UltraSAM3: A Concept-Driven Foundation Model for Universal Ultrasound Image Segmentation

Ultrasound imaging has become increasingly widespread in clinical practice due to its portability, low cost and real-time capability, making ultrasound image segmentation important. However, ultrasound images differ substantially from CT, MRI, and other medical imaging modalities, as they are often affected by speckle noise, low contrast, acoustic shadows and ambiguous boundaries. Existing ultrasound segmentation methods are still mainly limited to task-specific models or visual-prompt-based foundation models, which are either tailored to particular tasks or require expert-provided visual prompts, making them inconvenient for flexible clinical use. To address these challenges, we propose UltraSAM3, a concept-driven foundation model for universal ultrasound image segmentation. Unlike conventional models, UltraSAM3 enables text-based target specification by adapting SAM3 to ultrasound-specific image--mask--concept triplets. The model is trained on a large-scale ultrasound segmentation corpus covering 37 public datasets and 13 anatomical categories, allowing it to align ultrasound visual patterns with clinically meaningful concepts across diverse organs and lesions. To further improve usability under realistic clinical interaction, we propose an instruction-guided agent that parses complex natural language queries into concise ultrasound concept prompts for UltraSAM3. Extensive experiments demonstrate that UltraSAM3 consistently outperforms representative concept- and text-driven biomedical segmentation models on multi-organ ultrasound benchmarks, external datasets, and visual-prompt-enhanced settings. Moreover, the agent improves segmentation robustness for complex user instructions. These results indicate that ultrasound-specific concept adaptation is effective for building generalizable and interactive ultrasound segmentation foundation models.

Spiking Neural Networks for fMRI-Based Visual Semantic Decoding

Functional magnetic resonance imaging (fMRI)-based visual decoding aims to recover visual information from measured brain activity, commonly by mapping fMRI responses into latent visual features for downstream decoding tasks. Most existing methods learn mappings from fMRI responses to visual features extracted by artificial neural networks (ANNs), yet it remains unclear whether ANN-derived features provide suitable targets for brain decoding. In this study, we investigate spiking neural network (SNN)-derived visual features as alternative targets for fMRI-based visual decoding. We compare an ANN baseline with four SNN variants from the same architectural family, which differ in their spiking dynamics. To isolate the effect of the target features, all models use the same L2-regularized linear fMRI-to-feature decoder, while only the feature vectors used as regression targets are varied. Compared with the ANN baseline, SNN-derived features exhibit stronger alignment with fMRI responses and improve visual semantic decoding performance. For instance, on the GoD dataset, SNN-derived features reduce feature-prediction error from 0.7707 to 0.0282 and improve top-1 semantic decoding accuracy from 0.1800 to 0.4400. Ablation results further indicate that both spiking neural dynamics and temporal simulation steps contribute to the observed advantage. These findings support SNN-derived features as effective brain-decodable visual representations and highlight target feature design as an important component of fMRI-based visual decoding.

Burst Spiking Neural Networks

A central goal of current Spiking Neural Network (SNN) research is to improve their accuracy toward becoming low-power alternatives to Artificial Neural Networks (ANNs). This work further argues that realizing this ambition requires improving not only accuracy but also robustness, defined as the ability to maintain correct predictions under input perturbations. We identify two key issues in existing SNN methods that undermine robustness. First, binary spiking activations can produce large activation-state changes under small perturbations. Second, the lack of effective weight constraints makes network outputs more sensitive to input variations. To this end, we propose Burst Spiking Neural Networks (BuSNNs), built upon Burst-enhanced Spiking Neurons (BSNs) and a Dynamic Weight Constraint (DWC) mechanism. BSNs incorporate burst firing to provide a graded spiking pattern. This spiking mechanism mitigates perturbation-induced transitions in activation states and thereby enhances robustness. DWC penalizes connection weights based on activation states, effectively reducing weight magnitudes and improving robustness while preserving accuracy. We provide theoretical analyses to support these robustness effects. Experimental results further show that, on smaller-scale benchmarks such as CIFAR-10, BuSNNs outperform both SNN and ANN counterparts in accuracy and robustness. On large-scale ImageNet, BuSNN with the MS ResNet-34 backbone further improves top-1 accuracy and corruption robustness over the corresponding SNN baseline by 3.18% and 2.66%, respectively. Despite using spike-based activations, BuSNNs surpass 4-bit activation-quantized ANN baselines and approach 8-bit ANN baselines on ImageNet. They also preserve SNNs' low-power advantage. This work studies the accuracy-robustness problem in SNNs, advancing their practical viability in robust and energy-efficient applications.

RareDxR1: Autonomous Medical Reasoning for Rare Disease Diagnosis Beyond Human Annotation

Rare disease differential diagnosis is a critical yet arduous clinical task, requiring physicians to identify precise phenotypes from complex, unstructured patient symptoms and execute intricate reasoning within a vast search space. However, existing AI approaches typically rely on pipeline-based phenotype extraction or retrieval-augmented generation, which suffer from critical information loss due to predefined ontologies, retrieval bottlenecks, and a lack of diagnostic logic. To address these challenges, we introduce RareDxR1, an end-to-end reasoning-centric large language model designed for open-domain rare disease diagnosis directly from unstructured clinical notes. We design a progressive end-to-end training framework by synergizing knowledge internalization with autonomous evolutionary learning, thereby bypassing reliance on structured phenotypes and closed-set decision-making. To overcome the limitations of RAG and phenotype restriction, we enabled the deep internalization of fragmented rare-disease knowledge directly into the model's parameters. Moreover, to bridge the gap between model generation and expert reasoning, we propose Reflection-Enhanced Reasoning Sampling (RERS), a strategy that synthesizes expert-level diagnostic trajectories by learning from failures without human annotation. Additionally, we propose a dual-level curriculum reinforcement learning approach for gradually mastering rare disease diagnosis. Experimental results demonstrate that RareDxR1 achieves state-of-the-art accuracy across different benchmarks, marking a significant breakthrough in open-domain rare disease diagnosis. Our code and dataset will be publicly available.

Dual-Learning based Penalized Multi-Align Clustering for Multi-View Incomplete and Disorderly Data

Multimodal feature fusion can effectively capture complex patterns in real-world data by integrating complementary information from different modalities. However, in many applications, such as boiler combustion monitoring, equipment failure, inconsistent sensor sampling frequencies, and network delays often cause missing modalities and temporal asynchrony. These issues lead to incomplete and disorderly multimodal data. To address them, previous studies have proposed several data fusion methods that align cluster centers before fusion. However, these methods have two key limitations. First, they cannot guarantee accurate sample-level alignment of data pairs. Second, they do not address significant discrepancies in data sizes across different classes, which may affect subsequent fusion performance. To address these problems, we propose a dual-learning based penalized multi-align clustering model, named DLPMAC. The dual-learning mechanism enables the model to learn prior knowledge from each modality, including semantic and structural information. This helps preserve semantic consistency and structural similarity across modalities at both local and global levels. In addition, the penalized multi-align module performs multi-to-multi data alignment through a penalty mechanism. It allows one sample to form data pairs with different samples from other modalities, thereby improving data-pair alignment accuracy. The penalty mechanism also prevents data aggregation, avoiding the case where excessive samples are linked to a single sample. Experimental results demonstrate the effectiveness of DLPMAC in addressing data alignment and fusion challenges from both sampling and clustering perspectives.

Decoding Multimodal Cues: Unveiling the Implicit Meaning Behind Hateful Videos

Hateful videos have become prevalent on online platforms, highlighting an urgent need for effective detection. However, existing studies primarily focus on binary classification and fail to provide contextual rationales that reveal the implicit meanings behind these judgments, significantly undermining model explainability. To fill this gap, we aim to achieve explainable hateful video detection, enabling models to provide contextual rationales that integrate relevant evidence and logical reasoning alongside decisions. This approach can comprehensively enhance the understanding of video content and the explainability of the decision-making process. We first introduce two datasets, Ex-HateMM and Ex-ImpliHateVid, for explainable hateful video detection. Each dataset provides fine-grained annotations of multimodal harmful elements, along with contextual rationales. We then propose an Information Augmentation and Reasoning Enhancement (IARE) framework designed for explainable detection. The framework employs an information augmentation phase that leverages the multimodal chain-of-thought to integrate harmful elements, thereby enriching rationale evidence. Additionally, IARE incorporates a reasoning enhancement phase, in which Direct Preference Optimization guides the model toward correct reasoning paths and away from incorrect ones, thereby improving the logical coherence of its justifications. We conduct extensive experiments on the two datasets, comparing multiple baselines with our proposed IARE framework. The results demonstrate that IARE achieves state-of-the-art performance while also generating accurate rationales.

Shift-Dependent Asymmetry: Orthogonal Inverse Low-Rank Adaptation for Federated Medical Segmentation

Low-Rank Adaptation (LoRA) enables efficient federated fine-tuning of segmentation foundation models for medical imaging. However, most federated LoRA methods adopt a uniform aggregation rule, which breaks under the encoder-decoder asymmetry in medical segmentation: the encoder is dominated by appearance shifts, while the decoder is dominated by supervision variations. This mismatch entangles shared anatomy with site-specific biases and harms generalization. To address this, we propose Inverse Asymmetric Tuning (IAT). IAT aligns adaptation with heterogeneity sources by personalizing module-specific components in the encoder to absorb appearance shifts and in the decoder to accommodate site-dependent supervision, while retaining a shared pathway for transferable consensus. However, structural separation alone is insufficient under LoRA's bilinear parameterization, where multiplicative coupling can still cause site-specific updates to leak into the shared direction. We therefore introduce a Subspace Orthogonality Regularizer that penalizes shared-local collinearity in the effective update space, mitigating leakage without extra communication. Experiments show consistent improvements over strong federated LoRA and parameter-efficient FL baselines.

COLLIE: Guiding Skill Discovery in Semantically Coherent Latent Space

Unsupervised skill discovery (USD) aims to learn diverse behaviors without reward functions, but often results in task-irrelevant or hazardous behaviors due to uniform exploration. Guided skill discovery (GSD) addresses this issue by incorporating human intent to focus exploration on meaningful regions. However, existing GSD methods typically require training additional guidance models, and rely on pre-defined rules or expert demonstration, which can be ineffective under sparse, online-collected human feedback. To overcome this, we propose COLLIE, a GSD framework that leverages dense unsupervised data to construct a semantically coherent skill latent space. This latent space is well-structured, enabling reliable guidance with sparse online feedback. Moreover, its semantic coherence property enables training-free construction of guidance signals, eliminating the need for additional model training beyond skill learning. Theoretical analysis justifies the effectiveness of our training-free guidance signal, while experiments across diverse state-based and pixel-based tasks show that COLLIE learns diverse, human-aligned skills, avoids hazardous behaviors, and achieves superior downstream performance with minimal human feedback.

Distinguishing Right from Wrong in Debates: Attribution Analysis of Chinese Harmful Memes

Research on harmful meme detection has garnered significant attention, resulting in the development of numerous datasets and methods. However, progress in detecting Chinese harmful memes lags considerably, primarily due to two challenges: first, accurately assessing a meme's harmfulness depends heavily on understanding deep cultural context; second, many memes are semantically ambiguous, making harmfulness highly subjective. To address these issues, we focus on the interpretable detection of Chinese harmful memes by constructing the first Chinese harmful meme explanation dataset, Ex-ToxiCN-MM. This dataset offers opposing interpretations, categorized as "harmful" and "non-harmful", for each meme, aiming to rigorously evaluate a model's ability to discern and comprehend ambiguous, culturally grounded content. We built a specialized knowledge base of Chinese cultural concepts and offensive vocabulary to supply models with essential prior knowledge (C-HarmKB). To address the ambiguity and lack of background knowledge in meme attribution, we have developed a comprehensive attribution analysis framework, RIKE, which includes an Attribution Knowledge Enhancement module (AKE) and a Relative Intent Reasoning module (RIR). Extensive quantitative and qualitative experiments demonstrate that our method outperforms mainstream baseline models across multiple metrics in the task of attributing harmful memes in Chinese. The code, Ex-ToxiCN-MM dataset, and Chinese Harmful Semantic Knowledge Base (C-HarmKB) involved in this study have been open-sourced at https://github.com/wimiw123/Ex-ToxiCN-MM

Harder to Defend: Towards Chinese Toxicity Attacks via Implicit Enhancement and Obfuscation Rewriting

Large language models (LLMs) require robust toxicity evaluation beyond explicit wording. This setting remains underexplored in Chinese, where toxicity may combine semantic indirectness with surface obfuscation. We introduce Chinese Implicit Toxicity Attack (CITA), a controlled red-team evaluation and defense-data generation framework, not a deployable evasion tool. CITA uses three stages: (i) Harmful Intent Learning, (ii) Implicit Toxicity Enhancement, and (iii) Obfuscation Variant Rewriting, to preserve harmful intent, increase implicitness, and add controlled surface variants. On CITA-generated evaluation samples, the seven tested detectors exhibit substantial missed-detection risks, reaching an average ASR of 69.48%; human evaluation further confirms preserved harmfulness and increased implicitness/evasiveness. As a downstream defense application, we fine-tune a Chinese Implicit Toxicity Defense model (CITD) with CITA-generated red-team data, showing that such data can improve robustness through additional training.