Versatile Cardiovascular Signal Generation with a Unified Diffusion Transformer

Cardiovascular signals such as photoplethysmography (PPG), electrocardiography (ECG), and blood pressure (BP) are inherently correlated and complementary, together reflecting the health of cardiovascular system. However, their joint utilization in real-time monitoring is severely limited by diverse acquisition challenges from noisy wearable recordings to burdened invasive procedures. Here we propose UniCardio, a multi-modal diffusion transformer that reconstructs low-quality signals and synthesizes unrecorded signals in a unified generative framework. Its key innovations include a specialized model architecture to manage the signal modalities involved in generation tasks and a continual learning paradigm to incorporate varying modality combinations. By exploiting the complementary nature of cardiovascular signals, UniCardio clearly outperforms recent task-specific baselines in signal denoising, imputation, and translation. The generated signals match the performance of ground-truth signals in detecting abnormal health conditions and estimating vital signs, even in unseen domains, while ensuring interpretability for human experts. These advantages position UniCardio as a promising avenue for advancing AI-assisted healthcare.

Non-Invasive Arterial Pulse Detection with Millimeter-wave Radar and Comparison With Photoplethysmography

Cardiovascular diseases remain a leading cause of mortality and disability. The convenient measurement of cardiovascular health using smart systems is therefore a key enabler to foster accurate and early detection and diagnosis of cardiovascular diseases and it require accessing a correct pulse morphology similar to arterial pressure wave. This paper investigates the comparison between different sensor modalities, such as mmWave and photoplethysmography from the same physiological site and reference continuous non-invasive blood pressure devide. We have developed a hardware prototype and established an experiment consist of 23 test participants. Both mmWave and PPG are capable of detecting inter-beat intervals. mmWave is providing more accurate arterial pulse waveform than green photoplethysmography.

Uncertainty quantification with approximate variational learning for wearable photoplethysmography prediction tasks

Photoplethysmography (PPG) signals encode information about relative changes in blood volume that can be used to assess various aspects of cardiac health non-invasively, e.g.\ to detect atrial fibrillation (AF) or predict blood pressure (BP). Deep networks are well-equipped to handle the large quantities of data acquired from wearable measurement devices. However, they lack interpretability and are prone to overfitting, leaving considerable risk for poor performance on unseen data and misdiagnosis. Here, we describe the use of two scalable uncertainty quantification techniques: Monte Carlo Dropout and the recently proposed Improved Variational Online Newton. These techniques are used to assess the trustworthiness of models trained to perform AF classification and BP regression from raw PPG time series. We find that the choice of hyperparameters has a considerable effect on the predictive performance of the models and on the quality and composition of predicted uncertainties. E.g. the stochasticity of the model parameter sampling determines the proportion of the total uncertainty that is aleatoric, and has varying effects on predictive performance and calibration quality dependent on the chosen uncertainty quantification technique and the chosen expression of uncertainty. We find significant discrepancy in the quality of uncertainties over the predicted classes, emphasising the need for a thorough evaluation protocol that assesses local and adaptive calibration. This work suggests that the choice of hyperparameters must be carefully tuned to balance predictive performance and calibration quality, and that the optimal parameterisation may vary depending on the chosen expression of uncertainty.

Contactless pulse rate assessment: Results and insights for application in driving simulator

Camera-based monitoring of Pulse Rate (PR) enables continuous and unobtrusive assessment of driver's state, allowing estimation of fatigue or stress that could impact traffic safety. Commonly used wearable Photoplethysmography (PPG) sensors, while effective, suffer from motion artifacts and user discomfort. This study explores the feasibility of non-contact PR assessment using facial video recordings captured by a Red, Green, and Blue (RGB) camera in a driving simulation environment. The proposed approach detects subtle skin color variations due to blood flow and compares extracted PR values against reference measurements from a wearable wristband Empatica E4. We evaluate the impact of Eulerian Video Magnification (EVM) on signal quality and assess statistical differences in PR between age groups. Data obtained from 80 recordings from 64 healthy subjects covering a PR range of 45-160 bpm are analyzed, and signal extraction accuracy is quantified using metrics, such as Mean Absolute Error (MAE) and Root Mean Square Error (RMSE). Results show that EVM slightly improves PR estimation accuracy, reducing MAE from 6.48 bpm to 5.04 bpm and RMSE from 7.84 bpm to 6.38 bpm. A statistically significant difference is found between older and younger groups with both video-based and ground truth evaluation procedures. Additionally, we discuss Empatica E4 bias and its potential impact on the overall assessment of contact measurements. Altogether the findings demonstrate the feasibility of camera-based PR monitoring in dynamic environments and its potential integration into driving simulators for real-time physiological assessment.

Generalised Label-free Artefact Cleaning for Real-time Medical Pulsatile Time Series

Artefacts compromise clinical decision-making in the use of medical time series. Pulsatile waveforms offer probabilities for accurate artefact detection, yet most approaches rely on supervised manners and overlook patient-level distribution shifts. To address these issues, we introduce a generalised label-free framework, GenClean, for real-time artefact cleaning and leverage an in-house dataset of 180,000 ten-second arterial blood pressure (ABP) samples for training. We first investigate patient-level generalisation, demonstrating robust performances under both intra- and inter-patient distribution shifts. We further validate its effectiveness through challenging cross-disease cohort experiments on the MIMIC-III database. Additionally, we extend our method to photoplethysmography (PPG), highlighting its applicability to diverse medical pulsatile signals. Finally, its integration into ICM+, a clinical research monitoring software, confirms the real-time feasibility of our framework, emphasising its practical utility in continuous physiological monitoring. This work provides a foundational step toward precision medicine in improving the reliability of high-resolution medical time series analysis

PsyCounAssist: A Full-Cycle AI-Powered Psychological Counseling Assistant System

Psychological counseling is a highly personalized and dynamic process that requires therapists to continuously monitor emotional changes, document session insights, and maintain therapeutic continuity. In this paper, we introduce PsyCounAssist, a comprehensive AI-powered counseling assistant system specifically designed to augment psychological counseling practices. PsyCounAssist integrates multimodal emotion recognition combining speech and photoplethysmography (PPG) signals for accurate real-time affective analysis, automated structured session reporting using large language models (LLMs), and personalized AI-generated follow-up support. Deployed on Android-based tablet devices, the system demonstrates practical applicability and flexibility in real-world counseling scenarios. Experimental evaluation confirms the reliability of PPG-based emotional classification and highlights the system's potential for non-intrusive, privacy-aware emotional support. PsyCounAssist represents a novel approach to ethically and effectively integrating AI into psychological counseling workflows.

Pushing the Limit of PPG Sensing in Sedentary Conditions by Addressing Poor Skin-sensor Contact

Photoplethysmography (PPG) is a widely used non-invasive technique for monitoring cardiovascular health and various physiological parameters on consumer and medical devices. While motion artifacts are well-known challenges in dynamic settings, suboptimal skin-sensor contact in sedentary conditions - a critical issue often overlooked in existing literature - can distort PPG signal morphology, leading to the loss or shift of essential waveform features and therefore degrading sensing performance. In this work, we propose CP-PPG, a novel approach that transforms Contact Pressure-distorted PPG signals into ones with the ideal morphology. CP-PPG incorporates a novel data collection approach, a well-crafted signal processing pipeline, and an advanced deep adversarial model trained with a custom PPG-aware loss function. We validated CP-PPG through comprehensive evaluations, including 1) morphology transformation performance on our self-collected dataset, 2) downstream physiological monitoring performance on public datasets, and 3) in-the-wild performance. Extensive experiments demonstrate substantial and consistent improvements in signal fidelity (Mean Absolute Error: 0.09, 40% improvement over the original signal) as well as downstream performance across all evaluations in Heart Rate (HR), Heart Rate Variability (HRV), Respiration Rate (RR), and Blood Pressure (BP) estimation (on average, 21% improvement in HR; 41-46% in HRV; 6% in RR; and 4-5% in BP). These findings highlight the critical importance of addressing skin-sensor contact issues for accurate and dependable PPG-based physiological monitoring. Furthermore, CP-PPG can serve as a generic, plug-in API to enhance PPG signal quality.

Exploring Reliable PPG Authentication on Smartwatches in Daily Scenarios

Photoplethysmography (PPG) Sensors, widely deployed in smartwatches, offer a simple and non-invasive authentication approach for daily use. However, PPG authentication faces reliability issues due to motion artifacts from physical activity and physiological variability over time. To address these challenges, we propose MTL-RAPID, an efficient and reliable PPG authentication model, that employs a multitask joint training strategy, simultaneously assessing signal quality and verifying user identity. The joint optimization of these two tasks in MTL-RAPID results in a structure that outperforms models trained on individual tasks separately, achieving stronger performance with fewer parameters. In our comprehensive user studies regarding motion artifacts (N = 30), time variations (N = 32), and user preferences (N = 16), MTL-RAPID achieves a best AUC of 99.2\% and an EER of 3.5\%, outperforming existing baselines. We opensource our PPG authentication dataset along with the MTL-RAPID model to facilitate future research on GitHub.

TAU: Modeling Temporal Consistency Through Temporal Attentive U-Net for PPG Peak Detection

Photoplethysmography (PPG) sensors have been widely used in consumer wearable devices to monitor heart rates (HR) and heart rate variability (HRV). Despite the prevalence, PPG signals can be contaminated by motion artifacts induced from daily activities. Existing approaches mainly use the amplitude information to perform PPG peak detection. However, these approaches cannot accurately identify peaks, since motion artifacts may bring random and significant amplitude variations. To improve the performance of PPG peak detection, the time information can be used. Specifically, heart rates exhibit temporal consistency that consecutive heartbeat intervals in a normal person can have limited variations. To leverage the temporal consistency, we propose the Temporal Attentive U-Net, i.e., TAU, to accurately detect peaks from PPG signals. In TAU, we design a time module that encodes temporal consistency in temporal embeddings. We integrate the amplitude information with temporal embeddings using the attention mechanism to estimate peak labels. Our experimental results show that TAU outperforms eleven baselines on heart rate estimation by more than 22.4%. Our TAU model achieves the best performance across various Signal-to-Noise Ratio (SNR) levels. Moreover, we achieve Pearson correlation coefficients higher than 0.9 (p < 0.01) on estimating HRV features from low-noise-level PPG signals.

GPT-PPG: A GPT-based Foundation Model for Photoplethysmography Signals

This study introduces a novel application of a Generative Pre-trained Transformer (GPT) model tailored for photoplethysmography (PPG) signals, serving as a foundation model for various downstream tasks. Adapting the standard GPT architecture to suit the continuous characteristics of PPG signals, our approach demonstrates promising results. Our models are pre-trained on our extensive dataset that contains more than 200 million 30s PPG samples. We explored different supervised fine-tuning techniques to adapt our model to downstream tasks, resulting in performance comparable to or surpassing current state-of-the-art (SOTA) methods in tasks like atrial fibrillation detection. A standout feature of our GPT model is its inherent capability to perform generative tasks such as signal denoising effectively, without the need for further fine-tuning. This success is attributed to the generative nature of the GPT framework.