How Suboptimal is Training rPPG Models with Videos and Targets from Different Body Sites?

Remote camera measurement of the blood volume pulse via photoplethysmography (rPPG) is a compelling technology for scalable, low-cost, and accessible assessment of cardiovascular information. Neural networks currently provide the state-of-the-art for this task and supervised training or fine-tuning is an important step in creating these models. However, most current models are trained on facial videos using contact PPG measurements from the fingertip as targets/ labels. One of the reasons for this is that few public datasets to date have incorporated contact PPG measurements from the face. Yet there is copious evidence that the PPG signals at different sites on the body have very different morphological features. Is training a facial video rPPG model using contact measurements from another site on the body suboptimal? Using a recently released unique dataset with synchronized contact PPG and video measurements from both the hand and face, we can provide precise and quantitative answers to this question. We obtain up to 40 % lower mean squared errors between the waveforms of the predicted and the ground truth PPG signals using state-of-the-art neural models when using PPG signals from the forehead compared to using PPG signals from the fingertip. We also show qualitatively that the neural models learn to predict the morphology of the ground truth PPG signal better when trained on the forehead PPG signals. However, while models trained from the forehead PPG produce a more faithful waveform, models trained from a finger PPG do still learn the dominant frequency (i.e., the heart rate) well.

On the Standardization of Behavioral Use Clauses and Their Adoption for Responsible Licensing of AI

Growing concerns over negligent or malicious uses of AI have increased the appetite for tools that help manage the risks of the technology. In 2018, licenses with behaviorial-use clauses (commonly referred to as Responsible AI Licenses) were proposed to give developers a framework for releasing AI assets while specifying their users to mitigate negative applications. As of the end of 2023, on the order of 40,000 software and model repositories have adopted responsible AI licenses licenses. Notable models licensed with behavioral use clauses include BLOOM (language) and LLaMA2 (language), Stable Diffusion (image), and GRID (robotics). This paper explores why and how these licenses have been adopted, and why and how they have been adapted to fit particular use cases. We use a mixed-methods methodology of qualitative interviews, clustering of license clauses, and quantitative analysis of license adoption. Based on this evidence we take the position that responsible AI licenses need standardization to avoid confusing users or diluting their impact. At the same time, customization of behavioral restrictions is also appropriate in some contexts (e.g., medical domains). We advocate for ``standardized customization'' that can meet users' needs and can be supported via tooling.

Health-LLM: Large Language Models for Health Prediction via Wearable Sensor Data

Large language models (LLMs) are capable of many natural language tasks, yet they are far from perfect. In health applications, grounding and interpreting domain-specific and non-linguistic data is important. This paper investigates the capacity of LLMs to deliver multi-modal health predictions based on contextual information (e.g. user demographics, health knowledge) and physiological data (e.g. resting heart rate, sleep minutes). We present a comprehensive evaluation of eight state-of-the-art LLMs with diverse prompting and fine-tuning techniques on six public health datasets (PM-Data, LifeSnaps, GLOBEM, AW_FB, MIT-BIH & MIMIC-III). Our experiments cover thirteen consumer health prediction tasks in mental health, activity, metabolic, sleep, and cardiac assessment. Our fine-tuned model, Health-Alpaca exhibits comparable performance to larger models (GPT-3.5 and GPT-4), achieving the best performance in 5 out of 13 tasks. Ablation studies highlight the effectiveness of context enhancement strategies, and generalization capability of the fine-tuned models across training datasets and the size of training samples. Notably, we observe that our context enhancement can yield up to 23.8% improvement in performance. While constructing contextually rich prompts (combining user context, health knowledge and temporal information) exhibits synergistic improvement, the inclusion of health knowledge context in prompts significantly enhances overall performance.

Towards Accurate Differential Diagnosis with Large Language Models

An accurate differential diagnosis (DDx) is a cornerstone of medical care, often reached through an iterative process of interpretation that combines clinical history, physical examination, investigations and procedures. Interactive interfaces powered by Large Language Models (LLMs) present new opportunities to both assist and automate aspects of this process. In this study, we introduce an LLM optimized for diagnostic reasoning, and evaluate its ability to generate a DDx alone or as an aid to clinicians. 20 clinicians evaluated 302 challenging, real-world medical cases sourced from the New England Journal of Medicine (NEJM) case reports. Each case report was read by two clinicians, who were randomized to one of two assistive conditions: either assistance from search engines and standard medical resources, or LLM assistance in addition to these tools. All clinicians provided a baseline, unassisted DDx prior to using the respective assistive tools. Our LLM for DDx exhibited standalone performance that exceeded that of unassisted clinicians (top-10 accuracy 59.1% vs 33.6%, [p = 0.04]). Comparing the two assisted study arms, the DDx quality score was higher for clinicians assisted by our LLM (top-10 accuracy 51.7%) compared to clinicians without its assistance (36.1%) (McNemar's Test: 45.7, p < 0.01) and clinicians with search (44.4%) (4.75, p = 0.03). Further, clinicians assisted by our LLM arrived at more comprehensive differential lists than those without its assistance. Our study suggests that our LLM for DDx has potential to improve clinicians' diagnostic reasoning and accuracy in challenging cases, meriting further real-world evaluation for its ability to empower physicians and widen patients' access to specialist-level expertise.

From Classification to Clinical Insights: Towards Analyzing and Reasoning About Mobile and Behavioral Health Data With Large Language Models

Passively collected behavioral health data from ubiquitous sensors holds significant promise to provide mental health professionals insights from patient's daily lives; however, developing analysis tools to use this data in clinical practice requires addressing challenges of generalization across devices and weak or ambiguous correlations between the measured signals and an individual's mental health. To address these challenges, we take a novel approach that leverages large language models (LLMs) to synthesize clinically useful insights from multi-sensor data. We develop chain of thought prompting methods that use LLMs to generate reasoning about how trends in data such as step count and sleep relate to conditions like depression and anxiety. We first demonstrate binary depression classification with LLMs achieving accuracies of 61.1% which exceed the state of the art. While it is not robust for clinical use, this leads us to our key finding: even more impactful and valued than classification is a new human-AI collaboration approach in which clinician experts interactively query these tools and combine their domain expertise and context about the patient with AI generated reasoning to support clinical decision-making. We find models like GPT-4 correctly reference numerical data 75% of the time, and clinician participants express strong interest in using this approach to interpret self-tracking data.

Video-based sympathetic arousal assessment via peripheral blood flow estimation

Electrodermal activity (EDA) is considered a standard marker of sympathetic activity. However, traditional EDA measurement requires electrodes in steady contact with the skin. Can sympathetic arousal be measured using only an optical sensor, such as an RGB camera? This paper presents a novel approach to infer sympathetic arousal by measuring the peripheral blood flow on the face or hand optically. We contribute a self-recorded dataset of 21 participants, comprising synchronized videos of participants' faces and palms and gold-standard EDA and photoplethysmography (PPG) signals. Our results show that we can measure peripheral sympathetic responses that closely correlate with the ground truth EDA. We obtain median correlations of 0.57 to 0.63 between our inferred signals and the ground truth EDA using only videos of the participants' palms or foreheads or PPG signals from the foreheads or fingers. We also show that sympathetic arousal is best inferred from the forehead, finger, or palm.

The Capability of Large Language Models to Measure Psychiatric Functioning

The current work investigates the capability of Large language models (LLMs) that are explicitly trained on large corpuses of medical knowledge (Med-PaLM 2) to predict psychiatric functioning from patient interviews and clinical descriptions without being trained to do so. To assess this, n = 145 depression and n =115 PTSD assessments and n = 46 clinical case studies across high prevalence/high comorbidity disorders (Depressive, Anxiety, Psychotic, trauma and stress, Addictive disorders) were analyzed using prompts to extract estimated clinical scores and diagnoses. Results demonstrate that Med-PaLM 2 is capable of assessing psychiatric functioning across a range of psychiatric conditions with the strongest performance being the prediction of depression scores based on standardized assessments (Accuracy range= 0.80 - 0.84) which were statistically indistinguishable from human clinical raters t(1,144) = 1.20; p = 0.23. Results show the potential for general clinical language models to flexibly predict psychiatric risk based on free descriptions of functioning from both patients and clinicians.

Large Language Models are Few-Shot Health Learners

Large language models (LLMs) can capture rich representations of concepts that are useful for real-world tasks. However, language alone is limited. While existing LLMs excel at text-based inferences, health applications require that models be grounded in numerical data (e.g., vital signs, laboratory values in clinical domains; steps, movement in the wellness domain) that is not easily or readily expressed as text in existing training corpus. We demonstrate that with only few-shot tuning, a large language model is capable of grounding various physiological and behavioral time-series data and making meaningful inferences on numerous health tasks for both clinical and wellness contexts. Using data from wearable and medical sensor recordings, we evaluate these capabilities on the tasks of cardiac signal analysis, physical activity recognition, metabolic calculation (e.g., calories burned), and estimation of stress reports and mental health screeners.

"Can't Take the Pressure?": Examining the Challenges of Blood Pressure Estimation via Pulse Wave Analysis

The use of observed wearable sensor data (e.g., photoplethysmograms [PPG]) to infer health measures (e.g., glucose level or blood pressure) is a very active area of research. Such technology can have a significant impact on health screening, chronic disease management and remote monitoring. A common approach is to collect sensor data and corresponding labels from a clinical grade device (e.g., blood pressure cuff), and train deep learning models to map one to the other. Although well intentioned, this approach often ignores a principled analysis of whether the input sensor data has enough information to predict the desired metric. We analyze the task of predicting blood pressure from PPG pulse wave analysis. Our review of the prior work reveals that many papers fall prey data leakage, and unrealistic constraints on the task and the preprocessing steps. We propose a set of tools to help determine if the input signal in question (e.g., PPG) is indeed a good predictor of the desired label (e.g., blood pressure). Using our proposed tools, we have found that blood pressure prediction using PPG has a high multi-valued mapping factor of 33.2% and low mutual information of 9.8%. In comparison, heart rate prediction using PPG, a well-established task, has a very low multi-valued mapping factor of 0.75% and high mutual information of 87.7%. We argue that these results provide a more realistic representation of the current progress towards to goal of wearable blood pressure measurement via PPG pulse wave analysis.

A Review of Deep Learning for Video Captioning

Video captioning (VC) is a fast-moving, cross-disciplinary area of research that bridges work in the fields of computer vision, natural language processing (NLP), linguistics, and human-computer interaction. In essence, VC involves understanding a video and describing it with language. Captioning is used in a host of applications from creating more accessible interfaces (e.g., low-vision navigation) to video question answering (V-QA), video retrieval and content generation. This survey covers deep learning-based VC, including but, not limited to, attention-based architectures, graph networks, reinforcement learning, adversarial networks, dense video captioning (DVC), and more. We discuss the datasets and evaluation metrics used in the field, and limitations, applications, challenges, and future directions for VC.