geometry with time-aligned intraoperative perception and translating that alignment into tokenized, constrained actions is an effective path toward robust, interpretable autonomy in orthopedic robotic surgery.

MR-Compass: Inertial Navigation-Driven Motion Correction for Brain MRI

Inertial sensors can track object kinematics, however, unbounded drift from integrating noisy signals makes them impractical for MRI motion correction at millimeter resolution and minute-long scans. We introduce MR-Compass, which exploits the MRI system's static magnetic and gravitational fields to estimate 3-DOF orientation at 2 kHz directly, without integration, eliminating random-walk. The remaining 3-DOF translation is recovered via phase correlation from the MRI data. We experimentally validate the efficacy of the method retrospectively using a 3D radial koosh-ball sequence and prospectively using 2D EPI fMRI during large volunteer motions. MR-Compass followed by phase-correlation achieved a mean accuracy of 0.6$^o$ and 0.4 pixels across all experiments. Image quality improved when motion correction was applied in all volunteer scans for both retrospective and prospective correction cases. MR-Compass was effective in measuring head motion in the MRI scanner with high accuracy at unprecedented sample rates, and enabled both retrospective and prospective reconstruction to improve image quality by aligning the k-space data appropriately and by reducing the motion related artifacts.

Bridging Day and Night: Target-Class Hallucination Suppression in Unpaired Image Translation

Day-to-night unpaired image translation is important to downstream tasks but remains challenging due to large appearance shifts and the lack of direct pixel-level supervision. Existing methods often introduce semantic hallucinations, where objects from target classes such as traffic signs and vehicles, as well as man-made light effects, are incorrectly synthesized. These hallucinations significantly degrade downstream performance. We propose a novel framework that detects and suppresses hallucinations of target-class features during unpaired translation. To detect hallucination, we design a dual-head discriminator that additionally performs semantic segmentation to identify hallucinated content in background regions. To suppress these hallucinations, we introduce class-specific prototypes, constructed by aggregating features of annotated target-domain objects, which act as semantic anchors for each class. Built upon a Schrodinger Bridge-based translation model, our framework performs iterative refinement, where detected hallucination features are explicitly pushed away from class prototypes in feature space, thus preserving object semantics across the translation trajectory.Experiments show that our method outperforms existing approaches both qualitatively and quantitatively. On the BDD100K dataset, it improves mAP by 15.5% for day-to-night domain adaptation, with a notable 31.7% gain for classes such as traffic lights that are prone to hallucinations.

WildSVG: Towards Reliable SVG Generation Under Real-Word Conditions

We introduce the task of SVG extraction, which consists in translating specific visual inputs from an image into scalable vector graphics. Existing multimodal models achieve strong results when generating SVGs from clean renderings or textual descriptions, but they fall short in real-world scenarios where natural images introduce noise, clutter, and domain shifts. A central challenge in this direction is the lack of suitable benchmarks. To address this need, we introduce the WildSVG Benchmark, formed by two complementary datasets: Natural WildSVG, built from real images containing company logos paired with their SVG annotations, and Synthetic WildSVG, which blends complex SVG renderings into real scenes to simulate difficult conditions. Together, these resources provide the first foundation for systematic benchmarking SVG extraction. We benchmark state-of-the-art multimodal models and find that current approaches perform well below what is needed for reliable SVG extraction in real scenarios. Nonetheless, iterative refinement methods point to a promising path forward, and model capabilities are steadily improving

Provable Subspace Identification of Nonlinear Multi-view CCA

We investigate the identifiability of nonlinear Canonical Correlation Analysis (CCA) in a multi-view setup, where each view is generated by an unknown nonlinear map applied to a linear mixture of shared latents and view-private noise. Rather than attempting exact unmixing, a problem proven to be ill-posed, we instead reframe multi-view CCA as a basis-invariant subspace identification problem. We prove that, under suitable latent priors and spectral separation conditions, multi-view CCA recovers the pairwise correlated signal subspaces up to view-wise orthogonal ambiguity. For $N \geq 3$ views, the objective provably isolates the jointly correlated subspaces shared across all views while eliminating view-private variations. We further establish finite-sample consistency guarantees by translating the concentration of empirical cross-covariances into explicit subspace error bounds via spectral perturbation theory. Experiments on synthetic and rendered image datasets validate our theoretical findings and confirm the necessity of the assumed conditions.

Rate-Distortion Signatures of Generalization and Information Trade-offs

Generalization to novel visual conditions remains a central challenge for both human and machine vision, yet standard robustness metrics offer limited insight into how systems trade accuracy for robustness. We introduce a rate-distortion-theoretic framework that treats stimulus-response behavior as an effective communication channel, derives rate-distortion (RD) frontiers from confusion matrices, and summarizes each system with two interpretable geometric signatures - slope ($β$) and curvature ($κ$) - which capture the marginal cost and abruptness of accuracy-robustness trade-offs. Applying this framework to human psychophysics and 18 deep vision models under controlled image perturbations, we compare generalization geometry across model architectures and training regimes. We find that both biological and artificial systems follow a common lossy-compression principle but occupy systematically different regions of RD space. In particular, humans exhibit smoother, more flexible trade-offs, whereas modern deep networks operate in steeper and more brittle regimes even at matched accuracy. Across training regimes, robustness training induces systematic but dissociable shifts in beta/kappa, revealing cases where improved robustness or accuracy does not translate into more human-like generalization geometry. These results demonstrate that RD geometry provides a compact, model-agnostic lens for comparing generalization behavior across systems beyond standard accuracy-based metrics.