From Registration Uncertainty to Segmentation Uncertainty

Understanding the uncertainty inherent in deep learning-based image registration models has been an ongoing area of research. Existing methods have been developed to quantify both transformation and appearance uncertainties related to the registration process, elucidating areas where the model may exhibit ambiguity regarding the generated deformation. However, our study reveals that neither uncertainty effectively estimates the potential errors when the registration model is used for label propagation. Here, we propose a novel framework to concurrently estimate both the epistemic and aleatoric segmentation uncertainties for image registration. To this end, we implement a compact deep neural network (DNN) designed to transform the appearance discrepancy in the warping into aleatoric segmentation uncertainty by minimizing a negative log-likelihood loss function. Furthermore, we present epistemic segmentation uncertainty within the label propagation process as the entropy of the propagated labels. By introducing segmentation uncertainty along with existing methods for estimating registration uncertainty, we offer vital insights into the potential uncertainties at different stages of image registration. We validated our proposed framework using publicly available datasets, and the results prove that the segmentation uncertainties estimated with the proposed method correlate well with errors in label propagation, all while achieving superior registration performance.

One-for-All: Towards Universal Domain Translation with a Single StyleGAN

In this paper, we propose a novel translation model, UniTranslator, for transforming representations between visually distinct domains under conditions of limited training data and significant visual differences. The main idea behind our approach is leveraging the domain-neutral capabilities of CLIP as a bridging mechanism, while utilizing a separate module to extract abstract, domain-agnostic semantics from the embeddings of both the source and target realms. Fusing these abstract semantics with target-specific semantics results in a transformed embedding within the CLIP space. To bridge the gap between the disparate worlds of CLIP and StyleGAN, we introduce a new non-linear mapper, the CLIP2P mapper. Utilizing CLIP embeddings, this module is tailored to approximate the latent distribution in the P space, effectively acting as a connector between these two spaces. The proposed UniTranslator is versatile and capable of performing various tasks, including style mixing, stylization, and translations, even in visually challenging scenarios across different visual domains. Notably, UniTranslator generates high-quality translations that showcase domain relevance, diversity, and improved image quality. UniTranslator surpasses the performance of existing general-purpose models and performs well against specialized models in representative tasks. The source code and trained models will be released to the public.

A Survey on Deep Learning in Medical Image Registration: New Technologies, Uncertainty, Evaluation Metrics, and Beyond

Over the past decade, deep learning technologies have greatly advanced the field of medical image registration. The initial developments, such as ResNet-based and U-Net-based networks, laid the groundwork for deep learning-driven image registration. Subsequent progress has been made in various aspects of deep learning-based registration, including similarity measures, deformation regularizations, and uncertainty estimation. These advancements have not only enriched the field of deformable image registration but have also facilitated its application in a wide range of tasks, including atlas construction, multi-atlas segmentation, motion estimation, and 2D-3D registration. In this paper, we present a comprehensive overview of the most recent advancements in deep learning-based image registration. We begin with a concise introduction to the core concepts of deep learning-based image registration. Then, we delve into innovative network architectures, loss functions specific to registration, and methods for estimating registration uncertainty. Additionally, this paper explores appropriate evaluation metrics for assessing the performance of deep learning models in registration tasks. Finally, we highlight the practical applications of these novel techniques in medical imaging and discuss the future prospects of deep learning-based image registration.

Curricular Contrastive Regularization for Physics-aware Single Image Dehazing

Considering the ill-posed nature, contrastive regularization has been developed for single image dehazing, introducing the information from negative images as a lower bound. However, the contrastive samples are nonconsensual, as the negatives are usually represented distantly from the clear (i.e., positive) image, leaving the solution space still under-constricted. Moreover, the interpretability of deep dehazing models is underexplored towards the physics of the hazing process. In this paper, we propose a novel curricular contrastive regularization targeted at a consensual contrastive space as opposed to a non-consensual one. Our negatives, which provide better lower-bound constraints, can be assembled from 1) the hazy image, and 2) corresponding restorations by other existing methods. Further, due to the different similarities between the embeddings of the clear image and negatives, the learning difficulty of the multiple components is intrinsically imbalanced. To tackle this issue, we customize a curriculum learning strategy to reweight the importance of different negatives. In addition, to improve the interpretability in the feature space, we build a physics-aware dual-branch unit according to the atmospheric scattering model. With the unit, as well as curricular contrastive regularization, we establish our dehazing network, named C2PNet. Extensive experiments demonstrate that our C2PNet significantly outperforms state-of-the-art methods, with extreme PSNR boosts of 3.94dB and 1.50dB, respectively, on SOTS-indoor and SOTS-outdoor datasets.

Deformable Cross-Attention Transformer for Medical Image Registration

Transformers have recently shown promise for medical image applications, leading to an increasing interest in developing such models for medical image registration. Recent advancements in designing registration Transformers have focused on using cross-attention (CA) to enable a more precise understanding of spatial correspondences between moving and fixed images. Here, we propose a novel CA mechanism that computes windowed attention using deformable windows. In contrast to existing CA mechanisms that require intensive computational complexity by either computing CA globally or locally with a fixed and expanded search window, the proposed deformable CA can selectively sample a diverse set of features over a large search window while maintaining low computational complexity. The proposed model was extensively evaluated on multi-modal, mono-modal, and atlas-to-patient registration tasks, demonstrating promising performance against state-of-the-art methods and indicating its effectiveness for medical image registration. The source code for this work will be available after publication.

Spatially-varying Regularization with Conditional Transformer for Unsupervised Image Registration

In the past, optimization-based registration models have used spatially-varying regularization to account for deformation variations in different image regions. However, deep learning-based registration models have mostly relied on spatially-invariant regularization. Here, we introduce an end-to-end framework that uses neural networks to learn a spatially-varying deformation regularizer directly from data. The hyperparameter of the proposed regularizer is conditioned into the network, enabling easy tuning of the regularization strength. The proposed method is built upon a Transformer-based model, but it can be readily adapted to any network architecture. We thoroughly evaluated the proposed approach using publicly available datasets and observed a significant performance improvement while maintaining smooth deformation. The source code of this work will be made available after publication.

Editing Out-of-domain GAN Inversion via Differential Activations

Despite the demonstrated editing capacity in the latent space of a pretrained GAN model, inverting real-world images is stuck in a dilemma that the reconstruction cannot be faithful to the original input. The main reason for this is that the distributions between training and real-world data are misaligned, and because of that, it is unstable of GAN inversion for real image editing. In this paper, we propose a novel GAN prior based editing framework to tackle the out-of-domain inversion problem with a composition-decomposition paradigm. In particular, during the phase of composition, we introduce a differential activation module for detecting semantic changes from a global perspective, \ie, the relative gap between the features of edited and unedited images. With the aid of the generated Diff-CAM mask, a coarse reconstruction can intuitively be composited by the paired original and edited images. In this way, the attribute-irrelevant regions can be survived in almost whole, while the quality of such an intermediate result is still limited by an unavoidable ghosting effect. Consequently, in the decomposition phase, we further present a GAN prior based deghosting network for separating the final fine edited image from the coarse reconstruction. Extensive experiments exhibit superiorities over the state-of-the-art methods, in terms of qualitative and quantitative evaluations. The robustness and flexibility of our method is also validated on both scenarios of single attribute and multi-attribute manipulations.

TransMorph: Transformer for unsupervised medical image registration

In the last decade, convolutional neural networks (ConvNets) have dominated the field of medical image analysis. However, it is found that the performances of ConvNets may still be limited by their inability to model long-range spatial relations between voxels in an image. Numerous vision Transformers have been proposed recently to address the shortcomings of ConvNets, demonstrating state-of-the-art performances in many medical imaging applications. Transformers may be a strong candidate for image registration because their self-attention mechanism enables a more precise comprehension of the spatial correspondence between moving and fixed images. In this paper, we present TransMorph, a hybrid Transformer-ConvNet model for volumetric medical image registration. We also introduce three variants of TransMorph, with two diffeomorphic variants ensuring the topology-preserving deformations and a Bayesian variant producing a well-calibrated registration uncertainty estimate. The proposed models are extensively validated against a variety of existing registration methods and Transformer architectures using volumetric medical images from two applications: inter-patient brain MRI registration and phantom-to-CT registration. Qualitative and quantitative results demonstrate that TransMorph and its variants lead to a substantial performance improvement over the baseline methods, demonstrating the effectiveness of Transformers for medical image registration.

From Continuity to Editability: Inverting GANs with Consecutive Images

Existing GAN inversion methods are stuck in a paradox that the inverted codes can either achieve high-fidelity reconstruction, or retain the editing capability. Having only one of them clearly cannot realize real image editing. In this paper, we resolve this paradox by introducing consecutive images (\eg, video frames or the same person with different poses) into the inversion process. The rationale behind our solution is that the continuity of consecutive images leads to inherent editable directions. This inborn property is used for two unique purposes: 1) regularizing the joint inversion process, such that each of the inverted code is semantically accessible from one of the other and fastened in a editable domain; 2) enforcing inter-image coherence, such that the fidelity of each inverted code can be maximized with the complement of other images. Extensive experiments demonstrate that our alternative significantly outperforms state-of-the-art methods in terms of reconstruction fidelity and editability on both the real image dataset and synthesis dataset. Furthermore, our method provides the first support of video-based GAN inversion, and an interesting application of unsupervised semantic transfer from consecutive images. Source code can be found at: \url{https://github.com/cnnlstm/InvertingGANs_with_ConsecutiveImgs}.