Weak-for-Strong: Training Weak Meta-Agent to Harness Strong Executors

Efficiently leveraging of the capabilities of contemporary large language models (LLMs) is increasingly challenging, particularly when direct fine-tuning is expensive and often impractical. Existing training-free methods, including manually or automated designed workflows, typically demand substantial human effort or yield suboptimal results. This paper proposes Weak-for-Strong Harnessing (W4S), a novel framework that customizes smaller, cost-efficient language models to design and optimize workflows for harnessing stronger models. W4S formulates workflow design as a multi-turn markov decision process and introduces reinforcement learning for agentic workflow optimization (RLAO) to train a weak meta-agent. Through iterative interaction with the environment, the meta-agent learns to design increasingly effective workflows without manual intervention. Empirical results demonstrate the superiority of W4S that our 7B meta-agent, trained with just one GPU hour, outperforms the strongest baseline by 2.9% ~ 24.6% across eleven benchmarks, successfully elevating the performance of state-of-the-art models such as GPT-3.5-Turbo and GPT-4o. Notably, W4S exhibits strong generalization capabilities across both seen and unseen tasks, offering an efficient, high-performing alternative to directly fine-tuning strong models.

Protein Large Language Models: A Comprehensive Survey

Protein-specific large language models (Protein LLMs) are revolutionizing protein science by enabling more efficient protein structure prediction, function annotation, and design. While existing surveys focus on specific aspects or applications, this work provides the first comprehensive overview of Protein LLMs, covering their architectures, training datasets, evaluation metrics, and diverse applications. Through a systematic analysis of over 100 articles, we propose a structured taxonomy of state-of-the-art Protein LLMs, analyze how they leverage large-scale protein sequence data for improved accuracy, and explore their potential in advancing protein engineering and biomedical research. Additionally, we discuss key challenges and future directions, positioning Protein LLMs as essential tools for scientific discovery in protein science. Resources are maintained at https://github.com/Yijia-Xiao/Protein-LLM-Survey.

ChemAgent: Self-updating Library in Large Language Models Improves Chemical Reasoning

Chemical reasoning usually involves complex, multi-step processes that demand precise calculations, where even minor errors can lead to cascading failures. Furthermore, large language models (LLMs) encounter difficulties handling domain-specific formulas, executing reasoning steps accurately, and integrating code effectively when tackling chemical reasoning tasks. To address these challenges, we present ChemAgent, a novel framework designed to improve the performance of LLMs through a dynamic, self-updating library. This library is developed by decomposing chemical tasks into sub-tasks and compiling these sub-tasks into a structured collection that can be referenced for future queries. Then, when presented with a new problem, ChemAgent retrieves and refines pertinent information from the library, which we call memory, facilitating effective task decomposition and the generation of solutions. Our method designs three types of memory and a library-enhanced reasoning component, enabling LLMs to improve over time through experience. Experimental results on four chemical reasoning datasets from SciBench demonstrate that ChemAgent achieves performance gains of up to 46% (GPT-4), significantly outperforming existing methods. Our findings suggest substantial potential for future applications, including tasks such as drug discovery and materials science. Our code can be found at https://github.com/gersteinlab/chemagent

VISCO: Benchmarking Fine-Grained Critique and Correction Towards Self-Improvement in Visual Reasoning

The ability of large vision-language models (LVLMs) to critique and correct their reasoning is an essential building block towards their self-improvement. However, a systematic analysis of such capabilities in LVLMs is still lacking. We propose VISCO, the first benchmark to extensively analyze the fine-grained critique and correction capabilities of LVLMs. Compared to existing work that uses a single scalar value to critique the entire reasoning [4], VISCO features dense and fine-grained critique, requiring LVLMs to evaluate the correctness of each step in the chain-of-thought and provide natural language explanations to support their judgments. Extensive evaluation of 24 LVLMs demonstrates that human-written critiques significantly enhance the performance after correction, showcasing the potential of the self-improvement strategy. However, the model-generated critiques are less helpful and sometimes detrimental to the performance, suggesting that critique is the crucial bottleneck. We identified three common patterns in critique failures: failure to critique visual perception, reluctance to "say no", and exaggerated assumption of error propagation. To address these issues, we propose an effective LookBack strategy that revisits the image to verify each piece of information in the initial reasoning. LookBack significantly improves critique and correction performance by up to 13.5%.

MRAG-Bench: Vision-Centric Evaluation for Retrieval-Augmented Multimodal Models

Existing multimodal retrieval benchmarks primarily focus on evaluating whether models can retrieve and utilize external textual knowledge for question answering. However, there are scenarios where retrieving visual information is either more beneficial or easier to access than textual data. In this paper, we introduce a multimodal retrieval-augmented generation benchmark, MRAG-Bench, in which we systematically identify and categorize scenarios where visually augmented knowledge is better than textual knowledge, for instance, more images from varying viewpoints. MRAG-Bench consists of 16,130 images and 1,353 human-annotated multiple-choice questions across 9 distinct scenarios. With MRAG-Bench, we conduct an evaluation of 10 open-source and 4 proprietary large vision-language models (LVLMs). Our results show that all LVLMs exhibit greater improvements when augmented with images compared to textual knowledge, confirming that MRAG-Bench is vision-centric. Additionally, we conduct extensive analysis with MRAG-Bench, which offers valuable insights into retrieval-augmented LVLMs. Notably, the top-performing model, GPT-4o, faces challenges in effectively leveraging retrieved knowledge, achieving only a 5.82% improvement with ground-truth information, in contrast to a 33.16% improvement observed in human participants. These findings highlight the importance of MRAG-Bench in encouraging the community to enhance LVLMs' ability to utilize retrieved visual knowledge more effectively.

VDebugger: Harnessing Execution Feedback for Debugging Visual Programs

Visual programs are executable code generated by large language models to address visual reasoning problems. They decompose complex questions into multiple reasoning steps and invoke specialized models for each step to solve the problems. However, these programs are prone to logic errors, with our preliminary evaluation showing that 58% of the total errors are caused by program logic errors. Debugging complex visual programs remains a major bottleneck for visual reasoning. To address this, we introduce VDebugger, a novel critic-refiner framework trained to localize and debug visual programs by tracking execution step by step. VDebugger identifies and corrects program errors leveraging detailed execution feedback, improving interpretability and accuracy. The training data is generated through an automated pipeline that injects errors into correct visual programs using a novel mask-best decoding technique. Evaluations on six datasets demonstrate VDebugger's effectiveness, showing performance improvements of up to 3.2% in downstream task accuracy. Further studies show VDebugger's ability to generalize to unseen tasks, bringing a notable improvement of 2.3% on the unseen COVR task. Code, data and models are made publicly available at https://github.com/shirley-wu/vdebugger/

MuirBench: A Comprehensive Benchmark for Robust Multi-image Understanding

We introduce MuirBench, a comprehensive benchmark that focuses on robust multi-image understanding capabilities of multimodal LLMs. MuirBench consists of 12 diverse multi-image tasks (e.g., scene understanding, ordering) that involve 10 categories of multi-image relations (e.g., multiview, temporal relations). Comprising 11,264 images and 2,600 multiple-choice questions, MuirBench is created in a pairwise manner, where each standard instance is paired with an unanswerable variant that has minimal semantic differences, in order for a reliable assessment. Evaluated upon 20 recent multi-modal LLMs, our results reveal that even the best-performing models like GPT-4o and Gemini Pro find it challenging to solve MuirBench, achieving 68.0% and 49.3% in accuracy. Open-source multimodal LLMs trained on single images can hardly generalize to multi-image questions, hovering below 33.3% in accuracy. These results highlight the importance of MuirBench in encouraging the community to develop multimodal LLMs that can look beyond a single image, suggesting potential pathways for future improvements.

Enhancing Large Vision Language Models with Self-Training on Image Comprehension

Large vision language models (LVLMs) integrate large language models (LLMs) with pre-trained vision encoders, thereby activating the perception capability of the model to understand image inputs for different queries and conduct subsequent reasoning. Improving this capability requires high-quality vision-language data, which is costly and labor-intensive to acquire. Self-training approaches have been effective in single-modal settings to alleviate the need for labeled data by leveraging model's own generation. However, effective self-training remains a challenge regarding the unique visual perception and reasoning capability of LVLMs. To address this, we introduce Self-Training on Image Comprehension (STIC), which emphasizes a self-training approach specifically for image comprehension. First, the model self-constructs a preference dataset for image descriptions using unlabeled images. Preferred responses are generated through a step-by-step prompt, while dis-preferred responses are generated from either corrupted images or misleading prompts. To further self-improve reasoning on the extracted visual information, we let the model reuse a small portion of existing instruction-tuning data and append its self-generated image descriptions to the prompts. We validate the effectiveness of STIC across seven different benchmarks, demonstrating substantial performance gains of 4.0% on average while using 70% less supervised fine-tuning data than the current method. Further studies investigate various components of STIC and highlight its potential to leverage vast quantities of unlabeled images for self-training. Code and data are made publicly available.

MathVerse: Does Your Multi-modal LLM Truly See the Diagrams in Visual Math Problems?

The remarkable progress of Multi-modal Large Language Models (MLLMs) has garnered unparalleled attention, due to their superior performance in visual contexts. However, their capabilities in visual math problem-solving remain insufficiently evaluated and understood. We investigate current benchmarks to incorporate excessive visual content within textual questions, which potentially assist MLLMs in deducing answers without truly interpreting the input diagrams. To this end, we introduce MathVerse, an all-around visual math benchmark designed for an equitable and in-depth evaluation of MLLMs. We meticulously collect 2,612 high-quality, multi-subject math problems with diagrams from publicly available sources. Each problem is then transformed by human annotators into six distinct versions, each offering varying degrees of information content in multi-modality, contributing to 15K test samples in total. This approach allows MathVerse to comprehensively assess whether and how much MLLMs can truly understand the visual diagrams for mathematical reasoning. In addition, we propose a Chain-of-Thought (CoT) evaluation strategy for a fine-grained assessment of the output answers. Rather than naively judging True or False, we employ GPT-4(V) to adaptively extract crucial reasoning steps, and then score each step with detailed error analysis, which can reveal the intermediate CoT reasoning quality by MLLMs. We hope the MathVerse benchmark may provide unique insights to guide the future development of MLLMs. Project page: https://mathverse-cuhk.github.io

Are LLMs Capable of Data-based Statistical and Causal Reasoning? Benchmarking Advanced Quantitative Reasoning with Data

Quantitative reasoning is a critical skill to analyze data, yet the assessment of such ability remains limited. To address this gap, we introduce the Quantitative Reasoning with Data (QRData) benchmark, aiming to evaluate Large Language Models' capability in statistical and causal reasoning with real-world data. The benchmark comprises a carefully constructed dataset of 411 questions accompanied by data sheets from textbooks, online learning materials, and academic papers. To compare models' quantitative reasoning abilities on data and text, we enrich the benchmark with an auxiliary set of 290 text-only questions, namely QRText. We evaluate natural language reasoning, program-based reasoning, and agent reasoning methods including Chain-of-Thought, Program-of-Thoughts, ReAct, and code interpreter assistants on diverse models. The strongest model GPT-4 achieves an accuracy of 58%, which has a large room for improvement. Among open-source models, Deepseek-coder-instruct, a code LLM pretrained on 2T tokens, gets the highest accuracy of 37%. Analysis reveals that models encounter difficulties in data analysis and causal reasoning, and struggle in using causal knowledge and provided data simultaneously. Code and data are in https://github.com/xxxiaol/QRData.