RareDxR1: Autonomous Medical Reasoning for Rare Disease Diagnosis Beyond Human Annotation

Rare disease differential diagnosis is a critical yet arduous clinical task, requiring physicians to identify precise phenotypes from complex, unstructured patient symptoms and execute intricate reasoning within a vast search space. However, existing AI approaches typically rely on pipeline-based phenotype extraction or retrieval-augmented generation, which suffer from critical information loss due to predefined ontologies, retrieval bottlenecks, and a lack of diagnostic logic. To address these challenges, we introduce RareDxR1, an end-to-end reasoning-centric large language model designed for open-domain rare disease diagnosis directly from unstructured clinical notes. We design a progressive end-to-end training framework by synergizing knowledge internalization with autonomous evolutionary learning, thereby bypassing reliance on structured phenotypes and closed-set decision-making. To overcome the limitations of RAG and phenotype restriction, we enabled the deep internalization of fragmented rare-disease knowledge directly into the model's parameters. Moreover, to bridge the gap between model generation and expert reasoning, we propose Reflection-Enhanced Reasoning Sampling (RERS), a strategy that synthesizes expert-level diagnostic trajectories by learning from failures without human annotation. Additionally, we propose a dual-level curriculum reinforcement learning approach for gradually mastering rare disease diagnosis. Experimental results demonstrate that RareDxR1 achieves state-of-the-art accuracy across different benchmarks, marking a significant breakthrough in open-domain rare disease diagnosis. Our code and dataset will be publicly available.

World Models for Policy Refinement in StarCraft II

Large Language Models (LLMs) have recently shown strong reasoning and generalization capabilities, motivating their use as decision-making policies in complex environments. StarCraft II (SC2), with its massive state-action space and partial observability, is a challenging testbed. However, existing LLM-based SC2 agents primarily focus on improving the policy itself and overlook integrating a learnable, action-conditioned transition model into the decision loop. To bridge this gap, we propose StarWM, the first world model for SC2 that predicts future observations under partial observability. To facilitate learning SC2's hybrid dynamics, we introduce a structured textual representation that factorizes observations into five semantic modules, and construct SC2-Dynamics-50k, the first instruction-tuning dataset for SC2 dynamics prediction. We further develop a multi-dimensional offline evaluation framework for predicted structured observations. Offline results show StarWM's substantial gains over zero-shot baselines, including nearly 60% improvements in resource prediction accuracy and self-side macro-situation consistency. Finally, we propose StarWM-Agent, a world-model-augmented decision system that integrates StarWM into a Generate--Simulate--Refine decision loop for foresight-driven policy refinement. Online evaluation against SC2's built-in AI demonstrates consistent improvements, yielding win-rate gains of 30%, 15%, and 30% against Hard (LV5), Harder (LV6), and VeryHard (LV7), respectively, alongside improved macro-management stability and tactical risk assessment.

Enhancing Spatial Reasoning in Large Language Models for Metal-Organic Frameworks Structure Prediction

Metal-organic frameworks (MOFs) are porous crystalline materials with broad applications such as carbon capture and drug delivery, yet accurately predicting their 3D structures remains a significant challenge. While Large Language Models (LLMs) have shown promise in generating crystals, their application to MOFs is hindered by MOFs' high atomic complexity. Inspired by the success of block-wise paradigms in deep generative models, we pioneer the use of LLMs in this domain by introducing MOF-LLM, the first LLM framework specifically adapted for block-level MOF structure prediction. To effectively harness LLMs for this modular assembly task, our training paradigm integrates spatial-aware continual pre-training (CPT), structural supervised fine-tuning (SFT), and matching-driven reinforcement learning (RL). By incorporating explicit spatial priors and optimizing structural stability via Soft Adaptive Policy Optimization (SAPO), our approach substantially enhances the spatial reasoning capability of a Qwen-3 8B model for accurate MOF structure prediction. Comprehensive experiments demonstrate that MOF-LLM outperforms state-of-the-art denoising-based and LLM-based methods while exhibiting superior sampling efficiency.

Speech-Aware Long Context Pruning and Integration for Contextualized Automatic Speech Recognition

Automatic speech recognition (ASR) systems have achieved remarkable performance in common conditions but often struggle to leverage long-context information in contextualized scenarios that require domain-specific knowledge, such as conference presentations. This challenge arises primarily due to constrained model context windows and the sparsity of relevant information within extensive contextual noise. To solve this, we propose the SAP$^{2}$ method, a novel framework that dynamically prunes and integrates relevant contextual keywords in two stages. Specifically, each stage leverages our proposed Speech-Driven Attention-based Pooling mechanism, enabling efficient compression of context embeddings while preserving speech-salient information. Experimental results demonstrate state-of-the-art performance of SAP$^{2}$ on the SlideSpeech and LibriSpeech datasets, achieving word error rates (WER) of 7.71% and 1.12%, respectively. On SlideSpeech, our method notably reduces biased keyword error rates (B-WER) by 41.1% compared to non-contextual baselines. SAP$^{2}$ also exhibits robust scalability, consistently maintaining performance under extensive contextual input conditions on both datasets.

LVC: A Lightweight Compression Framework for Enhancing VLMs in Long Video Understanding

Long video understanding is a complex task that requires both spatial detail and temporal awareness. While Vision-Language Models (VLMs) obtain frame-level understanding capabilities through multi-frame input, they suffer from information loss due to the sparse sampling strategy. In contrast, Video Large Language Models (Video-LLMs) capture temporal relationships within visual features but are limited by the scarcity of high-quality video-text datasets. To transfer long video understanding capabilities to VLMs with minimal data and computational cost, we propose Lightweight Video Compression (LVC), a novel method featuring the Query-Attention Video Compression mechanism, which effectively tackles the sparse sampling problem in VLMs. By training only the alignment layer with 10k short video-text pairs, LVC significantly enhances the temporal reasoning abilities of VLMs. Extensive experiments show that LVC provides consistent performance improvements across various models, including the InternVL2 series and Phi-3.5-Vision. Notably, the InternVL2-40B-LVC achieves scores of 68.2 and 65.9 on the long video understanding benchmarks MLVU and Video-MME, respectively, with relative improvements of 14.6% and 7.7%. The enhanced models and code will be publicly available soon.