Towards Metric-Aware Multi-Person Mesh Recovery by Jointly Optimizing Human Crowd in Camera Space

Multi-person human mesh recovery from a single image is a challenging task, hindered by the scarcity of in-the-wild training data. Prevailing in-the-wild human mesh pseudo-ground-truth (pGT) generation pipelines are single-person-centric, where each human is processed individually without joint optimization. This oversight leads to a lack of scene-level consistency, producing individuals with conflicting depths and scales within the same image. To address this, we introduce Depth-conditioned Translation Optimization (DTO), a novel optimization-based method that jointly refines the camera-space translations of all individuals in a crowd. By leveraging anthropometric priors on human height and depth cues from a monocular depth estimator, DTO solves for a scene-consistent placement of all subjects within a principled Maximum a posteriori (MAP) framework. Applying DTO to the 4D-Humans dataset, we construct DTO-Humans, a new large-scale pGT dataset of 0.56M high-quality, scene-consistent multi-person images, featuring dense crowds with an average of 4.8 persons per image. Furthermore, we propose Metric-Aware HMR, an end-to-end network that directly estimates human mesh and camera parameters in metric scale. This is enabled by a camera branch and a novel relative metric loss that enforces plausible relative scales. Extensive experiments demonstrate that our method achieves state-of-the-art performance on relative depth reasoning and human mesh recovery. Code and data will be released publicly.

MOON Embedding: Multimodal Representation Learning for E-commerce Search Advertising

We introduce MOON, our comprehensive set of sustainable iterative practices for multimodal representation learning for e-commerce applications. MOON has already been fully deployed across all stages of Taobao search advertising system, including retrieval, relevance, ranking, and so on. The performance gains are particularly significant on click-through rate (CTR) prediction task, which achieves an overall +20.00% online CTR improvement. Over the past three years, this project has delivered the largest improvement on CTR prediction task and undergone five full-scale iterations. Throughout the exploration and iteration of our MOON, we have accumulated valuable insights and practical experience that we believe will benefit the research community. MOON contains a three-stage training paradigm of "Pretraining, Post-training, and Application", allowing effective integration of multimodal representations with downstream tasks. Notably, to bridge the misalignment between the objectives of multimodal representation learning and downstream training, we define the exchange rate to quantify how effectively improvements in an intermediate metric can translate into downstream gains. Through this analysis, we identify the image-based search recall as a critical intermediate metric guiding the optimization of multimodal models. Over three years and five iterations, MOON has evolved along four critical dimensions: data processing, training strategy, model architecture, and downstream application. The lessons and insights gained through the iterative improvements will also be shared. As part of our exploration into scaling effects in the e-commerce field, we further conduct a systematic study of the scaling laws governing multimodal representation learning, examining multiple factors such as the number of training tokens, negative samples, and the length of user behavior sequences.

US-X Complete: A Multi-Modal Approach to Anatomical 3D Shape Recovery

Ultrasound offers a radiation-free, cost-effective solution for real-time visualization of spinal landmarks, paraspinal soft tissues and neurovascular structures, making it valuable for intraoperative guidance during spinal procedures. However, ultrasound suffers from inherent limitations in visualizing complete vertebral anatomy, in particular vertebral bodies, due to acoustic shadowing effects caused by bone. In this work, we present a novel multi-modal deep learning method for completing occluded anatomical structures in 3D ultrasound by leveraging complementary information from a single X-ray image. To enable training, we generate paired training data consisting of: (1) 2D lateral vertebral views that simulate X-ray scans, and (2) 3D partial vertebrae representations that mimic the limited visibility and occlusions encountered during ultrasound spine imaging. Our method integrates morphological information from both imaging modalities and demonstrates significant improvements in vertebral reconstruction (p < 0.001) compared to state of art in 3D ultrasound vertebral completion. We perform phantom studies as an initial step to future clinical translation, and achieve a more accurate, complete volumetric lumbar spine visualization overlayed on the ultrasound scan without the need for registration with preoperative modalities such as computed tomography. This demonstrates that integrating a single X-ray projection mitigates ultrasound's key limitation while preserving its strengths as the primary imaging modality. Code and data can be found at https://github.com/miruna20/US-X-Complete

Fractional neural attention for efficient multiscale sequence processing

Attention mechanisms underpin the computational power of Transformer models, which have achieved remarkable success across diverse domains. Yet understanding and extending the principles underlying self-attention remains a key challenge for advancing artificial intelligence. Drawing inspiration from the multiscale dynamics of biological attention and from dynamical systems theory, we introduce Fractional Neural Attention (FNA), a principled, neuroscience-inspired framework for multiscale information processing. FNA models token interactions through Lévy diffusion governed by the fractional Laplacian, intrinsically realizing simultaneous short- and long-range dependencies across multiple scales. This mechanism yields greater expressivity and faster information mixing, advancing the foundational capacity of Transformers. Theoretically, we show that FNA's dynamics are governed by the fractional diffusion equation, and that the resulting attention networks exhibit larger spectral gaps and shorter path lengths -- mechanistic signatures of enhanced computational efficiency. Empirically, FNA achieves competitive text-classification performance even with a single layer and a single head; it also improves performance in image processing and neural machine translation. Finally, the diffusion map algorithm from geometric harmonics enables dimensionality reduction of FNA weights while preserving the intrinsic structure of embeddings and hidden states. Together, these results establish FNA as a principled mechanism connecting self-attention, stochastic dynamics, and geometry, providing an interpretable, biologically grounded foundation for powerful, neuroscience-inspired AI.

Building Trust in Virtual Immunohistochemistry: Automated Assessment of Image Quality

Deep learning models can generate virtual immunohistochemistry (IHC) stains from hematoxylin and eosin (H&E) images, offering a scalable and low-cost alternative to laboratory IHC. However, reliable evaluation of image quality remains a challenge as current texture- and distribution-based metrics quantify image fidelity rather than the accuracy of IHC staining. Here, we introduce an automated and accuracy grounded framework to determine image quality across sixteen paired or unpaired image translation models. Using color deconvolution, we generate masks of pixels stained brown (i.e., IHC-positive) as predicted by each virtual IHC model. We use the segmented masks of real and virtual IHC to compute stain accuracy metrics (Dice, IoU, Hausdorff distance) that directly quantify correct pixel - level labeling without needing expert manual annotations. Our results demonstrate that conventional image fidelity metrics, including Frechet Inception Distance (FID), peak signal-to-noise ratio (PSNR), and structural similarity (SSIM), correlate poorly with stain accuracy and pathologist assessment. Paired models such as PyramidPix2Pix and AdaptiveNCE achieve the highest stain accuracy, whereas unpaired diffusion- and GAN-based models are less reliable in providing accurate IHC positive pixel labels. Moreover, whole-slide images (WSI) reveal performance declines that are invisible in patch-based evaluations, emphasizing the need for WSI-level benchmarks. Together, this framework defines a reproducible approach for assessing the quality of virtual IHC models, a critical step to accelerate translation towards routine use by pathologists.

A Specialized Large Language Model for Clinical Reasoning and Diagnosis in Rare Diseases

Rare diseases affect hundreds of millions worldwide, yet diagnosis often spans years. Convectional pipelines decouple noisy evidence extraction from downstream inferential diagnosis, and general/medical large language models (LLMs) face scarce real world electronic health records (EHRs), stale domain knowledge, and hallucinations. We assemble a large, domain specialized clinical corpus and a clinician validated reasoning set, and develop RareSeek R1 via staged instruction tuning, chain of thought learning, and graph grounded retrieval. Across multicenter EHR narratives and public benchmarks, RareSeek R1 attains state of the art accuracy, robust generalization, and stability under noisy or overlapping phenotypes. Augmented retrieval yields the largest gains when narratives pair with prioritized variants by resolving ambiguity and aligning candidates to mechanisms. Human studies show performance on par with experienced physicians and consistent gains in assistive use. Notably, transparent reasoning highlights decisive non phenotypic evidence (median 23.1%, such as imaging, interventions, functional tests) underpinning many correct diagnoses. This work advances a narrative first, knowledge integrated reasoning paradigm that shortens the diagnostic odyssey and enables auditable, clinically translatable decision support.

Comprehension of Multilingual Expressions Referring to Target Objects in Visual Inputs

Referring Expression Comprehension (REC) requires models to localize objects in images based on natural language descriptions. Research on the area remains predominantly English-centric, despite increasing global deployment demands. This work addresses multilingual REC through two main contributions. First, we construct a unified multilingual dataset spanning 10 languages, by systematically expanding 12 existing English REC benchmarks through machine translation and context-based translation enhancement. The resulting dataset comprises approximately 8 million multilingual referring expressions across 177,620 images, with 336,882 annotated objects. Second, we introduce an attention-anchored neural architecture that uses multilingual SigLIP2 encoders. Our attention-based approach generates coarse spatial anchors from attention distributions, which are subsequently refined through learned residuals. Experimental evaluation demonstrates competitive performance on standard benchmarks, e.g. achieving 86.9% accuracy at IoU@50 on RefCOCO aggregate multilingual evaluation, compared to an English-only result of 91.3%. Multilingual evaluation shows consistent capabilities across languages, establishing the practical feasibility of multilingual visual grounding systems. The dataset and model are available at $\href{https://multilingual.franreno.com}{multilingual.franreno.com}$.

A Picture is Worth a Thousand (Correct) Captions: A Vision-Guided Judge-Corrector System for Multimodal Machine Translation

In this paper, we describe our system under the team name BLEU Monday for the English-to-Indic Multimodal Translation Task at WAT 2025. We participate in the text-only translation tasks for English-Hindi, English-Bengali, English-Malayalam, and English-Odia language pairs. We present a two-stage approach that addresses quality issues in the training data through automated error detection and correction, followed by parameter-efficient model fine-tuning. Our methodology introduces a vision-augmented judge-corrector pipeline that leverages multimodal language models to systematically identify and correct translation errors in the training data. The judge component classifies translations into three categories: correct, visually ambiguous (requiring image context), or mistranslated (poor translation quality). Identified errors are routed to specialized correctors: GPT-4o-mini regenerates captions requiring visual disambiguation, while IndicTrans2 retranslates cases with pure translation quality issues. This automated pipeline processes 28,928 training examples across four languages, correcting an average of 17.1% of captions per language. We then apply Low-Rank Adaptation (LoRA) to fine-tune the IndicTrans2 en-indic 200M distilled model on both original and corrected datasets. Training on corrected data yields consistent improvements, with BLEU score gains of +1.30 for English-Bengali on the evaluation set (42.00 -> 43.30) and +0.70 on the challenge set (44.90 -> 45.60), +0.60 for English-Odia on the evaluation set (41.00 -> 41.60), and +0.10 for English-Hindi on the challenge set (53.90 -> 54.00).

Free-Form Scene Editor: Enabling Multi-Round Object Manipulation like in a 3D Engine

Recent advances in text-to-image (T2I) diffusion models have significantly improved semantic image editing, yet most methods fall short in performing 3D-aware object manipulation. In this work, we present FFSE, a 3D-aware autoregressive framework designed to enable intuitive, physically-consistent object editing directly on real-world images. Unlike previous approaches that either operate in image space or require slow and error-prone 3D reconstruction, FFSE models editing as a sequence of learned 3D transformations, allowing users to perform arbitrary manipulations, such as translation, scaling, and rotation, while preserving realistic background effects (e.g., shadows, reflections) and maintaining global scene consistency across multiple editing rounds. To support learning of multi-round 3D-aware object manipulation, we introduce 3DObjectEditor, a hybrid dataset constructed from simulated editing sequences across diverse objects and scenes, enabling effective training under multi-round and dynamic conditions. Extensive experiments show that the proposed FFSE significantly outperforms existing methods in both single-round and multi-round 3D-aware editing scenarios.

MRIQT: Physics-Aware Diffusion Model for Image Quality Transfer in Neonatal Ultra-Low-Field MRI

Portable ultra-low-field MRI (uLF-MRI, 0.064 T) offers accessible neuroimaging for neonatal care but suffers from low signal-to-noise ratio and poor diagnostic quality compared to high-field (HF) MRI. We propose MRIQT, a 3D conditional diffusion framework for image quality transfer (IQT) from uLF to HF MRI. MRIQT combines realistic K-space degradation for physics-consistent uLF simulation, v-prediction with classifier-free guidance for stable image-to-image generation, and an SNR-weighted 3D perceptual loss for anatomical fidelity. The model denoises from a noised uLF input conditioned on the same scan, leveraging volumetric attention-UNet architecture for structure-preserving translation. Trained on a neonatal cohort with diverse pathologies, MRIQT surpasses recent GAN and CNN baselines in PSNR 15.3% with 1.78% over the state of the art, while physicians rated 85% of its outputs as good quality with clear pathology present. MRIQT enables high-fidelity, diffusion-based enhancement of portable ultra-low-field (uLF) MRI for deliable neonatal brain assessment.