AdvMIM: Adversarial Masked Image Modeling for Semi-Supervised Medical Image Segmentation

Vision Transformer has recently gained tremendous popularity in medical image segmentation task due to its superior capability in capturing long-range dependencies. However, transformer requires a large amount of labeled data to be effective, which hinders its applicability in annotation scarce semi-supervised learning scenario where only limited labeled data is available. State-of-the-art semi-supervised learning methods propose combinatorial CNN-Transformer learning to cross teach a transformer with a convolutional neural network, which achieves promising results. However, it remains a challenging task to effectively train the transformer with limited labeled data. In this paper, we propose an adversarial masked image modeling method to fully unleash the potential of transformer for semi-supervised medical image segmentation. The key challenge in semi-supervised learning with transformer lies in the lack of sufficient supervision signal. To this end, we propose to construct an auxiliary masked domain from original domain with masked image modeling and train the transformer to predict the entire segmentation mask with masked inputs to increase supervision signal. We leverage the original labels from labeled data and pseudo-labels from unlabeled data to learn the masked domain. To further benefit the original domain from masked domain, we provide a theoretical analysis of our method from a multi-domain learning perspective and devise a novel adversarial training loss to reduce the domain gap between the original and masked domain, which boosts semi-supervised learning performance. We also extend adversarial masked image modeling to CNN network. Extensive experiments on three public medical image segmentation datasets demonstrate the effectiveness of our method, where our method outperforms existing methods significantly. Our code is publicly available at https://github.com/zlheui/AdvMIM.

Text to Image for Multi-Label Image Recognition with Joint Prompt-Adapter Learning

Benefited from image-text contrastive learning, pre-trained vision-language models, e.g., CLIP, allow to direct leverage texts as images (TaI) for parameter-efficient fine-tuning (PEFT). While CLIP is capable of making image features to be similar to the corresponding text features, the modality gap remains a nontrivial issue and limits image recognition performance of TaI. Using multi-label image recognition (MLR) as an example, we present a novel method, called T2I-PAL to tackle the modality gap issue when using only text captions for PEFT. The core design of T2I-PAL is to leverage pre-trained text-to-image generation models to generate photo-realistic and diverse images from text captions, thereby reducing the modality gap. To further enhance MLR, T2I-PAL incorporates a class-wise heatmap and learnable prototypes. This aggregates local similarities, making the representation of local visual features more robust and informative for multi-label recognition. For better PEFT, we further combine both prompt tuning and adapter learning to enhance classification performance. T2I-PAL offers significant advantages: it eliminates the need for fully semantically annotated training images, thereby reducing the manual annotation workload, and it preserves the intrinsic mode of the CLIP model, allowing for seamless integration with any existing CLIP framework. Extensive experiments on multiple benchmarks, including MS-COCO, VOC2007, and NUS-WIDE, show that our T2I-PAL can boost recognition performance by 3.47% in average above the top-ranked state-of-the-art methods.

Is Quantum Optimization Ready? An Effort Towards Neural Network Compression using Adiabatic Quantum Computing

Quantum optimization is the most mature quantum computing technology to date, providing a promising approach towards efficiently solving complex combinatorial problems. Methods such as adiabatic quantum computing (AQC) have been employed in recent years on important optimization problems across various domains. In deep learning, deep neural networks (DNN) have reached immense sizes to support new predictive capabilities. Optimization of large-scale models is critical for sustainable deployment, but becomes increasingly challenging with ever-growing model sizes and complexity. While quantum optimization is suitable for solving complex problems, its application to DNN optimization is not straightforward, requiring thorough reformulation for compatibility with commercially available quantum devices. In this work, we explore the potential of adopting AQC for fine-grained pruning-quantization of convolutional neural networks. We rework established heuristics to formulate model compression as a quadratic unconstrained binary optimization (QUBO) problem, and assess the solution space offered by commercial quantum annealing devices. Through our exploratory efforts of reformulation, we demonstrate that AQC can achieve effective compression of practical DNN models. Experiments demonstrate that adiabatic quantum computing (AQC) not only outperforms classical algorithms like genetic algorithms and reinforcement learning in terms of time efficiency but also excels at identifying global optima.

An integrated language-vision foundation model for conversational diagnostics and triaging in primary eye care

Current deep learning models are mostly task specific and lack a user-friendly interface to operate. We present Meta-EyeFM, a multi-function foundation model that integrates a large language model (LLM) with vision foundation models (VFMs) for ocular disease assessment. Meta-EyeFM leverages a routing mechanism to enable accurate task-specific analysis based on text queries. Using Low Rank Adaptation, we fine-tuned our VFMs to detect ocular and systemic diseases, differentiate ocular disease severity, and identify common ocular signs. The model achieved 100% accuracy in routing fundus images to appropriate VFMs, which achieved $\ge$ 82.2% accuracy in disease detection, $\ge$ 89% in severity differentiation, $\ge$ 76% in sign identification. Meta-EyeFM was 11% to 43% more accurate than Gemini-1.5-flash and ChatGPT-4o LMMs in detecting various eye diseases and comparable to an ophthalmologist. This system offers enhanced usability and diagnostic performance, making it a valuable decision support tool for primary eye care or an online LLM for fundus evaluation.

Partially Supervised Unpaired Multi-Modal Learning for Label-Efficient Medical Image Segmentation

Unpaired Multi-Modal Learning (UMML) which leverages unpaired multi-modal data to boost model performance on each individual modality has attracted a lot of research interests in medical image analysis. However, existing UMML methods require multi-modal datasets to be fully labeled, which incurs tremendous annotation cost. In this paper, we investigate the use of partially labeled data for label-efficient unpaired multi-modal learning, which can reduce the annotation cost by up to one half. We term the new learning paradigm as Partially Supervised Unpaired Multi-Modal Learning (PSUMML) and propose a novel Decomposed partial class adaptation with snapshot Ensembled Self-Training (DEST) framework for it. Specifically, our framework consists of a compact segmentation network with modality specific normalization layers for learning with partially labeled unpaired multi-modal data. The key challenge in PSUMML lies in the complex partial class distribution discrepancy due to partial class annotation, which hinders effective knowledge transfer across modalities. We theoretically analyze this phenomenon with a decomposition theorem and propose a decomposed partial class adaptation technique to precisely align the partially labeled classes across modalities to reduce the distribution discrepancy. We further propose a snapshot ensembled self-training technique to leverage the valuable snapshot models during training to assign pseudo-labels to partially labeled pixels for self-training to boost model performance. We perform extensive experiments under different scenarios of PSUMML for two medical image segmentation tasks, namely cardiac substructure segmentation and abdominal multi-organ segmentation. Our framework outperforms existing methods significantly.

AiRacleX: Automated Detection of Price Oracle Manipulations via LLM-Driven Knowledge Mining and Prompt Generation

Decentralized finance applications depend on accurate price oracles to ensure secure transactions, yet these oracles are highly vulnerable to manipulation, enabling attackers to exploit smart contract vulnerabilities for unfair asset valuation and financial gain. Detecting such manipulations traditionally relies on the manual effort of experienced experts, presenting significant challenges. In this paper, we propose a novel LLM-driven framework that automates the detection of price oracle manipulations by leveraging the complementary strengths of different LLM models. Our approach begins with domain-specific knowledge extraction, where an LLM model synthesizes precise insights about price oracle vulnerabilities from top-tier academic papers, eliminating the need for profound expertise from developers or auditors. This knowledge forms the foundation for a second LLM model to generate structured, context-aware chain of thought prompts, which guide a third LLM model in accurately identifying manipulation patterns in smart contracts. We validate the framework effectiveness through experiments on 60 known vulnerabilities from 46 real-world DeFi attacks or projects spanning 2021 to 2023. The best performing combination of LLMs (Haiku-Haiku-4o-mini) identified by AiRacleX demonstrate a 2.58-times improvement in recall (0.667 vs 0.259) compared to the state-of-the-art tool GPTScan, while maintaining comparable precision. Furthermore, our framework demonstrates the feasibility of replacing commercial models with open-source alternatives, enhancing privacy and security for developers.

Semi-rPPG: Semi-Supervised Remote Physiological Measurement with Curriculum Pseudo-Labeling

Remote Photoplethysmography (rPPG) is a promising technique to monitor physiological signals such as heart rate from facial videos. However, the labeled facial videos in this research are challenging to collect. Current rPPG research is mainly based on several small public datasets collected in simple environments, which limits the generalization and scale of the AI models. Semi-supervised methods that leverage a small amount of labeled data and abundant unlabeled data can fill this gap for rPPG learning. In this study, a novel semi-supervised learning method named Semi-rPPG that combines curriculum pseudo-labeling and consistency regularization is proposed to extract intrinsic physiological features from unlabelled data without impairing the model from noises. Specifically, a curriculum pseudo-labeling strategy with signal-to-noise ratio (SNR) criteria is proposed to annotate the unlabelled data while adaptively filtering out the low-quality unlabelled data. Besides, a novel consistency regularization term for quasi-periodic signals is proposed through weak and strong augmented clips. To benefit the research on semi-supervised rPPG measurement, we establish a novel semi-supervised benchmark for rPPG learning through intra-dataset and cross-dataset evaluation on four public datasets. The proposed Semi-rPPG method achieves the best results compared with three classical semi-supervised methods under different protocols. Ablation studies are conducted to prove the effectiveness of the proposed methods.

Are Traditional Deep Learning Model Approaches as Effective as a Retinal-Specific Foundation Model for Ocular and Systemic Disease Detection?

Background: RETFound, a self-supervised, retina-specific foundation model (FM), showed potential in downstream applications. However, its comparative performance with traditional deep learning (DL) models remains incompletely understood. This study aimed to evaluate RETFound against three ImageNet-pretrained supervised DL models (ResNet50, ViT-base, SwinV2) in detecting ocular and systemic diseases. Methods: We fine-tuned/trained RETFound and three DL models on full datasets, 50%, 20%, and fixed sample sizes (400, 200, 100 images, with half comprising disease cases; for each DR severity class, 100 and 50 cases were used. Fine-tuned models were tested internally using the SEED (53,090 images) and APTOS-2019 (3,672 images) datasets and externally validated on population-based (BES, CIEMS, SP2, UKBB) and open-source datasets (ODIR-5k, PAPILA, GAMMA, IDRiD, MESSIDOR-2). Model performance was compared using area under the receiver operating characteristic curve (AUC) and Z-tests with Bonferroni correction (P<0.05/3). Interpretation: Traditional DL models are mostly comparable to RETFound for ocular disease detection with large datasets. However, RETFound is superior in systemic disease detection with smaller datasets. These findings offer valuable insights into the respective merits and limitation of traditional models and FMs.

Look Back for More: Harnessing Historical Sequential Updates for Personalized Federated Adapter Tuning

Personalized federated learning (PFL) studies effective model personalization to address the data heterogeneity issue among clients in traditional federated learning (FL). Existing PFL approaches mainly generate personalized models by relying solely on the clients' latest updated models while ignoring their previous updates, which may result in suboptimal personalized model learning. To bridge this gap, we propose a novel framework termed pFedSeq, designed for personalizing adapters to fine-tune a foundation model in FL. In pFedSeq, the server maintains and trains a sequential learner, which processes a sequence of past adapter updates from clients and generates calibrations for personalized adapters. To effectively capture the cross-client and cross-step relations hidden in previous updates and generate high-performing personalized adapters, pFedSeq adopts the powerful selective state space model (SSM) as the architecture of sequential learner. Through extensive experiments on four public benchmark datasets, we demonstrate the superiority of pFedSeq over state-of-the-art PFL methods.

Diffusion-Enhanced Test-time Adaptation with Text and Image Augmentation

Existing test-time prompt tuning (TPT) methods focus on single-modality data, primarily enhancing images and using confidence ratings to filter out inaccurate images. However, while image generation models can produce visually diverse images, single-modality data enhancement techniques still fail to capture the comprehensive knowledge provided by different modalities. Additionally, we note that the performance of TPT-based methods drops significantly when the number of augmented images is limited, which is not unusual given the computational expense of generative augmentation. To address these issues, we introduce IT3A, a novel test-time adaptation method that utilizes a pre-trained generative model for multi-modal augmentation of each test sample from unknown new domains. By combining augmented data from pre-trained vision and language models, we enhance the ability of the model to adapt to unknown new test data. Additionally, to ensure that key semantics are accurately retained when generating various visual and text enhancements, we employ cosine similarity filtering between the logits of the enhanced images and text with the original test data. This process allows us to filter out some spurious augmentation and inadequate combinations. To leverage the diverse enhancements provided by the generation model across different modals, we have replaced prompt tuning with an adapter for greater flexibility in utilizing text templates. Our experiments on the test datasets with distribution shifts and domain gaps show that in a zero-shot setting, IT3A outperforms state-of-the-art test-time prompt tuning methods with a 5.50% increase in accuracy.