CellAgent: An LLM-driven Multi-Agent Framework for Automated Single-cell Data Analysis

Single-cell RNA sequencing (scRNA-seq) data analysis is crucial for biological research, as it enables the precise characterization of cellular heterogeneity. However, manual manipulation of various tools to achieve desired outcomes can be labor-intensive for researchers. To address this, we introduce CellAgent (http://cell.agent4science.cn/), an LLM-driven multi-agent framework, specifically designed for the automatic processing and execution of scRNA-seq data analysis tasks, providing high-quality results with no human intervention. Firstly, to adapt general LLMs to the biological field, CellAgent constructs LLM-driven biological expert roles - planner, executor, and evaluator - each with specific responsibilities. Then, CellAgent introduces a hierarchical decision-making mechanism to coordinate these biological experts, effectively driving the planning and step-by-step execution of complex data analysis tasks. Furthermore, we propose a self-iterative optimization mechanism, enabling CellAgent to autonomously evaluate and optimize solutions, thereby guaranteeing output quality. We evaluate CellAgent on a comprehensive benchmark dataset encompassing dozens of tissues and hundreds of distinct cell types. Evaluation results consistently show that CellAgent effectively identifies the most suitable tools and hyperparameters for single-cell analysis tasks, achieving optimal performance. This automated framework dramatically reduces the workload for science data analyses, bringing us into the "Agent for Science" era.

LLM-Powered Explanations: Unraveling Recommendations Through Subgraph Reasoning

Recommender systems are pivotal in enhancing user experiences across various web applications by analyzing the complicated relationships between users and items. Knowledge graphs(KGs) have been widely used to enhance the performance of recommender systems. However, KGs are known to be noisy and incomplete, which are hard to provide reliable explanations for recommendation results. An explainable recommender system is crucial for the product development and subsequent decision-making. To address these challenges, we introduce a novel recommender that synergies Large Language Models (LLMs) and KGs to enhance the recommendation and provide interpretable results. Specifically, we first harness the power of LLMs to augment KG reconstruction. LLMs comprehend and decompose user reviews into new triples that are added into KG. In this way, we can enrich KGs with explainable paths that express user preferences. To enhance the recommendation on augmented KGs, we introduce a novel subgraph reasoning module that effectively measures the importance of nodes and discovers reasoning for recommendation. Finally, these reasoning paths are fed into the LLMs to generate interpretable explanations of the recommendation results. Our approach significantly enhances both the effectiveness and interpretability of recommender systems, especially in cross-selling scenarios where traditional methods falter. The effectiveness of our approach has been rigorously tested on four open real-world datasets, with our methods demonstrating a superior performance over contemporary state-of-the-art techniques by an average improvement of 12%. The application of our model in a multinational engineering and technology company cross-selling recommendation system further underscores its practical utility and potential to redefine recommendation practices through improved accuracy and user trust.

Variational Bayesian Framework for Advanced Image Generation with Domain-Related Variables

Deep generative models (DGMs) and their conditional counterparts provide a powerful ability for general-purpose generative modeling of data distributions. However, it remains challenging for existing methods to address advanced conditional generative problems without annotations, which can enable multiple applications like image-to-image translation and image editing. We present a unified Bayesian framework for such problems, which introduces an inference stage on latent variables within the learning process. In particular, we propose a variational Bayesian image translation network (VBITN) that enables multiple image translation and editing tasks. Comprehensive experiments show the effectiveness of our method on unsupervised image-to-image translation, and demonstrate the novel advanced capabilities for semantic editing and mixed domain translation.

Deep GEM-Based Network for Weakly Supervised UWB Ranging Error Mitigation

Ultra-wideband (UWB)-based techniques, while becoming mainstream approaches for high-accurate positioning, tend to be challenged by ranging bias in harsh environments. The emerging learning-based methods for error mitigation have shown great performance improvement via exploiting high semantic features from raw data. However, these methods rely heavily on fully labeled data, leading to a high cost for data acquisition. We present a learning framework based on weak supervision for UWB ranging error mitigation. Specifically, we propose a deep learning method based on the generalized expectation-maximization (GEM) algorithm for robust UWB ranging error mitigation under weak supervision. Such method integrate probabilistic modeling into the deep learning scheme, and adopt weakly supervised labels as prior information. Extensive experiments in various supervision scenarios illustrate the superiority of the proposed method.

Generalized Expectation Maximization Framework for Blind Image Super Resolution

Learning-based methods for blind single image super resolution (SISR) conduct the restoration by a learned mapping between high-resolution (HR) images and their low-resolution (LR) counterparts degraded with arbitrary blur kernels. However, these methods mostly require an independent step to estimate the blur kernel, leading to error accumulation between steps. We propose an end-to-end learning framework for the blind SISR problem, which enables image restoration within a unified Bayesian framework with either full- or semi-supervision. The proposed method, namely SREMN, integrates learning techniques into the generalized expectation-maximization (GEM) algorithm and infers HR images from the maximum likelihood estimation (MLE). Extensive experiments show the superiority of the proposed method with comparison to existing work and novelty in semi-supervised learning.

A Deep Learning Approach for Generating Soft Range Information from RF Data

Radio frequency (RF)-based techniques are widely adopted for indoor localization despite the challenges in extracting sufficient information from measurements. Soft range information (SRI) offers a promising alternative for highly accurate localization that gives all probable range values rather than a single estimate of distance. We propose a deep learning approach to generate accurate SRI from RF measurements. In particular, the proposed approach is implemented by a network with two neural modules and conducts the generation directly from raw data. Extensive experiments on a case study with two public datasets are conducted to quantify the efficiency in different indoor localization tasks. The results show that the proposed approach can generate highly accurate SRI, and significantly outperforms conventional techniques in both non-line-of-sight (NLOS) detection and ranging error mitigation.

Benchmarking Interpretability Tools for Deep Neural Networks

Interpreting deep neural networks is the topic of much current research in AI. However, few interpretability techniques have shown to be competitive tools in practical applications. Inspired by how benchmarks tend to guide progress in AI, we make three contributions. First, we propose trojan rediscovery as a benchmarking task to evaluate how useful interpretability tools are for generating engineering-relevant insights. Second, we design two such approaches for benchmarking: one for feature attribution methods and one for feature synthesis methods. Third, we apply our benchmarks to evaluate 16 feature attribution/saliency methods and 9 feature synthesis methods. This approach finds large differences in the capabilities of these existing tools and shows significant room for improvement. Finally, we propose several directions for future work. Resources are available at https://github.com/thestephencasper/benchmarking_interpretability

An Improved Equiangular Division Algorithm for SBR based Ray Tracing Channel Modeling

Compared with image method (IM) based ray tracing (RT), shooting and bouncing ray (SBR) method is characterized by fast speed but low accuracy. In this paper, an iterative precise algorithm based on equiangular division is proposed to make rough paths accurate, allowing SBR to calculate exact channel information. Different ray launching methods are compared to obtain a better launching method. By using equiangular division, rays are launched more uniformly from transmitter (Tx) compared with the current equidistant division method. With the proposed iterative precise algorithm, error of angle of departure (AOD) and angle of arrival (AOA) is below 0.01 degree. The relationship between the number of iterations and error reduction is also given. It is illustrated that the proposed method has the same accuracy as IM by comparing the power delay profile (PDP) and angle distribution of paths. This can solve the problem of low accuracy brougth by SBR.

An Improved Ray Tracing Acceleration Algorithm Based on Bounding Volume Hierarchies

Ray tracing is an efficient channel modeling method. However, the traditional ray tracing method has high computation complexity. To solve this problem, an improved bounding volume hierarchies (BVH) algorithm is proposed in this paper. Based on surface area heuristic (SAH) and spatial distance, the proposed algorithm can effectively reduce the number of unnecessary intersection tests between ray and triangular facets. In addition, the algorithm fully considers the influence of ray action range, which can not only make up for the defects of spatial division based on uniform grid method and k-dimensional (KD) tree, but also solve the problem of unsatisfactory spatial division based on traditional BVH algorithm. The simulation results show that compared with the traditional BVH algorithm, the proposed algorithm can improve the computation efficiency by 20% to 35% while ensuring the computation accuracy.

An SBR Based Ray Tracing Channel Modeling Method for THz and Massive MIMO Communications

Terahertz (THz) communication and the application of massive multiple-input multiple-output (MIMO) technology have been proved significant for the sixth generation (6G) communication systems, and have gained global interests. In this paper, we employ the shooting and bouncing ray (SBR) method integrated with acceleration technology to model THz and massive MIMO channel. The results of ray tracing (RT) simulation in this paper, i.e., angle of departure (AoD), angle of arrival (AoA), and power delay profile (PDP) under the frequency band supported by the commercial RT software Wireless Insite (WI) are in agreement with those produced by WI. Based on the Kirchhoff scattering effect on material surfaces and atmospheric absorption loss showing at THz frequency band, the modified propagation models of Fresnel reflection coefficients and free-space attenuation are consistent with the measured results. For massive MIMO, the channel capacity and the stochastic power distribution are analyzed. The results indicate the applicability of SBR method for building deterministic models of THz and massive MIMO channels with extensive functions and acceptable accuracy.