Abstract:Credit assignment is a fundamental challenge in cooperative multi-agent reinforcement learning, particularly in embodied AI settings characterized by limited and delayed feedback as well as dynamically changing numbers of active agents. We propose MARS-RA, a framework that reformulates credit assignment as a rank aggregation problem using contribution-based pairwise comparisons among agents generated by large multimodal models. This shift from absolute to relative estimation ensures robustness against noise and dynamic agent participation, converting comparison results into contribution scores for potential-based reward shaping. We provide theoretical justification for the convergence and robustness of the proposed framework, and show that Shapley values can be used as an interpretive reference. Experimental results on challenging tasks of different types indicate that MARS-RA can guide agents toward effective cooperation.
Abstract:Predicting the absorption, distribution, metabolism, excretion and toxicity (ADMET) properties of small molecules remains a major challenge in drug discovery. Here, we present MEGA-CL, a foundation graph neural network framework for universal molecular ADMET prediction. MEGA-CL integrates self-supervised contrastive learning with a multi-head external attention mechanism and an enhanced message-passing architecture, enabling simultaneous modeling of local chemical substructures and global inter-graph relationships while mitigating over-smoothing effects commonly observed in deep graph networks. Across 13 benchmark datasets and 21 downstream ADMET tasks, MEGA-CL consistently outperforms state-of-the-art baseline models. In particular, the framework demonstrates robust performance on challenging regression tasks, including clearance (CL) and steady-state volume of distribution (VDss), while maintaining strong generalization ability in independent external validation. Clinically relevant predictive accuracy was achieved, with more than 75% of predictions falling within a 3-fold error range. In an external evaluation on 18 novel compounds derived from recently approved FDA drugs, over 50% of human liver microsome clearance (HLMC) predictions were within a 2-fold error range. To further assess its practical applicability, MEGA-CL was prospectively evaluated on three preclinical drug candidates using in vitro hepatic microsomal metabolism assays and CYP450 inhibition assays guided by model predictions. The predicted HLMC values for all candidates were within 2.5-fold of the experimentally measured values, and 73.3% of CYP450 inhibition endpoints (11/15) were correctly classified. These results demonstrate the potential of MEGA-CL as a generalizable framework for accelerating in silico ADMET evaluation and early-stage drug candidate optimization.
Abstract:GUI grounding maps natural language instructions to the correct interface elements, serving as the perception foundation for GUI agents. Existing approaches predominantly rely on fine-tuning multimodal large language models (MLLMs) using large-scale GUI datasets to predict target element coordinates, which is data-intensive and generalizes poorly to unseen interfaces. Recent attention-based alternatives exploit localization signals in MLLMs attention mechanisms without task-specific fine-tuning, but suffer from low reliability due to the lack of explicit and complementary spatial anchors in GUI images. To address this limitation, we propose Trifuse, an attention-based grounding framework that explicitly integrates complementary spatial anchors. Trifuse integrates attention, OCR-derived textual cues, and icon-level caption semantics via a Consensus-SinglePeak (CS) fusion strategy that enforces cross-modal agreement while retaining sharp localization peaks. Extensive evaluations on four grounding benchmarks demonstrate that Trifuse achieves strong performance without task-specific fine-tuning, substantially reducing the reliance on expensive annotated data. Moreover, ablation studies reveal that incorporating OCR and caption cues consistently improves attention-based grounding performance across different backbones, highlighting its effectiveness as a general framework for GUI grounding.
Abstract:Recent breakthroughs in Large Language Models (LLMs) have positioned them as a promising paradigm for agents, with long-term planning and decision-making emerging as core general-purpose capabilities for adapting to diverse scenarios and tasks. Real-time strategy (RTS) games serve as an ideal testbed for evaluating these two capabilities, as their inherent gameplay requires both macro-level strategic planning and micro-level tactical adaptation and action execution. Existing RTS game-based environments either suffer from relatively high computational demands or lack support for textual observations, which has constrained the use of RTS games for LLM evaluation. Motivated by this, we present TowerMind, a novel environment grounded in the tower defense (TD) subgenre of RTS games. TowerMind preserves the key evaluation strengths of RTS games for assessing LLMs, while featuring low computational demands and a multimodal observation space, including pixel-based, textual, and structured game-state representations. In addition, TowerMind supports the evaluation of model hallucination and provides a high degree of customizability. We design five benchmark levels to evaluate several widely used LLMs under different multimodal input settings. The results reveal a clear performance gap between LLMs and human experts across both capability and hallucination dimensions. The experiments further highlight key limitations in LLM behavior, such as inadequate planning validation, a lack of multifinality in decision-making, and inefficient action use. We also evaluate two classic reinforcement learning algorithms: Ape-X DQN and PPO. By offering a lightweight and multimodal design, TowerMind complements the existing RTS game-based environment landscape and introduces a new benchmark for the AI agent field. The source code is publicly available on GitHub(https://github.com/tb6147877/TowerMind).




Abstract:Camera-based animal re-identification (Animal Re-ID) can support wildlife monitoring and precision livestock management in large outdoor environments with limited wireless connectivity. In these settings, inference must run directly on collar tags or low-power edge nodes built around microcontrollers (MCUs), yet most Animal Re-ID models are designed for workstations or servers and are too large for devices with small memory and low-resolution inputs. We propose an on-device framework. First, we characterise the gap between state-of-the-art Animal Re-ID models and MCU-class hardware, showing that straightforward knowledge distillation from large teachers offers limited benefit once memory and input resolution are constrained. Second, guided by this analysis, we design a high-accuracy Animal Re-ID architecture by systematically scaling a CNN-based MobileNetV2 backbone for low-resolution inputs. Third, we evaluate the framework with a real-world dataset and introduce a data-efficient fine-tuning strategy to enable fast adaptation with just three images per animal identity at a new site. Across six public Animal Re-ID datasets, our compact model achieves competitive retrieval accuracy while reducing model size by over two orders of magnitude. On a self-collected cattle dataset, the deployed model performs fully on-device inference with only a small accuracy drop and unchanged Top-1 accuracy relative to its cluster version. We demonstrate that practical, adaptable Animal Re-ID is achievable on MCU-class devices, paving the way for scalable deployment in real field environments.
Abstract:Three-dimensional (3D) ultrasound imaging can overcome the limitations of conventional two dimensional (2D) ultrasound imaging in structural observation and measurement. However, conducting volumetric ultrasound imaging for large-sized organs still faces difficulties including long acquisition time, inevitable patient movement, and 3D feature recognition. In this study, we proposed a real-time volumetric free-hand ultrasound imaging system optimized for the above issues and applied it to the clinical diagnosis of scoliosis. This study employed an incremental imaging method coupled with algorithmic acceleration to enable real-time processing and visualization of the large amounts of data generated when scanning large-sized organs. Furthermore, to deal with the difficulty of image feature recognition, we proposed two tissue segmentation algorithms to reconstruct and visualize the spinal anatomy in 3D space by approximating the depth at which the bone structures are located and segmenting the ultrasound images at different depths. We validated the adaptability of our system by deploying it to multiple models of ultra-sound equipment and conducting experiments using different types of ultrasound probes. We also conducted experiments on 6 scoliosis patients and 10 normal volunteers to evaluate the performance of our proposed method. Ultrasound imaging of a volunteer spine from shoulder to crotch (more than 500 mm) was performed in 2 minutes, and the 3D imaging results displayed in real-time were compared with the corresponding X-ray images with a correlation coefficient of 0.96 in spinal curvature. Our proposed volumetric ultrasound imaging system might hold the potential to be clinically applied to other large-sized organs.




Abstract:Reliable re-identification of individuals within large wildlife populations is crucial for biological studies, ecological research, and wildlife conservation. Classic computer vision techniques offer a promising direction for Animal Re-identification (Animal ReID), but their backbones' close-set nature limits their applicability and generalizability. Despite the demonstrated effectiveness of vision-language models like CLIP in re-identifying persons and vehicles, their application to Animal ReID remains limited due to unique challenges, such as the various visual representations of animals, including variations in poses and forms. To address these limitations, we leverage CLIP's cross-modal capabilities to introduce a two-stage framework, the \textbf{Indiv}idual \textbf{A}nimal \textbf{ID}entity-Driven (IndivAID) framework, specifically designed for Animal ReID. In the first stage, IndivAID trains a text description generator by extracting individual semantic information from each image, generating both image-specific and individual-specific textual descriptions that fully capture the diverse visual concepts of each individual across animal images. In the second stage, IndivAID refines its learning of visual concepts by dynamically incorporating individual-specific textual descriptions with an integrated attention module to further highlight discriminative features of individuals for Animal ReID. Evaluation against state-of-the-art methods across eight benchmark datasets and a real-world Stoat dataset demonstrates IndivAID's effectiveness and applicability. Code is available at \url{https://github.com/ywu840/IndivAID}.




Abstract:Aiming at the metro video surveillance system has not been able to effectively solve the metro crowd density estimation problem, a Metro Crowd density estimation Network (called MCNet) is proposed to automatically classify crowd density level of passengers. Firstly, an Integrating Multi-scale Attention (IMA) module is proposed to enhance the ability of the plain classifiers to extract semantic crowd texture features to accommodate to the characteristics of the crowd texture feature. The innovation of the IMA module is to fuse the dilation convolution, multiscale feature extraction and attention mechanism to obtain multi-scale crowd feature activation from a larger receptive field with lower computational cost, and to strengthen the crowds activation state of convolutional features in top layers. Secondly, a novel lightweight crowd texture feature extraction network is proposed, which can directly process video frames and automatically extract texture features for crowd density estimation, while its faster image processing speed and fewer network parameters make it flexible to be deployed on embedded platforms with limited hardware resources. Finally, this paper integrates IMA module and the lightweight crowd texture feature extraction network to construct the MCNet, and validate the feasibility of this network on image classification dataset: Cifar10 and four crowd density datasets: PETS2009, Mall, QUT and SH_METRO to validate the MCNet whether can be a suitable solution for crowd density estimation in metro video surveillance where there are image processing challenges such as high density, high occlusion, perspective distortion and limited hardware resources.




Abstract:Atrial Fibrillation (AF) is characterized by rapid, irregular heartbeats, and can lead to fatal complications such as heart failure. The disease is divided into two sub-types based on severity, which can be automatically classified through CT volumes for disease screening of severe cases. However, existing classification approaches rely on generic radiomic features that may not be optimal for the task, whilst deep learning methods tend to over-fit to the high-dimensional volume inputs. In this work, we propose a novel radiomics-informed deep-learning method, RIDL, that combines the advantages of deep learning and radiomic approaches to improve AF sub-type classification. Unlike existing hybrid techniques that mostly rely on na\"ive feature concatenation, we observe that radiomic feature selection methods can serve as an information prior, and propose supplementing low-level deep neural network (DNN) features with locally computed radiomic features. This reduces DNN over-fitting and allows local variations between radiomic features to be better captured. Furthermore, we ensure complementary information is learned by deep and radiomic features by designing a novel feature de-correlation loss. Combined, our method addresses the limitations of deep learning and radiomic approaches and outperforms state-of-the-art radiomic, deep learning, and hybrid approaches, achieving 86.9% AUC for the AF sub-type classification task. Code is available at https://github.com/xmed-lab/RIDL.




Abstract:In recent decades, neuromorphic computing aiming to imitate brains' behaviors has been developed in various fields of computer science. The Artificial Neural Network (ANN) is an important concept in Artificial Intelligence (AI). It is utilized in recognition and classification. To explore a better way to simulate obtained brain behaviors, which is fast and energy-efficient, on hardware, researchers need an advanced method such as neuromorphic computing. In this case, Spiking Neural Network (SNN) becomes an optimal choice in hardware implementation. Recent works are focusing on accelerating SNN computing. However, most accelerator solutions are based on CPU-accelerator architecture which is energy-inefficient due to the complex control flows in this structure. This paper proposes Wenquxing 22A, a low-power neuromorphic processor that combines general-purpose CPU functions and SNN to efficiently compute it with RISC-V SNN extension instructions. The main idea of Wenquxing 22A is to integrate the SNN calculation unit into the pipeline of a general-purpose CPU to achieve low-power computing with customized RISC-V SNN instructions version 1.0 (RV-SNN V1.0), Streamlined Leaky Integrate-and-Fire (LIF) model, and the binary stochastic Spike-timing-dependent-plasticity (STDP). The source code of Wenquxing 22A is released online on Gitee and GitHub. We apply Wenquxing 22A to the recognition of the MNIST dataset to make a comparison with other SNN systems. Our experiment results show that Wenquxing 22A improves the energy expenses by 5.13 times over the accelerator solution, ODIN, with approximately classification accuracy, 85.00% for 3-bit ODIN online learning, and 91.91% for 1-bit Wenquxing 22A.