PointAD+: Learning Hierarchical Representations for Zero-shot 3D Anomaly Detection

In this paper, we aim to transfer CLIP's robust 2D generalization capabilities to identify 3D anomalies across unseen objects of highly diverse class semantics. To this end, we propose a unified framework to comprehensively detect and segment 3D anomalies by leveraging both point- and pixel-level information. We first design PointAD, which leverages point-pixel correspondence to represent 3D anomalies through their associated rendering pixel representations. This approach is referred to as implicit 3D representation, as it focuses solely on rendering pixel anomalies but neglects the inherent spatial relationships within point clouds. Then, we propose PointAD+ to further broaden the interpretation of 3D anomalies by introducing explicit 3D representation, emphasizing spatial abnormality to uncover abnormal spatial relationships. Hence, we propose G-aggregation to involve geometry information to enable the aggregated point representations spatially aware. To simultaneously capture rendering and spatial abnormality, PointAD+ proposes hierarchical representation learning, incorporating implicit and explicit anomaly semantics into hierarchical text prompts: rendering prompts for the rendering layer and geometry prompts for the geometry layer. A cross-hierarchy contrastive alignment is further introduced to promote the interaction between the rendering and geometry layers, facilitating mutual anomaly learning. Finally, PointAD+ integrates anomaly semantics from both layers to capture the generalized anomaly semantics. During the test, PointAD+ can integrate RGB information in a plug-and-play manner and further improve its detection performance. Extensive experiments demonstrate the superiority of PointAD+ in ZS 3D anomaly detection across unseen objects with highly diverse class semantics, achieving a holistic understanding of abnormality.

A Survey of Scientific Large Language Models: From Data Foundations to Agent Frontiers

Scientific Large Language Models (Sci-LLMs) are transforming how knowledge is represented, integrated, and applied in scientific research, yet their progress is shaped by the complex nature of scientific data. This survey presents a comprehensive, data-centric synthesis that reframes the development of Sci-LLMs as a co-evolution between models and their underlying data substrate. We formulate a unified taxonomy of scientific data and a hierarchical model of scientific knowledge, emphasizing the multimodal, cross-scale, and domain-specific challenges that differentiate scientific corpora from general natural language processing datasets. We systematically review recent Sci-LLMs, from general-purpose foundations to specialized models across diverse scientific disciplines, alongside an extensive analysis of over 270 pre-/post-training datasets, showing why Sci-LLMs pose distinct demands -- heterogeneous, multi-scale, uncertainty-laden corpora that require representations preserving domain invariance and enabling cross-modal reasoning. On evaluation, we examine over 190 benchmark datasets and trace a shift from static exams toward process- and discovery-oriented assessments with advanced evaluation protocols. These data-centric analyses highlight persistent issues in scientific data development and discuss emerging solutions involving semi-automated annotation pipelines and expert validation. Finally, we outline a paradigm shift toward closed-loop systems where autonomous agents based on Sci-LLMs actively experiment, validate, and contribute to a living, evolving knowledge base. Collectively, this work provides a roadmap for building trustworthy, continually evolving artificial intelligence (AI) systems that function as a true partner in accelerating scientific discovery.

AdaptCLIP: Adapting CLIP for Universal Visual Anomaly Detection

Universal visual anomaly detection aims to identify anomalies from novel or unseen vision domains without additional fine-tuning, which is critical in open scenarios. Recent studies have demonstrated that pre-trained vision-language models like CLIP exhibit strong generalization with just zero or a few normal images. However, existing methods struggle with designing prompt templates, complex token interactions, or requiring additional fine-tuning, resulting in limited flexibility. In this work, we present a simple yet effective method called AdaptCLIP based on two key insights. First, adaptive visual and textual representations should be learned alternately rather than jointly. Second, comparative learning between query and normal image prompt should incorporate both contextual and aligned residual features, rather than relying solely on residual features. AdaptCLIP treats CLIP models as a foundational service, adding only three simple adapters, visual adapter, textual adapter, and prompt-query adapter, at its input or output ends. AdaptCLIP supports zero-/few-shot generalization across domains and possesses a training-free manner on target domains once trained on a base dataset. AdaptCLIP achieves state-of-the-art performance on 12 anomaly detection benchmarks from industrial and medical domains, significantly outperforming existing competitive methods. We will make the code and model of AdaptCLIP available at https://github.com/gaobb/AdaptCLIP.