Big2Small: A Unifying Neural Network Framework for Model Compression

With the development of foundational models, model compression has become a critical requirement. Various model compression approaches have been proposed such as low-rank decomposition, pruning, quantization, ergodic dynamic systems, and knowledge distillation, which are based on different heuristics. To elevate the field from fragmentation to a principled discipline, we construct a unifying mathematical framework for model compression grounded in measure theory. We further demonstrate that each model compression technique is mathematically equivalent to a neural network subject to a regularization. Building upon this mathematical and structural equivalence, we propose an experimentally-verified data-free model compression framework, termed \textit{Big2Small}, which translates Implicit Neural Representations (INRs) from data domain to the domain of network parameters. \textit{Big2Small} trains compact INRs to encode the weights of larger models and reconstruct the weights during inference. To enhance reconstruction fidelity, we introduce Outlier-Aware Preprocessing to handle extreme weight values and a Frequency-Aware Loss function to preserve high-frequency details. Experiments on image classification and segmentation demonstrate that \textit{Big2Small} achieves competitive accuracy and compression ratios compared to state-of-the-art baselines.

MEDIC-AD: Towards Medical Vision-Language Model's Clinical Intelligence

Lesion detection, symptom tracking, and visual explainability are central to real-world medical image analysis, yet current medical Vision-Language Models (VLMs) still lack mechanisms that translate their broad knowledge into clinically actionable outputs. To bridge this gap, we present MEDIC-AD, a clinically oriented VLM that strengthens these three capabilities through a stage-wise framework. First, learnable anomaly-aware tokens (<Ano>) encourage the model to focus on abnormal regions and build more discriminative lesion centered representations. Second, inter image difference tokens (<Diff>) explicitly encode temporal changes between studies, allowing the model to distinguish worsening, improvement, and stability in disease burden. Finally, a dedicated explainability stage trains the model to generate heatmaps that highlight lesion-related regions, offering clear visual evidence that is consistent with the model's reasoning. Through our staged design, MEDIC-AD steadily boosts performance across anomaly detection, symptom tracking, and anomaly segmentation, achieving state-of-the-art results compared with both closed source and medical-specialized baselines. Evaluations on real longitudinal clinical data collected from real hospital workflows further show that MEDIC-AD delivers stable predictions and clinically faithful explanations in practical patient-monitoring and decision-support workflows

Improving Image-to-Image Translation via a Rectified Flow Reformulation

In this work, we propose Image-to-Image Rectified Flow Reformulation (I2I-RFR), a practical plug-in reformulation that recasts standard I2I regression networks as continuous-time transport models. While pixel-wise I2I regression is simple, stable, and easy to adapt across tasks, it often over-smooths ill-posed and multimodal targets, whereas generative alternatives often require additional components, task-specific tuning, and more complex training and inference pipelines. Our method augments the backbone input by channel-wise concatenation with a noise-corrupted version of the ground-truth target and optimizes a simple t-reweighted pixel loss. This objective admits a rectified-flow interpretation via an induced velocity field, enabling ODE-based progressive refinement at inference time while largely preserving the standard supervised training pipeline. In most cases, adopting I2I-RFR requires only expanding the input channels, and inference can be performed with a few explicit solver steps (e.g., 3 steps) without distillation. Extensive experiments across multiple image-to-image translation and video restoration tasks show that I2I-RFR generally improves performance across a wide range of tasks and backbones, with particularly clear gains in perceptual quality and detail preservation. Overall, I2I-RFR provides a lightweight way to incorporate continuous-time refinement into conventional I2I models without requiring a heavy generative pipeline.

Uncertainty Quantification for Distribution-to-Distribution Flow Matching in Scientific Imaging

Distribution-to-distribution generative models support scientific imaging tasks ranging from modeling cellular perturbation responses to translating medical images across conditions. Trustworthy generation requires both reliability (generalization across labs, devices, and experimental conditions) and accountability (detecting out-of-distribution cases where predictions may be unreliable). Uncertainty quantification (UQ) based approaches serve as promising candidates for these tasks, yet UQ for distribution-to-distribution generative models remains underexplored. We present a unified UQ framework, Bayesian Stochastic Flow Matching (BSFM), that disentangles aleatoric and epistemic uncertainty. The Stochastic Flow Matching (SFM) component augments deterministic flows with a diffusion term to improve model generalization to unseen scenarios. For UQ, we develop a scalable Bayesian approach -- MCD-Antithetic -- that combines Monte Carlo Dropout with sample-efficient antithetic sampling to produce effective anomaly scores for out-of-distribution detection. Experiments on cellular imaging (BBBC021, JUMP) and brain fMRI (Theory of Mind) across diverse scenarios show that SFM improves reliability while MCD-Antithetic enhances accountability.

Why not to use Cosine Similarity between Label Representations

Cosine similarity is often used to measure the similarity of vectors. These vectors might be the representations of neural network models. However, it is not guaranteed that cosine similarity of model representations will tell us anything about model behaviour. In this paper we show that when using a softmax classifier, be it an image classifier or an autoregressive language model, measuring the cosine similarity between label representations (called unembeddings in the paper) does not give any information on the probabilities assigned by the model. Specifically, we prove that for any softmax classifier model, given two label representations, it is possible to make another model which gives the same probabilities for all labels and inputs, but where the cosine similarity between the representations is now either 1 or -1. We give specific examples of models with very high or low cosine simlarity between representations and show how to we can make equivalent models where the cosine similarity is now -1 or 1. This translation ambiguity can be fixed by centering the label representations, however, labels with representations with low cosine similarity can still have high probability for the same inputs. Fixing the length of the representations still does not give a guarantee that high(or low) cosine similarity will give high(or low) probability to the labels for the same inputs. This means that when working with softmax classifiers, cosine similarity values between label representations should not be used to explain model probabilities.

SciVisAgentBench: A Benchmark for Evaluating Scientific Data Analysis and Visualization Agents

Recent advances in large language models (LLMs) have enabled agentic systems that translate natural language intent into executable scientific visualization (SciVis) tasks. Despite rapid progress, the community lacks a principled and reproducible benchmark for evaluating these emerging SciVis agents in realistic, multi-step analysis settings. We present SciVisAgentBench, a comprehensive and extensible benchmark for evaluating scientific data analysis and visualization agents. Our benchmark is grounded in a structured taxonomy spanning four dimensions: application domain, data type, complexity level, and visualization operation. It currently comprises 108 expert-crafted cases covering diverse SciVis scenarios. To enable reliable assessment, we introduce a multimodal outcome-centric evaluation pipeline that combines LLM-based judging with deterministic evaluators, including image-based metrics, code checkers, rule-based verifiers, and case-specific evaluators. We also conduct a validity study with 12 SciVis experts to examine the agreement between human and LLM judges. Using this framework, we evaluate representative SciVis agents and general-purpose coding agents to establish initial baselines and reveal capability gaps. SciVisAgentBench is designed as a living benchmark to support systematic comparison, diagnose failure modes, and drive progress in agentic SciVis. The benchmark is available at https://scivisagentbench.github.io/.

Ontology-Guided Diffusion for Zero-Shot Visual Sim2Real Transfer

Bridging the simulation-to-reality (sim2real) gap remains challenging as labelled real-world data is scarce. Existing diffusion-based approaches rely on unstructured prompts or statistical alignment, which do not capture the structured factors that make images look real. We introduce Ontology- Guided Diffusion (OGD), a neuro-symbolic zero-shot sim2real image translation framework that represents realism as structured knowledge. OGD decomposes realism into an ontology of interpretable traits -- such as lighting and material properties -- and encodes their relationships in a knowledge graph. From a synthetic image, OGD infers trait activations and uses a graph neural network to produce a global embedding. In parallel, a symbolic planner uses the ontology traits to compute a consistent sequence of visual edits needed to narrow the realism gap. The graph embedding conditions a pretrained instruction-guided diffusion model via cross-attention, while the planned edits are converted into a structured instruction prompt. Across benchmarks, our graph-based embeddings better distinguish real from synthetic imagery than baselines, and OGD outperforms state-of-the-art diffusion methods in sim2real image translations. Overall, OGD shows that explicitly encoding realism structure enables interpretable, data-efficient, and generalisable zero-shot sim2real transfer.

Translating MRI to PET through Conditional Diffusion Models with Enhanced Pathology Awareness

Positron emission tomography (PET) is a widely recognized technique for diagnosing neurodegenerative diseases, offering critical functional insights. However, its high costs and radiation exposure hinder its widespread use. In contrast, magnetic resonance imaging (MRI) does not involve such limitations. While MRI also detects neurodegenerative changes, it is less sensitive for diagnosis compared to PET. To overcome such limitations, one approach is to generate synthetic PET from MRI. Recent advances in generative models have paved the way for cross-modality medical image translation; however, existing methods largely emphasize structural preservation while neglecting the critical need for pathology awareness. To address this gap, we propose PASTA, a novel image translation framework built on conditional diffusion models with enhanced pathology awareness. PASTA surpasses state-of-the-art methods by preserving both structural and pathological details through its highly interactive dual-arm architecture and multi-modal condition integration. Additionally, we introduce a novel cycle exchange consistency and volumetric generation strategy that significantly enhances PASTA's ability to produce high-quality 3D PET images. Our qualitative and quantitative results demonstrate the high quality and pathology awareness of the synthesized PET scans. For Alzheimer's diagnosis, the performance of these synthesized scans improves over MRI by 4%, almost reaching the performance of actual PET. Our code is available at https://github.com/ai-med/PASTA.

Designing Any Imaging System from Natural Language: Agent-Constrained Composition over a Finite Primitive Basis

Designing a computational imaging system -- selecting operators, setting parameters, validating consistency -- requires weeks of specialist effort per modality, creating an expertise bottleneck that excludes the broader scientific community from prototyping imaging instruments. We introduce spec.md, a structured specification format, and three autonomous agents -- Plan, Judge, and Execute -- that translate a one-sentence natural-language description into a validated forward model with bounded reconstruction error. A design-to-real error theorem decomposes total reconstruction error into five independently bounded terms, each linked to a corrective action. On 6 real-data modalities spanning all 5 carrier families, the automated pipeline matches expert-library quality (98.1 +/- 4.2%). Ten novel designs -- composing primitives into chains from 3D to 5D -- demonstrate compositional reach beyond any single-modality tool.

PSDesigner: Automated Graphic Design with a Human-Like Creative Workflow

Graphic design is a creative and innovative process that plays a crucial role in applications such as e-commerce and advertising. However, developing an automated design system that can faithfully translate user intentions into editable design files remains an open challenge. Although recent studies have leveraged powerful text-to-image models and MLLMs to assist graphic design, they typically simplify professional workflows, resulting in limited flexibility and intuitiveness. To address these limitations, we propose PSDesigner, an automated graphic design system that emulates the creative workflow of human designers. Building upon multiple specialized components, PSDesigner collects theme-related assets based on user instructions, and autonomously infers and executes tool calls to manipulate design files, such as integrating new assets or refining inferior elements. To endow the system with strong tool-use capabilities, we construct a design dataset, CreativePSD, which contains a large amount of high-quality PSD design files annotated with operation traces across a wide range of design scenarios and artistic styles, enabling models to learn expert design procedures. Extensive experiments demonstrate that PSDesigner outperforms existing methods across diverse graphic design tasks, empowering non-specialists to conveniently create production-quality designs.