Thyroid ultrasound diagnosis improvement via multi-view self-supervised learning and two-stage pre-training

Thyroid nodule classification and segmentation in ultrasound images are crucial for computer-aided diagnosis; however, they face limitations owing to insufficient labeled data. In this study, we proposed a multi-view contrastive self-supervised method to improve thyroid nodule classification and segmentation performance with limited manual labels. Our method aligns the transverse and longitudinal views of the same nodule, thereby enabling the model to focus more on the nodule area. We designed an adaptive loss function that eliminates the limitations of the paired data. Additionally, we adopted a two-stage pre-training to exploit the pre-training on ImageNet and thyroid ultrasound images. Extensive experiments were conducted on a large-scale dataset collected from multiple centers. The results showed that the proposed method significantly improves nodule classification and segmentation performance with limited manual labels and outperforms state-of-the-art self-supervised methods. The two-stage pre-training also significantly exceeded ImageNet pre-training.

CMG-Net: Robust Normal Estimation for Point Clouds via Chamfer Normal Distance and Multi-scale Geometry

This work presents an accurate and robust method for estimating normals from point clouds. In contrast to predecessor approaches that minimize the deviations between the annotated and the predicted normals directly, leading to direction inconsistency, we first propose a new metric termed Chamfer Normal Distance to address this issue. This not only mitigates the challenge but also facilitates network training and substantially enhances the network robustness against noise. Subsequently, we devise an innovative architecture that encompasses Multi-scale Local Feature Aggregation and Hierarchical Geometric Information Fusion. This design empowers the network to capture intricate geometric details more effectively and alleviate the ambiguity in scale selection. Extensive experiments demonstrate that our method achieves the state-of-the-art performance on both synthetic and real-world datasets, particularly in scenarios contaminated by noise. Our implementation is available at https://github.com/YingruiWoo/CMG-Net_Pytorch.

Multi-Attribute Attention Network for Interpretable Diagnosis of Thyroid Nodules in Ultrasound Images

Ultrasound (US) is the primary imaging technique for the diagnosis of thyroid cancer. However, accurate identification of nodule malignancy is a challenging task that can elude less-experienced clinicians. Recently, many computer-aided diagnosis (CAD) systems have been proposed to assist this process. However, most of them do not provide the reasoning of their classification process, which may jeopardize their credibility in practical use. To overcome this, we propose a novel deep learning framework called multi-attribute attention network (MAA-Net) that is designed to mimic the clinical diagnosis process. The proposed model learns to predict nodular attributes and infer their malignancy based on these clinically-relevant features. A multi-attention scheme is adopted to generate customized attention to improve each task and malignancy diagnosis. Furthermore, MAA-Net utilizes nodule delineations as nodules spatial prior guidance for the training rather than cropping the nodules with additional models or human interventions to prevent losing the context information. Validation experiments were performed on a large and challenging dataset containing 4554 patients. Results show that the proposed method outperformed other state-of-the-art methods and provides interpretable predictions that may better suit clinical needs.

Personalized Diagnostic Tool for Thyroid Cancer Classification using Multi-view Ultrasound

Over the past decades, the incidence of thyroid cancer has been increasing globally. Accurate and early diagnosis allows timely treatment and helps to avoid over-diagnosis. Clinically, a nodule is commonly evaluated from both transverse and longitudinal views using thyroid ultrasound. However, the appearance of the thyroid gland and lesions can vary dramatically across individuals. Identifying key diagnostic information from both views requires specialized expertise. Furthermore, finding an optimal way to integrate multi-view information also relies on the experience of clinicians and adds further difficulty to accurate diagnosis. To address these, we propose a personalized diagnostic tool that can customize its decision-making process for different patients. It consists of a multi-view classification module for feature extraction and a personalized weighting allocation network that generates optimal weighting for different views. It is also equipped with a self-supervised view-aware contrastive loss to further improve the model robustness towards different patient groups. Experimental results show that the proposed framework can better utilize multi-view information and outperform the competing methods.

Adaptive Morphological Reconstruction for Seeded Image Segmentation

Morphological reconstruction (MR) is often employed by seeded image segmentation algorithms such as watershed transform and power watershed as it is able to filter seeds (regional minima) to reduce over-segmentation. However, MR might mistakenly filter meaningful seeds that are required for generating accurate segmentation and it is also sensitive to the scale because a single-scale structuring element is employed. In this paper, a novel adaptive morphological reconstruction (AMR) operation is proposed that has three advantages. Firstly, AMR can adaptively filter useless seeds while preserving meaningful ones. Secondly, AMR is insensitive to the scale of structuring elements because multiscale structuring elements are employed. Finally, AMR has two attractive properties: monotonic increasingness and convergence that help seeded segmentation algorithms to achieve a hierarchical segmentation. Experiments clearly demonstrate that AMR is useful for improving algorithms of seeded image segmentation and seed-based spectral segmentation. Compared to several state-of-the-art algorithms, the proposed algorithms provide better segmentation results requiring less computing time. Source code is available at https://github.com/SUST-reynole/AMR.