Automated Detection of Multiple Sclerosis Lesions on 7-tesla MRI Using U-net and Transformer-based Segmentation

Ultra-high field 7-tesla (7T) MRI improves visualization of multiple sclerosis (MS) white matter lesions (WML) but differs sufficiently in contrast and artifacts from 1.5-3T imaging - suggesting that widely used automated segmentation tools may not translate directly. We analyzed 7T FLAIR scans and generated reference WML masks from Lesion Segmentation Tool (LST) outputs followed by expert manual revision. As external comparators, we applied LST-LPA and the more recent LST-AI ensemble, both originally developed on lower-field data. We then trained 3D UNETR and SegFormer transformer-based models on 7T FLAIR at multiple resolutions (0.5x0.5x0.5^3, 1.0x1.0x1.0^3, and 1.5x1.5x2.0^3) and evaluated all methods using voxel-wise and lesion-wise metrics from the BraTS 2023 framework. On the held-out test set at native 0.5x0.5x0.5^3 resolution, 7T-trained transformers achieved competitive overlap with LST-AI while recovering additional small lesions that were missed by classical methods, at the cost of some boundary variability and occasional artifact-related false positives. On a held-out 7 T test set, our best transformer model (SegFormer) achieved a voxel-wise Dice of 0.61 and lesion-wise Dice of 0.20, improving on the classical LST-LPA tool (Dice 0.39, lesion-wise Dice 0.02). Performance decreased for models trained on downsampled images, underscoring the value of native 7T resolution for small-lesion detection. By releasing our 7T-trained models, we aim to provide a reproducible, ready-to-use resource for automated lesion quantification in ultra-high field MS research (https://github.com/maynord/7T-MS-lesion-segmentation).

Jagle: Building a Large-Scale Japanese Multimodal Post-Training Dataset for Vision-Language Models

Developing vision-language models (VLMs) that generalize across diverse tasks requires large-scale training datasets with diverse content. In English, such datasets are typically constructed by aggregating and curating numerous existing visual question answering (VQA) resources. However, this strategy does not readily extend to other languages, where VQA datasets remain limited in both scale and domain coverage, posing a major obstacle to building high-quality multilingual and non-English VLMs. In this work, we introduce Jagle, the largest Japanese multimodal post-training dataset to date, comprising approximately 9.2 million instances across diverse tasks. Rather than relying on existing VQA datasets, we collect heterogeneous source data, including images, image-text pairs, and PDF documents, and generate VQA pairs through multiple strategies such as VLM-based QA generation, translation, and text rendering. Experiments demonstrate that a 2.2B model trained with Jagle achieves strong performance on Japanese tasks, surpassing InternVL3.5-2B in average score across ten Japanese evaluation tasks and approaching within five points of Qwen3-VL-2B-Instruct. Furthermore, combining Jagle with FineVision does not degrade English performance; instead, it improves English performance compared to training with FineVision alone. To facilitate reproducibility and future research, we release the dataset, trained models, and code.

MERIT: Multi-domain Efficient RAW Image Translation

RAW images captured by different camera sensors exhibit substantial domain shifts due to varying spectral responses, noise characteristics, and tone behaviors, complicating their direct use in downstream computer vision tasks. Prior methods address this problem by training domain-specific RAW-to-RAW translators for each source-target pair, but such approaches do not scale to real-world scenarios involving multiple types of commercial cameras. In this work, we introduce MERIT, the first unified framework for multi-domain RAW image translation, which leverages a single model to perform translations across arbitrary camera domains. To address domain-specific noise discrepancies, we propose a sensor-aware noise modeling loss that explicitly aligns the signal-dependent noise statistics of the generated images with those of the target domain. We further enhance the generator with a conditional multi-scale large kernel attention module for improved context and sensor-aware feature modeling. To facilitate standardized evaluation, we introduce MDRAW, the first dataset tailored for multi-domain RAW image translation, comprising both paired and unpaired RAW captures from five diverse camera sensors across a wide range of scenes. Extensive experiments demonstrate that MERIT outperforms prior models in both quality (5.56 dB improvement) and scalability (80% reduction in training iterations).

SD-FSMIS: Adapting Stable Diffusion for Few-Shot Medical Image Segmentation

Few-Shot Medical Image Segmentation (FSMIS) aims to segment novel object classes in medical images using only minimal annotated examples, addressing the critical challenges of data scarcity and domain shifts prevalent in medical imaging. While Diffusion Models (DM) excel in visual tasks, their potential for FSMIS remains largely unexplored. We propose that the rich visual priors learned by large-scale DMs offer a powerful foundation for a more robust and data-efficient segmentation approach. In this paper, we introduce SD-FSMIS, a novel framework designed to effectively adapt the powerful pre-trained Stable Diffusion (SD) model for the FSMIS task. Our approach repurposes its conditional generative architecture by introducing two key components: a Support-Query Interaction (SQI) and a Visual-to-Textual Condition Translator (VTCT). Specifically, SQI provides a straightforward yet powerful means of adapting SD to the FSMIS paradigm. The VTCT module translates visual cues from the support set into an implicit textual embedding that guides the diffusion model, enabling precise conditioning of the generation process. Extensive experiments demonstrate that SD-FSMIS achieves competitive results compared to state-of-the-art methods in standard settings. Surprisingly, it also demonstrated excellent generalization ability in more challenging cross-domain scenarios. These findings highlight the immense potential of adapting large-scale generative models to advance data-efficient and robust medical image segmentation.

EarthEmbeddingExplorer: A Web Application for Cross-Modal Retrieval of Global Satellite Images

While the Earth observation community has witnessed a surge in high-impact foundation models and global Earth embedding datasets, a significant barrier remains in translating these academic assets into freely accessible tools. This tutorial introduces EarthEmbeddingExplorer, an interactive web application designed to bridge this gap, transforming static research artifacts into dynamic, practical workflows for discovery. We will provide a comprehensive hands-on guide to the system, detailing its cloud-native software architecture, demonstrating cross-modal queries (natural language, visual, and geolocation), and showcasing how to derive scientific insights from retrieval results. By democratizing access to precomputed Earth embeddings, this tutorial empowers researchers to seamlessly transition from state-of-the-art models and data archives to real-world application and analysis. The web application is available at https://modelscope.ai/studios/Major-TOM/EarthEmbeddingExplorer.

Enhancing behavioral nudges with large language model-based iterative personalization: A field experiment on electricity and hot-water conservation

Nudging is widely used to promote behavioral change, but its effectiveness is often limited when recipients must repeatedly translate feedback into workable next steps under changing circumstances. Large language models (LLMs) may help reduce part of this cognitive work by generating personalized guidance and updating it iteratively across intervention rounds. We developed an LLM agent for iterative personalization and tested it in a three-arm randomized experiment among 233 university residents in China, using daily electricity and shower hot-water conservation as objectively measured cases differing in friction. LLM-personalized nudges (T2) produced the largest conservation effects, while image-enhanced conventional nudges (T1) and text-based conventional nudges (C) showed similar outcomes (omnibus p = 0.009). Relative to C, T2 reduced electricity consumption by 0.56 kWh per room-day (p = 0.014), corresponding to an 18.3 percentage-point higher adjusted saving rate. This advantage emerged within the first two intervention rounds, alongside iterative updating of personalized guidance, and persisted thereafter. Hot-water outcomes followed the same direction but were smaller, less precisely estimated, and attenuated over time, consistent with stronger friction in this domain. LLM-personalized nudges emphasized prospective and context-specific guidance and were associated with higher participant engagement. This study provides field evidence that LLM-based iterative personalization can enhance behavioral nudging, with behavioral friction as a potential boundary condition. Larger trials and extension to more behaviors are warranted.

Adversarial Attacks on Multimodal Large Language Models: A Comprehensive Survey

Multimodal large language models (MLLMs) integrate information from multiple modalities such as text, images, audio, and video, enabling complex capabilities such as visual question answering and audio translation. While powerful, this increased expressiveness introduces new and amplified vulnerabilities to adversarial manipulation. This survey provides a comprehensive and systematic analysis of adversarial threats to MLLMs, moving beyond enumerating attack techniques to explain the underlying causes of model susceptibility. We introduce a taxonomy that organizes adversarial attacks according to attacker objectives, unifying diverse attack surfaces across modalities and deployment settings. Additionally, we also present a vulnerability-centric analysis that links integrity attacks, safety and jailbreak failures, control and instruction hijacking, and training-time poisoning to shared architectural and representational weaknesses in multimodal systems. Together, this framework provides an explanatory foundation for understanding adversarial behavior in MLLMs and informs the development of more robust and secure multimodal language systems.

Improving Image-to-Image Translation via a Rectified Flow Reformulation

In this work, we propose Image-to-Image Rectified Flow Reformulation (I2I-RFR), a practical plug-in reformulation that recasts standard I2I regression networks as continuous-time transport models. While pixel-wise I2I regression is simple, stable, and easy to adapt across tasks, it often over-smooths ill-posed and multimodal targets, whereas generative alternatives often require additional components, task-specific tuning, and more complex training and inference pipelines. Our method augments the backbone input by channel-wise concatenation with a noise-corrupted version of the ground-truth target and optimizes a simple t-reweighted pixel loss. This objective admits a rectified-flow interpretation via an induced velocity field, enabling ODE-based progressive refinement at inference time while largely preserving the standard supervised training pipeline. In most cases, adopting I2I-RFR requires only expanding the input channels, and inference can be performed with a few explicit solver steps (e.g., 3 steps) without distillation. Extensive experiments across multiple image-to-image translation and video restoration tasks show that I2I-RFR generally improves performance across a wide range of tasks and backbones, with particularly clear gains in perceptual quality and detail preservation. Overall, I2I-RFR provides a lightweight way to incorporate continuous-time refinement into conventional I2I models without requiring a heavy generative pipeline.

M2H-MX: Multi-Task Dense Visual Perception for Real-Time Monocular Spatial Understanding

Monocular cameras are attractive for robotic perception due to their low cost and ease of deployment, yet achieving reliable real-time spatial understanding from a single image stream remains challenging. While recent multi-task dense prediction models have improved per-pixel depth and semantic estimation, translating these advances into stable monocular mapping systems is still non-trivial. This paper presents M2H-MX, a real-time multi-task perception model for monocular spatial understanding. The model preserves multi-scale feature representations while introducing register-gated global context and controlled cross-task interaction in a lightweight decoder, enabling depth and semantic predictions to reinforce each other under strict latency constraints. Its outputs integrate directly into an unmodified monocular SLAM pipeline through a compact perception-to-mapping interface. We evaluate both dense prediction accuracy and in-the-loop system performance. On NYUDv2, M2H-MX-L achieves state-of-the-art results, improving semantic mIoU by 6.6% and reducing depth RMSE by 9.4% over representative multi-task baselines. When deployed in a real-time monocular mapping system on ScanNet, M2H-MX reduces average trajectory error by 60.7% compared to a strong monocular SLAM baseline while producing cleaner metric-semantic maps. These results demonstrate that modern multi-task dense prediction can be reliably deployed for real-time monocular spatial perception in robotic systems.

Image-based Quantification of Postural Deviations on Patients with Cervical Dystonia: A Machine Learning Approach Using Synthetic Training Data

Cervical dystonia (CD) is the most common form of dystonia, yet current assessment relies on subjective clinical rating scales, such as the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS), which requires expertise, is subjective and faces low inter-rater reliability some items of the score. To address the lack of established objective tools for monitoring disease severity and treatment response, this study validates an automated image-based head pose and shift estimation system for patients with CD. We developed an assessment tool that combines a pretrained head-pose estimation algorithm for rotational symptoms with a deep learning model trained exclusively on ~16,000 synthetic avatar images to evaluate rare translational symptoms, specifically lateral shift. This synthetic data approach overcomes the scarcity of clinical training examples. The system's performance was validated in a multicenter study by comparing its predicted scores against the consensus ratings of 20 clinical experts using a dataset of 100 real patient images and 100 labeled synthetic avatars. The automated system demonstrated strong agreement with expert clinical ratings for rotational symptoms, achieving high correlations for torticollis (r=0.91), laterocollis (r=0.81), and anteroretrocollis (r=0.78). For lateral shift, the tool achieved a moderate correlation (r=0.55) with clinical ratings and demonstrated higher accuracy than human raters in controlled benchmark tests on avatars. By leveraging synthetic training data to bridge the clinical data gap, this model successfully generalizes to real-world patients, providing a validated, objective tool for CD postural assessment that can enable standardized clinical decision-making and trial evaluation.