Self-Supervised Spatial And Zero-Shot Angular Super-Resolution by Spatial-Angular Implicit Representation For Rotating-View SNR-Efficient Diffusion MRI

Rotating-view thick-slice acquisition is highly SNR-efficient for mesoscale diffusion MRI (dMRI) but requires numerous rotating views to satisfy Nyquist sampling, resulting in long scan time. We propose a self-supervised Spatial-Angular Implicit Neural Representation (SA-INR) that reconstructs high-resolution dMRI from a single view per diffusion direction, representing a massive acceleration. Our model, an MLP conditioned on a b=0 structural prior and the b-direction via FiLM, is trained end-to-end on the anisotropic input. The framework not only accurately reconstructs the trained b-directions (spatial SR) but also learns a continuous q-space representation, enabling high-fidelity "zero-shot" synthesis of unseen b-directions (angular SR). On simulated data, our method achieved high fidelity for both trained (34.82 dB) and unseen (33.08 dB) directions. Most importantly, the synthesized angular data also improved the quantitative accuracy of downstream DTI model fitting. Our SA-INR framework breaks the classical sampling limits, paving the way for fast, quantitative high-resolution dMRI.

Co-evolving Agent Architectures and Interpretable Reasoning for Automated Optimization

Automating operations research (OR) with large language models (LLMs) remains limited by hand-crafted reasoning--execution workflows. Complex OR tasks require adaptive coordination among problem interpretation, mathematical formulation, solver selection, code generation, and iterative debugging. To address this limitation, we propose EvoOR-Agent, a co-evolutionary framework for automated optimization. The framework represents agent workflows as activity-on-edge (AOE)-style networks, making workflow topology, execution dependencies, and alternative reasoning paths explicit. On this representation, the framework maintains an architecture graph and evolves a population of reasoning individuals through graph-mediated path-conditioned recombination, multi-granularity semantic mutation, and elitist population update. A knowledge-base-assisted experience-acquisition module further injects reusable OR practices into initialization and semantic variation. Empirical results on heterogeneous OR benchmarks show that the proposed framework consistently improves over zero-shot LLMs, fixed-pipeline OR agents, and representative evolutionary agent frameworks. Case studies and ablation analyses further indicate that explicit architecture evolution and graph-supported reasoning-trajectory search contribute to both performance improvement and structural interpretability. These results suggest that treating agent architectures and reasoning trajectories as evolvable objects provides an effective route toward adaptive and interpretable automated optimization.

Unleashing Video Language Models for Fine-grained HRCT Report Generation

Generating precise diagnostic reports from High-Resolution Computed Tomography (HRCT) is critical for clinical workflow, yet it remains a formidable challenge due to the high pathological diversity and spatial sparsity within 3D volumes. While Video Language Models (VideoLMs) have demonstrated remarkable spatio-temporal reasoning in general domains, their adaptability to domain-specific, high-volume medical interpretation remains underexplored. In this work, we present AbSteering, an abnormality-centric framework that steers VideoLMs toward precise HRCT report generation. Specifically, AbSteering introduces: (i) an abnormality-centric Chain-of-Thought scheme that enforces abnormality reasoning, and (ii) a Direct Preference Optimization objective that utilizes clinically confusable abnormalities as hard negatives to enhance fine-grained discrimination. Our results demonstrate that general-purpose VideoLMs possess strong transferability to high-volume medical imaging when guided by this paradigm. Notably, AbSteering outperforms state-of-the-art domain-specific CT foundation models, which are pretrained with large-scale CTs, achieving superior detection sensitivity while simultaneously mitigating hallucinations. Our data and model weights are released at https://anonymous.4open.science/r/hrct-report-generation-video-vlm-728C/

Nano-EmoX: Unifying Multimodal Emotional Intelligence from Perception to Empathy

The development of affective multimodal language models (MLMs) has long been constrained by a gap between low-level perception and high-level interaction, leading to fragmented affective capabilities and limited generalization. To bridge this gap, we propose a cognitively inspired three-level hierarchy that organizes affective tasks according to their cognitive depth-perception, understanding, and interaction-and provides a unified conceptual foundation for advancing affective modeling. Guided by this hierarchy, we introduce Nano-EmoX, a small-scale multitask MLM, and P2E (Perception-to-Empathy), a curriculum-based training framework. Nano-EmoX integrates a suite of omni-modal encoders, including an enhanced facial encoder and a fusion encoder, to capture key multimodal affective cues and improve cross-task transferability. The outputs are projected into a unified language space via heterogeneous adapters, empowering a lightweight language model to tackle diverse affective tasks. Concurrently, P2E progressively cultivates emotional intelligence by aligning rapid perception with chain-of-thought-driven empathy. To the best of our knowledge, Nano-EmoX is the first compact MLM (2.2B) to unify six core affective tasks across all three hierarchy levels, achieving state-of-the-art or highly competitive performance across multiple benchmarks, demonstrating excellent efficiency and generalization.

Med-CoReasoner: Reducing Language Disparities in Medical Reasoning via Language-Informed Co-Reasoning

While reasoning-enhanced large language models perform strongly on English medical tasks, a persistent multilingual gap remains, with substantially weaker reasoning in local languages, limiting equitable global medical deployment. To bridge this gap, we introduce Med-CoReasoner, a language-informed co-reasoning framework that elicits parallel English and local-language reasoning, abstracts them into structured concepts, and integrates local clinical knowledge into an English logical scaffold via concept-level alignment and retrieval. This design combines the structural robustness of English reasoning with the practice-grounded expertise encoded in local languages. To evaluate multilingual medical reasoning beyond multiple-choice settings, we construct MultiMed-X, a benchmark covering seven languages with expert-annotated long-form question answering and natural language inference tasks, comprising 350 instances per language. Experiments across three benchmarks show that Med-CoReasoner improves multilingual reasoning performance by an average of 5%, with particularly substantial gains in low-resource languages. Moreover, model distillation and expert evaluation analysis further confirm that Med-CoReasoner produces clinically sound and culturally grounded reasoning traces.

Convergent and divergent connectivity patterns of the arcuate fasciculus in macaques and humans

The organization and connectivity of the arcuate fasciculus (AF) in nonhuman primates remain contentious, especially concerning how its anatomy diverges from that of humans. Here, we combined cross-scale single-neuron tracing - using viral-based genetic labeling and fluorescence micro-optical sectioning tomography in macaques (n = 4; age 3 - 11 years) - with whole-brain tractography from 11.7T diffusion MRI. Complemented by spectral embedding analysis of 7.0T MRI in humans, we performed a comparative connectomic analysis of the AF across species. We demonstrate that the macaque AF originates in the temporal-parietal cortex, traverses the auditory cortex and parietal operculum, and projects into prefrontal regions. In contrast, the human AF exhibits greater expansion into the middle temporal gyrus and stronger prefrontal and parietal operculum connectivity - divergences quantified by Kullback-Leibler analysis that likely underpin the evolutionary specialization of human language networks. These interspecies differences - particularly the human AF's broader temporal integration and strengthened frontoparietal linkages - suggest a connectivity-based substrate for the emergence of advanced language processing unique to humans. Furthermore, our findings offer a neuroanatomical framework for understanding AF-related disorders such as aphasia and dyslexia, where aberrant connectivity disrupts language function.

Topology-Assisted Spatio-Temporal Pattern Disentangling for Scalable MARL in Large-scale Autonomous Traffic Control

Intelligent Transportation Systems (ITSs) have emerged as a promising solution towards ameliorating urban traffic congestion, with Traffic Signal Control (TSC) identified as a critical component. Although Multi-Agent Reinforcement Learning (MARL) algorithms have shown potential in optimizing TSC through real-time decision-making, their scalability and effectiveness often suffer from large-scale and complex environments. Typically, these limitations primarily stem from a fundamental mismatch between the exponential growth of the state space driven by the environmental heterogeneities and the limited modeling capacity of current solutions. To address these issues, this paper introduces a novel MARL framework that integrates Dynamic Graph Neural Networks (DGNNs) and Topological Data Analysis (TDA), aiming to enhance the expressiveness of environmental representations and improve agent coordination. Furthermore, inspired by the Mixture of Experts (MoE) architecture in Large Language Models (LLMs), a topology-assisted spatial pattern disentangling (TSD)-enhanced MoE is proposed, which leverages topological signatures to decouple graph features for specialized processing, thus improving the model's ability to characterize dynamic and heterogeneous local observations. The TSD module is also integrated into the policy and value networks of the Multi-agent Proximal Policy Optimization (MAPPO) algorithm, further improving decision-making efficiency and robustness. Extensive experiments conducted on real-world traffic scenarios, together with comprehensive theoretical analysis, validate the superior performance of the proposed framework, highlighting the model's scalability and effectiveness in addressing the complexities of large-scale TSC tasks.

Dynamic Dual Buffer with Divide-and-Conquer Strategy for Online Continual Learning

Online Continual Learning (OCL) presents a complex learning environment in which new data arrives in a batch-to-batch online format, and the risk of catastrophic forgetting can significantly impair model efficacy. In this study, we address OCL by introducing an innovative memory framework that incorporates a short-term memory system to retain dynamic information and a long-term memory system to archive enduring knowledge. Specifically, the long-term memory system comprises a collection of sub-memory buffers, each linked to a cluster prototype and designed to retain data samples from distinct categories. We propose a novel $K$-means-based sample selection method to identify cluster prototypes for each encountered category. To safeguard essential and critical samples, we introduce a novel memory optimisation strategy that selectively retains samples in the appropriate sub-memory buffer by evaluating each cluster prototype against incoming samples through an optimal transportation mechanism. This approach specifically promotes each sub-memory buffer to retain data samples that exhibit significant discrepancies from the corresponding cluster prototype, thereby ensuring the preservation of semantically rich information. In addition, we propose a novel Divide-and-Conquer (DAC) approach that formulates the memory updating as an optimisation problem and divides it into several subproblems. As a result, the proposed DAC approach can solve these subproblems separately and thus can significantly reduce computations of the proposed memory updating process. We conduct a series of experiments across standard and imbalanced learning settings, and the empirical findings indicate that the proposed memory framework achieves state-of-the-art performance in both learning contexts.

Enhancing Diffusion-Weighted Images (DWI) for Diffusion MRI: Is it Enough without Non-Diffusion-Weighted B=0 Reference?

Diffusion MRI (dMRI) is essential for studying brain microstructure, but high-resolution imaging remains challenging due to the inherent trade-offs between acquisition time and signal-to-noise ratio (SNR). Conventional methods often optimize only the diffusion-weighted images (DWIs) without considering their relationship with the non-diffusion-weighted (b=0) reference images. However, calculating diffusion metrics, such as the apparent diffusion coefficient (ADC) and diffusion tensor with its derived metrics like fractional anisotropy (FA) and mean diffusivity (MD), relies on the ratio between each DWI and the b=0 image, which is crucial for clinical observation and diagnostics. In this study, we demonstrate that solely enhancing DWIs using a conventional pixel-wise mean squared error (MSE) loss is insufficient, as the error in ratio between generated DWIs and b=0 diverges. We propose a novel ratio loss, defined as the MSE loss between the predicted and ground-truth log of DWI/b=0 ratios. Our results show that incorporating the ratio loss significantly improves the convergence of this ratio error, achieving lower ratio MSE and slightly enhancing the peak signal-to-noise ratio (PSNR) of generated DWIs. This leads to improved dMRI super-resolution and better preservation of b=0 ratio-based features for the derivation of diffusion metrics.

Decoupling Multi-Contrast Super-Resolution: Pairing Unpaired Synthesis with Implicit Representations

Magnetic Resonance Imaging (MRI) is critical for clinical diagnostics but is often limited by long acquisition times and low signal-to-noise ratios, especially in modalities like diffusion and functional MRI. The multi-contrast nature of MRI presents a valuable opportunity for cross-modal enhancement, where high-resolution (HR) modalities can serve as references to boost the quality of their low-resolution (LR) counterparts-motivating the development of Multi-Contrast Super-Resolution (MCSR) techniques. Prior work has shown that leveraging complementary contrasts can improve SR performance; however, effective feature extraction and fusion across modalities with varying resolutions remains a major challenge. Moreover, existing MCSR methods often assume fixed resolution settings and all require large, perfectly paired training datasets-conditions rarely met in real-world clinical environments. To address these challenges, we propose a novel Modular Multi-Contrast Super-Resolution (MCSR) framework that eliminates the need for paired training data and supports arbitrary upscaling. Our method decouples the MCSR task into two stages: (1) Unpaired Cross-Modal Synthesis (U-CMS), which translates a high-resolution reference modality into a synthesized version of the target contrast, and (2) Unsupervised Super-Resolution (U-SR), which reconstructs the final output using implicit neural representations (INRs) conditioned on spatial coordinates. This design enables scale-agnostic and anatomically faithful reconstruction by bridging un-paired cross-modal synthesis with unsupervised resolution enhancement. Experiments show that our method achieves superior performance at 4x and 8x upscaling, with improved fidelity and anatomical consistency over existing baselines. Our framework demonstrates strong potential for scalable, subject-specific, and data-efficient MCSR in real-world clinical settings.