Heterogeneity-Aware Deep Learning for Tumour Classification from Multiparametric MRI

Intra-tumoural heterogeneity (ITH) reflects spatial variation in tumour biology and is an important determinant of tumour behaviour, prognosis, and treatment response. Radiomics and deep learning have shown promise for tumour classification from multiparametric MRI (mp-MRI), but radiomics relies on handcrafted features, while most deep learning methods use whole-tumour representations or manually defined sub-regions, limiting scalable modelling of tumour heterogeneity. We propose a Heterogeneity-Aware Deep Learning Classification (HA-DLC) framework that explicitly models imaging-derived tumour sub-regions for lesion-type diagnosis and molecular-status prediction. HA-DLC consists of: (1) a Heterogeneous Sub-region Generation (HSG) module that produces initial pseudo-labelled sub-regions via unsupervised clustering, followed by Cross-Patient Sub-region Alignment (CPSA), which maps cluster-derived regions to a shared label space using soft assignments; and (2) a Dual-Stream Feature Extraction (DSFE) module that integrates local heterogeneity-aware features with global tumour representations. Given the initial clustering masks, CPSA, segmentation, feature extraction, and classification are jointly optimized end-to-end using soft-target segmentation and classification objectives. We evaluate HA-DLC on the LLD-MMRI2023 liver lesion dataset and the RSNA-ASNR-MICCAI 2021 Radiogenomic Brain Tumour dataset. HA-DLC consistently outperforms state-of-the-art radiomics and deep learning baselines, demonstrating the value of cross-patient sub-region alignment and dual-stream heterogeneity modelling for tumour classification from mp-MRI.

TDD-Agent: Test-Driven Reasoning for Code Generation

Large Language Models (LLMs) have achieved remarkable progress in code generation, yet ensuring correctness in complex, repository-level tasks remains challenging. Existing approaches often use generated tests as static post-hoc validators, which limits their ability to guide implementation and may introduce misleading feedback when the tests themselves are incomplete or incorrect. In this paper, we introduce TDD-Agent, which operationalizes the test-driven development paradigm for code generation. TDD-Agent first prompts the model to generate executable tests, encouraging it to clarify expected behaviors before implementation, and then performs iterative dual-track refinement over both the generated code and tests using execution feedback. We first isolate the effect of test-first reasoning through a prompt variant TDD-prompt on LiveCodeBench, where it consistently improves upon reasoning-based prompting baselines. Building on this finding, we evaluate the full TDD-Agent framework on RepoEval, a repository-level benchmark, and show that it consistently outperforms retrieval-based and agent-based baselines. Additional analyses show that iterative refinement improves not only code correctness but also the effectiveness of the generated tests, yielding higher pass rates, coverage, and mutation scores, suggesting that tests can serve as evolving reasoning artifacts rather than fixed validators. Our source code is available at https://anonymous.4open.science/r/TDD-Agent-Framework-6370/.

VQ-Transplant: Efficient VQ-Module Integration for Pre-trained Visual Tokenizers

Vector Quantization (VQ) underpins modern discrete visual tokenization. However, training quantization modules for state-of-the-art VQ-based models requires significant computational resources which, in practice, all but prevents the development of novel, cutting-edge VQ techniques under resource constraints. To address this limitation, we propose {\bf VQ-Transplant}, a simple framework that enables plug-and-play integration of new VQ modules into frozen, pre-trained tokenizers by replacing their native VQ modules. Crucially, the proposed transplantation process preserves all encoder-decoder parameters, obviating the need for costly end-to-end retraining when modifying the quantization method. To mitigate decoder-quantization mismatch, we introduce a lightweight decoder adaptation strategy (trained for only 5 epochs on ImageNet-1k) to align feature priors with the new quantization space. In our empirical evaluation, we find that VQ-Transplant allows obtaining near state-of-the-art reconstruction fidelity for industry-level models like VAR while reducing the training cost by 95\%. VQ-Transplant democratizes quantization research by enabling resource-efficient integration of novel VQ techniques while matching industry-level reconstruction performance.

Distributional Matching for Vector Quantization: A Unified Theoretical and Empirical Framework

The effectiveness of modern visual representation learning and autoregressive models critically depends on vector quantization (VQ), which discretizes continuous feature representations using a learnable codebook. Despite its widespread use, existing VQ methods often suffer from training instability and codebook collapse, arising from gradient mismatch induced by the straight-through estimator and the under-utilization of code vectors. In this work, we show that both issues can be traced to a fundamental mismatch between the distributions of feature vectors and code vectors, leading to inefficient representation and information loss. Building on this observation, we propose a distributional matching framework for vector quantization. We introduce principled criteria for desirable VQ behavior and demonstrate through theoretical analysis and empirical evaluation that aligning feature and code vector distributions provides a unifying mechanism for mitigating training instability and codebook collapse. We instantiate this framework using a Wasserstein-based objective with an efficient closed-form under a mild Gaussian approximation, and further show that a nonparametric alternative based on maximum mean discrepancy yields comparable performance. Extensive experiments on visual tokenization benchmarks support the effectiveness and robustness of the proposed approach.

The Dual Nature of LLM Persona: Aggregated Tendencies and Frame-Dependent Geometry

Evaluations of LLM personas via psychometric questionnaires typically rely on aggregate scores, discarding within-instance correlation structure. We test whether this geometric structure is intrinsic or frame-dependent. Constructing within-instance correlation matrices from IPIP-50 responses, we analyze geometry on SPD manifolds under manipulated question orderings in GPT-4o simulating American and Chinese-American personas. We find that persona expression comprises two dissociable components: aggregated features (Big Five scores) degrade under randomization (21% drop) but are frame-robust; geometric features (SPD manifold) collapse under frame misalignment (42% drop) but recover substantially (to 84%) under shared frames, surpassing aggregated features (76%). This collapse-recovery pattern reveals that persona geometry is not intrinsic but a frame-dependent coordination pattern encoding information invisible to aggregation. Our findings establish a dual-nature framework for LLM personas, frame-dependent geometry versus frame-robust aggregates, necessitating frame-aware evaluation and challenging static trait conceptions.

Clarus: Coordinating Autonomous Research Agents toward Web-Scale Scientific Collaboration

Existing autonomous research agents can support parts of the research process, but most systems still treat research as either an isolated assistant task or a closed workflow. Therefore, autonomous science needs a collaboration infrastructure that coordinates projects, agents, and digital and physical resources. We identify this as a shift from code-centered execution loops to research-oriented collaboration processes, where questions, evidence, participants, and resources must be coordinated under uncertainty. In this framing, an agent may be an AI system, a human researcher, a team, a laboratory, or an organization-backed participant. To this end, we present Clarus, a collaboration infrastructure for coordinating autonomous research agents toward web-scale scientific collaboration. Clarus reformulates research as an open, auditable, attributable, and resource-aware multi-phase collaboration process. It defines a minimal project-agent-resource object model and organizes scientific collaboration through four layers including Research Application, Digital Collaboration, Physical Substrate, and Physical World. Core modules are implemented as pluggable mechanisms, allowing Clarus to adapt to task risk, collaboration structure, and resource constraints. Through a controlled paper-generation case study, we show that Clarus can organize a research goal into a traceable, reviewable, attributable, and accumulative collaboration network across phases, tasks, and participants. Together, the object model, collaboration protocol, trust mechanisms, and prototype validation provide an initial foundation for open research networks. Clarus is now available at clarus.holosai.io.

Scaling LLM Knowledge Boundaries via Distribution-Optimized Synthesis

Knowledge injection via synthetic data is crucial for enhancing Large Language Models (LLMs). However, current synthesis methods simply stop at preset token counts or fixed data ratios, lacking awareness of knowledge distribution. This results in some domains being sparse while others are redundant, limiting LLM knowledge boundaries. We revisit knowledge injection from a distribution perspective and hypothesize that an optimal knowledge distribution exists to maximize knowledge boundary expansion. We propose KDoS (Knowledge Distribution-optimized Synthesis), a framework that introduces knowledge density to drive synthesis through a three-stage feedback mechanism, shifting from blind generation to distribution-optimized synthesis. We construct Wikipedia-based synthetic data with varying knowledge distributions and conduct experiments on models from 0.6B to 16B (Qwen, Ling, LLaMA) and data scales from 1B to 5B tokens. Our key findings are: (1) an optimal knowledge distribution consistently maximizes boundary expansion; (2) this distribution is stable across backbones and scales; (3) KDoS outperforms baselines across six knowledge benchmarks. Our work offers a new perspective and practical framework for synthetic data-driven knowledge injection.

Retrieval-as-a-Service:A System-Oriented Analysis of Industrial Retrieval Pipelines in Web Systems

Retrieval systems have become a foundational infrastructure component in modern Web services, supporting applications such as content recommendation, advertising targeting, and API discovery. In large-scale industrial environments, retrieval is increasingly deployed as an independent service layer, commonly referred to as Retrieval-as-a-Service (RaaS). This paper presents a system-oriented survey of industrial retrieval pipelines, focusing on architectural design and deployment trade-offs under real-world constraints. Unlike prior surveys that emphasize algorithmic developments, we analyze retrieval systems from an infrastructure perspective, highlighting how latency requirements, scalability constraints, and resource limitations shape system design in production environments. We introduce a unified RaaS pipeline abstraction that models retrieval as a multi-stage service, including high-efficiency candidate generation, embedding-based semantic matching, and resource-aware re-ranking. We further examine the integration of Large Language Model (LLM)-based retrieval mechanisms and analyze their impact on semantic performance, latency, and computational overhead. The results provide a system-level understanding of retrieval as a service-oriented infrastructure and offer practical guidelines for designing scalable, efficient, and QoS-aware retrieval architectures in large-scale Web systems.

Harmonizing Real-Time Constraints and Long-Horizon Reasoning: An Asynchronous Agentic Framework for Dynamic Scheduling

The Dynamic Flexible Job Shop Scheduling Problem (DFJSP) necessitates a trade-off between instant reaction to stochastic disturbances and global optimization of production goals. Conventional priority rules are insufficiently flexible to handle complex disruptions, whereas learning-based approaches often compromise interpretability or fail to generalize across problem scales. Although Large Language Models (LLMs) offer advanced reasoning capabilities to bridge this gap, their substantial inference latency is incompatible with the millisecond-level decision cycles of industrial control systems. To resolve this conflict, we introduce RACE-Sched, an asynchronous agent-based framework that decouples policy execution from logical reasoning via a dual-stream architecture. The Reactive Stream executes low-latency symbolic heuristics to enable real-time dispatching, while the parallel Deliberative Stream leverages an LLM to synthesize, validate, and evolve these rules. Candidate rules undergo rigorous testing in a sandbox and are deployed via atomic updates, ensuring safety without blocking the control loop. Additionally, a semantic rule repository indexes validated heuristics for retrieval-based initialization which enhances transferability across problem scales. Extensive evaluations on GEN-Bench, MK-Bench, and JMS-Bench demonstrate that RACE-Sched outperforms leading Deep Reinforcement Learning and other LLM-based baselines. This approach harmonizes real-time constraints with long-horizon reasoning to achieve superior solution quality and robust adaptation to dynamic events.

MemTrace: Tracing and Attributing Errors in Large Language Model Memory Systems

Memory is essential for enabling large language models to support long-horizon reasoning, yet existing memory systems remain unreliable and difficult to debug. Tracing memory's dynamic evolution is crucial to understand how information is synthesized, propagated, or corrupted over time. In this work, we study the new problem of error tracing and attribution in LLM memory systems. We propose a novel framework that transforms memory pipelines into executable memory evolution graphs, enabling fine-grained tracing of operational information flow. We then construct MemTraceBench, a benchmark collected from representative memory systems such as Long-Context, RAG, Mem0, and EverMemOS, to systematically study memory failure modes. We further introduce an automatic attribution method that iteratively traces operation subgraphs to pinpoint the root cause of any failed case. Our analysis reveals that memory failures are systematic, stemming from operation-level issues like information loss and retrieval misalignment. Crucially, we leverage these fine-grained attribution signals to guide downstream prompt optimization, establishing a closed-loop system that automatically corrects faults and boosts end-task performance by up to 7.62%. Code will be released at https://github.com/zjunlp/MemTrace.