ProMoral-Bench: Evaluating Prompting Strategies for Moral Reasoning and Safety in LLMs

Prompt design significantly impacts the moral competence and safety alignment of large language models (LLMs), yet empirical comparisons remain fragmented across datasets and models.We introduce ProMoral-Bench, a unified benchmark evaluating 11 prompting paradigms across four LLM families. Using ETHICS, Scruples, WildJailbreak, and our new robustness test, ETHICS-Contrast, we measure performance via our proposed Unified Moral Safety Score (UMSS), a metric balancing accuracy and safety. Our results show that compact, exemplar-guided scaffolds outperform complex multi-stage reasoning, providing higher UMSS scores and greater robustness at a lower token cost. While multi-turn reasoning proves fragile under perturbations, few-shot exemplars consistently enhance moral stability and jailbreak resistance. ProMoral-Bench establishes a standardized framework for principled, cost-effective prompt engineering.

SAGE: Agentic Framework for Interpretable and Clinically Translatable Computational Pathology Biomarker Discovery

Despite significant progress in computational pathology, many AI models remain black-box and difficult to interpret, posing a major barrier to clinical adoption due to limited transparency and explainability. This has motivated continued interest in engineered image-based biomarkers, which offer greater interpretability but are often proposed based on anecdotal evidence or fragmented prior literature rather than systematic biological validation. We introduce SAGE (Structured Agentic system for hypothesis Generation and Evaluation), an agentic AI system designed to identify interpretable, engineered pathology biomarkers by grounding them in biological evidence. SAGE integrates literature-anchored reasoning with multimodal data analysis to correlate image-derived features with molecular biomarkers, such as gene expression, and clinically relevant outcomes. By coordinating specialized agents for biological contextualization and empirical hypothesis validation, SAGE prioritizes transparent, biologically supported biomarkers and advances the clinical translation of computational pathology.