Towards Reliable Stain Transfer: An Iterative Data-Model Co-Optimization Framework Based on Multimodal Expert-Guided Assessment

Histopathological examination primarily relies on hematoxylin and eosin (H&E) and immunohistochemistry (IHC) staining. Although IHC provides critical molecular information, it is costly and requires specialized expertise. Stain transfer provides an efficient alternative by computationally generating IHC from H&E images, but remains challenged by unified and interpretable modeling for heterogeneous biomarkers under pixel-unaligned supervision. We propose DMCoStain, a novel Data-Model Co-optimization framework for Stain transfer. It iteratively co-refines training data and model capability, improving staining accuracy and interpretability in both pathological and structural consistency. To refine training data in a clinically meaningful manner, it incorporates the Multimodal Expert-Guided Finer Selection (MEGFS) strategy, built upon a pioneering IHC-positive-expression (IPE) vision-language model (VLM) that emulates pathologist reasoning. To support MEGFS, we construct ImmunoInstruction, the first large-scale IPE instruction-following dataset with 150K VQA samples. Extensive experiments on multiple tissues and biomarkers demonstrate that DMCoStain achieves state-of-the-art (SOTA) accuracy. This paradigm offers strong practical value, and MEGFS also functions as a specialized evaluation tool for future model development. Dataset, code, and more details are in https://github.com/SikangSHU/DMCoStain.

Focus Is All You Need: Adaptive Goal-aware Attention Orchestration for Multi-Agent Graph Systems

Large language models (LLMs) enable autonomous agents for reasoning, planning, and tool use. Recent systems increasingly organize these agents as graphs of specialized, interconnected nodes. Although graph-based orchestration supports flexible decomposition and coordination, it creates a key challenge: \textbf{attention allocation}. As workflows grow, existing approaches often execute graph components uniformly, wasting resources on irrelevant or low-impact tasks. We introduce \textbf{Attention Orchestration}, a paradigm that extends Transformer-style attention from token representations to workflow-level agent coordination. Our framework, \textbf{Adaptive Goal-aware Attention Orchestration (AGAO)}, dynamically estimates agent importance based on user objectives, graph dependencies, and computational constraints. AGAO combines three components: (1) goal-aware attention, measuring semantic relevance between user goals and agent capabilities; (2) topology-aware attention, modeling structural dependencies in agent graphs; and (3) resource-aware attention, allocating budgets and execution priorities across heterogeneous agents. Together, these mechanisms transform static agent graphs into adaptive systems that focus computation on goal-critical reasoning paths. Experiments across diverse multi-agent workloads show that AGAO improves task effectiveness while reducing unnecessary computation, latency, and token consumption compared with existing graph-based execution strategies. Our work establishes \textbf{Attention Engineering} as a direction for scalable, intelligent multi-agent systems. Code: https://github.com/MingzhouFan97/AGAO.

Spiking Neural Networks for fMRI-Based Visual Semantic Decoding

Functional magnetic resonance imaging (fMRI)-based visual decoding aims to recover visual information from measured brain activity, commonly by mapping fMRI responses into latent visual features for downstream decoding tasks. Most existing methods learn mappings from fMRI responses to visual features extracted by artificial neural networks (ANNs), yet it remains unclear whether ANN-derived features provide suitable targets for brain decoding. In this study, we investigate spiking neural network (SNN)-derived visual features as alternative targets for fMRI-based visual decoding. We compare an ANN baseline with four SNN variants from the same architectural family, which differ in their spiking dynamics. To isolate the effect of the target features, all models use the same L2-regularized linear fMRI-to-feature decoder, while only the feature vectors used as regression targets are varied. Compared with the ANN baseline, SNN-derived features exhibit stronger alignment with fMRI responses and improve visual semantic decoding performance. For instance, on the GoD dataset, SNN-derived features reduce feature-prediction error from 0.7707 to 0.0282 and improve top-1 semantic decoding accuracy from 0.1800 to 0.4400. Ablation results further indicate that both spiking neural dynamics and temporal simulation steps contribute to the observed advantage. These findings support SNN-derived features as effective brain-decodable visual representations and highlight target feature design as an important component of fMRI-based visual decoding.

Dual-Prior Guided Null-Space Learning with Mixture-of-Splines for Arbitrary Medical Slice Super-Resolution

Arbitrary slice super-resolution reconstructs isotropic volumes from anisotropic clinical acquisitions by synthesizing intermediate slices at arbitrary scales. However, treating this ill-posed inverse problem as unconstrained residual-based regression risks hallucinating anatomically implausible structures or altering the originally observed data. To address both concerns, this paper presents the Dual-Prior Null-space Learning (DP-NSL) framework, which reformulates the task as a constrained recovery process guided by two complementary priors. A Measurement-Consistent Projection (MCP) enforces a Deterministic Observation Prior: the reconstruction undergoes an exact orthogonal projection that reproduces every acquired slice with zero error, confining all learned details to the unobservable null space. Within this null space, a Mixture-of-Splines (MoS) module imposes a Geometric Continuity Prior by dynamically mixing B-spline experts of different analytic orders, allowing each anatomical region to be modeled with a content-aware level of continuity. To promote spatial coherence, a Local Spatial Consistency Decoder (LSCD) further injects local inductive bias. Experiments on three CT and one MRI benchmark show that DP-NSL outperforms existing approaches while strictly preserving measurement consistency. Code is available at https://github.com/DeepMed-Lab-ECNU/Medical-Image-Reconstruction.

Seeing Without Exposing: Adaptive Privacy Control for Open-World, Context-Hungry MLLMs

Multimodal large language models (MLLMs) have raised new privacy challenges. On the data side, user-provided inputs often include unpredictable sensitive information; while on the downstream task side, model reasoning depends on rich visual context that may itself be privacy-sensitive. Existing privacy protection methods, however, rely on predefined sensitive categories and fixed obfuscation strategies, struggling to tackle such challenges in MLLMs. To address this dilemma, we propose Anchored Privacy Drifting (APD), a training-free method that drifts privacy-sensitive elements toward semantically equivalent alternatives while anchoring contextual cues to the source image. To systematically evaluate this dual objective of privacy protection and contextual preservation, we introduce AdaptShield, a comprehensive benchmark covering 22 privacy categories, which combines conventional privacy metrics with MLLM-based assessments of contextual utility. Extensive experiments show that our method achieves balanced improvements in both privacy sanitization and content retention, with average gains of 10.4% on textual categories and 8.5% under MLLM-based evaluation across four MLLM series, i.e., Qwen2.5, Qwen3, InternVL3, and InternVL3.5.

When Recovery Matters: The Blind Spot of Surrogate Privacy in MLLM Editing

Multimodal Large Language Models (MLLMs) enable flexible instruction-driven image editing, but privacy risks arise when user images expose diverse and user-specific private content. Canonical privacy protection strategies typically substitute sensitive regions with surrogate content before cloud editing. Yet, the resulting output is often an edited surrogate rather than the desired edited source image, neglecting the local recovery in both design and evaluation scope. To this end, we introduce SPPE (Surrogate-based Privacy-Preserving Editing), the first recovery-oriented benchmark covering 36 fine-grained privacy categories and 65 editing instructions. It defines two complementary tasks: 1) editability assessment, which estimates before cloud interaction whether a surrogate can induce an edit consistent with the original image; and 2) surrogate-to-source edit recovery, which evaluates whether the edited surrogate can be transferred back to the private source with the edit effect preserved. We address each task with a dedicated method: ERMA predicts surrogate editability through instruction-aware multimodal relation modeling, while \method performs cycle-consistent recovery by using the surrogate editing pair as visual edit evidence and the source image as a source-preserving anchor. Experiments on SPPE and InstructPix2Pix show consistent improvements on both tasks. For editability assessment, ERMA improves over the best-performing baselines by 13.9% in SRCC and 12.3% in PLCC. For surrogate-to-source edit recovery, C2E-S2SER outperforms SOER across all 8 source integrity and edit consistency metrics on SPPE.

How Can Reinforcement Learning Achieve Expert-level Placement?

Chip placement is a critical step in physical design. While reinforcement learning (RL)-based methods have recently emerged, their training primarily focuses on wirelength optimization, and therefore often fail to achieve expert-quality layouts. We identify the reward design as the primary cause for the performance gap with experts, and instead of formalizing intricate processes, we circumvent this by directly learning from expert layouts to derive a reward model. Our approach starts from the final expert layouts to infer step-by-step expert trajectories. Using these trajectories as demonstrations or preferences, we train a model that captures the latent implicit rewards in expert results. Experiments show that our framework can efficiently learn from even a single design and generalize well to unseen cases.

FlowPlace: Flow Matching for Chip Placement

Chip placement plays an important role in physical design. While generative models like diffusion models offer promising learning-based solutions, current methods have the following limitations: they use random synthetic data for pre-training, require long sampling times, and often result in overlaps due to their dependence on gradient-based solvers during the sampling process. To overcome these issues, we propose FlowPlace, which features mask-guided synthetic data generation, flow-based efficient training with flexible prior injection, and hard constraint sampling for overlap-free layouts. Experiments on OpenROAD and ICCAD 2015 benchmarks show FlowPlace achieves better PPA metrics, 10-50$\times$ faster sampling efficiency, and zero overlaps.

DA-PTQ: Drift-Aware Post-Training Quantization for Efficient Vision-Language-Action Models

Vision-Language-Action models (VLAs) have demonstrated strong potential for embodied AI, yet their deployment on resource-limited robots remains challenging due to high memory and computational demands. While Post-Training Quantization (PTQ) provides an efficient solution, directly applying PTQ to VLAs often results in severe performance degradation during sequential control. We identify temporal error accumulation as a key factor, where quantization perturbations at the vision-language-to-action interface are progressively amplified, leading to kinematic drift in executed trajectories. To address this issue, we propose Drift-Aware Post-Training Quantization (DA-PTQ), which formulates quantization as a drift-aware optimization problem over sequential decision processes. DA-PTQ consists of two components: (1) Cross-Space Representation Compensation, which mitigates structured distortions between multimodal representations and action space to improve action consistency, and (2) Motion-Driven Mixed-Precision Allocation, which assigns bit-widths by minimizing trajectory-level motion errors. Extensive experiments show that DA-PTQ significantly reduces kinematic drift and achieves comparable performance to full-precision models under low-bit settings, enabling practical deployment of VLAs on resource-limited robotic platforms.

Controllable and Verifiable Tool-Use Data Synthesis for Agentic Reinforcement Learning

Existing synthetic tool-use corpora are primarily designed for offline supervised fine-tuning, yet reinforcement learning (RL) requires executable environments that support reward-checkable online rollouts. We propose COVERT, a two-stage pipeline that first generates reliable base tool-use trajectories through self-evolving synthesis with multi-level validation, and then applies oracle-preserving augmentations that systematically increase environmental complexity. These augmentations introduce distractor tools, indirect or ambiguous user queries, and noisy, multi-format, or erroneous tool outputs, while strictly preserving oracle tool calls and final answers as ground truth. This design enables automatic reward computation via reference matching for standard cases and lightweight judge-assisted verification for special behaviors such as error detection, supporting RL optimization of tool-calling policies. On Qwen2.5-Instruct-14B, COVERT-RL improves overall accuracy on BFCL v3 from 56.5 to 59.9 and on ACEBench from 53.0 to 59.3, with minimal regressions on general-ability benchmarks; when stacked on SFT, it further reaches 62.1 and 61.8, confirming additive gains. These results suggest that oracle-preserving synthetic environments offer a practical RL refinement stage, complementary to SFT, for improving tool-use robustness under ambiguity and unreliable tool feedback.