A Dataset for Distilling Knowledge Priors from Literature for Therapeutic Design

AI-driven discovery can greatly reduce design time and enhance new therapeutics' effectiveness. Models using simulators explore broad design spaces but risk violating implicit constraints due to a lack of experimental priors. For example, in a new analysis we performed on a diverse set of models on the GuacaMol benchmark using supervised classifiers, over 60\% of molecules proposed had high probability of being mutagenic. In this work, we introduce \ourdataset, a dataset of priors for design problems extracted from literature describing compounds used in lab settings. It is constructed with LLM pipelines for discovering therapeutic entities in relevant paragraphs and summarizing information in concise fair-use facts. \ourdataset~ consists of 32.3 million pairs of natural language facts, and appropriate entity representations (i.e. SMILES or refseq IDs). To demonstrate the potential of the data, we train LLM, CLIP, and LLava architectures to reason jointly about text and design targets and evaluate on tasks from the Therapeutic Data Commons (TDC). \ourdataset~is highly effective for creating models with strong priors: in supervised prediction problems that use our data as pretraining, our best models with 15M learnable parameters outperform larger 2B TxGemma on both regression and classification TDC tasks, and perform comparably to 9B models on average. Models built with \ourdataset~can be used as constraints while optimizing for novel molecules in GuacaMol, resulting in proposals that are safer and nearly as effective. We release our dataset at \href{https://huggingface.co/datasets/medexanon/Medex}{huggingface.co/datasets/medexanon/Medex}, and will provide expanded versions as available literature grows.

Improving Audio Classification by Transitioning from Zero- to Few-Shot

State-of-the-art audio classification often employs a zero-shot approach, which involves comparing audio embeddings with embeddings from text describing the respective audio class. These embeddings are usually generated by neural networks trained through contrastive learning to align audio and text representations. Identifying the optimal text description for an audio class is challenging, particularly when the class comprises a wide variety of sounds. This paper examines few-shot methods designed to improve classification accuracy beyond the zero-shot approach. Specifically, audio embeddings are grouped by class and processed to replace the inherently noisy text embeddings. Our results demonstrate that few-shot classification typically outperforms the zero-shot baseline.

Pixels Under Pressure: Exploring Fine-Tuning Paradigms for Foundation Models in High-Resolution Medical Imaging

Advancements in diffusion-based foundation models have improved text-to-image generation, yet most efforts have been limited to low-resolution settings. As high-resolution image synthesis becomes increasingly essential for various applications, particularly in medical imaging domains, fine-tuning emerges as a crucial mechanism for adapting these powerful pre-trained models to task-specific requirements and data distributions. In this work, we present a systematic study, examining the impact of various fine-tuning techniques on image generation quality when scaling to high resolution 512x512 pixels. We benchmark a diverse set of fine-tuning methods, including full fine-tuning strategies and parameter-efficient fine-tuning (PEFT). We dissect how different fine-tuning methods influence key quality metrics, including Fr\'echet Inception Distance (FID), Vendi score, and prompt-image alignment. We also evaluate the utility of generated images in a downstream classification task under data-scarce conditions, demonstrating that specific fine-tuning strategies improve both generation fidelity and downstream performance when synthetic images are used for classifier training and evaluation on real images. Our code is accessible through the project website - https://tehraninasab.github.io/PixelUPressure/.

Multi-Rationale Explainable Object Recognition via Contrastive Conditional Inference

Explainable object recognition using vision-language models such as CLIP involves predicting accurate category labels supported by rationales that justify the decision-making process. Existing methods typically rely on prompt-based conditioning, which suffers from limitations in CLIP's text encoder and provides weak conditioning on explanatory structures. Additionally, prior datasets are often restricted to single, and frequently noisy, rationales that fail to capture the full diversity of discriminative image features. In this work, we introduce a multi-rationale explainable object recognition benchmark comprising datasets in which each image is annotated with multiple ground-truth rationales, along with evaluation metrics designed to offer a more comprehensive representation of the task. To overcome the limitations of previous approaches, we propose a contrastive conditional inference (CCI) framework that explicitly models the probabilistic relationships among image embeddings, category labels, and rationales. Without requiring any training, our framework enables more effective conditioning on rationales to predict accurate object categories. Our approach achieves state-of-the-art results on the multi-rationale explainable object recognition benchmark, including strong zero-shot performance, and sets a new standard for both classification accuracy and rationale quality. Together with the benchmark, this work provides a more complete framework for evaluating future models in explainable object recognition. The code will be made available online.

Large Language Model Data Generation for Enhanced Intent Recognition in German Speech

Intent recognition (IR) for speech commands is essential for artificial intelligence (AI) assistant systems; however, most existing approaches are limited to short commands and are predominantly developed for English. This paper addresses these limitations by focusing on IR from speech by elderly German speakers. We propose a novel approach that combines an adapted Whisper ASR model, fine-tuned on elderly German speech (SVC-de), with Transformer-based language models trained on synthetic text datasets generated by three well-known large language models (LLMs): LeoLM, Llama3, and ChatGPT. To evaluate the robustness of our approach, we generate synthetic speech with a text-to-speech model and conduct extensive cross-dataset testing. Our results show that synthetic LLM-generated data significantly boosts classification performance and robustness to different speaking styles and unseen vocabulary. Notably, we find that LeoLM, a smaller, domain-specific 13B LLM, surpasses the much larger ChatGPT (175B) in dataset quality for German intent recognition. Our approach demonstrates that generative AI can effectively bridge data gaps in low-resource domains. We provide detailed documentation of our data generation and training process to ensure transparency and reproducibility.

Text2VLM: Adapting Text-Only Datasets to Evaluate Alignment Training in Visual Language Models

The increasing integration of Visual Language Models (VLMs) into AI systems necessitates robust model alignment, especially when handling multimodal content that combines text and images. Existing evaluation datasets heavily lean towards text-only prompts, leaving visual vulnerabilities under evaluated. To address this gap, we propose \textbf{Text2VLM}, a novel multi-stage pipeline that adapts text-only datasets into multimodal formats, specifically designed to evaluate the resilience of VLMs against typographic prompt injection attacks. The Text2VLM pipeline identifies harmful content in the original text and converts it into a typographic image, creating a multimodal prompt for VLMs. Also, our evaluation of open-source VLMs highlights their increased susceptibility to prompt injection when visual inputs are introduced, revealing critical weaknesses in the current models' alignment. This is in addition to a significant performance gap compared to closed-source frontier models. We validate Text2VLM through human evaluations, ensuring the alignment of extracted salient concepts; text summarization and output classification align with human expectations. Text2VLM provides a scalable tool for comprehensive safety assessment, contributing to the development of more robust safety mechanisms for VLMs. By enhancing the evaluation of multimodal vulnerabilities, Text2VLM plays a role in advancing the safe deployment of VLMs in diverse, real-world applications.

Explaining Similarity in Vision-Language Encoders with Weighted Banzhaf Interactions

Language-image pre-training (LIP) enables the development of vision-language models capable of zero-shot classification, localization, multimodal retrieval, and semantic understanding. Various explanation methods have been proposed to visualize the importance of input image-text pairs on the model's similarity outputs. However, popular saliency maps are limited by capturing only first-order attributions, overlooking the complex cross-modal interactions intrinsic to such encoders. We introduce faithful interaction explanations of LIP models (FIxLIP) as a unified approach to decomposing the similarity in vision-language encoders. FIxLIP is rooted in game theory, where we analyze how using the weighted Banzhaf interaction index offers greater flexibility and improves computational efficiency over the Shapley interaction quantification framework. From a practical perspective, we propose how to naturally extend explanation evaluation metrics, like the pointing game and area between the insertion/deletion curves, to second-order interaction explanations. Experiments on MS COCO and ImageNet-1k benchmarks validate that second-order methods like FIxLIP outperform first-order attribution methods. Beyond delivering high-quality explanations, we demonstrate the utility of FIxLIP in comparing different models like CLIP vs. SigLIP-2 and ViT-B/32 vs. ViT-L/16.

On the Risk of Misleading Reports: Diagnosing Textual Biases in Multimodal Clinical AI

Clinical decision-making relies on the integrated analysis of medical images and the associated clinical reports. While Vision-Language Models (VLMs) can offer a unified framework for such tasks, they can exhibit strong biases toward one modality, frequently overlooking critical visual cues in favor of textual information. In this work, we introduce Selective Modality Shifting (SMS), a perturbation-based approach to quantify a model's reliance on each modality in binary classification tasks. By systematically swapping images or text between samples with opposing labels, we expose modality-specific biases. We assess six open-source VLMs-four generalist models and two fine-tuned for medical data-on two medical imaging datasets with distinct modalities: MIMIC-CXR (chest X-ray) and FairVLMed (scanning laser ophthalmoscopy). By assessing model performance and the calibration of every model in both unperturbed and perturbed settings, we reveal a marked dependency on text input, which persists despite the presence of complementary visual information. We also perform a qualitative attention-based analysis which further confirms that image content is often overshadowed by text details. Our findings highlight the importance of designing and evaluating multimodal medical models that genuinely integrate visual and textual cues, rather than relying on single-modality signals.

Hot-Swap MarkBoard: An Efficient Black-box Watermarking Approach for Large-scale Model Distribution

Recently, Deep Learning (DL) models have been increasingly deployed on end-user devices as On-Device AI, offering improved efficiency and privacy. However, this deployment trend poses more serious Intellectual Property (IP) risks, as models are distributed on numerous local devices, making them vulnerable to theft and redistribution. Most existing ownership protection solutions (e.g., backdoor-based watermarking) are designed for cloud-based AI-as-a-Service (AIaaS) and are not directly applicable to large-scale distribution scenarios, where each user-specific model instance must carry a unique watermark. These methods typically embed a fixed watermark, and modifying the embedded watermark requires retraining the model. To address these challenges, we propose Hot-Swap MarkBoard, an efficient watermarking method. It encodes user-specific $n$-bit binary signatures by independently embedding multiple watermarks into a multi-branch Low-Rank Adaptation (LoRA) module, enabling efficient watermark customization without retraining through branch swapping. A parameter obfuscation mechanism further entangles the watermark weights with those of the base model, preventing removal without degrading model performance. The method supports black-box verification and is compatible with various model architectures and DL tasks, including classification, image generation, and text generation. Extensive experiments across three types of tasks and six backbone models demonstrate our method's superior efficiency and adaptability compared to existing approaches, achieving 100\% verification accuracy.

LET-US: Long Event-Text Understanding of Scenes

Event cameras output event streams as sparse, asynchronous data with microsecond-level temporal resolution, enabling visual perception with low latency and a high dynamic range. While existing Multimodal Large Language Models (MLLMs) have achieved significant success in understanding and analyzing RGB video content, they either fail to interpret event streams effectively or remain constrained to very short sequences. In this paper, we introduce LET-US, a framework for long event-stream--text comprehension that employs an adaptive compression mechanism to reduce the volume of input events while preserving critical visual details. LET-US thus establishes a new frontier in cross-modal inferential understanding over extended event sequences. To bridge the substantial modality gap between event streams and textual representations, we adopt a two-stage optimization paradigm that progressively equips our model with the capacity to interpret event-based scenes. To handle the voluminous temporal information inherent in long event streams, we leverage text-guided cross-modal queries for feature reduction, augmented by hierarchical clustering and similarity computation to distill the most representative event features. Moreover, we curate and construct a large-scale event-text aligned dataset to train our model, achieving tighter alignment of event features within the LLM embedding space. We also develop a comprehensive benchmark covering a diverse set of tasks -- reasoning, captioning, classification, temporal localization and moment retrieval. Experimental results demonstrate that LET-US outperforms prior state-of-the-art MLLMs in both descriptive accuracy and semantic comprehension on long-duration event streams. All datasets, codes, and models will be publicly available.