SD-MAD: Sign-Driven Few-shot Multi-Anomaly Detection in Medical Images

Medical anomaly detection (AD) is crucial for early clinical intervention, yet it faces challenges due to limited access to high-quality medical imaging data, caused by privacy concerns and data silos. Few-shot learning has emerged as a promising approach to alleviate these limitations by leveraging the large-scale prior knowledge embedded in vision-language models (VLMs). Recent advancements in few-shot medical AD have treated normal and abnormal cases as a one-class classification problem, often overlooking the distinction among multiple anomaly categories. Thus, in this paper, we propose a framework tailored for few-shot medical anomaly detection in the scenario where the identification of multiple anomaly categories is required. To capture the detailed radiological signs of medical anomaly categories, our framework incorporates diverse textual descriptions for each category generated by a Large-Language model, under the assumption that different anomalies in medical images may share common radiological signs in each category. Specifically, we introduce SD-MAD, a two-stage Sign-Driven few-shot Multi-Anomaly Detection framework: (i) Radiological signs are aligned with anomaly categories by amplifying inter-anomaly discrepancy; (ii) Aligned signs are selected further to mitigate the effect of the under-fitting and uncertain-sample issue caused by limited medical data, employing an automatic sign selection strategy at inference. Moreover, we propose three protocols to comprehensively quantify the performance of multi-anomaly detection. Extensive experiments illustrate the effectiveness of our method.

ChromFound: Towards A Universal Foundation Model for Single-Cell Chromatin Accessibility Data

The advent of single-cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) offers an innovative perspective for deciphering regulatory mechanisms by assembling a vast repository of single-cell chromatin accessibility data. While foundation models have achieved significant success in single-cell transcriptomics, there is currently no foundation model for scATAC-seq that supports zero-shot high-quality cell identification and comprehensive multi-omics analysis simultaneously. Key challenges lie in the high dimensionality and sparsity of scATAC-seq data, as well as the lack of a standardized schema for representing open chromatin regions (OCRs). Here, we present \textbf{ChromFound}, a foundation model tailored for scATAC-seq. ChromFound utilizes a hybrid architecture and genome-aware tokenization to effectively capture genome-wide long contexts and regulatory signals from dynamic chromatin landscapes. Pretrained on 1.97 million cells from 30 tissues and 6 disease conditions, ChromFound demonstrates broad applicability across 6 diverse tasks. Notably, it achieves robust zero-shot performance in generating universal cell representations and exhibits excellent transferability in cell type annotation and cross-omics prediction. By uncovering enhancer-gene links undetected by existing computational methods, ChromFound offers a promising framework for understanding disease risk variants in the noncoding genome.

SegAnyPET: Universal Promptable Segmentation from Positron Emission Tomography Images

Positron Emission Tomography (PET) imaging plays a crucial role in modern medical diagnostics by revealing the metabolic processes within a patient's body, which is essential for quantification of therapy response and monitoring treatment progress. However, the segmentation of PET images presents unique challenges due to their lower contrast and less distinct boundaries compared to other structural medical modalities. Recent developments in segmentation foundation models have shown superior versatility across diverse natural image segmentation tasks. Despite the efforts of medical adaptations, these works primarily focus on structural medical images with detailed physiological structural information and exhibit poor generalization ability when adapted to molecular PET imaging. In this paper, we collect and construct PETS-5k, the largest PET segmentation dataset to date, comprising 5,731 three-dimensional whole-body PET images and encompassing over 1.3M 2D images. Based on the established dataset, we develop SegAnyPET, a modality-specific 3D foundation model for universal promptable segmentation from PET images. To issue the challenge of discrepant annotation quality of PET images, we adopt a cross prompting confident learning (CPCL) strategy with an uncertainty-guided self-rectification process to robustly learn segmentation from high-quality labeled data and low-quality noisy labeled data. Experimental results demonstrate that SegAnyPET can correctly segment seen and unseen targets using only one or a few prompt points, outperforming state-of-the-art foundation models and task-specific fully supervised models with higher accuracy and strong generalization ability for universal segmentation. As the first foundation model for PET images, we believe that SegAnyPET will advance the applications to various downstream tasks for molecular imaging.

Aneumo: A Large-Scale Comprehensive Synthetic Dataset of Aneurysm Hemodynamics

Intracranial aneurysm (IA) is a common cerebrovascular disease that is usually asymptomatic but may cause severe subarachnoid hemorrhage (SAH) if ruptured. Although clinical practice is usually based on individual factors and morphological features of the aneurysm, its pathophysiology and hemodynamic mechanisms remain controversial. To address the limitations of current research, this study constructed a comprehensive hemodynamic dataset of intracranial aneurysms. The dataset is based on 466 real aneurysm models, and 10,000 synthetic models were generated by resection and deformation operations, including 466 aneurysm-free models and 9,534 deformed aneurysm models. The dataset also provides medical image-like segmentation mask files to support insightful analysis. In addition, the dataset contains hemodynamic data measured at eight steady-state flow rates (0.001 to 0.004 kg/s), including critical parameters such as flow velocity, pressure, and wall shear stress, providing a valuable resource for investigating aneurysm pathogenesis and clinical prediction. This dataset will help advance the understanding of the pathologic features and hemodynamic mechanisms of intracranial aneurysms and support in-depth research in related fields. Dataset hosted at https://github.com/Xigui-Li/Aneumo.

Personalize to generalize: Towards a universal medical multi-modality generalization through personalization

The differences among medical imaging modalities, driven by distinct underlying principles, pose significant challenges for generalization in multi-modal medical tasks. Beyond modality gaps, individual variations, such as differences in organ size and metabolic rate, further impede a model's ability to generalize effectively across both modalities and diverse populations. Despite the importance of personalization, existing approaches to multi-modal generalization often neglect individual differences, focusing solely on common anatomical features. This limitation may result in weakened generalization in various medical tasks. In this paper, we unveil that personalization is critical for multi-modal generalization. Specifically, we propose an approach to achieve personalized generalization through approximating the underlying personalized invariant representation ${X}_h$ across various modalities by leveraging individual-level constraints and a learnable biological prior. We validate the feasibility and benefits of learning a personalized ${X}_h$, showing that this representation is highly generalizable and transferable across various multi-modal medical tasks. Extensive experimental results consistently show that the additionally incorporated personalization significantly improves performance and generalization across diverse scenarios, confirming its effectiveness.

JoyType: A Robust Design for Multilingual Visual Text Creation

Generating images with accurately represented text, especially in non-Latin languages, poses a significant challenge for diffusion models. Existing approaches, such as the integration of hint condition diagrams via auxiliary networks (e.g., ControlNet), have made strides towards addressing this issue. However, diffusion models often fall short in tasks requiring controlled text generation, such as specifying particular fonts or producing text in small fonts. In this paper, we introduce a novel approach for multilingual visual text creation, named JoyType, designed to maintain the font style of text during the image generation process. Our methodology begins with assembling a training dataset, JoyType-1M, comprising 1 million pairs of data. Each pair includes an image, its description, and glyph instructions corresponding to the font style within the image. We then developed a text control network, Font ControlNet, tasked with extracting font style information to steer the image generation. To further enhance our model's ability to maintain font style, notably in generating small-font text, we incorporated a multi-layer OCR-aware loss into the diffusion process. This enhancement allows JoyType to direct text rendering using low-level descriptors. Our evaluations, based on both visual and accuracy metrics, demonstrate that JoyType significantly outperforms existing state-of-the-art methods. Additionally, JoyType can function as a plugin, facilitating the creation of varied image styles in conjunction with other stable diffusion models on HuggingFace and CivitAI. Our project is open-sourced on https://jdh-algo.github.io/JoyType/.

Robot Manipulation in Salient Vision through Referring Image Segmentation and Geometric Constraints

In this paper, we perform robot manipulation activities in real-world environments with language contexts by integrating a compact referring image segmentation model into the robot's perception module. First, we propose CLIPU$^2$Net, a lightweight referring image segmentation model designed for fine-grain boundary and structure segmentation from language expressions. Then, we deploy the model in an eye-in-hand visual servoing system to enact robot control in the real world. The key to our system is the representation of salient visual information as geometric constraints, linking the robot's visual perception to actionable commands. Experimental results on 46 real-world robot manipulation tasks demonstrate that our method outperforms traditional visual servoing methods relying on labor-intensive feature annotations, excels in fine-grain referring image segmentation with a compact decoder size of 6.6 MB, and supports robot control across diverse contexts.

On the Sequence Evaluation based on Stochastic Processes

Modeling and analyzing long sequences of text is an essential task for Natural Language Processing. Success in capturing long text dynamics using neural language models will facilitate many downstream tasks such as coherence evaluation, text generation, machine translation and so on. This paper presents a novel approach to model sequences through a stochastic process. We introduce a likelihood-based training objective for the text encoder and design a more thorough measurement (score) for long text evaluation compared to the previous approach. The proposed training objective effectively preserves the sequence coherence, while the new score comprehensively captures both temporal and spatial dependencies. Theoretical properties of our new score show its advantages in sequence evaluation. Experimental results show superior performance in various sequence evaluation tasks, including global and local discrimination within and between documents of different lengths. We also demonstrate the encoder achieves competitive results on discriminating human and AI written text.

SHE-Net: Syntax-Hierarchy-Enhanced Text-Video Retrieval

The user base of short video apps has experienced unprecedented growth in recent years, resulting in a significant demand for video content analysis. In particular, text-video retrieval, which aims to find the top matching videos given text descriptions from a vast video corpus, is an essential function, the primary challenge of which is to bridge the modality gap. Nevertheless, most existing approaches treat texts merely as discrete tokens and neglect their syntax structures. Moreover, the abundant spatial and temporal clues in videos are often underutilized due to the lack of interaction with text. To address these issues, we argue that using texts as guidance to focus on relevant temporal frames and spatial regions within videos is beneficial. In this paper, we propose a novel Syntax-Hierarchy-Enhanced text-video retrieval method (SHE-Net) that exploits the inherent semantic and syntax hierarchy of texts to bridge the modality gap from two perspectives. First, to facilitate a more fine-grained integration of visual content, we employ the text syntax hierarchy, which reveals the grammatical structure of text descriptions, to guide the visual representations. Second, to further enhance the multi-modal interaction and alignment, we also utilize the syntax hierarchy to guide the similarity calculation. We evaluated our method on four public text-video retrieval datasets of MSR-VTT, MSVD, DiDeMo, and ActivityNet. The experimental results and ablation studies confirm the advantages of our proposed method.

Knowledge-enhanced Multi-perspective Video Representation Learning for Scene Recognition

With the explosive growth of video data in real-world applications, a comprehensive representation of videos becomes increasingly important. In this paper, we address the problem of video scene recognition, whose goal is to learn a high-level video representation to classify scenes in videos. Due to the diversity and complexity of video contents in realistic scenarios, this task remains a challenge. Most existing works identify scenes for videos only from visual or textual information in a temporal perspective, ignoring the valuable information hidden in single frames, while several earlier studies only recognize scenes for separate images in a non-temporal perspective. We argue that these two perspectives are both meaningful for this task and complementary to each other, meanwhile, externally introduced knowledge can also promote the comprehension of videos. We propose a novel two-stream framework to model video representations from multiple perspectives, i.e. temporal and non-temporal perspectives, and integrate the two perspectives in an end-to-end manner by self-distillation. Besides, we design a knowledge-enhanced feature fusion and label prediction method that contributes to naturally introducing knowledge into the task of video scene recognition. Experiments conducted on a real-world dataset demonstrate the effectiveness of our proposed method.