TractoRC: A Unified Probabilistic Learning Framework for Joint Tractography Registration and Clustering

Diffusion MRI tractography enables in vivo reconstruction of white matter (WM) pathways. Two key tasks in tractography analysis include: 1) tractogram registration that aligns streamlines across individuals, and 2) streamline clustering that groups streamlines into compact fiber bundles. Although both tasks share the goal of capturing geometrically similar structures to characterize consistent WM organization, they are typically performed independently. In this work, we propose TractoRC, a unified probabilistic framework that jointly performs tractogram registration and streamline clustering within a single optimization scheme, enabling the two tasks to leverage complementary information. TractoRC learns a latent embedding space for streamline points, which serves as a shared representation for both tasks. Within this space, both tasks are formulated as probabilistic inference over structural representations: registration learns the distribution of anatomical landmarks as probabilistic keypoints to align tractograms across subjects, and clustering learns streamline structural prototypes that capture geometric similarity to form coherent streamline clusters. To support effective learning of this shared space, we introduce a transformation-equivariant self-supervised strategy to learn geometry-aware and transformation-invariant embeddings. Experiments demonstrate that jointly optimizing registration and clustering significantly improves performance in both tasks over state-of-the-art methods that treat them independently. Code will be made publicly available at https://github.com/yishengpoxiao/TractoRC .

Hierarchical Multi-Scale Graph Learning with Knowledge-Guided Attention for Whole-Slide Image Survival Analysis

We propose a Hierarchical Multi-scale Knowledge-aware Graph Network (HMKGN) that models multi-scale interactions and spatially hierarchical relationships within whole-slide images (WSIs) for cancer prognostication. Unlike conventional attention-based MIL, which ignores spatial organization, or graph-based MIL, which relies on static handcrafted graphs, HMKGN enforces a hierarchical structure with spatial locality constraints, wherein local cellular-level dynamic graphs aggregate spatially proximate patches within each region of interest (ROI) and a global slide-level dynamic graph integrates ROI-level features into WSI-level representations. Moreover, multi-scale integration at the ROI level combines coarse contextual features from broader views with fine-grained structural representations from local patch-graph aggregation. We evaluate HMKGN on four TCGA cohorts (KIRC, LGG, PAAD, and STAD; N=513, 487, 138, and 370) for survival prediction. It consistently outperforms existing MIL-based models, yielding improved concordance indices (10.85% better) and statistically significant stratification of patient survival risk (log-rank p < 0.05).

Towards Privacy-Preserving LLM Inference via Collaborative Obfuscation (Technical Report)

The rapid development of large language models (LLMs) has driven the widespread adoption of cloud-based LLM inference services, while also bringing prominent privacy risks associated with the transmission and processing of private data in remote inference. For privacy-preserving LLM inference technologies to be practically applied in industrial scenarios, three core requirements must be satisfied simultaneously: (1) Accuracy and efficiency losses should be minimized to mitigate degradation in service experience. (2) The inference process can be run on large-scale clusters consist of heterogeneous legacy xPUs. (3) Compatibility with existing LLM infrastructures should be ensured to reuse their engineering optimizations. To the best of our knowledge, none of the existing privacy-preserving LLM inference methods satisfy all the above constraints while delivering meaningful privacy guarantees. In this paper, we propose AloePri, the first privacy-preserving LLM inference method for industrial applications. AloePri protects both the input and output data by covariant obfuscation, which jointly transforms data and model parameters to achieve better accuracy and privacy. We carefully design the transformation for each model component to ensure inference accuracy and data privacy while keeping full compatibility with existing infrastructures of Language Model as a Service. AloePri has been integrated into an industrial system for the evaluation of mainstream LLMs. The evaluation on Deepseek-V3.1-Terminus model (671B parameters) demonstrates that AloePri causes accuracy loss of 0.0%~3.5% and exhibits efficiency equivalent to that of plaintext inference. Meanwhile, AloePri successfully resists state-of-the-art attacks, with less than 5\% of tokens recovered. To the best of our knowledge, AloePri is the first method to exhibit practical applicability to large-scale models in real-world systems.

OptiLeak: Efficient Prompt Reconstruction via Reinforcement Learning in Multi-tenant LLM Services

Multi-tenant LLM serving frameworks widely adopt shared Key-Value caches to enhance efficiency. However, this creates side-channel vulnerabilities enabling prompt leakage attacks. Prior studies identified these attack surfaces yet focused on expanding attack vectors rather than optimizing attack performance, reporting impractically high attack costs that underestimate the true privacy risk. We propose OptiLeak, a reinforcement learning-enhanced framework that maximizes prompt reconstruction efficiency through two-stage fine-tuning. Our key insight is that domain-specific ``hard tokens'' -- terms difficult to predict yet carrying sensitive information -- can be automatically identified via likelihood ranking and used to construct preference pairs for Direct Preference Optimization, eliminating manual annotation. This enables effective preference alignment while avoiding the overfitting issues of extended supervised fine-tuning. Evaluated on three benchmarks spanning medical and financial domains, OptiLeak achieves up to $12.48\times$ reduction in average requests per token compared to baseline approaches, with consistent improvements across model scales from 3B to 14B parameters. Our findings demonstrate that cache-based prompt leakage poses a more severe threat than previously reported, underscoring the need for robust cache isolation in production deployments.

PubSub-VFL: Towards Efficient Two-Party Split Learning in Heterogeneous Environments via Publisher/Subscriber Architecture

With the rapid advancement of the digital economy, data collaboration between organizations has become a well-established business model, driving the growth of various industries. However, privacy concerns make direct data sharing impractical. To address this, Two-Party Split Learning (a.k.a. Vertical Federated Learning (VFL)) has emerged as a promising solution for secure collaborative learning. Despite its advantages, this architecture still suffers from low computational resource utilization and training efficiency. Specifically, its synchronous dependency design increases training latency, while resource and data heterogeneity among participants further hinder efficient computation. To overcome these challenges, we propose PubSub-VFL, a novel VFL paradigm with a Publisher/Subscriber architecture optimized for two-party collaborative learning with high computational efficiency. PubSub-VFL leverages the decoupling capabilities of the Pub/Sub architecture and the data parallelism of the parameter server architecture to design a hierarchical asynchronous mechanism, reducing training latency and improving system efficiency. Additionally, to mitigate the training imbalance caused by resource and data heterogeneity, we formalize an optimization problem based on participants' system profiles, enabling the selection of optimal hyperparameters while preserving privacy. We conduct a theoretical analysis to demonstrate that PubSub-VFL achieves stable convergence and is compatible with security protocols such as differential privacy. Extensive case studies on five benchmark datasets further validate its effectiveness, showing that, compared to state-of-the-art baselines, PubSub-VFL not only accelerates training by $2 \sim 7\times$ without compromising accuracy, but also achieves a computational resource utilization rate of up to 91.07%.

DDTracking: A Deep Generative Framework for Diffusion MRI Tractography with Streamline Local-Global Spatiotemporal Modeling

This paper presents DDTracking, a novel deep generative framework for diffusion MRI tractography that formulates streamline propagation as a conditional denoising diffusion process. In DDTracking, we introduce a dual-pathway encoding network that jointly models local spatial encoding (capturing fine-scale structural details at each streamline point) and global temporal dependencies (ensuring long-range consistency across the entire streamline). Furthermore, we design a conditional diffusion model module, which leverages the learned local and global embeddings to predict streamline propagation orientations for tractography in an end-to-end trainable manner. We conduct a comprehensive evaluation across diverse, independently acquired dMRI datasets, including both synthetic and clinical data. Experiments on two well-established benchmarks with ground truth (ISMRM Challenge and TractoInferno) demonstrate that DDTracking largely outperforms current state-of-the-art tractography methods. Furthermore, our results highlight DDTracking's strong generalizability across heterogeneous datasets, spanning varying health conditions, age groups, imaging protocols, and scanner types. Collectively, DDTracking offers anatomically plausible and robust tractography, presenting a scalable, adaptable, and end-to-end learnable solution for broad dMRI applications. Code is available at: https://github.com/yishengpoxiao/DDtracking.git

Medical Image De-Identification Benchmark Challenge

The de-identification (deID) of protected health information (PHI) and personally identifiable information (PII) is a fundamental requirement for sharing medical images, particularly through public repositories, to ensure compliance with patient privacy laws. In addition, preservation of non-PHI metadata to inform and enable downstream development of imaging artificial intelligence (AI) is an important consideration in biomedical research. The goal of MIDI-B was to provide a standardized platform for benchmarking of DICOM image deID tools based on a set of rules conformant to the HIPAA Safe Harbor regulation, the DICOM Attribute Confidentiality Profiles, and best practices in preservation of research-critical metadata, as defined by The Cancer Imaging Archive (TCIA). The challenge employed a large, diverse, multi-center, and multi-modality set of real de-identified radiology images with synthetic PHI/PII inserted. The MIDI-B Challenge consisted of three phases: training, validation, and test. Eighty individuals registered for the challenge. In the training phase, we encouraged participants to tune their algorithms using their in-house or public data. The validation and test phases utilized the DICOM images containing synthetic identifiers (of 216 and 322 subjects, respectively). Ten teams successfully completed the test phase of the challenge. To measure success of a rule-based approach to image deID, scores were computed as the percentage of correct actions from the total number of required actions. The scores ranged from 97.91% to 99.93%. Participants employed a variety of open-source and proprietary tools with customized configurations, large language models, and optical character recognition (OCR). In this paper we provide a comprehensive report on the MIDI-B Challenge's design, implementation, results, and lessons learned.

SimWorld: A Unified Benchmark for Simulator-Conditioned Scene Generation via World Model

With the rapid advancement of autonomous driving technology, a lack of data has become a major obstacle to enhancing perception model accuracy. Researchers are now exploring controllable data generation using world models to diversify datasets. However, previous work has been limited to studying image generation quality on specific public datasets. There is still relatively little research on how to build data generation engines for real-world application scenes to achieve large-scale data generation for challenging scenes. In this paper, a simulator-conditioned scene generation engine based on world model is proposed. By constructing a simulation system consistent with real-world scenes, simulation data and labels, which serve as the conditions for data generation in the world model, for any scenes can be collected. It is a novel data generation pipeline by combining the powerful scene simulation capabilities of the simulation engine with the robust data generation capabilities of the world model. In addition, a benchmark with proportionally constructed virtual and real data, is provided for exploring the capabilities of world models in real-world scenes. Quantitative results show that these generated images significantly improve downstream perception models performance. Finally, we explored the generative performance of the world model in urban autonomous driving scenarios. All the data and code will be available at https://github.com/Li-Zn-H/SimWorld.

Deep Learning-Based Diffusion MRI Tractography: Integrating Spatial and Anatomical Information

Diffusion MRI tractography technique enables non-invasive visualization of the white matter pathways in the brain. It plays a crucial role in neuroscience and clinical fields by facilitating the study of brain connectivity and neurological disorders. However, the accuracy of reconstructed tractograms has been a longstanding challenge. Recently, deep learning methods have been applied to improve tractograms for better white matter coverage, but often comes at the expense of generating excessive false-positive connections. This is largely due to their reliance on local information to predict long range streamlines. To improve the accuracy of streamline propagation predictions, we introduce a novel deep learning framework that integrates image-domain spatial information and anatomical information along tracts, with the former extracted through convolutional layers and the later modeled via a Transformer-decoder. Additionally, we employ a weighted loss function to address fiber class imbalance encountered during training. We evaluate the proposed method on the simulated ISMRM 2015 Tractography Challenge dataset, achieving a valid streamline rate of 66.2%, white matter coverage of 63.8%, and successfully reconstructing 24 out of 25 bundles. Furthermore, on the multi-site Tractoinferno dataset, the proposed method demonstrates its ability to handle various diffusion MRI acquisition schemes, achieving a 5.7% increase in white matter coverage and a 4.1% decrease in overreach compared to RNN-based methods.

A Novel Streamline-based diffusion MRI Tractography Registration Method with Probabilistic Keypoint Detection

Registration of diffusion MRI tractography is an essential step for analyzing group similarities and variations in the brain's white matter (WM). Streamline-based registration approaches can leverage the 3D geometric information of fiber pathways to enable spatial alignment after registration. Existing methods usually rely on the optimization of the spatial distances to identify the optimal transformation. However, such methods overlook point connectivity patterns within the streamline itself, limiting their ability to identify anatomical correspondences across tractography datasets. In this work, we propose a novel unsupervised approach using deep learning to perform streamline-based dMRI tractography registration. The overall idea is to identify corresponding keypoint pairs across subjects for spatial alignment of tractography datasets. We model tractography as point clouds to leverage the graph connectivity along streamlines. We propose a novel keypoint detection method for streamlines, framed as a probabilistic classification task to identify anatomically consistent correspondences across unstructured streamline sets. In the experiments, we compare several existing methods and show highly effective and efficient tractography registration performance.