Machine Learning for Biomedical Raman Spectroscopy: From Spectral Acquisition to Clinical Translation

Raman spectroscopy provides label-free, chemically specific characterization of biological systems and has become an important tool for cancer diagnosis, molecular subtyping, microbiological identification, and intraoperative decision support. Biomedical Raman spectra are, however, high-dimensional, noisy, and affected by fluorescence background, acquisition variability, and biological heterogeneity, making robust computational analysis essential. This review examines the role of machine learning across the biomedical Raman spectroscopy pipeline, from preprocessing and signal correction to unsupervised structure discovery, supervised diagnosis and molecular stratification, representation and transfer learning, explainability, biomarker discovery, and multimodal integration with imaging, pathology, and molecular profiling. Emphasis is placed on the use of machine learning not only for diagnostic classification, but also for biologically interpretable and clinically actionable analysis. We also discuss the main barriers to clinical translation, including limited dataset sizes, inter-instrument variability, inconsistent preprocessing, insufficient external validation, reproducibility concerns, and limited sharing of software, data, and metadata. We argue that progress will require methodological advances together with standardization, robust validation, explainability, and deployment-ready analytical frameworks. By integrating methodological, biomedical, and translational perspectives, this review outlines key directions for developing reliable and clinically deployable Raman-AI systems.

MoVerse: Real-Time Video World Modeling with Panoramic Gaussian Scaffold

We present MoVerse, a real-time video world model that creates an interactively navigable scene from a single narrow-field-of-view image. This setting is challenging because the input observes only a small fraction of the environment, while interactive roaming requires a complete surrounding world, persistent geometry, controllable camera motion, and temporally coherent high-fidelity observations. MoVerse addresses this problem by separating world construction from observation rendering. It first expands the input into a gravity-aligned 360$^\circ$ panorama with topology-aware diffusion, closing the missing field of view before 3D reasoning. It then lifts the panorama into a persistent 3D Gaussian scaffold using panoramic geometry-aware residual prediction, yielding a dense and directly renderable spatial memory. Finally, a Gaussian-conditioned video renderer translates scaffold renderings along user-specified camera trajectories into photorealistic video. To make this renderer practical for interaction, we train a bidirectional diffusion teacher for high-quality conditional rendering and distill it into a causal autoregressive student for bounded-latency streaming. This design combines the controllability and long-range consistency of explicit 3D representations with the perceptual quality of generative video models. MoVerse supports real-time scene roaming at 8~FPS on a single NVIDIA RTX~4090 GPU, demonstrating a practical path toward single-image world creation with interactive video output.

Reconstructing Synthetic SDO/AIA 193 A EUV Images from He I 10830 A Observations with Diffusion Model Translator

Routine full-disk EUV imaging has been available only since the modern era, such as SOHO and SDO. To extend EUV coronal context into earlier periods, we leverage the multi-decade availability of full-disk \HeI{} observations, whose absorption is modulated by coronal irradiance and magnetic topology and is widely used as a proxy for open-field regions. We present a diffusion-based conditional image translation framework, Coronal Hole-aware Diffusion Model Translator (CH-aware DMT), to reconstruct synthetic SDO/AIA 193 Å EUV images from \HeI{} inputs. The model is trained on temporally co-aligned SOLIS \HeI{} and AIA 193 Å pairs spanning 2011--2015 using a month-based split, where January--October are used for training, November is used for validation, and December for testing. On the held-out test set, the reconstructions preserve dominant full-disk EUV morphology (CC=0.92) and recover CH-related low-intensity structure (CC=0.84). We further assess historical applicability by (1) comparing reconstructed AIA 193 Å morphology with SOHO/EIT 195 Å over 2005--2015; (2) comparing reconstructed AIA 193 Å images generated from KPVT \HeI{} inputs against Yohkoh/SXT soft X-ray observations; and (3) evaluating long-term reconstructed disk-integrated emission statistics against observational EUV series and independent solar activity proxies (sunspot number and F10.7 radio flux over 1974--2015). These results indicate that CH-aware DMT conditioned on \HeI{} can provide a physically plausible synthetic AIA 193 Å coronal proxy for historical studies, supporting multi-decade analyses of large-scale coronal evolution before the direct EUV imaging was available.

iMaC: Translating Actions into Motion and Contact Images for Embodied World Models

Embodied world models have emerged as a pivotal paradigm for visual robotic decision-making and interactive environment simulation. However, conventional embodied frameworks rely on low-dimensional structured action vectors (e.g., joint angles and end-effector poses), which suffer from limited expressive capacity, poor generalization across diverse embodiments, and unnatural dynamic modeling for complex physical interactions. To address these limitations, this paper proposesiMac (Image as Action Control), a novel unified control paradigm that treats raw visual images as native action representations for embodied world models. Departing from traditional explicit kinematic action encoding, iMac formulates continuous visual manipulation as image-based action tokens, which inherently encapsulate spatial motion intentions, interactive geometric constraints and subtle physical dynamics. We construct a dual-branch embodied architecture consisting of an image-action encoder and a dynamic world predictor: the encoder compresses target-driven visual images into compact action embeddings, while the predictor learns environment transition rules conditioned on image actions to achieve high-fidelity future state prediction and closed-loop embodied control. Extensive experiments are conducted on public embodied manipulation benchmarks and real-world robotic scenarios. The results demonstrate that iMac outperforms vector-based action control baselines in prediction accuracy, task success rate and cross-scene generalization ability. Moreover, our image-action design eliminates the reliance on manually defined action spaces, realizing flexible and universal control for heterogeneous embodied agents. This work provides an innovative visual-action perspective for embodied world models, offering a simple yet effective paradigm for scalable robotic perception and manipulation.

nD-RoPE: A Generalized RoPE for n-Dimensional Position Embedding

Rotary Position Embedding (RoPE) is widely adopted in Transformer models, yet its extension to high-dimensional domains lacks a unified theoretical formulation. Most existing approaches either apply rotations independently along each axis or empirically mix frequencies, which limits cross-dimensional interactions and yields direction-dependent representations. To address these limitations, we propose nD-RoPE, a decomposition-free generalization of RoPE to arbitrary dimensions. From a translation-invariant formulation in continuous Hilbert space, we derive a spectral condition for isotropy that requires treating positions and frequencies as coupled \(n\)-dimensional vectors. We instantiate this formulation with a multi-scale regular-simplex wave-vector design, which provides non-degenerate spatial coverage and a symmetric, directionally balanced second-order response. Experiments across images, videos, and point clouds demonstrate consistent performance gains and improved generalization in high-dimensional settings.

MedCTA: A Benchmark for Clinical Tool Agents

To make clinically grounded decisions, medical AI agents are expected to go beyond simple recognition and be capable of tool retrieval, evidence acquisition, and integration. Existing benchmarks largely evaluate isolated perception or single-turn question answering, and therefore provide limited visibility into failures of planning, tool recruitment, and rollout reliability. We introduce MedCTA, a benchmark for evaluating medical tool agents on clinician-validated, step-implicit tasks grounded in realistic multimodal clinical inputs, including radiology images, pathology slides, and reports. MedCTA comprises 107 real-world clinical tasks with clinician-verified executable trajectories over 5 deployed tools, and supports process-aware evaluation of tool selection, argument validity, execution stability, trajectory fidelity, and outcome quality. We benchmark 18 open- and closed-source multimodal models and find that even frontier systems remain brittle in multi-step clinical tool use: autonomous rollouts are dominated by protocol failures, premature stopping, and incorrect tool recruitment, while gold-standard tool routing yields large but still incomplete gains. These results show that strong backbone perception does not translate into reliable agentic behavior in clinical settings. MedCTA provides a rigorous testbed for auditing, diagnosing, and advancing trustworthy medical AI agents. The dataset and evaluation suite are available at https://ivul-kaust.github.io/MedCTA/

AnimaSpark: A Feed-Forward Method for Animating Arbitrary 3D Objects

While recent advancements in generative AI have substantially accelerated static 3D model creation workflows, the synthesis of category-agnostic 3D animations remains a significant bottleneck in 3D asset production. Current methods for category-agnostic animation generation exhibit critical limitations in inference speed, motion quality, and adherence to textual prompts, thereby leaving the process dependent on labor-intensive manual artistry. To address these challenges, this paper introduces AnimaSpark, a novel pipeline for category-agnostic 3D animation generation. Our approach is motivated by the key insight that for many fundamental motions in the 3D world, the corresponding joint transformations can often be effectively modeled within a two-dimensional subspace. The pipeline begins by rendering a rigged static 3D model into multi-layered image representations of its mesh and skeleton, which are subsequently fed into a video generation model. We then employ a keypoint tracking algorithm on the generated video to capture the motion of the skeletal joints projected onto the camera's viewing plane. In the final stage, we distill the planar translations and rotations from these tracked keypoints and lift them from the 2D domain into 3D space to animate the character. Comprehensive evaluations reveal that our method achieves superior performance over existing state-of-the-art techniques across key metrics, including text-motion alignment, quality of motion, and computational efficiency.

AnyMod-LLVE: Low-Light Video Enhancement with Modality-Agnostic Inference

Low-light video enhancement (LLVE) remains a challenging task due to severe information degradation under low-illumination conditions. Recent multimodal approaches have significantly improved enhancement performance by incorporating auxiliary modalities, such as event streams and infrared images. However, these methods typically assume the availability of these modalities at inference, which is often not feasible in real-world scenarios. To solve this problem, in this work, we propose AMNet, a unified multimodal framework for LLVE, to support flexible modality-agnostic inference, where auxiliary modalities may be unavailable. To address the issue of modality absence, we introduce a Spatial-Spectral Dual-Gated Translator that learns the correspondence between auxiliary modalities and RGB inputs, producing implicit auxiliary representations to support the robust enhancement. Additionally, to fully facilitate the learning of cross-modal correspondence, we conduct large-scale multimodal pretraining based on the RGB-only dataset with synthetic auxiliary modalities. Extensive experiments demonstrate that AMNet could handle arbitrary inference-time modality combinations and exhibits superior performance for LLVE under modality absence conditions. Code and models are available on the project page.

SheafStain: Sheaf-Theoretic Schrödinger Bridge for Spatially and Biologically Coherent Virtual Staining

Current virtual staining approaches offer the potential for time- and cost-efficient biomarker quantification in cancer diagnostics and prognostics. However, patch-wise inference for gigapixel whole slide images (WSIs) fails to maintain spatial continuity, yielding artifacts that cause catastrophic mismatches with ground-truth images. Although pathology Vision Foundation Models (VFMs) offer rich representations, their self-attention causes varying global contexts to produce inconsistent embeddings for the same physical region. We formalize and validate this ``context contamination'' as a sheaf-theoretic problem where these embeddings form a presheaf that violates the gluing axiom. To address this, we propose SheafStain, a new approach that reinterprets VFM features as sheaf-like sections for spatially and biologically coherent virtual staining. Specifically, SheafStain integrates class and patch tokens into a Schrödinger Bridge framework as sheaf-like sections. While the class token anchors biological consistency, patch tokens form a per-position spatial map. A backbone co-pretrained on Hematoxylin \& Eosin (H\&E) and Immunohistochemistry (IHC) yields non-degenerate cross-stain stalks, so a single VFM feature space supervises both input conditioning and output stain alignment. Departing from prior work that evaluates on isolated $256 \times 256$ patches and either random-crops or resizes the $1024 \times 1024$ ground truth, we translate at $256 \times 256$ and evaluate on the stitched $1024 \times 1024$ outputs across HER2, ER, PR, and Ki-67. SheafStain demonstrates promising results against six prior methods while mitigating patch-boundary stitching artifacts. Code will soon be released.

MariData: One-Step Unpaired Image Translation for Maritime Environments

The development on robust perception systems for Maritime Autonomous Surface Ships (MASS) is heavily constrained by the scarcity of diverse training data, particularly for adverse weather and low-light conditions. Because collecting paired images in dynamic maritime environments is physically impossible, synthetic data generation via unpaired image-to-image translation offers a critical solution. However, existing generative models suffer from failing to preserve the fine structural details of small navigational objects due to latent compression bottlenecks. In this paper, we introduce a framework for generating synthetic maritime data using CycleGAN-turbo, a one-step unpaired translation architecture. By incorporating zero-convolution skip connections to bypass the Variational Autoencoder (VAE) bottleneck, our approach explicitly preserves small object details (e.g., distant vessels and sea marks) during translation. We compiled a dataset of 7,000 maritime images to train and evaluate models for Day-to-Foggy, Day-to-Sunset, and Day-to-Night domain translations. Qualitative evaluations and variable-strength inference studies demonstrate that our method effectively synthesizes realistic atmospheric conditions while maintaining the underlying semantic structure of the scene. The Day-to-Foggy and Day-to-Sunset models exhibit great structural retention, whereas the Day-to-Night model highlights the challenge of semantic hallucination, such as generating artificial coastal lights, induced by unbalanced training distributions. Ultimately, this work establishes an efficient, structure-aware data synthesis pipeline that directly addresses the data scarcity bottleneck in autonomous maritime navigation.