Robust and Clinically Reliable EEG Biomarkers: A Cross Population Framework for Generalizable Parkinson's Disease Detection

Developing robust and clinically reliable EEG biomarkers requires evaluation frameworks that explicitly address cross population generalization in multi site settings such as Parkinsons disease (PD) detection. Models trained under i.i.d. assumptions often capture population specific artifacts rather than disease relevant neural structure, leading to poor generalization across clinical cohorts. EEG further amplifies this challenge due to low signal to noise ratio and heterogeneous acquisition conditions. We propose a population aware evaluation framework to assess the robustness and clinical reliability of EEG biomarkers under distribution shift. Using an n gram expansion strategy, we enumerate all cross population train test configurations across five independent cohorts, resulting in 75 directional evaluations. A nested cross validation design with integrated channel selection ensures prospective biomarker identification without population leakage. Results show that cross population transfer is asymmetric and that both accuracy and biomarker stability improve with increasing training population diversity, achieving up to 94.1% accuracy on held out cohorts. A theoretical analysis based on mixture risk optimization and hypothesis space contraction explains these trends, showing that multi population training promotes population robust representations. This work establishes a principled framework for learning robust, generalizable, and clinically reliable EEG biomarkers for multi site biomedical applications.

Fragile Reasoning: A Mechanistic Analysis of LLM Sensitivity to Meaning-Preserving Perturbations

Large language models demonstrate strong performance on mathematical reasoning benchmarks, yet remain surprisingly fragile to meaning-preserving surface perturbations. We systematically evaluate three open-weight LLMs, Mistral-7B, Llama-3-8B, and Qwen2.5-7B, on 677 GSM8K problems paired with semantically equivalent variants generated through name substitution and number format paraphrasing. All three models exhibit substantial answer-flip rates (28.8%-45.1%), with number paraphrasing consistently more disruptive than name swaps. To trace the mechanistic basis of these failures, we introduce the Mechanistic Perturbation Diagnostics (MPD) framework, combining logit lens analysis, activation patching, component ablation, and the Cascading Amplification Index (CAI) into a unified diagnostic pipeline. CAI, a novel metric quantifying layer-wise divergence amplification, outperforms first divergence layer as a failure predictor for two of three architectures (AUC up to 0.679). Logit lens reveals that flipped samples diverge from correct predictions at significantly earlier layers than stable samples. Activation patching reveals a stark architectural divide in failure localizability: Llama-3 failures are recoverable by patching at specific layers (43/60 samples), while Mistral and Qwen failures are broadly distributed (3/60 and 0/60). Based on these diagnostic signals, we propose a mechanistic failure taxonomy (localized, distributed, and entangled) and validate it through targeted repair experiments: steering vectors and layer fine-tuning recover 12.2% of localized failures (Llama-3) but only 7.2% of entangled (Qwen) and 5.2% of distributed (Mistral) failures.

MFil-Mamba: Multi-Filter Scanning for Spatial Redundancy-Aware Visual State Space Models

State Space Models (SSMs), especially recent Mamba architecture, have achieved remarkable success in sequence modeling tasks. However, extending SSMs to computer vision remains challenging due to the non-sequential structure of visual data and its complex 2D spatial dependencies. Although several early studies have explored adapting selective SSMs for vision applications, most approaches primarily depend on employing various traversal strategies over the same input. This introduces redundancy and distorts the intricate spatial relationships within images. To address these challenges, we propose MFil-Mamba, a novel visual state space architecture built on a multi-filter scanning backbone. Unlike fixed multi-directional traversal methods, our design enables each scan to capture unique and contextually relevant spatial information while minimizing redundancy. Furthermore, we incorporate an adaptive weighting mechanism to effectively fuse outputs from multiple scans in addition to architectural enhancements. MFil-Mamba achieves superior performance over existing state-of-the-art models across various benchmarks that include image classification, object detection, instance segmentation, and semantic segmentation. For example, our tiny variant attains 83.2% top-1 accuracy on ImageNet-1K, 47.3% box AP and 42.7% mask AP on MS COCO, and 48.5% mIoU on the ADE20K dataset. Code and models are available at https://github.com/puskal-khadka/MFil-Mamba.

AI-CARE: Carbon-Aware Reporting Evaluation Metric for AI Models

As machine learning (ML) continues its rapid expansion, the environmental cost of model training and inference has become a critical societal concern. Existing benchmarks overwhelmingly focus on standard performance metrics such as accuracy, BLEU, or mAP, while largely ignoring energy consumption and carbon emissions. This single-objective evaluation paradigm is increasingly misaligned with the practical requirements of large-scale deployment, particularly in energy-constrained environments such as mobile devices, developing regions, and climate-aware enterprises. In this paper, we propose AI-CARE, an evaluation tool for reporting energy consumption, and carbon emissions of ML models. In addition, we introduce the carbon-performance tradeoff curve, an interpretable tool that visualizes the Pareto frontier between performance and carbon cost. We demonstrate, through theoretical analysis and empirical validation on representative ML workloads, that carbon-aware benchmarking changes the relative ranking of models and encourages architectures that are simultaneously accurate and environmentally responsible. Our proposal aims to shift the research community toward transparent, multi-objective evaluation and align ML progress with global sustainability goals. The tool and documentation are available at https://github.com/USD-AI-ResearchLab/ai-care.

Learning to Select Like Humans: Explainable Active Learning for Medical Imaging

Medical image analysis requires substantial labeled data for model training, yet expert annotation is expensive and time-consuming. Active learning (AL) addresses this challenge by strategically selecting the most informative samples for the annotation purpose, but traditional methods solely rely on predictive uncertainty while ignoring whether models learn from clinically meaningful features a critical requirement for clinical deployment. We propose an explainability-guided active learning framework that integrates spatial attention alignment into a sample acquisition process. Our approach advocates for a dual-criterion selection strategy combining: (i) classification uncertainty to identify informative examples, and (ii) attention misalignment with radiologist-defined regions-of-interest (ROIs) to target samples where the model focuses on incorrect features. By measuring misalignment between Grad-CAM attention maps and expert annotations using \emph{Dice similarity}, our acquisition function judiciously identifies samples that enhance both predictive performance and spatial interpretability. We evaluate the framework using three expert-annotated medical imaging datasets, namely, BraTS (MRI brain tumors), VinDr-CXR (chest X-rays), and SIIM-COVID-19 (chest X-rays). Using only 570 strategically selected samples, our explainability-guided approach consistently outperforms random sampling across all the datasets, achieving 77.22\% accuracy on BraTS, 52.37\% on VinDr-CXR, and 52.66\% on SIIM-COVID. Grad-CAM visualizations confirm that the models trained by our dual-criterion selection focus on diagnostically relevant regions, demonstrating that incorporating explanation guidance into sample acquisition yields superior data efficiency while maintaining clinical interpretability.

Explainability-Guided Defense: Attribution-Aware Model Refinement Against Adversarial Data Attacks

The growing reliance on deep learning models in safety-critical domains such as healthcare and autonomous navigation underscores the need for defenses that are both robust to adversarial perturbations and transparent in their decision-making. In this paper, we identify a connection between interpretability and robustness that can be directly leveraged during training. Specifically, we observe that spurious, unstable, or semantically irrelevant features identified through Local Interpretable Model-Agnostic Explanations (LIME) contribute disproportionately to adversarial vulnerability. Building on this insight, we introduce an attribution-guided refinement framework that transforms LIME from a passive diagnostic into an active training signal. Our method systematically suppresses spurious features using feature masking, sensitivity-aware regularization, and adversarial augmentation in a closed-loop refinement pipeline. This approach does not require additional datasets or model architectures and integrates seamlessly into standard adversarial training. Theoretically, we derive an attribution-aware lower bound on adversarial distortion that formalizes the link between explanation alignment and robustness. Empirical evaluations on CIFAR-10, CIFAR-10-C, and CIFAR-100 demonstrate substantial improvements in adversarial robustness and out-of-distribution generalization.

Expert-Guided Explainable Few-Shot Learning with Active Sample Selection for Medical Image Analysis

Medical image analysis faces two critical challenges: scarcity of labeled data and lack of model interpretability, both hindering clinical AI deployment. Few-shot learning (FSL) addresses data limitations but lacks transparency in predictions. Active learning (AL) methods optimize data acquisition but overlook interpretability of acquired samples. We propose a dual-framework solution: Expert-Guided Explainable Few-Shot Learning (EGxFSL) and Explainability-Guided AL (xGAL). EGxFSL integrates radiologist-defined regions-of-interest as spatial supervision via Grad-CAM-based Dice loss, jointly optimized with prototypical classification for interpretable few-shot learning. xGAL introduces iterative sample acquisition prioritizing both predictive uncertainty and attention misalignment, creating a closed-loop framework where explainability guides training and sample selection synergistically. On the BraTS (MRI), VinDr-CXR (chest X-ray), and SIIM-COVID-19 (chest X-ray) datasets, we achieve accuracies of 92\%, 76\%, and 62\%, respectively, consistently outperforming non-guided baselines across all datasets. Under severe data constraints, xGAL achieves 76\% accuracy with only 680 samples versus 57\% for random sampling. Grad-CAM visualizations demonstrate guided models focus on diagnostically relevant regions, with generalization validated on breast ultrasound confirming cross-modality applicability.

I Detect What I Don't Know: Incremental Anomaly Learning with Stochastic Weight Averaging-Gaussian for Oracle-Free Medical Imaging

Unknown anomaly detection in medical imaging remains a fundamental challenge due to the scarcity of labeled anomalies and the high cost of expert supervision. We introduce an unsupervised, oracle-free framework that incrementally expands a trusted set of normal samples without any anomaly labels. Starting from a small, verified seed of normal images, our method alternates between lightweight adapter updates and uncertainty-gated sample admission. A frozen pretrained vision backbone is augmented with tiny convolutional adapters, ensuring rapid domain adaptation with negligible computational overhead. Extracted embeddings are stored in a compact coreset enabling efficient k-nearest neighbor anomaly (k-NN) scoring. Safety during incremental expansion is enforced by dual probabilistic gates, a sample is admitted into the normal memory only if its distance to the existing coreset lies within a calibrated z-score threshold, and its SWAG-based epistemic uncertainty remains below a seed-calibrated bound. This mechanism prevents drift and false inclusions without relying on generative reconstruction or replay buffers. Empirically, our system steadily refines the notion of normality as unlabeled data arrive, producing substantial gains over baselines. On COVID-CXR, ROC-AUC improves from 0.9489 to 0.9982 (F1: 0.8048 to 0.9746); on Pneumonia CXR, ROC-AUC rises from 0.6834 to 0.8968; and on Brain MRI ND-5, ROC-AUC increases from 0.6041 to 0.7269 and PR-AUC from 0.7539 to 0.8211. These results highlight the effectiveness and efficiency of the proposed framework for real-world, label-scarce medical imaging applications.

CoSwin: Convolution Enhanced Hierarchical Shifted Window Attention For Small-Scale Vision

Vision Transformers (ViTs) have achieved impressive results in computer vision by leveraging self-attention to model long-range dependencies. However, their emphasis on global context often comes at the expense of local feature extraction in small datasets, particularly due to the lack of key inductive biases such as locality and translation equivariance. To mitigate this, we propose CoSwin, a novel feature-fusion architecture that augments the hierarchical shifted window attention with localized convolutional feature learning. Specifically, CoSwin integrates a learnable local feature enhancement module into each attention block, enabling the model to simultaneously capture fine-grained spatial details and global semantic structure. We evaluate CoSwin on multiple image classification benchmarks including CIFAR-10, CIFAR-100, MNIST, SVHN, and Tiny ImageNet. Our experimental results show consistent performance gains over state-of-the-art convolutional and transformer-based models. Notably, CoSwin achieves improvements of 2.17% on CIFAR-10, 4.92% on CIFAR-100, 0.10% on MNIST, 0.26% on SVHN, and 4.47% on Tiny ImageNet over the baseline Swin Transformer. These improvements underscore the effectiveness of local-global feature fusion in enhancing the generalization and robustness of transformers for small-scale vision. Code and pretrained weights available at https://github.com/puskal-khadka/coswin

Ecologically Valid Benchmarking and Adaptive Attention: Scalable Marine Bioacoustic Monitoring

Underwater Passive Acoustic Monitoring (UPAM) provides rich spatiotemporal data for long-term ecological analysis, but intrinsic noise and complex signal dependencies hinder model stability and generalization. Multilayered windowing has improved target sound localization, yet variability from shifting ambient noise, diverse propagation effects, and mixed biological and anthropogenic sources demands robust architectures and rigorous evaluation. We introduce GetNetUPAM, a hierarchical nested cross-validation framework designed to quantify model stability under ecologically realistic variability. Data are partitioned into distinct site-year segments, preserving recording heterogeneity and ensuring each validation fold reflects a unique environmental subset, reducing overfitting to localized noise and sensor artifacts. Site-year blocking enforces evaluation against genuine environmental diversity, while standard cross-validation on random subsets measures generalization across UPAM's full signal distribution, a dimension absent from current benchmarks. Using GetNetUPAM as the evaluation backbone, we propose the Adaptive Resolution Pooling and Attention Network (ARPA-N), a neural architecture for irregular spectrogram dimensions. Adaptive pooling with spatial attention extends the receptive field, capturing global context without excessive parameters. Under GetNetUPAM, ARPA-N achieves a 14.4% gain in average precision over DenseNet baselines and a log2-scale order-of-magnitude drop in variability across all metrics, enabling consistent detection across site-year folds and advancing scalable, accurate bioacoustic monitoring.