Generalizable Whole Slide Image Classification with Fine-Grained Visual-Semantic Interaction

Whole Slide Image (WSI) classification is often formulated as a Multiple Instance Learning (MIL) problem. Recently, Vision-Language Models (VLMs) have demonstrated remarkable performance in WSI classification. However, existing methods leverage coarse-grained pathogenetic descriptions for visual representation supervision, which are insufficient to capture the complex visual appearance of pathogenetic images, hindering the generalizability of models on diverse downstream tasks. Additionally, processing high-resolution WSIs can be computationally expensive. In this paper, we propose a novel "Fine-grained Visual-Semantic Interaction" (FiVE) framework for WSI classification. It is designed to enhance the model's generalizability by leveraging the interplay between localized visual patterns and fine-grained pathological semantics. Specifically, with meticulously designed queries, we start by utilizing a large language model to extract fine-grained pathological descriptions from various non-standardized raw reports. The output descriptions are then reconstructed into fine-grained labels used for training. By introducing a Task-specific Fine-grained Semantics (TFS) module, we enable prompts to capture crucial visual information in WSIs, which enhances representation learning and augments generalization capabilities significantly. Furthermore, given that pathological visual patterns are redundantly distributed across tissue slices, we sample a subset of visual instances during training. Our method demonstrates robust generalizability and strong transferability, dominantly outperforming the counterparts on the TCGA Lung Cancer dataset with at least 9.19% higher accuracy in few-shot experiments.

Modality Adaption or Regularization? A Case Study on End-to-End Speech Translation

Pre-training and fine-tuning is a paradigm for alleviating the data scarcity problem in end-to-end speech translation (E2E ST). The commonplace "modality gap" between speech and text data often leads to inconsistent inputs between pre-training and fine-tuning. However, we observe that this gap occurs in the early stages of fine-tuning, but does not have a major impact on the final performance. On the other hand, we find that there has another gap, which we call the "capacity gap": high resource tasks (such as ASR and MT) always require a large model to fit, when the model is reused for a low resource task (E2E ST), it will get a sub-optimal performance due to the over-fitting. In a case study, we find that the regularization plays a more important role than the well-designed modality adaption method, which achieves 29.0 for en-de and 40.3 for en-fr on the MuST-C dataset. Code and models are available at https://github.com/hannlp/TAB.