A Safety Report on GPT-5.2, Gemini 3 Pro, Qwen3-VL, Grok 4.1 Fast, Nano Banana Pro, and Seedream 4.5

The rapid evolution of Large Language Models (LLMs) and Multimodal Large Language Models (MLLMs) has driven major gains in reasoning, perception, and generation across language and vision, yet whether these advances translate into comparable improvements in safety remains unclear, partly due to fragmented evaluations that focus on isolated modalities or threat models. In this report, we present an integrated safety evaluation of six frontier models--GPT-5.2, Gemini 3 Pro, Qwen3-VL, Grok 4.1 Fast, Nano Banana Pro, and Seedream 4.5--assessing each across language, vision-language, and image generation using a unified protocol that combines benchmark, adversarial, multilingual, and compliance evaluations. By aggregating results into safety leaderboards and model profiles, we reveal a highly uneven safety landscape: while GPT-5.2 demonstrates consistently strong and balanced performance, other models exhibit clear trade-offs across benchmark safety, adversarial robustness, multilingual generalization, and regulatory compliance. Despite strong results under standard benchmarks, all models remain highly vulnerable under adversarial testing, with worst-case safety rates dropping below 6%. Text-to-image models show slightly stronger alignment in regulated visual risk categories, yet remain fragile when faced with adversarial or semantically ambiguous prompts. Overall, these findings highlight that safety in frontier models is inherently multidimensional--shaped by modality, language, and evaluation design--underscoring the need for standardized, holistic safety assessments to better reflect real-world risk and guide responsible deployment.

An analytic theory of convolutional neural network inverse problems solvers

Supervised convolutional neural networks (CNNs) are widely used to solve imaging inverse problems, achieving state-of-the-art performance in numerous applications. However, despite their empirical success, these methods are poorly understood from a theoretical perspective and often treated as black boxes. To bridge this gap, we analyze trained neural networks through the lens of the Minimum Mean Square Error (MMSE) estimator, incorporating functional constraints that capture two fundamental inductive biases of CNNs: translation equivariance and locality via finite receptive fields. Under the empirical training distribution, we derive an analytic, interpretable, and tractable formula for this constrained variant, termed Local-Equivariant MMSE (LE-MMSE). Through extensive numerical experiments across various inverse problems (denoising, inpainting, deconvolution), datasets (FFHQ, CIFAR-10, FashionMNIST), and architectures (U-Net, ResNet, PatchMLP), we demonstrate that our theory matches the neural networks outputs (PSNR $\gtrsim25$dB). Furthermore, we provide insights into the differences between \emph{physics-aware} and \emph{physics-agnostic} estimators, the impact of high-density regions in the training (patch) distribution, and the influence of other factors (dataset size, patch size, etc).

MultiCaption: Detecting disinformation using multilingual visual claims

Online disinformation poses an escalating threat to society, driven increasingly by the rapid spread of misleading content across both multimedia and multilingual platforms. While automated fact-checking methods have advanced in recent years, their effectiveness remains constrained by the scarcity of datasets that reflect these real-world complexities. To address this gap, we first present MultiCaption, a new dataset specifically designed for detecting contradictions in visual claims. Pairs of claims referring to the same image or video were labeled through multiple strategies to determine whether they contradict each other. The resulting dataset comprises 11,088 visual claims in 64 languages, offering a unique resource for building and evaluating misinformation-detection systems in truly multimodal and multilingual environments. We then provide comprehensive experiments using transformer-based architectures, natural language inference models, and large language models, establishing strong baselines for future research. The results show that MultiCaption is more challenging than standard NLI tasks, requiring task-specific finetuning for strong performance. Moreover, the gains from multilingual training and testing highlight the dataset's potential for building effective multilingual fact-checking pipelines without relying on machine translation.

Edit2Restore:Few-Shot Image Restoration via Parameter-Efficient Adaptation of Pre-trained Editing Models

Image restoration has traditionally required training specialized models on thousands of paired examples per degradation type. We challenge this paradigm by demonstrating that powerful pre-trained text-conditioned image editing models can be efficiently adapted for multiple restoration tasks through parameter-efficient fine-tuning with remarkably few examples. Our approach fine-tunes LoRA adapters on FLUX.1 Kontext, a state-of-the-art 12B parameter flow matching model for image-to-image translation, using only 16-128 paired images per task, guided by simple text prompts that specify the restoration operation. Unlike existing methods that train specialized restoration networks from scratch with thousands of samples, we leverage the rich visual priors already encoded in large-scale pre-trained editing models, dramatically reducing data requirements while maintaining high perceptual quality. A single unified LoRA adapter, conditioned on task-specific text prompts, effectively handles multiple degradations including denoising, deraining, and dehazing. Through comprehensive ablation studies, we analyze: (i) the impact of training set size on restoration quality, (ii) trade-offs between task-specific versus unified multi-task adapters, (iii) the role of text encoder fine-tuning, and (iv) zero-shot baseline performance. While our method prioritizes perceptual quality over pixel-perfect reconstruction metrics like PSNR/SSIM, our results demonstrate that pre-trained image editing models, when properly adapted, offer a compelling and data-efficient alternative to traditional image restoration approaches, opening new avenues for few-shot, prompt-guided image enhancement. The code to reproduce our results are available at: https://github.com/makinyilmaz/Edit2Restore

Few-Shot LoRA Adaptation of a Flow-Matching Foundation Model for Cross-Spectral Object Detection

Foundation models for vision are predominantly trained on RGB data, while many safety-critical applications rely on non-visible modalities such as infrared (IR) and synthetic aperture radar (SAR). We study whether a single flow-matching foundation model pre-trained primarily on RGB images can be repurposed as a cross-spectral translator using only a few co-measured examples, and whether the resulting synthetic data can enhance downstream detection. Starting from FLUX.1 Kontext, we insert low-rank adaptation (LoRA) modules and fine-tune them on just 100 paired images per domain for two settings: RGB to IR on the KAIST dataset and RGB to SAR on the M4-SAR dataset. The adapted model translates RGB images into pixel-aligned IR/SAR, enabling us to reuse existing bounding boxes and train object detection models purely in the target modality. Across a grid of LoRA hyperparameters, we find that LPIPS computed on only 50 held-out pairs is a strong proxy for downstream performance: lower LPIPS consistently predicts higher mAP for YOLOv11n on both IR and SAR, and for DETR on KAIST IR test data. Using the best LPIPS-selected LoRA adapter, synthetic IR from external RGB datasets (LLVIP, FLIR ADAS) improves KAIST IR pedestrian detection, and synthetic SAR significantly boosts infrastructure detection on M4-SAR when combined with limited real SAR. Our results suggest that few-shot LoRA adaptation of flow-matching foundation models is a promising path toward foundation-style support for non-visible modalities.

Domain Adaptation of Carotid Ultrasound Images using Generative Adversarial Network

Deep learning has been extensively used in medical imaging applications, assuming that the test and training datasets belong to the same probability distribution. However, a common challenge arises when working with medical images generated by different systems or even the same system with different parameter settings. Such images contain diverse textures and reverberation noise that violate the aforementioned assumption. Consequently, models trained on data from one device or setting often struggle to perform effectively with data from other devices or settings. In addition, retraining models for each specific device or setting is labor-intensive and costly. To address these issues in ultrasound images, we propose a novel Generative Adversarial Network (GAN)-based model. We formulated the domain adaptation tasks as an image-to-image translation task, in which we modified the texture patterns and removed reverberation noise in the test data images from the source domain to align with those in the target domain images while keeping the image content unchanged. We applied the proposed method to two datasets containing carotid ultrasound images from three different domains. The experimental results demonstrate that the model successfully translated the texture pattern of images and removed reverberation noise from the ultrasound images. Furthermore, we evaluated the CycleGAN approaches for a comparative study with the proposed model. The experimental findings conclusively demonstrated that the proposed model achieved domain adaptation (histogram correlation (0.960 (0.019), & 0.920 (0.043) and bhattacharya distance (0.040 (0.020), & 0.085 (0.048)), compared to no adaptation (0.916 (0.062) & 0.890 (0.077), 0.090 (0.070) & 0.121 (0.095)) for both datasets.

Imaging-anchored Multiomics in Cardiovascular Disease: Integrating Cardiac Imaging, Bulk, Single-cell, and Spatial Transcriptomics

Cardiovascular disease arises from interactions between inherited risk, molecular programmes, and tissue-scale remodelling that are observed clinically through imaging. Health systems now routinely generate large volumes of cardiac MRI, CT and echocardiography together with bulk, single-cell and spatial transcriptomics, yet these data are still analysed in separate pipelines. This review examines joint representations that link cardiac imaging phenotypes to transcriptomic and spatially resolved molecular states. An imaging-anchored perspective is adopted in which echocardiography, cardiac MRI and CT define a spatial phenotype of the heart, and bulk, single-cell and spatial transcriptomics provide cell-type- and location-specific molecular context. The biological and technical characteristics of these modalities are first summarised, and representation-learning strategies for each are outlined. Multimodal fusion approaches are reviewed, with emphasis on handling missing data, limited sample size, and batch effects. Finally, integrative pipelines for radiogenomics, spatial molecular alignment, and image-based prediction of gene expression are discussed, together with common failure modes, practical considerations, and open challenges. Spatial multiomics of human myocardium and atherosclerotic plaque, single-cell and spatial foundation models, and multimodal medical foundation models are collectively bringing imaging-anchored multiomics closer to large-scale cardiovascular translation.

From Performance to Practice: Knowledge-Distilled Segmentator for On-Premises Clinical Workflows

Deploying medical image segmentation models in routine clinical workflows is often constrained by on-premises infrastructure, where computational resources are fixed and cloud-based inference may be restricted by governance and security policies. While high-capacity models achieve strong segmentation accuracy, their computational demands hinder practical deployment and long-term maintainability in hospital environments. We present a deployment-oriented framework that leverages knowledge distillation to translate a high-performing segmentation model into a scalable family of compact student models, without modifying the inference pipeline. The proposed approach preserves architectural compatibility with existing clinical systems while enabling systematic capacity reduction. The framework is evaluated on a multi-site brain MRI dataset comprising 1,104 3D volumes, with independent testing on 101 curated cases, and is further examined on abdominal CT to assess cross-modality generalizability. Under aggressive parameter reduction (94%), the distilled student model preserves nearly all of the teacher's segmentation accuracy (98.7%), while achieving substantial efficiency gains, including up to a 67% reduction in CPU inference latency without additional deployment overhead. These results demonstrate that knowledge distillation provides a practical and reliable pathway for converting research-grade segmentation models into maintainable, deployment-ready components for on-premises clinical workflows in real-world health systems.

MHub.ai: A Simple, Standardized, and Reproducible Platform for AI Models in Medical Imaging

Artificial intelligence (AI) has the potential to transform medical imaging by automating image analysis and accelerating clinical research. However, research and clinical use are limited by the wide variety of AI implementations and architectures, inconsistent documentation, and reproducibility issues. Here, we introduce MHub.ai, an open-source, container-based platform that standardizes access to AI models with minimal configuration, promoting accessibility and reproducibility in medical imaging. MHub.ai packages models from peer-reviewed publications into standardized containers that support direct processing of DICOM and other formats, provide a unified application interface, and embed structured metadata. Each model is accompanied by publicly available reference data that can be used to confirm model operation. MHub.ai includes an initial set of state-of-the-art segmentation, prediction, and feature extraction models for different modalities. The modular framework enables adaptation of any model and supports community contributions. We demonstrate the utility of the platform in a clinical use case through comparative evaluation of lung segmentation models. To further strengthen transparency and reproducibility, we publicly release the generated segmentations and evaluation metrics and provide interactive dashboards that allow readers to inspect individual cases and reproduce or extend our analysis. By simplifying model use, MHub.ai enables side-by-side benchmarking with identical execution commands and standardized outputs, and lowers the barrier to clinical translation.

IntraStyler: Exemplar-based Style Synthesis for Cross-modality Domain Adaptation

Image-level domain alignment is the de facto approach for unsupervised domain adaptation, where unpaired image translation is used to minimize the domain gap. Prior studies mainly focus on the domain shift between the source and target domains, whereas the intra-domain variability remains under-explored. To address the latter, an effective strategy is to diversify the styles of the synthetic target domain data during image translation. However, previous methods typically require intra-domain variations to be pre-specified for style synthesis, which may be impractical. In this paper, we propose an exemplar-based style synthesis method named IntraStyler, which can capture diverse intra-domain styles without any prior knowledge. Specifically, IntraStyler uses an exemplar image to guide the style synthesis such that the output style matches the exemplar style. To extract the style-only features, we introduce a style encoder to learn styles discriminatively based on contrastive learning. We evaluate the proposed method on the largest public dataset for cross-modality domain adaptation, CrossMoDA 2023. Our experiments show the efficacy of our method in controllable style synthesis and the benefits of diverse synthetic data for downstream segmentation. Code is available at https://github.com/han-liu/IntraStyler.