Topology-Unified 2D Pose Estimation across Intact, Residual and Prosthetic Limbs

Driven by the availability of large-scale datasets, Human Pose Estimation (HPE) plays a critical role in numerous downstream tasks. However, mainstream benchmarks exhibit severe representation bias, predominantly featuring able-bodied individuals. While a few pioneering datasets have attempted to address limb differences, their annotation protocols fail to generalize, struggling to represent specialized mechanical structures like running blades or unprosthetized residual limbs. To bridge this gap, we introduce ProPose, a large-scale benchmark featuring a novel annotation protocol that unifies the topological representation of biological limbs, diverse prostheses, and physical absences within a single framework. Because real-world prosthetic images are inherently scarce and exhibit extreme long-tail distributions, we design a Real-to-Synthetic data expansion pipeline to explicitly synthesize and expand the underrepresented cases. However, simply training existing models on this enriched dataset often leads to suboptimal solutions, as they estimate each keypoint independently and might hallucinate non-existent joints on mechanical structures. To resolve this, we propose ProLoss, a structure-aware objective that enforces keypoint dependencies within a single limb to prevent unrealistic limb predictions. Extensive experiments demonstrate that our approach improves the classification accuracy of long-tail prosthetic joints by 2% to 6% without compromising spatial coordinate localization performance. This work sets a foundation for inclusive pose estimation, unlocking new possibilities for understanding the interactions between human bodies and assistive devices.

OmniVAE: An Audio-Video VAE with Cross-Modal Alignment for Joint Generation

Recent generative models are moving beyond silent video or standalone audio synthesis toward the joint generation of synchronized audio and video. Despite this progress, jointly generating audio and video with fine-grained cross-modal correspondence remains challenging due to their fundamental structural differences. Most existing methods use audio and video VAEs trained separately. As a result, the two latent spaces lack cross-modal alignment, leaving the downstream generative model to learn cross-modal synchronization from scratch. We present OmniVAE, a jointly trained audio-video VAE that learns fine-grained semantic alignment between audio and video latent representations. Beyond reconstruction, OmniVAE uses a segment-level audio-video contrastive objective to capture temporal-semantic correspondence and align the two latent spaces. In parallel, it distills features from pretrained modality-specific semantic encoders into each modality, improving the downstream learnability of both latent spaces. Extensive experiments show that both objectives consistently improve the learnability of the latent spaces, translating into higher generation quality and more accurate cross-modal synchronization in downstream text-to-audio-video generation. These findings underscore the importance of learning unified representations as a foundation for omnimodal modeling.1

Co4ICF: Co-evolving Physics-Informed Surrogate and RL-based Pulse Optimizer for Inertial Confinement Fusion

Offline-trained surrogates for Inertial Confinement Fusion (ICF) suffer a well-known failure mode that iterative optimizers drive inputs into out-of-distribution (OOD) regions where predictions become unreliable. Here we present Co4ICF, a co-evolving framework that couples a physics-informed surrogate with a PPO-based pulse optimizer. The surrogate is iteratively fine-tuned on policy-induced trajectories, correcting extrapolation errors as the optimizer shifts the input distribution; the optimizer queries this evolving surrogate as a fast environment. In the 1D MULTI environment, Co4ICF achieves 146.1% normalized yield based on current laser design baseline; as a post-hoc cross-fidelity check, the optimized pulse further attains 246.9% normalized yield when directly evaluated in 2D-MULTI without any 2D training or fine-tuning. Budget-matched ablations support that the gains are not explained solely by additional simulation data and are consistent with the co-evolving mechanism playing a key role. We release a large-scale MULTI-IFE simulation dataset to support future benchmarking.

Semi-Supervised Domain Adaptation with Latent Diffusion for Pathology Image Classification

Deep learning models in computational pathology often fail to generalize across cohorts and institutions due to domain shift. Existing approaches either fail to leverage unlabeled data from the target domain or rely on image-to-image translation, which can distort tissue structures and compromise model accuracy. In this work, we propose a semi-supervised domain adaptation (SSDA) framework that utilizes a latent diffusion model trained on unlabeled data from both the source and target domains to generate morphology-preserving and target-aware synthetic images. By conditioning the diffusion model on foundation model features, cohort identity, and tissue preparation method, we preserve tissue structure in the source domain while introducing target-domain appearance characteristics. The target-aware synthetic images, combined with real, labeled images from the source cohort, are subsequently used to train a downstream classifier, which is then tested on the target cohort. The effectiveness of the proposed SSDA framework is demonstrated on the task of lung adenocarcinoma prognostication. The proposed augmentation yielded substantially better performance on the held-out test set from the target cohort, without degrading source-cohort performance. The approach improved the weighted F1 score on the target-cohort held-out test set from 0.611 to 0.706 and the macro F1 score from 0.641 to 0.716. Our results demonstrate that target-aware diffusion-based synthetic data augmentation provides a promising and effective approach for improving domain generalization in computational pathology.