Semi-Supervised Video Inpainting with Cycle Consistency Constraints

Deep learning-based video inpainting has yielded promising results and gained increasing attention from researchers. Generally, these methods usually assume that the corrupted region masks of each frame are known and easily obtained. However, the annotation of these masks are labor-intensive and expensive, which limits the practical application of current methods. Therefore, we expect to relax this assumption by defining a new semi-supervised inpainting setting, making the networks have the ability of completing the corrupted regions of the whole video using the annotated mask of only one frame. Specifically, in this work, we propose an end-to-end trainable framework consisting of completion network and mask prediction network, which are designed to generate corrupted contents of the current frame using the known mask and decide the regions to be filled of the next frame, respectively. Besides, we introduce a cycle consistency loss to regularize the training parameters of these two networks. In this way, the completion network and the mask prediction network can constrain each other, and hence the overall performance of the trained model can be maximized. Furthermore, due to the natural existence of prior knowledge (e.g., corrupted contents and clear borders), current video inpainting datasets are not suitable in the context of semi-supervised video inpainting. Thus, we create a new dataset by simulating the corrupted video of real-world scenarios. Extensive experimental results are reported to demonstrate the superiority of our model in the video inpainting task. Remarkably, although our model is trained in a semi-supervised manner, it can achieve comparable performance as fully-supervised methods.

Description-based Label Attention Classifier for Explainable ICD-9 Classification

ICD-9 coding is a relevant clinical billing task, where unstructured texts with information about a patient's diagnosis and treatments are annotated with multiple ICD-9 codes. Automated ICD-9 coding is an active research field, where CNN- and RNN-based model architectures represent the state-of-the-art approaches. In this work, we propose a description-based label attention classifier to improve the model explainability when dealing with noisy texts like clinical notes. We evaluate our proposed method with different transformer-based encoders on the MIMIC-III-50 dataset. Our method achieves strong results together with augmented explainablilty.

Categorical EHR Imputation with Generative Adversarial Nets

Electronic Health Records often suffer from missing data, which poses a major problem in clinical practice and clinical studies. A novel approach for dealing with missing data are Generative Adversarial Nets (GANs), which have been generating huge research interest in image generation and transformation. Recently, researchers have attempted to apply GANs to missing data generation and imputation for EHR data: a major challenge here is the categorical nature of the data. State-of-the-art solutions to the GAN-based generation of categorical data involve either reinforcement learning, or learning a bidirectional mapping between the categorical and the real latent feature space, so that the GANs only need to generate real-valued features. However, these methods are designed to generate complete feature vectors instead of imputing only the subsets of missing features. In this paper we propose a simple and yet effective approach that is based on previous work on GANs for data imputation. We first motivate our solution by discussing the reason why adversarial training often fails in case of categorical features. Then we derive a novel way to re-code the categorical features to stabilize the adversarial training. Based on experiments on two real-world EHR data with multiple settings, we show that our imputation approach largely improves the prediction accuracy, compared to more traditional data imputation approaches.

Uncertainty-Aware Time-to-Event Prediction using Deep Kernel Accelerated Failure Time Models

Recurrent neural network based solutions are increasingly being used in the analysis of longitudinal Electronic Health Record data. However, most works focus on prediction accuracy and neglect prediction uncertainty. We propose Deep Kernel Accelerated Failure Time models for the time-to-event prediction task, enabling uncertainty-awareness of the prediction by a pipeline of a recurrent neural network and a sparse Gaussian Process. Furthermore, a deep metric learning based pre-training step is adapted to enhance the proposed model. Our model shows better point estimate performance than recurrent neural network based baselines in experiments on two real-world datasets. More importantly, the predictive variance from our model can be used to quantify the uncertainty estimates of the time-to-event prediction: Our model delivers better performance when it is more confident in its prediction. Compared to related methods, such as Monte Carlo Dropout, our model offers better uncertainty estimates by leveraging an analytical solution and is more computationally efficient.

Quantifying Predictive Uncertainty in Medical Image Analysis with Deep Kernel Learning

Deep neural networks are increasingly being used for the analysis of medical images. However, most works neglect the uncertainty in the model's prediction. We propose an uncertainty-aware deep kernel learning model which permits the estimation of the uncertainty in the prediction by a pipeline of a Convolutional Neural Network and a sparse Gaussian Process. Furthermore, we adapt different pre-training methods to investigate their impacts on the proposed model. We apply our approach to Bone Age Prediction and Lesion Localization. In most cases, the proposed model shows better performance compared to common architectures. More importantly, our model expresses systematically higher confidence in more accurate predictions and less confidence in less accurate ones. Our model can also be used to detect challenging and controversial test samples. Compared to related methods such as Monte-Carlo Dropout, our approach derives the uncertainty information in a purely analytical fashion and is thus computationally more efficient.

Introspective Learning by Distilling Knowledge from Online Self-explanation

In recent years, many explanation methods have been proposed to explain individual classifications of deep neural networks. However, how to leverage the created explanations to improve the learning process has been less explored. As the privileged information, the explanations of a model can be used to guide the learning process of the model itself. In the community, another intensively investigated privileged information used to guide the training of a model is the knowledge from a powerful teacher model. The goal of this work is to leverage the self-explanation to improve the learning process by borrowing ideas from knowledge distillation. We start by investigating the effective components of the knowledge transferred from the teacher network to the student network. Our investigation reveals that both the responses in non-ground-truth classes and class-similarity information in teacher's outputs contribute to the success of the knowledge distillation. Motivated by the conclusion, we propose an implementation of introspective learning by distilling knowledge from online self-explanations. The models trained with the introspective learning procedure outperform the ones trained with the standard learning procedure, as well as the ones trained with different regularization methods. When compared to the models learned from peer networks or teacher networks, our models also show competitive performance and requires neither peers nor teachers.

Learning Individualized Treatment Rules with Estimated Translated Inverse Propensity Score

Randomized controlled trials typically analyze the effectiveness of treatments with the goal of making treatment recommendations for patient subgroups. With the advance of electronic health records, a great variety of data has been collected in clinical practice, enabling the evaluation of treatments and treatment policies based on observational data. In this paper, we focus on learning individualized treatment rules (ITRs) to derive a treatment policy that is expected to generate a better outcome for an individual patient. In our framework, we cast ITRs learning as a contextual bandit problem and minimize the expected risk of the treatment policy. We conduct experiments with the proposed framework both in a simulation study and based on a real-world dataset. In the latter case, we apply our proposed method to learn the optimal ITRs for the administration of intravenous (IV) fluids and vasopressors (VP). Based on various offline evaluation methods, we could show that the policy derived in our framework demonstrates better performance compared to both the physicians and other baselines, including a simple treatment prediction approach. As a long-term goal, our derived policy might eventually lead to better clinical guidelines for the administration of IV and VP.