Measuring Intelligence Beyond Human Scale

How can we measure intelligence beyond human capability? Human-authored benchmarks saturate, and above human capability, examiners may not know which tasks are both hard and verifiable. We argue that this difficulty is inherent to absolute-scale evaluation and propose a new paradigm based on relative measurement in which models generate public challenges that separate other systems. Aggregating these outcomes yields an adversarial psychometric rating system that can scale with the systems being measured. We describe practical protocols that reduce incentives for private-information attacks, support judge-free adjudication, and naturally scale with agent capabilities. We instantiate the framework across verifiable and open-ended, non-verifiable domains, illustrating how model-generated evaluation can continue to measure systems beyond the human frontier.

Uncertainty-Guided Selective Adaptation Enables Cross-Platform Predictive Fluorescence Microscopy

Deep learning is transforming microscopy, yet models often fail when applied to images from new instruments or acquisition settings. Conventional adversarial domain adaptation (ADDA) retrains entire networks, often disrupting learned semantic representations. Here, we overturn this paradigm by showing that adapting only the earliest convolutional layers, while freezing deeper layers, yields reliable transfer. Building on this principle, we introduce Subnetwork Image Translation ADDA with automatic depth selection (SIT-ADDA-Auto), a self-configuring framework that integrates shallow-layer adversarial alignment with predictive uncertainty to automatically select adaptation depth without target labels. We demonstrate robustness via multi-metric evaluation, blinded expert assessment, and uncertainty-depth ablations. Across exposure and illumination shifts, cross-instrument transfer, and multiple stains, SIT-ADDA improves reconstruction and downstream segmentation over full-encoder adaptation and non-adversarial baselines, with reduced drift of semantic features. Our results provide a design rule for label-free adaptation in microscopy and a recipe for field settings; the code is publicly available.