Polar-Net: A Clinical-Friendly Model for Alzheimer's Disease Detection in OCTA Images

Optical Coherence Tomography Angiography (OCTA) is a promising tool for detecting Alzheimer's disease (AD) by imaging the retinal microvasculature. Ophthalmologists commonly use region-based analysis, such as the ETDRS grid, to study OCTA image biomarkers and understand the correlation with AD. However, existing studies have used general deep computer vision methods, which present challenges in providing interpretable results and leveraging clinical prior knowledge. To address these challenges, we propose a novel deep-learning framework called Polar-Net. Our approach involves mapping OCTA images from Cartesian coordinates to polar coordinates, which allows for the use of approximate sector convolution and enables the implementation of the ETDRS grid-based regional analysis method commonly used in clinical practice. Furthermore, Polar-Net incorporates clinical prior information of each sector region into the training process, which further enhances its performance. Additionally, our framework adapts to acquire the importance of the corresponding retinal region, which helps researchers and clinicians understand the model's decision-making process in detecting AD and assess its conformity to clinical observations. Through evaluations on private and public datasets, we have demonstrated that Polar-Net outperforms existing state-of-the-art methods and provides more valuable pathological evidence for the association between retinal vascular changes and AD. In addition, we also show that the two innovative modules introduced in our framework have a significant impact on improving overall performance.

Federated Learning for Clinical Structured Data: A Benchmark Comparison of Engineering and Statistical Approaches

Federated learning (FL) has shown promising potential in safeguarding data privacy in healthcare collaborations. While the term "FL" was originally coined by the engineering community, the statistical field has also explored similar privacy-preserving algorithms. Statistical FL algorithms, however, remain considerably less recognized than their engineering counterparts. Our goal was to bridge the gap by presenting the first comprehensive comparison of FL frameworks from both engineering and statistical domains. We evaluated five FL frameworks using both simulated and real-world data. The results indicate that statistical FL algorithms yield less biased point estimates for model coefficients and offer convenient confidence interval estimations. In contrast, engineering-based methods tend to generate more accurate predictions, sometimes surpassing central pooled and statistical FL models. This study underscores the relative strengths and weaknesses of both types of methods, emphasizing the need for increased awareness and their integration in future FL applications.

Adapting Large Language Models for Content Moderation: Pitfalls in Data Engineering and Supervised Fine-tuning

Nowadays, billions of people engage in communication and express their opinions on the internet daily. Unfortunately, not all of these expressions are friendly or compliant, making content moderation an indispensable task. With the successful development of Large Language Models (LLMs) in recent years, LLM-based methods have become a feasible solution for handling tasks in various domains. However, in the field of content moderation, there is still a lack of detailed work that systematically introduces implementation details. In this paper, we introduce how to fine-tune an LLM model that can be privately deployed for content moderation. Specifically, we discuss whether incorporating reasons during the fine-tuning process would be better or if it should be treated as a classification task directly. We also explore the benefits of utilizing reasons generated by more powerful LLMs for fine-tuning privately deployed models and the impact of different processing approaches when the answers generated by the more powerful LLMs are incorrect. We report the entire research process and the key findings in this paper, hoping to provide valuable experience for researchers who are fine-tuning privately deployed models in their domain-specific research.

ACT-Net: Anchor-context Action Detection in Surgery Videos

Recognition and localization of surgical detailed actions is an essential component of developing a context-aware decision support system. However, most existing detection algorithms fail to provide high-accuracy action classes even having their locations, as they do not consider the surgery procedure's regularity in the whole video. This limitation hinders their application. Moreover, implementing the predictions in clinical applications seriously needs to convey model confidence to earn entrustment, which is unexplored in surgical action prediction. In this paper, to accurately detect fine-grained actions that happen at every moment, we propose an anchor-context action detection network (ACTNet), including an anchor-context detection (ACD) module and a class conditional diffusion (CCD) module, to answer the following questions: 1) where the actions happen; 2) what actions are; 3) how confidence predictions are. Specifically, the proposed ACD module spatially and temporally highlights the regions interacting with the extracted anchor in surgery video, which outputs action location and its class distribution based on anchor-context interactions. Considering the full distribution of action classes in videos, the CCD module adopts a denoising diffusion-based generative model conditioned on our ACD estimator to further reconstruct accurately the action predictions. Moreover, we utilize the stochastic nature of the diffusion model outputs to access model confidence for each prediction. Our method reports the state-of-the-art performance, with improvements of 4.0% mAP against baseline on the surgical video dataset.

Shifting More Attention to Breast Lesion Segmentation in Ultrasound Videos

Breast lesion segmentation in ultrasound (US) videos is essential for diagnosing and treating axillary lymph node metastasis. However, the lack of a well-established and large-scale ultrasound video dataset with high-quality annotations has posed a persistent challenge for the research community. To overcome this issue, we meticulously curated a US video breast lesion segmentation dataset comprising 572 videos and 34,300 annotated frames, covering a wide range of realistic clinical scenarios. Furthermore, we propose a novel frequency and localization feature aggregation network (FLA-Net) that learns temporal features from the frequency domain and predicts additional lesion location positions to assist with breast lesion segmentation. We also devise a localization-based contrastive loss to reduce the lesion location distance between neighboring video frames within the same video and enlarge the location distances between frames from different ultrasound videos. Our experiments on our annotated dataset and two public video polyp segmentation datasets demonstrate that our proposed FLA-Net achieves state-of-the-art performance in breast lesion segmentation in US videos and video polyp segmentation while significantly reducing time and space complexity. Our model and dataset are available at https://github.com/jhl-Det/FLA-Net.

Video Adverse-Weather-Component Suppression Network via Weather Messenger and Adversarial Backpropagation

Although convolutional neural networks (CNNs) have been proposed to remove adverse weather conditions in single images using a single set of pre-trained weights, they fail to restore weather videos due to the absence of temporal information. Furthermore, existing methods for removing adverse weather conditions (e.g., rain, fog, and snow) from videos can only handle one type of adverse weather. In this work, we propose the first framework for restoring videos from all adverse weather conditions by developing a video adverse-weather-component suppression network (ViWS-Net). To achieve this, we first devise a weather-agnostic video transformer encoder with multiple transformer stages. Moreover, we design a long short-term temporal modeling mechanism for weather messenger to early fuse input adjacent video frames and learn weather-specific information. We further introduce a weather discriminator with gradient reversion, to maintain the weather-invariant common information and suppress the weather-specific information in pixel features, by adversarially predicting weather types. Finally, we develop a messenger-driven video transformer decoder to retrieve the residual weather-specific feature, which is spatiotemporally aggregated with hierarchical pixel features and refined to predict the clean target frame of input videos. Experimental results, on benchmark datasets and real-world weather videos, demonstrate that our ViWS-Net outperforms current state-of-the-art methods in terms of restoring videos degraded by any weather condition.

A Spatial-Temporal Deformable Attention based Framework for Breast Lesion Detection in Videos

Detecting breast lesion in videos is crucial for computer-aided diagnosis. Existing video-based breast lesion detection approaches typically perform temporal feature aggregation of deep backbone features based on the self-attention operation. We argue that such a strategy struggles to effectively perform deep feature aggregation and ignores the useful local information. To tackle these issues, we propose a spatial-temporal deformable attention based framework, named STNet. Our STNet introduces a spatial-temporal deformable attention module to perform local spatial-temporal feature fusion. The spatial-temporal deformable attention module enables deep feature aggregation in each stage of both encoder and decoder. To further accelerate the detection speed, we introduce an encoder feature shuffle strategy for multi-frame prediction during inference. In our encoder feature shuffle strategy, we share the backbone and encoder features, and shuffle encoder features for decoder to generate the predictions of multiple frames. The experiments on the public breast lesion ultrasound video dataset show that our STNet obtains a state-of-the-art detection performance, while operating twice as fast inference speed. The code and model are available at https://github.com/AlfredQin/STNet.

A Generic Fundus Image Enhancement Network Boosted by Frequency Self-supervised Representation Learning

Fundus photography is prone to suffer from image quality degradation that impacts clinical examination performed by ophthalmologists or intelligent systems. Though enhancement algorithms have been developed to promote fundus observation on degraded images, high data demands and limited applicability hinder their clinical deployment. To circumvent this bottleneck, a generic fundus image enhancement network (GFE-Net) is developed in this study to robustly correct unknown fundus images without supervised or extra data. Levering image frequency information, self-supervised representation learning is conducted to learn robust structure-aware representations from degraded images. Then with a seamless architecture that couples representation learning and image enhancement, GFE-Net can accurately correct fundus images and meanwhile preserve retinal structures. Comprehensive experiments are implemented to demonstrate the effectiveness and advantages of GFE-Net. Compared with state-of-the-art algorithms, GFE-Net achieves superior performance in data dependency, enhancement performance, deployment efficiency, and scale generalizability. Follow-up fundus image analysis is also facilitated by GFE-Net, whose modules are respectively verified to be effective for image enhancement.

Federated Model Aggregation via Self-Supervised Priors for Highly Imbalanced Medical Image Classification

In the medical field, federated learning commonly deals with highly imbalanced datasets, including skin lesions and gastrointestinal images. Existing federated methods under highly imbalanced datasets primarily focus on optimizing a global model without incorporating the intra-class variations that can arise in medical imaging due to different populations, findings, and scanners. In this paper, we study the inter-client intra-class variations with publicly available self-supervised auxiliary networks. Specifically, we find that employing a shared auxiliary pre-trained model, like MoCo-V2, locally on every client yields consistent divergence measurements. Based on these findings, we derive a dynamic balanced model aggregation via self-supervised priors (MAS) to guide the global model optimization. Fed-MAS can be utilized with different local learning methods for effective model aggregation toward a highly robust and unbiased global model. Our code is available at \url{https://github.com/xmed-lab/Fed-MAS}.

DVPT: Dynamic Visual Prompt Tuning of Large Pre-trained Models for Medical Image Analysis

Limited labeled data makes it hard to train models from scratch in medical domain, and an important paradigm is pre-training and then fine-tuning. Large pre-trained models contain rich representations, which can be adapted to downstream medical tasks. However, existing methods either tune all the parameters or the task-specific layers of the pre-trained models, ignoring the input variations of medical images, and thus they are not efficient or effective. In this work, we aim to study parameter-efficient fine-tuning (PEFT) for medical image analysis, and propose a dynamic visual prompt tuning method, named DVPT. It can extract knowledge beneficial to downstream tasks from large models with a few trainable parameters. Firstly, the frozen features are transformed by an lightweight bottleneck layer to learn the domain-specific distribution of downstream medical tasks, and then a few learnable visual prompts are used as dynamic queries and then conduct cross-attention with the transformed features, attempting to acquire sample-specific knowledge that are suitable for each sample. Finally, the features are projected to original feature dimension and aggregated with the frozen features. This DVPT module can be shared between different Transformer layers, further reducing the trainable parameters. To validate DVPT, we conduct extensive experiments with different pre-trained models on medical classification and segmentation tasks. We find such PEFT method can not only efficiently adapt the pre-trained models to the medical domain, but also brings data efficiency with partial labeled data. For example, with 0.5\% extra trainable parameters, our method not only outperforms state-of-the-art PEFT methods, even surpasses the full fine-tuning by more than 2.20\% Kappa score on medical classification task. It can saves up to 60\% labeled data and 99\% storage cost of ViT-B/16.