CTT-Net: A Multi-view Cross-token Transformer for Cataract Postoperative Visual Acuity Prediction

Surgery is the only viable treatment for cataract patients with visual acuity (VA) impairment. Clinically, to assess the necessity of cataract surgery, accurately predicting postoperative VA before surgery by analyzing multi-view optical coherence tomography (OCT) images is crucially needed. Unfortunately, due to complicated fundus conditions, determining postoperative VA remains difficult for medical experts. Deep learning methods for this problem were developed in recent years. Although effective, these methods still face several issues, such as not efficiently exploring potential relations between multi-view OCT images, neglecting the key role of clinical prior knowledge (e.g., preoperative VA value), and using only regression-based metrics which are lacking reference. In this paper, we propose a novel Cross-token Transformer Network (CTT-Net) for postoperative VA prediction by analyzing both the multi-view OCT images and preoperative VA. To effectively fuse multi-view features of OCT images, we develop cross-token attention that could restrict redundant/unnecessary attention flow. Further, we utilize the preoperative VA value to provide more information for postoperative VA prediction and facilitate fusion between views. Moreover, we design an auxiliary classification loss to improve model performance and assess VA recovery more sufficiently, avoiding the limitation by only using the regression metrics. To evaluate CTT-Net, we build a multi-view OCT image dataset collected from our collaborative hospital. A set of extensive experiments validate the effectiveness of our model compared to existing methods in various metrics. Code is available at: https://github.com/wjh892521292/Cataract OCT.

Learning Temporal Logic Properties: an Overview of Two Recent Methods

Learning linear temporal logic (LTL) formulas from examples labeled as positive or negative has found applications in inferring descriptions of system behavior. We summarize two methods to learn LTL formulas from examples in two different problem settings. The first method assumes noise in the labeling of the examples. For that, they define the problem of inferring an LTL formula that must be consistent with most but not all of the examples. The second method considers the other problem of inferring meaningful LTL formulas in the case where only positive examples are given. Hence, the first method addresses the robustness to noise, and the second method addresses the balance between conciseness and specificity (i.e., language minimality) of the inferred formula. The summarized methods propose different algorithms to solve the aforementioned problems, as well as to infer other descriptions of temporal properties, such as signal temporal logic or deterministic finite automata.

Human-machine Interactive Tissue Prototype Learning for Label-efficient Histopathology Image Segmentation

Recently, deep neural networks have greatly advanced histopathology image segmentation but usually require abundant annotated data. However, due to the gigapixel scale of whole slide images and pathologists' heavy daily workload, obtaining pixel-level labels for supervised learning in clinical practice is often infeasible. Alternatively, weakly-supervised segmentation methods have been explored with less laborious image-level labels, but their performance is unsatisfactory due to the lack of dense supervision. Inspired by the recent success of self-supervised learning methods, we present a label-efficient tissue prototype dictionary building pipeline and propose to use the obtained prototypes to guide histopathology image segmentation. Particularly, taking advantage of self-supervised contrastive learning, an encoder is trained to project the unlabeled histopathology image patches into a discriminative embedding space where these patches are clustered to identify the tissue prototypes by efficient pathologists' visual examination. Then, the encoder is used to map the images into the embedding space and generate pixel-level pseudo tissue masks by querying the tissue prototype dictionary. Finally, the pseudo masks are used to train a segmentation network with dense supervision for better performance. Experiments on two public datasets demonstrate that our human-machine interactive tissue prototype learning method can achieve comparable segmentation performance as the fully-supervised baselines with less annotation burden and outperform other weakly-supervised methods. Codes will be available upon publication.

Learning Interpretable Temporal Properties from Positive Examples Only

We consider the problem of explaining the temporal behavior of black-box systems using human-interpretable models. To this end, based on recent research trends, we rely on the fundamental yet interpretable models of deterministic finite automata (DFAs) and linear temporal logic (LTL) formulas. In contrast to most existing works for learning DFAs and LTL formulas, we rely on only positive examples. Our motivation is that negative examples are generally difficult to observe, in particular, from black-box systems. To learn meaningful models from positive examples only, we design algorithms that rely on conciseness and language minimality of models as regularizers. To this end, our algorithms adopt two approaches: a symbolic and a counterexample-guided one. While the symbolic approach exploits an efficient encoding of language minimality as a constraint satisfaction problem, the counterexample-guided one relies on generating suitable negative examples to prune the search. Both the approaches provide us with effective algorithms with theoretical guarantees on the learned models. To assess the effectiveness of our algorithms, we evaluate all of them on synthetic data.

A Hybrid Tracking Control Strategy for an Unmanned Underwater Vehicle Aided with Bioinspired Neural Dynamics

Tracking control has been a vital research topic in robotics. This paper presents a novel hybrid control strategy for an unmanned underwater vehicle (UUV) based on a bioinspired neural dynamics model. An enhanced backstepping kinematic control strategy is first developed to avoid sharp velocity jumps and provides smooth velocity commands relative to conventional methods. Then, a novel sliding mode control is proposed, which is capable of providing smooth and continuous torque commands free from chattering. In comparative studies, the proposed combined hybrid control strategy has ensured control signals smoothness, which is critical in real world applications, especially for an unmanned underwater vehicle that needs to operate in complex underwater environments.

Towards Better Dermoscopic Image Feature Representation Learning for Melanoma Classification

Deep learning-based melanoma classification with dermoscopic images has recently shown great potential in automatic early-stage melanoma diagnosis. However, limited by the significant data imbalance and obvious extraneous artifacts, i.e., the hair and ruler markings, discriminative feature extraction from dermoscopic images is very challenging. In this study, we seek to resolve these problems respectively towards better representation learning for lesion features. Specifically, a GAN-based data augmentation (GDA) strategy is adapted to generate synthetic melanoma-positive images, in conjunction with the proposed implicit hair denoising (IHD) strategy. Wherein the hair-related representations are implicitly disentangled via an auxiliary classifier network and reversely sent to the melanoma-feature extraction backbone for better melanoma-specific representation learning. Furthermore, to train the IHD module, the hair noises are additionally labeled on the ISIC2020 dataset, making it the first large-scale dermoscopic dataset with annotation of hair-like artifacts. Extensive experiments demonstrate the superiority of the proposed framework as well as the effectiveness of each component. The improved dataset publicly avaliable at https://github.com/kirtsy/DermoscopicDataset.

Deformer: Towards Displacement Field Learning for Unsupervised Medical Image Registration

Recently, deep-learning-based approaches have been widely studied for deformable image registration task. However, most efforts directly map the composite image representation to spatial transformation through the convolutional neural network, ignoring its limited ability to capture spatial correspondence. On the other hand, Transformer can better characterize the spatial relationship with attention mechanism, its long-range dependency may be harmful to the registration task, where voxels with too large distances are unlikely to be corresponding pairs. In this study, we propose a novel Deformer module along with a multi-scale framework for the deformable image registration task. The Deformer module is designed to facilitate the mapping from image representation to spatial transformation by formulating the displacement vector prediction as the weighted summation of several bases. With the multi-scale framework to predict the displacement fields in a coarse-to-fine manner, superior performance can be achieved compared with traditional and learning-based approaches. Comprehensive experiments on two public datasets are conducted to demonstrate the effectiveness of the proposed Deformer module as well as the multi-scale framework.

Approximating Discontinuous Nash Equilibrial Values of Two-Player General-Sum Differential Games

Finding Nash equilibrial policies for two-player differential games requires solving Hamilton-Jacobi-Isaacs PDEs. Recent studies achieved success in circumventing the curse of dimensionality in solving such PDEs with underlying applications to human-robot interactions (HRI), by adopting self-supervised (physics-informed) neural networks as universal value approximators. This paper extends from previous SOTA on zero-sum games with continuous values to general-sum games with discontinuous values, where the discontinuity is caused by that of the players' losses. We show that due to its lack of convergence proof and generalization analysis on discontinuous losses, the existing self-supervised learning technique fails to generalize and raises safety concerns in an autonomous driving application. Our solution is to first pre-train the value network on supervised Nash equilibria, and then refine it by minimizing a loss that combines the supervised data with the PDE and boundary conditions. Importantly, the demonstrated advantage of the proposed learning method against purely supervised and self-supervised approaches requires careful choice of the neural activation function: Among $\texttt{relu}$, $\texttt{sin}$, and $\texttt{tanh}$, we show that $\texttt{tanh}$ is the only choice that achieves optimal generalization and safety performance. Our conjecture is that $\texttt{tanh}$ (similar to $\texttt{sin}$) allows continuity of value and its gradient, which is sufficient for the convergence of learning, and at the same time is expressive enough (similar to $\texttt{relu}$) at approximating discontinuous value landscapes. Lastly, we apply our method to approximating control policies for an incomplete-information interaction and demonstrate its contribution to safe interactions.

Bio-inspired Intelligence with Applications to Robotics: A Survey

In the past decades, considerable attention has been paid to bio-inspired intelligence and its applications to robotics. This paper provides a comprehensive survey of bio-inspired intelligence, with a focus on neurodynamics approaches, to various robotic applications, particularly to path planning and control of autonomous robotic systems. Firstly, the bio-inspired shunting model and its variants (additive model and gated dipole model) are introduced, and their main characteristics are given in detail. Then, two main neurodynamics applications to real-time path planning and control of various robotic systems are reviewed. A bio-inspired neural network framework, in which neurons are characterized by the neurodynamics models, is discussed for mobile robots, cleaning robots, and underwater robots. The bio-inspired neural network has been widely used in real-time collision-free navigation and cooperation without any learning procedures, global cost functions, and prior knowledge of the dynamic environment. In addition, bio-inspired backstepping controllers for various robotic systems, which are able to eliminate the speed jump when a large initial tracking error occurs, are further discussed. Finally, the current challenges and future research directions are discussed in this paper.

Consensus Formation Tracking for Multiple AUV Systems Using Distributed Bioinspired Sliding Mode Control

Consensus formation tracking of multiple autonomous underwater vehicles (AUVs) subject to nonlinear and uncertain dynamics is a challenging problem in robotics. To tackle this challenge, a distributed bioinspired sliding mode controller is proposed in this paper. First, the conventional sliding mode controller (SMC) is presented, and the consensus problem is addressed on the basis of graph theory. Next, to tackle the high frequency chattering issue in SMC scheme and meanwhile improve the robustness to the noises, a bioinspired approach is introduced, in which a neural dynamic model is employed to replace the nonlinear sign or saturation function in the synthesis of conventional sliding mode controllers. Furthermore, the input-to-state stability of the resulting closed-loop system is proved in the presence of bounded lumped disturbance by the Lyapunov stability theory. Finally, simulation experiments are conducted to demonstrate the effectiveness of the proposed distributed formation control protocol.