Deep Radon Prior: A Fully Unsupervised Framework for Sparse-View CT Reconstruction

Although sparse-view computed tomography (CT) has significantly reduced radiation dose, it also introduces severe artifacts which degrade the image quality. In recent years, deep learning-based methods for inverse problems have made remarkable progress and have become increasingly popular in CT reconstruction. However, most of these methods suffer several limitations: dependence on high-quality training data, weak interpretability, etc. In this study, we propose a fully unsupervised framework called Deep Radon Prior (DRP), inspired by Deep Image Prior (DIP), to address the aforementioned limitations. DRP introduces a neural network as an implicit prior into the iterative method, thereby realizing cross-domain gradient feedback. During the reconstruction process, the neural network is progressively optimized in multiple stages to narrow the solution space in radon domain for the under-constrained imaging protocol, and the convergence of the proposed method has been discussed in this work. Compared with the popular pre-trained method, the proposed framework requires no dataset and exhibits superior interpretability and generalization ability. The experimental results demonstrate that the proposed method can generate detailed images while effectively suppressing image artifacts.Meanwhile, DRP achieves comparable or better performance than the supervised methods.

MovieChat: From Dense Token to Sparse Memory for Long Video Understanding

Recently, integrating video foundation models and large language models to build a video understanding system overcoming the limitations of specific pre-defined vision tasks. Yet, existing systems can only handle videos with very few frames. For long videos, the computation complexity, memory cost, and long-term temporal connection are the remaining challenges. Inspired by Atkinson-Shiffrin memory model, we develop an memory mechanism including a rapidly updated short-term memory and a compact thus sustained long-term memory. We employ tokens in Transformers as the carriers of memory. MovieChat achieves state-of-the-art performace in long video understanding.

PALF: Pre-Annotation and Camera-LiDAR Late Fusion for the Easy Annotation of Point Clouds

3D object detection has become indispensable in the field of autonomous driving. To date, gratifying breakthroughs have been recorded in 3D object detection research, attributed to deep learning. However, deep learning algorithms are data-driven and require large amounts of annotated point cloud data for training and evaluation. Unlike 2D image labels, annotating point cloud data is difficult due to the limitations of sparsity, irregularity, and low resolution, which requires more manual work, and the annotation efficiency is much lower than 2D image.Therefore, we propose an annotation algorithm for point cloud data, which is pre-annotation and camera-LiDAR late fusion algorithm to easily and accurately annotate. The contributions of this study are as follows. We propose (1) a pre-annotation algorithm that employs 3D object detection and auto fitting for the easy annotation of point clouds, (2) a camera-LiDAR late fusion algorithm using 2D and 3D results for easily error checking, which helps annotators easily identify missing objects, and (3) a point cloud annotation evaluation pipeline to evaluate our experiments. The experimental results show that the proposed algorithm improves the annotating speed by 6.5 times and the annotation quality in terms of the 3D Intersection over Union and precision by 8.2 points and 5.6 points, respectively; additionally, the miss rate is reduced by 31.9 points.

Explaining COVID-19 and Thoracic Pathology Model Predictions by Identifying Informative Input Features

Neural networks have demonstrated remarkable performance in classification and regression tasks on chest X-rays. In order to establish trust in the clinical routine, the networks' prediction mechanism needs to be interpretable. One principal approach to interpretation is feature attribution. Feature attribution methods identify the importance of input features for the output prediction. Building on Information Bottleneck Attribution (IBA) method, for each prediction we identify the chest X-ray regions that have high mutual information with the network's output. Original IBA identifies input regions that have sufficient predictive information. We propose Inverse IBA to identify all informative regions. Thus all predictive cues for pathologies are highlighted on the X-rays, a desirable property for chest X-ray diagnosis. Moreover, we propose Regression IBA for explaining regression models. Using Regression IBA we observe that a model trained on cumulative severity score labels implicitly learns the severity of different X-ray regions. Finally, we propose Multi-layer IBA to generate higher resolution and more detailed attribution/saliency maps. We evaluate our methods using both human-centric (ground-truth-based) interpretability metrics, and human-independent feature importance metrics on NIH Chest X-ray8 and BrixIA datasets. The Code is publicly available.

Improving Prognostic Performance in Resectable Pancreatic Ductal Adenocarcinoma using Radiomics and Deep Learning Features Fusion in CT Images

As an analytic pipeline for quantitative imaging feature extraction and analysis, radiomics has grown rapidly in the past a few years. Recent studies in radiomics aim to investigate the relationship between tumors imaging features and clinical outcomes. Open source radiomics feature banks enable the extraction and analysis of thousands of predefined features. On the other hand, recent advances in deep learning have shown significant potential in the quantitative medical imaging field, raising the research question of whether predefined radiomics features have predictive information in addition to deep learning features. In this study, we propose a feature fusion method and investigate whether a combined feature bank of deep learning and predefined radiomics features can improve the prognostics performance. CT images from resectable Pancreatic Adenocarcinoma (PDAC) patients were used to compare the prognosis performance of common feature reduction and fusion methods and the proposed risk-score based feature fusion method for overall survival. It was shown that the proposed feature fusion method significantly improves the prognosis performance for overall survival in resectable PDAC cohorts, elevating the area under ROC curve by 51% compared to predefined radiomics features alone, by 16% compared to deep learning features alone, and by 32% compared to existing feature fusion and reduction methods for a combination of deep learning and predefined radiomics features.

CNN-based Survival Model for Pancreatic Ductal Adenocarcinoma in Medical Imaging

Cox proportional hazard model (CPH) is commonly used in clinical research for survival analysis. In quantitative medical imaging (radiomics) studies, CPH plays an important role in feature reduction and modeling. However, the underlying linear assumption of CPH model limits the prognostic performance. In addition, the multicollinearity of radiomic features and multiple testing problem further impedes the CPH models performance. In this work, using transfer learning, a convolutional neural network (CNN) based survival model was built and tested on preoperative CT images of resectable Pancreatic Ductal Adenocarcinoma (PDAC) patients. The proposed CNN-based survival model outperformed the traditional CPH-based radiomics approach in terms of concordance index by 22%, providing a better fit for patients' survival patterns. The proposed CNN-based survival model outperforms CPH-based radiomics pipeline in PDAC prognosis. This approach offers a better fit for survival patterns based on CT images and overcomes the limitations of conventional survival models.

Improving Prognostic Value of CT Deep Radiomic Features in Pancreatic Ductal Adenocarcinoma Using Transfer Learning

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with an extremely poor prognosis. Radiomics has shown prognostic ability in multiple types of cancer including PDAC. However, the prognostic value of traditional radiomics pipelines, which are based on hand-crafted radiomic features alone, is limited due to multicollinearity of features and multiple testing problem, and limited performance of conventional machine learning classifiers. Deep learning architectures, such as convolutional neural networks (CNNs), have been shown to outperform traditional techniques in computer vision tasks, such as object detection. However, they require large sample sizes for training which limits their development. As an alternative solution, CNN-based transfer learning has shown the potential for achieving reasonable performance using datasets with small sample sizes. In this work, we developed a CNN-based transfer learning approach for prognostication in PDAC patients for overall survival. The results showed that transfer learning approach outperformed the traditional radiomics model on PDAC data. A transfer learning approach may fill the gap between radiomics and deep learning analytics for cancer prognosis and improve performance beyond what CNNs can achieve using small datasets.