Senior Member, IEEE
Abstract:General audio understanding is a fundamental goal for large audio-language models, with audio captioning serving as a cornerstone task for their development. However, progress in this domain is hindered by existing datasets, which lack the scale and descriptive granularity required to train truly versatile models. To address this gap, we introduce ACAVCaps, a new large-scale, fine-grained, and multi-faceted audio captioning dataset. Derived from the ACAV100M collection, ACAVCaps is constructed using a multi-expert pipeline that analyzes audio from diverse perspectives-including speech, music, and acoustic properties-which are then synthesized into rich, detailed descriptions by a large language model. Experimental results demonstrate that models pre-trained on ACAVCaps exhibit substantially stronger generalization capabilities on various downstream tasks compared to those trained on other leading captioning datasets. The dataset is available at https://github.com/xiaomi-research/acavcaps.
Abstract:Zero-shot (ZS) 3D anomaly detection is crucial for reliable industrial inspection, as it enables detecting and localizing defects without requiring any target-category training data. Existing approaches render 3D point clouds into 2D images and leverage pre-trained Vision-Language Models (VLMs) for anomaly detection. However, such strategies inevitably discard geometric details and exhibit limited sensitivity to local anomalies. In this paper, we revisit intrinsic 3D representations and explore the potential of pre-trained Point-Language Models (PLMs) for ZS 3D anomaly detection. We propose BTP (Back To Point), a novel framework that effectively aligns 3D point cloud and textual embeddings. Specifically, BTP aligns multi-granularity patch features with textual representations for localized anomaly detection, while incorporating geometric descriptors to enhance sensitivity to structural anomalies. Furthermore, we introduce a joint representation learning strategy that leverages auxiliary point cloud data to improve robustness and enrich anomaly semantics. Extensive experiments on Real3D-AD and Anomaly-ShapeNet demonstrate that BTP achieves superior performance in ZS 3D anomaly detection. Code will be available at \href{https://github.com/wistful-8029/BTP-3DAD}{https://github.com/wistful-8029/BTP-3DAD}.
Abstract:Unsupervised Continuous Anomaly Detection (UCAD) is gaining attention for effectively addressing the catastrophic forgetting and heavy computational burden issues in traditional Unsupervised Anomaly Detection (UAD). However, existing UCAD approaches that rely solely on visual information are insufficient to capture the manifold of normality in complex scenes, thereby impeding further gains in anomaly detection accuracy. To overcome this limitation, we propose an unsupervised continual anomaly detection framework grounded in multimodal prompting. Specifically, we introduce a Continual Multimodal Prompt Memory Bank (CMPMB) that progressively distills and retains prototypical normal patterns from both visual and textual domains across consecutive tasks, yielding a richer representation of normality. Furthermore, we devise a Defect-Semantic-Guided Adaptive Fusion Mechanism (DSG-AFM) that integrates an Adaptive Normalization Module (ANM) with a Dynamic Fusion Strategy (DFS) to jointly enhance detection accuracy and adversarial robustness. Benchmark experiments on MVTec AD and VisA datasets show that our approach achieves state-of-the-art (SOTA) performance on image-level AUROC and pixel-level AUPR metrics.
Abstract:This paper introduces DashengTokenizer, a continuous audio tokenizer engineered for joint use in both understanding and generation tasks. Unlike conventional approaches, which train acoustic tokenizers and subsequently integrate frozen semantic knowledge, our method inverts this paradigm: we leverage frozen semantic features and inject acoustic information. In linear evaluation across 22 diverse tasks, our method outperforms previous audio codec and audio encoder baselines by a significant margin while maintaining competitive audio reconstruction quality. Notably, we demonstrate that this acoustic injection improves performance for tasks such as speech emotion recognition, music understanding, and acoustic scene classification. We further evaluate the tokenizer's generative performance on text-to-audio (TTA), text-to-music (TTM), and speech enhancement (SE). Our approach surpasses standard variational autoencoder (VAE)-based methods on TTA and TTM tasks, while its effectiveness on SE underscores its capabilities as a general-purpose audio encoder. Finally, our results challenge the prevailing assumption that VAE-based architectures are a prerequisite for audio synthesis. Checkpoints are available at https://huggingface.co/mispeech/dashengtokenizer.
Abstract:Recent years have witnessed remarkable progress in multimodal learning within computational pathology. Existing models primarily rely on vision and language modalities; however, language alone lacks molecular specificity and offers limited pathological supervision, leading to representational bottlenecks. In this paper, we propose STAMP, a Spatial Transcriptomics-Augmented Multimodal Pathology representation learning framework that integrates spatially-resolved gene expression profiles to enable molecule-guided joint embedding of pathology images and transcriptomic data. Our study shows that self-supervised, gene-guided training provides a robust and task-agnostic signal for learning pathology image representations. Incorporating spatial context and multi-scale information further enhances model performance and generalizability. To support this, we constructed SpaVis-6M, the largest Visium-based spatial transcriptomics dataset to date, and trained a spatially-aware gene encoder on this resource. Leveraging hierarchical multi-scale contrastive alignment and cross-scale patch localization mechanisms, STAMP effectively aligns spatial transcriptomics with pathology images, capturing spatial structure and molecular variation. We validate STAMP across six datasets and four downstream tasks, where it consistently achieves strong performance. These results highlight the value and necessity of integrating spatially resolved molecular supervision for advancing multimodal learning in computational pathology. The code is included in the supplementary materials. The pretrained weights and SpaVis-6M are available at: https://github.com/Hanminghao/STAMP.
Abstract:Large language models (LLMs) have demonstrated strong performance and rapid progress in a wide range of medical reasoning tasks. However, their sequential autoregressive decoding forces inherently parallel clinical reasoning, such as differential diagnosis, into a single linear reasoning path, limiting both efficiency and reliability for complex medical problems. To address this, we propose MedVerse, a reasoning framework for complex medical inference that reformulates medical reasoning as a parallelizable directed acyclic graph (DAG) process based on Petri net theory. The framework adopts a full-stack design across data, model architecture, and system execution. For data creation, we introduce the MedVerse Curator, an automated pipeline that synthesizes knowledge-grounded medical reasoning paths and transforms them into Petri net-structured representations. At the architectural level, we propose a topology-aware attention mechanism with adaptive position indices that supports parallel reasoning while preserving logical consistency. Systematically, we develop a customized inference engine that supports parallel execution without additional overhead. Empirical evaluations show that MedVerse improves strong general-purpose LLMs by up to 8.9%. Compared to specialized medical LLMs, MedVerse achieves comparable performance while delivering a 1.3x reduction in inference latency and a 1.7x increase in generation throughput, enabled by its parallel decoding capability.
Abstract:Mixture of Experts (MoE) architectures significantly enhance the capacity of LLMs without proportional increases in computation, but at the cost of a vast parameter size. Offloading MoE expert parameters to host memory and leveraging both CPU and GPU computation has recently emerged as a promising direction to support such models on resourceconstrained local PC platforms. While promising, we notice that existing approaches mismatch the dynamic nature of expert workloads, which leads to three fundamental inefficiencies: (1) Static expert assignment causes severe CPUGPU load imbalance, underutilizing CPU and GPU resources; (2) Existing prefetching techniques fail to accurately predict high-workload experts, leading to costly inaccurate prefetches; (3) GPU cache policies neglect workload dynamics, resulting in poor hit rates and limited effectiveness. To address these challenges, we propose DALI, a workloaDAware offLoadIng framework for efficient MoE inference on local PCs. To fully utilize hardware resources, DALI first dynamically assigns experts to CPU or GPU by modeling assignment as a 0-1 integer optimization problem and solving it efficiently using a Greedy Assignment strategy at runtime. To improve prefetching accuracy, we develop a Residual-Based Prefetching method leveraging inter-layer residual information to accurately predict high-workload experts. Additionally, we introduce a Workload-Aware Cache Replacement policy that exploits temporal correlation in expert activations to improve GPU cache efficiency. By evaluating across various MoE models and settings, DALI achieves significant speedups in the both prefill and decoding phases over the state-of-the-art offloading frameworks.
Abstract:Test-time scaling improves LLM performance by generating multiple candidate solutions, yet token-level sampling requires temperature tuning that trades off diversity against stability. Fine-grained MoE, featuring hundreds of well-trained experts per layer and multi-expert activation per token, offers an unexplored alternative through its rich routing space. We empirically characterize fine-grained MoE routing and uncover an informative pattern: router scores exhibit a certain head of high-confidence experts followed by an uncertain tail of low-confidence candidates. While single-run greedy accuracy remains stable when fewer experts are activated, multi-sample pass@n degrades significantly-suggesting that the certain head governs core reasoning capability while the uncertain tail correlates with reasoning diversity. Motivated by these findings, we propose Expert-Sample, a training-free method that preserves high-confidence selections while injecting controlled stochasticity into the uncertain tail, enabling diverse generation without destabilizing outputs. Evaluated on multiple fine-grained MoE models across math, knowledge reasoning, and code tasks, Expert-Sample consistently improves pass@n and verification-based accuracy. On Qwen3-30B-A3B-Instruct evaluated on GPQA-Diamond with 32 parallel samples, pass@32 rises from 85.4% to 91.9%, and accuracy improves from 59.1% to 62.6% with Best-of-N verification.
Abstract:Molecular function is largely determined by structure. Accurately aligning molecular structure with natural language is therefore essential for enabling large language models (LLMs) to reason about downstream chemical tasks. However, the substantial cost of human annotation makes it infeasible to construct large-scale, high-quality datasets of structure-grounded descriptions. In this work, we propose a fully automated annotation framework for generating precise molecular structure descriptions at scale. Our approach builds upon and extends a rule-based chemical nomenclature parser to interpret IUPAC names and construct enriched, structured XML metadata that explicitly encodes molecular structure. This metadata is then used to guide LLMs in producing accurate natural-language descriptions. Using this framework, we curate a large-scale dataset of approximately $163$k molecule-description pairs. A rigorous validation protocol combining LLM-based and expert human evaluation on a subset of $2,000$ molecules demonstrates a high description precision of $98.6\%$. The resulting dataset provides a reliable foundation for future molecule-language alignment, and the proposed annotation method is readily extensible to larger datasets and broader chemical tasks that rely on structural descriptions.
Abstract:Existing Large Language Model (LLM) agent frameworks face two significant challenges: high configuration costs and static capabilities. Building a high-quality agent often requires extensive manual effort in tool integration and prompt engineering, while deployed agents struggle to adapt to dynamic environments without expensive fine-tuning. To address these issues, we propose \textbf{Youtu-Agent}, a modular framework designed for the automated generation and continuous evolution of LLM agents. Youtu-Agent features a structured configuration system that decouples execution environments, toolkits, and context management, enabling flexible reuse and automated synthesis. We introduce two generation paradigms: a \textbf{Workflow} mode for standard tasks and a \textbf{Meta-Agent} mode for complex, non-standard requirements, capable of automatically generating tool code, prompts, and configurations. Furthermore, Youtu-Agent establishes a hybrid policy optimization system: (1) an \textbf{Agent Practice} module that enables agents to accumulate experience and improve performance through in-context optimization without parameter updates; and (2) an \textbf{Agent RL} module that integrates with distributed training frameworks to enable scalable and stable reinforcement learning of any Youtu-Agents in an end-to-end, large-scale manner. Experiments demonstrate that Youtu-Agent achieves state-of-the-art performance on WebWalkerQA (71.47\%) and GAIA (72.8\%) using open-weight models. Our automated generation pipeline achieves over 81\% tool synthesis success rate, while the Practice module improves performance on AIME 2024/2025 by +2.7\% and +5.4\% respectively. Moreover, our Agent RL training achieves 40\% speedup with steady performance improvement on 7B LLMs, enhancing coding/reasoning and searching capabilities respectively up to 35\% and 21\% on Maths and general/multi-hop QA benchmarks.