Advancing Machine Learning Optimization of Chiral Photonic Metasurface: Comparative Study of Neural Network and Genetic Algorithm Approaches

Chiral photonic metasurfaces provide unique capabilities for tailoring light-matter interactions, which are essential for next-generation photonic devices. Here, we report an advanced optimization framework that combines deep learning and evolutionary algorithms to significantly improve both the design and performance of chiral photonic nanostructures. Building on previous work utilizing a three-layer perceptron reinforced learning and stochastic evolutionary algorithm with decaying changes and mass extinction for chiral photonic optimization, our study introduces a refined pipeline featuring a two-output neural network architecture to reduce the trade-off between high chiral dichroism (CD) and reflectivity. Additionally, we use an improved fitness function, and efficient data augmentation techniques. A comparative analysis between a neural network (NN)-based approach and a genetic algorithm (GA) is presented for structures of different interface pattern depth, material combinations, and geometric complexity. We demonstrate a twice higher CD and the impact of both the corner number and the refractive index contrast at the example of a GaP/air and PMMA/air metasurface as a result of superior optimization performance. Additionally, a substantial increase in the number of structures explored within limited computational resources is highlighted, with tailored spectral reflectivity suggested by our electromagnetic simulations, paving the way for chiral mirrors applicable to polarization-selective light-matter interaction studies.

COMPARE: Clinical Optimization with Modular Planning and Assessment via RAG-Enhanced AI-OCT: Superior Decision Support for Percutaneous Coronary Intervention Compared to ChatGPT-5 and Junior Operators

Background: While intravascular imaging, particularly optical coherence tomography (OCT), improves percutaneous coronary intervention (PCI) outcomes, its interpretation is operator-dependent. General-purpose artificial intelligence (AI) shows promise but lacks domain-specific reliability. We evaluated the performance of CA-GPT, a novel large model deployed on an AI-OCT system, against that of the general-purpose ChatGPT-5 and junior physicians for OCT-guided PCI planning and assessment. Methods: In this single-center analysis of 96 patients who underwent OCT-guided PCI, the procedural decisions generated by the CA-GPT, ChatGPT-5, and junior physicians were compared with an expert-derived procedural record. Agreement was assessed using ten pre-specified metrics across pre-PCI and post-PCI phases. Results: For pre-PCI planning, CA-GPT demonstrated significantly higher median agreement scores (5[IQR 3.75-5]) compared to both ChatGPT-5 (3[2-4], P<0.001) and junior physicians (4[3-4], P<0.001). CA-GPT significantly outperformed ChatGPT-5 across all individual pre-PCI metrics and showed superior performance to junior physicians in stent diameter (90.3% vs. 72.2%, P<0.05) and length selection (80.6% vs. 52.8%, P<0.01). In post-PCI assessment, CA-GPT maintained excellent overall agreement (5[4.75-5]), significantly higher than both ChatGPT-5 (4[4-5], P<0.001) and junior physicians (5[4-5], P<0.05). Subgroup analysis confirmed CA-GPT's robust performance advantage in complex scenarios. Conclusion: The CA-GPT-based AI-OCT system achieved superior decision-making agreement versus a general-purpose large language model and junior physicians across both PCI planning and assessment phases. This approach provides a standardized and reliable method for intravascular imaging interpretation, demonstrating significant potential to augment operator expertise and optimize OCT-guided PCI.

FIA-Edit: Frequency-Interactive Attention for Efficient and High-Fidelity Inversion-Free Text-Guided Image Editing

Text-guided image editing has advanced rapidly with the rise of diffusion models. While flow-based inversion-free methods offer high efficiency by avoiding latent inversion, they often fail to effectively integrate source information, leading to poor background preservation, spatial inconsistencies, and over-editing due to the lack of effective integration of source information. In this paper, we present FIA-Edit, a novel inversion-free framework that achieves high-fidelity and semantically precise edits through a Frequency-Interactive Attention. Specifically, we design two key components: (1) a Frequency Representation Interaction (FRI) module that enhances cross-domain alignment by exchanging frequency components between source and target features within self-attention, and (2) a Feature Injection (FIJ) module that explicitly incorporates source-side queries, keys, values, and text embeddings into the target branch's cross-attention to preserve structure and semantics. Comprehensive and extensive experiments demonstrate that FIA-Edit supports high-fidelity editing at low computational cost (~6s per 512 * 512 image on an RTX 4090) and consistently outperforms existing methods across diverse tasks in visual quality, background fidelity, and controllability. Furthermore, we are the first to extend text-guided image editing to clinical applications. By synthesizing anatomically coherent hemorrhage variations in surgical images, FIA-Edit opens new opportunities for medical data augmentation and delivers significant gains in downstream bleeding classification. Our project is available at: https://github.com/kk42yy/FIA-Edit.

Anatomy-Aware Low-Dose CT Denoising via Pretrained Vision Models and Semantic-Guided Contrastive Learning

To reduce radiation exposure and improve the diagnostic efficacy of low-dose computed tomography (LDCT), numerous deep learning-based denoising methods have been developed to mitigate noise and artifacts. However, most of these approaches ignore the anatomical semantics of human tissues, which may potentially result in suboptimal denoising outcomes. To address this problem, we propose ALDEN, an anatomy-aware LDCT denoising method that integrates semantic features of pretrained vision models (PVMs) with adversarial and contrastive learning. Specifically, we introduce an anatomy-aware discriminator that dynamically fuses hierarchical semantic features from reference normal-dose CT (NDCT) via cross-attention mechanisms, enabling tissue-specific realism evaluation in the discriminator. In addition, we propose a semantic-guided contrastive learning module that enforces anatomical consistency by contrasting PVM-derived features from LDCT, denoised CT and NDCT, preserving tissue-specific patterns through positive pairs and suppressing artifacts via dual negative pairs. Extensive experiments conducted on two LDCT denoising datasets reveal that ALDEN achieves the state-of-the-art performance, offering superior anatomy preservation and substantially reducing over-smoothing issue of previous work. Further validation on a downstream multi-organ segmentation task (encompassing 117 anatomical structures) affirms the model's ability to maintain anatomical awareness.

Event2Vec: Processing neuromorphic events directly by representations in vector space

The neuromorphic event cameras have overwhelming advantages in temporal resolution, power efficiency, and dynamic range compared to traditional cameras. However, the event cameras output asynchronous, sparse, and irregular events, which are not compatible with mainstream computer vision and deep learning methods. Various methods have been proposed to solve this issue but at the cost of long preprocessing procedures, losing temporal resolutions, or being incompatible with massively parallel computation. Inspired by the great success of the word to vector, we summarize the similarities between words and events, then propose the first event to vector (event2vec) representation. We validate event2vec on classifying the ASL-DVS dataset, showing impressive parameter efficiency, accuracy, and speed than previous graph/image/voxel-based representations. Beyond task performance, the most attractive advantage of event2vec is that it aligns events to the domain of natural language processing, showing the promising prospect of integrating events into large language and multimodal models. Our codes, models, and training logs are available at https://github.com/fangwei123456/event2vec.

Mamba-3D as Masked Autoencoders for Accurate and Data-Efficient Analysis of Medical Ultrasound Videos

Ultrasound videos are an important form of clinical imaging data, and deep learning-based automated analysis can improve diagnostic accuracy and clinical efficiency. However, the scarcity of labeled data and the inherent challenges of video analysis have impeded the advancement of related methods. In this work, we introduce E-ViM$^3$, a data-efficient Vision Mamba network that preserves the 3D structure of video data, enhancing long-range dependencies and inductive biases to better model space-time correlations. With our design of Enclosure Global Tokens (EGT), the model captures and aggregates global features more effectively than competing methods. To further improve data efficiency, we employ masked video modeling for self-supervised pre-training, with the proposed Spatial-Temporal Chained (STC) masking strategy designed to adapt to various video scenarios. Experiments demonstrate that E-ViM$^3$ performs as the state-of-the-art in two high-level semantic analysis tasks across four datasets of varying sizes: EchoNet-Dynamic, CAMUS, MICCAI-BUV, and WHBUS. Furthermore, our model achieves competitive performance with limited labels, highlighting its potential impact on real-world clinical applications.

PLAY2PROMPT: Zero-shot Tool Instruction Optimization for LLM Agents via Tool Play

Large language models (LLMs) are increasingly integrated with specialized external tools, yet many tasks demand zero-shot tool usage with minimal or noisy documentation. Existing solutions rely on manual rewriting or labeled data for validation, making them inapplicable in true zero-shot settings. To address these challenges, we propose PLAY2PROMPT, an automated framework that systematically "plays" with each tool to explore its input-output behaviors. Through this iterative trial-and-error process, PLAY2PROMPT refines tool documentation and generates usage examples without any labeled data. These examples not only guide LLM inference but also serve as validation to further enhance tool utilization. Extensive experiments on real-world tasks demonstrate that PLAY2PROMPT significantly improves zero-shot tool performance across both open and closed models, offering a scalable and effective solution for domain-specific tool integration.

MRS: A Fast Sampler for Mean Reverting Diffusion based on ODE and SDE Solvers

In applications of diffusion models, controllable generation is of practical significance, but is also challenging. Current methods for controllable generation primarily focus on modifying the score function of diffusion models, while Mean Reverting (MR) Diffusion directly modifies the structure of the stochastic differential equation (SDE), making the incorporation of image conditions simpler and more natural. However, current training-free fast samplers are not directly applicable to MR Diffusion. And thus MR Diffusion requires hundreds of NFEs (number of function evaluations) to obtain high-quality samples. In this paper, we propose a new algorithm named MRS (MR Sampler) to reduce the sampling NFEs of MR Diffusion. We solve the reverse-time SDE and the probability flow ordinary differential equation (PF-ODE) associated with MR Diffusion, and derive semi-analytical solutions. The solutions consist of an analytical function and an integral parameterized by a neural network. Based on this solution, we can generate high-quality samples in fewer steps. Our approach does not require training and supports all mainstream parameterizations, including noise prediction, data prediction and velocity prediction. Extensive experiments demonstrate that MR Sampler maintains high sampling quality with a speedup of 10 to 20 times across ten different image restoration tasks. Our algorithm accelerates the sampling procedure of MR Diffusion, making it more practical in controllable generation.

Channel-wise Parallelizable Spiking Neuron with Multiplication-free Dynamics and Large Temporal Receptive Fields

Spiking Neural Networks (SNNs) are distinguished from Artificial Neural Networks (ANNs) for their sophisticated neuronal dynamics and sparse binary activations (spikes) inspired by the biological neural system. Traditional neuron models use iterative step-by-step dynamics, resulting in serial computation and slow training speed of SNNs. Recently, parallelizable spiking neuron models have been proposed to fully utilize the massive parallel computing ability of graphics processing units to accelerate the training of SNNs. However, existing parallelizable spiking neuron models involve dense floating operations and can only achieve high long-term dependencies learning ability with a large order at the cost of huge computational and memory costs. To solve the dilemma of performance and costs, we propose the mul-free channel-wise Parallel Spiking Neuron, which is hardware-friendly and suitable for SNNs' resource-restricted application scenarios. The proposed neuron imports the channel-wise convolution to enhance the learning ability, induces the sawtooth dilations to reduce the neuron order, and employs the bit shift operation to avoid multiplications. The algorithm for design and implementation of acceleration methods is discussed meticulously. Our methods are validated in neuromorphic Spiking Heidelberg Digits voices, sequential CIFAR images, and neuromorphic DVS-Lip vision datasets, achieving the best accuracy among SNNs. Training speed results demonstrate the effectiveness of our acceleration methods, providing a practical reference for future research.

Flexible and Scalable Deep Dendritic Spiking Neural Networks with Multiple Nonlinear Branching

Recent advances in spiking neural networks (SNNs) have a predominant focus on network architectures, while relatively little attention has been paid to the underlying neuron model. The point neuron models, a cornerstone of deep SNNs, pose a bottleneck on the network-level expressivity since they depict somatic dynamics only. In contrast, the multi-compartment models in neuroscience offer remarkable expressivity by introducing dendritic morphology and dynamics, but remain underexplored in deep learning due to their unaffordable computational cost and inflexibility. To combine the advantages of both sides for a flexible, efficient yet more powerful model, we propose the dendritic spiking neuron (DendSN) incorporating multiple dendritic branches with nonlinear dynamics. Compared to the point spiking neurons, DendSN exhibits significantly higher expressivity. DendSN's flexibility enables its seamless integration into diverse deep SNN architectures. To accelerate dendritic SNNs (DendSNNs), we parallelize dendritic state updates across time steps, and develop Triton kernels for GPU-level acceleration. As a result, we can construct large-scale DendSNNs with depth comparable to their point SNN counterparts. Next, we comprehensively evaluate DendSNNs' performance on various demanding tasks. By modulating dendritic branch strengths using a context signal, catastrophic forgetting of DendSNNs is substantially mitigated. Moreover, DendSNNs demonstrate enhanced robustness against noise and adversarial attacks compared to point SNNs, and excel in few-shot learning settings. Our work firstly demonstrates the possibility of training bio-plausible dendritic SNNs with depths and scales comparable to traditional point SNNs, and reveals superior expressivity and robustness of reduced dendritic neuron models in deep learning, thereby offering a fresh perspective on advancing neural network design.