Implicit Motion Handling for Video Camouflaged Object Detection

We propose a new video camouflaged object detection (VCOD) framework that can exploit both short-term dynamics and long-term temporal consistency to detect camouflaged objects from video frames. An essential property of camouflaged objects is that they usually exhibit patterns similar to the background and thus make them hard to identify from still images. Therefore, effectively handling temporal dynamics in videos becomes the key for the VCOD task as the camouflaged objects will be noticeable when they move. However, current VCOD methods often leverage homography or optical flows to represent motions, where the detection error may accumulate from both the motion estimation error and the segmentation error. On the other hand, our method unifies motion estimation and object segmentation within a single optimization framework. Specifically, we build a dense correlation volume to implicitly capture motions between neighbouring frames and utilize the final segmentation supervision to optimize the implicit motion estimation and segmentation jointly. Furthermore, to enforce temporal consistency within a video sequence, we jointly utilize a spatio-temporal transformer to refine the short-term predictions. Extensive experiments on VCOD benchmarks demonstrate the architectural effectiveness of our approach. We also provide a large-scale VCOD dataset named MoCA-Mask with pixel-level handcrafted ground-truth masks and construct a comprehensive VCOD benchmark with previous methods to facilitate research in this direction. Dataset Link: https://xueliancheng.github.io/SLT-Net-project.

Exploring Smoothness and Class-Separation for Semi-supervised Medical Image Segmentation

Semi-supervised segmentation remains challenging in medical imaging since the amount of annotated medical data is often limited and there are many blurred pixels near the adhesive edges or low-contrast regions. To address the issues, we advocate to firstly constrain the consistency of samples with and without strong perturbations to apply sufficient smoothness regularization and further encourage the class-level separation to exploit the unlabeled ambiguous pixels for the model training. Particularly, in this paper, we propose the SS-Net for semi-supervised medical image segmentation tasks, via exploring the pixel-level Smoothness and inter-class Separation at the same time. The pixel-level smoothness forces the model to generate invariant results under adversarial perturbations. Meanwhile, the inter-class separation constrains individual class features should approach their corresponding high-quality prototypes, in order to make each class distribution compact and separate different classes. We evaluated our SS-Net against five recent methods on the public LA and ACDC datasets. The experimental results under two semi-supervised settings demonstrate the superiority of our proposed SS-Net, achieving new state-of-the-art (SOTA) performance on both datasets. The codes will be released.

Label uncertainty-guided multi-stream model for disease screening

The annotation of disease severity for medical image datasets often relies on collaborative decisions from multiple human graders. The intra-observer variability derived from individual differences always persists in this process, yet the influence is often underestimated. In this paper, we cast the intra-observer variability as an uncertainty problem and incorporate the label uncertainty information as guidance into the disease screening model to improve the final decision. The main idea is dividing the images into simple and hard cases by uncertainty information, and then developing a multi-stream network to deal with different cases separately. Particularly, for hard cases, we strengthen the network's capacity in capturing the correct disease features and resisting the interference of uncertainty. Experiments on a fundus image-based glaucoma screening case study show that the proposed model outperforms several baselines, especially in screening hard cases.

Anomaly Detection in Retinal Images using Multi-Scale Deep Feature Sparse Coding

Convolutional Neural Network models have successfully detected retinal illness from optical coherence tomography (OCT) and fundus images. These CNN models frequently rely on vast amounts of labeled data for training, difficult to obtain, especially for rare diseases. Furthermore, a deep learning system trained on a data set with only one or a few diseases cannot detect other diseases, limiting the system's practical use in disease identification. We have introduced an unsupervised approach for detecting anomalies in retinal images to overcome this issue. We have proposed a simple, memory efficient, easy to train method which followed a multi-step training technique that incorporated autoencoder training and Multi-Scale Deep Feature Sparse Coding (MDFSC), an extended version of normal sparse coding, to accommodate diverse types of retinal datasets. We achieve relative AUC score improvement of 7.8\%, 6.7\% and 12.1\% over state-of-the-art SPADE on Eye-Q, IDRiD and OCTID datasets respectively.

Medical Visual Question Answering: A Survey

Medical Visual Question Answering (VQA) is a combination of medical artificial intelligence and popular VQA challenges. Given a medical image and a clinically relevant question in natural language, the medical VQA system is expected to predict a plausible and convincing answer. Although the general-domain VQA has been extensively studied, the medical VQA still needs specific investigation and exploration due to its task features. In the first part of this survey, we cover and discuss the publicly available medical VQA datasets up to date about the data source, data quantity, and task feature. In the second part, we review the approaches used in medical VQA tasks. In the last part, we analyze some medical-specific challenges for the field and discuss future research directions.

Long-Tailed Multi-Label Retinal Diseases Recognition Using Hierarchical Information and Hybrid Knowledge Distillation

In the real world, medical datasets often exhibit a long-tailed data distribution (i.e., a few classes occupy most of the data, while most classes have rarely few samples), which results in a challenging imbalance learning scenario. For example, there are estimated more than 40 different kinds of retinal diseases with variable morbidity, however with more than 30+ conditions are very rare from the global patient cohorts, which results in a typical long-tailed learning problem for deep learning-based screening models. Moreover, there may exist more than one kind of disease on the retina, which results in a multi-label scenario and bring label co-occurrence issue for re-sampling strategy. In this work, we propose a novel framework that leverages the prior knowledge in retinal diseases for training a more robust representation of the model under a hierarchy-sensible constraint. Then, an instance-wise class-balanced sampling strategy and hybrid knowledge distillation manner are firstly introduced to learn from the long-tailed multi-label distribution. Our experiments training on the retinal dataset of more than one million samples demonstrate the superiority of our proposed methods which outperform all competitors and significantly improve the recognition accuracy of most diseases especially those rare diseases.

Evaluation of Various Open-Set Medical Imaging Tasks with Deep Neural Networks

The current generation of deep neural networks has achieved close-to-human results on "closed-set" image recognition; that is, the classes being evaluated overlap with the training classes. Many recent methods attempt to address the importance of the unknown, which are termed "open-set" recognition algorithms, try to reject unknown classes as well as maintain high recognition accuracy on known classes. However, it is still unclear how different general domain-trained open-set methods from ImageNet would perform on a different but more specific domain, such as the medical domain. Without principled and formal evaluations to measure the effectiveness of those general open-set methods, artificial intelligence (AI)-based medical diagnostics would experience ineffective adoption and increased risks of bad decision making. In this paper, we conduct rigorous evaluations amongst state-of-the-art open-set methods, exploring different open-set scenarios from "similar-domain" to "different-domain" scenarios and comparing them on various general and medical domain datasets. We summarise the results and core ideas and explain how the models react to various degrees of openness and different distributions of open classes. We show the main difference between general domain-trained and medical domain-trained open-set models with our quantitative and qualitative analysis of the results. We also identify aspects of model robustness in real clinical workflow usage according to confidence calibration and the inference efficiency.

Early Melanoma Diagnosis with Sequential Dermoscopic Images

Dermatologists often diagnose or rule out early melanoma by evaluating the follow-up dermoscopic images of skin lesions. However, existing algorithms for early melanoma diagnosis are developed using single time-point images of lesions. Ignoring the temporal, morphological changes of lesions can lead to misdiagnosis in borderline cases. In this study, we propose a framework for automated early melanoma diagnosis using sequential dermoscopic images. To this end, we construct our method in three steps. First, we align sequential dermoscopic images of skin lesions using estimated Euclidean transformations, extract the lesion growth region by computing image differences among the consecutive images, and then propose a spatio-temporal network to capture the dermoscopic changes from aligned lesion images and the corresponding difference images. Finally, we develop an early diagnosis module to compute probability scores of malignancy for lesion images over time. We collected 179 serial dermoscopic imaging data from 122 patients to verify our method. Extensive experiments show that the proposed model outperforms other commonly used sequence models. We also compared the diagnostic results of our model with those of seven experienced dermatologists and five registrars. Our model achieved higher diagnostic accuracy than clinicians (63.69% vs. 54.33%, respectively) and provided an earlier diagnosis of melanoma (60.7% vs. 32.7% of melanoma correctly diagnosed on the first follow-up images). These results demonstrate that our model can be used to identify melanocytic lesions that are at high-risk of malignant transformation earlier in the disease process and thereby redefine what is possible in the early detection of melanoma.

Enforcing Mutual Consistency of Hard Regions for Semi-supervised Medical Image Segmentation

In this paper, we proposed a novel mutual consistency network (MC-Net+) to effectively exploit the unlabeled hard regions for semi-supervised medical image segmentation. The MC-Net+ model is motivated by the observation that deep models trained with limited annotations are prone to output highly uncertain and easily mis-classified predictions in the ambiguous regions (e.g. adhesive edges or thin branches) for the image segmentation task. Leveraging these region-level challenging samples can make the semi-supervised segmentation model training more effective. Therefore, our proposed MC-Net+ model consists of two new designs. First, the model contains one shared encoder and multiple sightly different decoders (i.e. using different up-sampling strategies). The statistical discrepancy of multiple decoders' outputs is computed to denote the model's uncertainty, which indicates the unlabeled hard regions. Second, a new mutual consistency constraint is enforced between one decoder's probability output and other decoders' soft pseudo labels. In this way, we minimize the model's uncertainty during training and force the model to generate invariant and low-entropy results in such challenging areas of unlabeled data, in order to learn a generalized feature representation. We compared the segmentation results of the MC-Net+ with five state-of-the-art semi-supervised approaches on three public medical datasets. Extension experiments with two common semi-supervised settings demonstrate the superior performance of our model over other existing methods, which sets a new state of the art for semi-supervised medical image segmentation.

Unsupervised Domain Adaptation for Retinal Vessel Segmentation with Adversarial Learning and Transfer Normalization

Retinal vessel segmentation plays a key role in computer-aided screening, diagnosis, and treatment of various cardiovascular and ophthalmic diseases. Recently, deep learning-based retinal vessel segmentation algorithms have achieved remarkable performance. However, due to the domain shift problem, the performance of these algorithms often degrades when they are applied to new data that is different from the training data. Manually labeling new data for each test domain is often a time-consuming and laborious task. In this work, we explore unsupervised domain adaptation in retinal vessel segmentation by using entropy-based adversarial learning and transfer normalization layer to train a segmentation network, which generalizes well across domains and requires no annotation of the target domain. Specifically, first, an entropy-based adversarial learning strategy is developed to reduce the distribution discrepancy between the source and target domains while also achieving the objective of entropy minimization on the target domain. In addition, a new transfer normalization layer is proposed to further boost the transferability of the deep network. It normalizes the features of each domain separately to compensate for the domain distribution gap. Besides, it also adaptively selects those feature channels that are more transferable between domains, thus further enhancing the generalization performance of the network. We conducted extensive experiments on three regular fundus image datasets and an ultra-widefield fundus image dataset, and the results show that our approach yields significant performance gains compared to other state-of-the-art methods.