MEGA-CL: A Molecular Foundation Model for Generalizable ADMET Prediction through Graph External Attention and Contrastive Learning

Predicting the absorption, distribution, metabolism, excretion and toxicity (ADMET) properties of small molecules remains a major challenge in drug discovery. Here, we present MEGA-CL, a foundation graph neural network framework for universal molecular ADMET prediction. MEGA-CL integrates self-supervised contrastive learning with a multi-head external attention mechanism and an enhanced message-passing architecture, enabling simultaneous modeling of local chemical substructures and global inter-graph relationships while mitigating over-smoothing effects commonly observed in deep graph networks. Across 13 benchmark datasets and 21 downstream ADMET tasks, MEGA-CL consistently outperforms state-of-the-art baseline models. In particular, the framework demonstrates robust performance on challenging regression tasks, including clearance (CL) and steady-state volume of distribution (VDss), while maintaining strong generalization ability in independent external validation. Clinically relevant predictive accuracy was achieved, with more than 75% of predictions falling within a 3-fold error range. In an external evaluation on 18 novel compounds derived from recently approved FDA drugs, over 50% of human liver microsome clearance (HLMC) predictions were within a 2-fold error range. To further assess its practical applicability, MEGA-CL was prospectively evaluated on three preclinical drug candidates using in vitro hepatic microsomal metabolism assays and CYP450 inhibition assays guided by model predictions. The predicted HLMC values for all candidates were within 2.5-fold of the experimentally measured values, and 73.3% of CYP450 inhibition endpoints (11/15) were correctly classified. These results demonstrate the potential of MEGA-CL as a generalizable framework for accelerating in silico ADMET evaluation and early-stage drug candidate optimization.

MissingBench-Verified: Probing Vision-Language Models' Inability to Detect Missing Object Parts

Vision Language Models (VLMs) are well known for hallucinating non-existent objects in images. Objects with missing parts present a unique challenge for VLMs, stemming from both real-world knowledge bias and the scarcity of such images in training data. We present MissingBench-Verified, a benchmark designed to evaluate a specific and practically relevant scenario: when vision-language models fail to recognize that an essential component of an object has been removed. Across ten leading models, we observe consistent and significant failure rates that persist even when external tool evidence explicitly contradicts the model's visual perception. We further ask whether granting models access to image processing tools (e.g., cropping, contrast adjustment) enables autonomous inspection to resolve these failures. We find that existing mitigation strategies, including tool-assisted verification, autonomous visual reasoning, longer reasoning durations, and fine-tuning on an easier dataset, provide negligible improvement, indicating that this failure mode cannot be addressed through current prompting or post-hoc correction techniques. Our findings highlight a fundamental limitation of current VLM for inspection and monitoring tasks and underscore the need for architectural or training-level interventions that enable models to override internal expectations when confronted with contradictory evidence.

World Models for Policy Refinement in StarCraft II

Large Language Models (LLMs) have recently shown strong reasoning and generalization capabilities, motivating their use as decision-making policies in complex environments. StarCraft II (SC2), with its massive state-action space and partial observability, is a challenging testbed. However, existing LLM-based SC2 agents primarily focus on improving the policy itself and overlook integrating a learnable, action-conditioned transition model into the decision loop. To bridge this gap, we propose StarWM, the first world model for SC2 that predicts future observations under partial observability. To facilitate learning SC2's hybrid dynamics, we introduce a structured textual representation that factorizes observations into five semantic modules, and construct SC2-Dynamics-50k, the first instruction-tuning dataset for SC2 dynamics prediction. We further develop a multi-dimensional offline evaluation framework for predicted structured observations. Offline results show StarWM's substantial gains over zero-shot baselines, including nearly 60% improvements in resource prediction accuracy and self-side macro-situation consistency. Finally, we propose StarWM-Agent, a world-model-augmented decision system that integrates StarWM into a Generate--Simulate--Refine decision loop for foresight-driven policy refinement. Online evaluation against SC2's built-in AI demonstrates consistent improvements, yielding win-rate gains of 30%, 15%, and 30% against Hard (LV5), Harder (LV6), and VeryHard (LV7), respectively, alongside improved macro-management stability and tactical risk assessment.

Speech-Aware Long Context Pruning and Integration for Contextualized Automatic Speech Recognition

Automatic speech recognition (ASR) systems have achieved remarkable performance in common conditions but often struggle to leverage long-context information in contextualized scenarios that require domain-specific knowledge, such as conference presentations. This challenge arises primarily due to constrained model context windows and the sparsity of relevant information within extensive contextual noise. To solve this, we propose the SAP$^{2}$ method, a novel framework that dynamically prunes and integrates relevant contextual keywords in two stages. Specifically, each stage leverages our proposed Speech-Driven Attention-based Pooling mechanism, enabling efficient compression of context embeddings while preserving speech-salient information. Experimental results demonstrate state-of-the-art performance of SAP$^{2}$ on the SlideSpeech and LibriSpeech datasets, achieving word error rates (WER) of 7.71% and 1.12%, respectively. On SlideSpeech, our method notably reduces biased keyword error rates (B-WER) by 41.1% compared to non-contextual baselines. SAP$^{2}$ also exhibits robust scalability, consistently maintaining performance under extensive contextual input conditions on both datasets.

Token-level Speaker Change Detection Using Speaker Difference and Speech Content via Continuous Integrate-and-fire

In multi-talker scenarios such as meetings and conversations, speech processing systems are usually required to segment the audio and then transcribe each segmentation. These two stages are addressed separately by speaker change detection (SCD) and automatic speech recognition (ASR). Most previous SCD systems rely solely on speaker information and ignore the importance of speech content. In this paper, we propose a novel SCD system that considers both cues of speaker difference and speech content. These two cues are converted into token-level representations by the continuous integrate-and-fire (CIF) mechanism and then combined for detecting speaker changes on the token acoustic boundaries. We evaluate the performance of our approach on a public real-recorded meeting dataset, AISHELL-4. The experiment results show that our method outperforms a competitive frame-level baseline system by 2.45% equal coverage-purity (ECP). In addition, we demonstrate the importance of speech content and speaker difference to the SCD task, and the advantages of conducting SCD on the token acoustic boundaries compared with conducting SCD frame by frame.

Improving End-to-End Contextual Speech Recognition with Fine-grained Contextual Knowledge Selection

Nowadays, most methods in end-to-end contextual speech recognition bias the recognition process towards contextual knowledge. Since all-neural contextual biasing methods rely on phrase-level contextual modeling and attention-based relevance modeling, they may encounter confusion between similar context-specific phrases, which hurts predictions at the token level. In this work, we focus on mitigating confusion problems with fine-grained contextual knowledge selection (FineCoS). In FineCoS, we introduce fine-grained knowledge to reduce the uncertainty of token predictions. Specifically, we first apply phrase selection to narrow the range of phrase candidates, and then conduct token attention on the tokens in the selected phrase candidates. Moreover, we re-normalize the attention weights of most relevant phrases in inference to obtain more focused phrase-level contextual representations, and inject position information to better discriminate phrases or tokens. On LibriSpeech and an in-house 160,000-hour dataset, we explore the proposed methods based on a controllable all-neural biasing method, collaborative decoding (ColDec). The proposed methods provide at most 6.1% relative word error rate reduction on LibriSpeech and 16.4% relative character error rate reduction on the in-house dataset over ColDec.

OPT: Omni-Perception Pre-Trainer for Cross-Modal Understanding and Generation

In this paper, we propose an Omni-perception Pre-Trainer (OPT) for cross-modal understanding and generation, by jointly modeling visual, text and audio resources. OPT is constructed in an encoder-decoder framework, including three single-modal encoders to generate token-based embeddings for each modality, a cross-modal encoder to encode the correlations among the three modalities, and two cross-modal decoders to generate text and image respectively. For the OPT's pre-training, we design a multi-task pretext learning scheme to model multi-modal resources from three different data granularities, \ie, token-, modality-, and sample-level modeling, through which OPT learns to align and translate among different modalities. The pre-training task is carried out on a large amount of image-text-audio triplets from Open Images. Experimental results show that OPT can learn strong image-text-audio multi-modal representations and achieve promising results on a variety of cross-modal understanding and generation tasks.

Long-Running Speech Recognizer:An End-to-End Multi-Task Learning Framework for Online ASR and VAD

When we use End-to-end automatic speech recognition (E2E-ASR) system for real-world applications, a voice activity detection (VAD) system is usually needed to improve the performance and to reduce the computational cost by discarding non-speech parts in the audio. This paper presents a novel end-to-end (E2E), multi-task learning (MTL) framework that integrates ASR and VAD into one model. The proposed system, which we refer to as Long-Running Speech Recognizer (LR-SR), learns ASR and VAD jointly from two seperate task-specific datasets in the training stage. With the assistance of VAD, the ASR performance improves as its connectionist temporal classification (CTC) loss function can leverage the VAD alignment information. In the inference stage, the LR-SR system removes non-speech parts at low computational cost and recognizes speech parts with high robustness. Experimental results on segmented speech data show that the proposed MTL framework outperforms the baseline single-task learning (STL) framework in ASR task. On unsegmented speech data, we find that the LR-SR system outperforms the baseline ASR systems that build an extra GMM-based or DNN-based voice activity detector.

Efficiently Fusing Pretrained Acoustic and Linguistic Encoders for Low-resource Speech Recognition

End-to-end models have achieved impressive results on the task of automatic speech recognition (ASR). For low-resource ASR tasks, however, labeled data can hardly satisfy the demand of end-to-end models. Self-supervised acoustic pre-training has already shown its amazing ASR performance, while the transcription is still inadequate for language modeling in end-to-end models. In this work, we fuse a pre-trained acoustic encoder (wav2vec2.0) and a pre-trained linguistic encoder (BERT) into an end-to-end ASR model. The fused model only needs to learn the transfer from speech to language during fine-tuning on limited labeled data. The length of the two modalities is matched by a monotonic attention mechanism without additional parameters. Besides, a fully connected layer is introduced for the hidden mapping between modalities. We further propose a scheduled fine-tuning strategy to preserve and utilize the text context modeling ability of the pre-trained linguistic encoder. Experiments show our effective utilizing of pre-trained modules. Our model achieves better recognition performance on CALLHOME corpus (15 hours) than other end-to-end models.

Applying Wav2vec2.0 to Speech Recognition in Various Low-resource Languages

There are several domains that own corresponding widely used feature extractors, such as ResNet, BERT, and GPT-x. These models are usually pre-trained on large amounts of unlabeled data by self-supervision and can be effectively applied to downstream tasks. In the speech domain, wav2vec2.0 starts to show its powerful representation ability and feasibility of ultra-low resource speech recognition on the Librispeech corpus, which belongs to the audiobook domain. However, wav2vec2.0 has not been examined on real spoken scenarios and languages other than English. To verify its universality over languages, we apply pre-trained models to solve low-resource speech recognition tasks in various spoken languages. We achieve more than 20% relative improvements in six languages compared with previous work. Among these languages, English achieves a gain of 52.4%. Moreover, using coarse-grained modeling units, such as subword or character, achieves better results than fine-grained modeling units, such as phone or letter.