A Cascaded Approach for ultraly High Performance Lesion Detection and False Positive Removal in Liver CT Scans

Liver cancer has high morbidity and mortality rates in the world. Multi-phase CT is a main medical imaging modality for detecting/identifying and diagnosing liver tumors. Automatically detecting and classifying liver lesions in CT images have the potential to improve the clinical workflow. This task remains challenging due to liver lesions' large variations in size, appearance, image contrast, and the complexities of tumor types or subtypes. In this work, we customize a multi-object labeling tool for multi-phase CT images, which is used to curate a large-scale dataset containing 1,631 patients with four-phase CT images, multi-organ masks, and multi-lesion (six major types of liver lesions confirmed by pathology) masks. We develop a two-stage liver lesion detection pipeline, where the high-sensitivity detecting algorithms in the first stage discover as many lesion proposals as possible, and the lesion-reclassification algorithms in the second stage remove as many false alarms as possible. The multi-sensitivity lesion detection algorithm maximizes the information utilization of the individual probability maps of segmentation, and the lesion-shuffle augmentation effectively explores the texture contrast between lesions and the liver. Independently tested on 331 patient cases, the proposed model achieves high sensitivity and specificity for malignancy classification in the multi-phase contrast-enhanced CT (99.2%, 97.1%, diagnosis setting) and in the noncontrast CT (97.3%, 95.7%, screening setting).

An Efficient Learning-Based Solver for Two-Stage DC Optimal Power Flow with Feasibility Guarantees

In this paper, we consider the scenario-based two-stage stochastic DC optimal power flow (OPF) problem for optimal and reliable dispatch when the load is facing uncertainty. Although this problem is a linear program, it remains computationally challenging to solve due to the large number of scenarios needed to accurately represent the uncertainties. To mitigate the computational issues, many techniques have been proposed to approximate the second-stage decisions so they can dealt more efficiently. The challenge of finding good policies to approximate the second-stage decisions is that these solutions need to be feasible, which has been difficult to achieve with existing policies. To address these challenges, this paper proposes a learning method to solve the two-stage problem in a more efficient and optimal way. A technique called the gauge map is incorporated into the learning architecture design to guarantee the learned solutions' feasibility to the network constraints. Namely, we can design policies that are feed forward functions that only output feasible solutions. Simulation results on standard IEEE systems show that, compared to iterative solvers and the widely used affine policy, our proposed method not only learns solutions of good quality but also accelerates the computation by orders of magnitude.

Devil is in the Queries: Advancing Mask Transformers for Real-world Medical Image Segmentation and Out-of-Distribution Localization

Real-world medical image segmentation has tremendous long-tailed complexity of objects, among which tail conditions correlate with relatively rare diseases and are clinically significant. A trustworthy medical AI algorithm should demonstrate its effectiveness on tail conditions to avoid clinically dangerous damage in these out-of-distribution (OOD) cases. In this paper, we adopt the concept of object queries in Mask Transformers to formulate semantic segmentation as a soft cluster assignment. The queries fit the feature-level cluster centers of inliers during training. Therefore, when performing inference on a medical image in real-world scenarios, the similarity between pixels and the queries detects and localizes OOD regions. We term this OOD localization as MaxQuery. Furthermore, the foregrounds of real-world medical images, whether OOD objects or inliers, are lesions. The difference between them is less than that between the foreground and background, possibly misleading the object queries to focus redundantly on the background. Thus, we propose a query-distribution (QD) loss to enforce clear boundaries between segmentation targets and other regions at the query level, improving the inlier segmentation and OOD indication. Our proposed framework is tested on two real-world segmentation tasks, i.e., segmentation of pancreatic and liver tumors, outperforming previous state-of-the-art algorithms by an average of 7.39% on AUROC, 14.69% on AUPR, and 13.79% on FPR95 for OOD localization. On the other hand, our framework improves the performance of inlier segmentation by an average of 5.27% DSC when compared with the leading baseline nnUNet.

Meta-information-aware Dual-path Transformer for Differential Diagnosis of Multi-type Pancreatic Lesions in Multi-phase CT

Pancreatic cancer is one of the leading causes of cancer-related death. Accurate detection, segmentation, and differential diagnosis of the full taxonomy of pancreatic lesions, i.e., normal, seven major types of lesions, and other lesions, is critical to aid the clinical decision-making of patient management and treatment. However, existing works focus on segmentation and classification for very specific lesion types (PDAC) or groups. Moreover, none of the previous work considers using lesion prevalence-related non-imaging patient information to assist the differential diagnosis. To this end, we develop a meta-information-aware dual-path transformer and exploit the feasibility of classification and segmentation of the full taxonomy of pancreatic lesions. Specifically, the proposed method consists of a CNN-based segmentation path (S-path) and a transformer-based classification path (C-path). The S-path focuses on initial feature extraction by semantic segmentation using a UNet-based network. The C-path utilizes both the extracted features and meta-information for patient-level classification based on stacks of dual-path transformer blocks that enhance the modeling of global contextual information. A large-scale multi-phase CT dataset of 3,096 patients with pathology-confirmed pancreatic lesion class labels, voxel-wise manual annotations of lesions from radiologists, and patient meta-information, was collected for training and evaluations. Our results show that our method can enable accurate classification and segmentation of the full taxonomy of pancreatic lesions, approaching the accuracy of the radiologist's report and significantly outperforming previous baselines. Results also show that adding the common meta-information, i.e., gender and age, can boost the model's performance, thus demonstrating the importance of meta-information for aiding pancreatic disease diagnosis.

Towards a Single Unified Model for Effective Detection, Segmentation, and Diagnosis of Eight Major Cancers Using a Large Collection of CT Scans

Human readers or radiologists routinely perform full-body multi-organ multi-disease detection and diagnosis in clinical practice, while most medical AI systems are built to focus on single organs with a narrow list of a few diseases. This might severely limit AI's clinical adoption. A certain number of AI models need to be assembled non-trivially to match the diagnostic process of a human reading a CT scan. In this paper, we construct a Unified Tumor Transformer (UniT) model to detect (tumor existence and location) and diagnose (tumor characteristics) eight major cancer-prevalent organs in CT scans. UniT is a query-based Mask Transformer model with the output of multi-organ and multi-tumor semantic segmentation. We decouple the object queries into organ queries, detection queries and diagnosis queries, and further establish hierarchical relationships among the three groups. This clinically-inspired architecture effectively assists inter- and intra-organ representation learning of tumors and facilitates the resolution of these complex, anatomically related multi-organ cancer image reading tasks. UniT is trained end-to-end using a curated large-scale CT images of 10,042 patients including eight major types of cancers and occurring non-cancer tumors (all are pathology-confirmed with 3D tumor masks annotated by radiologists). On the test set of 631 patients, UniT has demonstrated strong performance under a set of clinically relevant evaluation metrics, substantially outperforming both multi-organ segmentation methods and an assembly of eight single-organ expert models in tumor detection, segmentation, and diagnosis. Such a unified multi-cancer image reading model (UniT) can significantly reduce the number of false positives produced by combined multi-system models. This moves one step closer towards a universal high-performance cancer screening tool.

An Electromagnetic-Information-Theory Based Model for Efficient Characterization of MIMO Systems in Complex Space

It is the pursuit of a multiple-input-multiple-output (MIMO) system to approach and even break the limit of channel capacity. However, it is always a big challenge to efficiently characterize the MIMO systems in complex space and get better propagation performance than the conventional MIMO systems considering only free space, which is important for guiding the power and phase allocation of antenna units. In this manuscript, an Electromagnetic-Information-Theory (EMIT) based model is developed for efficient characterization of MIMO systems in complex space. The group-T-matrix-based multiple scattering fast algorithm, the mode-decomposition-based characterization method, and their joint theoretical framework in complex space are discussed. Firstly, key informatics parameters in free electromagnetic space based on a dyadic Green's function are derived. Next, a novel group-T-matrix-based multiple scattering fast algorithm is developed to describe a representative inhomogeneous electromagnetic space. All the analytical results are validated by simulations. In addition, the complete form of the EMIT-based model is proposed to derive the informatics parameters frequently used in electromagnetic propagation, through integrating the mode analysis method with the dyadic Green's function matrix. Finally, as a proof-or-concept, microwave anechoic chamber measurements of a cylindrical array is performed, demonstrating the effectiveness of the EMIT-based model. Meanwhile, a case of image transmission with limited power is presented to illustrate how to use this EMIT-based model to guide the power and phase allocation of antenna units for real MIMO applications.

A deep local attention network for pre-operative lymph node metastasis prediction in pancreatic cancer via multiphase CT imaging

Lymph node (LN) metastasis status is one of the most critical prognostic and cancer staging factors for patients with resectable pancreatic ductal adenocarcinoma (PDAC), or in general, for any types of solid malignant tumors. Preoperative prediction of LN metastasis from non-invasive CT imaging is highly desired, as it might be straightforwardly used to guide the following neoadjuvant treatment decision and surgical planning. Most studies only capture the tumor characteristics in CT imaging to implicitly infer LN metastasis and very few work exploit direct LN's CT imaging information. To the best of our knowledge, this is the first work to propose a fully-automated LN segmentation and identification network to directly facilitate the LN metastasis status prediction task. Nevertheless LN segmentation/detection is very challenging since LN can be easily confused with other hard negative anatomic structures (e.g., vessels) from radiological images. We explore the anatomical spatial context priors of pancreatic LN locations by generating a guiding attention map from related organs and vessels to assist segmentation and infer LN status. As such, LN segmentation is impelled to focus on regions that are anatomically adjacent or plausible with respect to the specific organs and vessels. The metastasized LN identification network is trained to classify the segmented LN instances into positives or negatives by reusing the segmentation network as a pre-trained backbone and padding a new classification head. More importantly, we develop a LN metastasis status prediction network that combines the patient-wise aggregation results of LN segmentation/identification and deep imaging features extracted from the tumor region. Extensive quantitative nested five-fold cross-validation is conducted on a discovery dataset of 749 patients with PDAC.

FedTADBench: Federated Time-Series Anomaly Detection Benchmark

Time series anomaly detection strives to uncover potential abnormal behaviors and patterns from temporal data, and has fundamental significance in diverse application scenarios. Constructing an effective detection model usually requires adequate training data stored in a centralized manner, however, this requirement sometimes could not be satisfied in realistic scenarios. As a prevailing approach to address the above problem, federated learning has demonstrated its power to cooperate with the distributed data available while protecting the privacy of data providers. However, it is still unclear that how existing time series anomaly detection algorithms perform with decentralized data storage and privacy protection through federated learning. To study this, we conduct a federated time series anomaly detection benchmark, named FedTADBench, which involves five representative time series anomaly detection algorithms and four popular federated learning methods. We would like to answer the following questions: (1)How is the performance of time series anomaly detection algorithms when meeting federated learning? (2) Which federated learning method is the most appropriate one for time series anomaly detection? (3) How do federated time series anomaly detection approaches perform on different partitions of data in clients? Numbers of results as well as corresponding analysis are provided from extensive experiments with various settings. The source code of our benchmark is publicly available at https://github.com/fanxingliu2020/FedTADBench.

SnapshotNet: Self-supervised Feature Learning for Point Cloud Data Segmentation Using Minimal Labeled Data

Manually annotating complex scene point cloud datasets is both costly and error-prone. To reduce the reliance on labeled data, a new model called SnapshotNet is proposed as a self-supervised feature learning approach, which directly works on the unlabeled point cloud data of a complex 3D scene. The SnapshotNet pipeline includes three stages. In the snapshot capturing stage, snapshots, which are defined as local collections of points, are sampled from the point cloud scene. A snapshot could be a view of a local 3D scan directly captured from the real scene, or a virtual view of such from a large 3D point cloud dataset. Snapshots could also be sampled at different sampling rates or fields of view (FOVs), thus multi-FOV snapshots, to capture scale information from the scene. In the feature learning stage, a new pre-text task called multi-FOV contrasting is proposed to recognize whether two snapshots are from the same object or not, within the same FOV or across different FOVs. Snapshots go through two self-supervised learning steps: the contrastive learning step with both part and scale contrasting, followed by a snapshot clustering step to extract higher level semantic features. Then a weakly-supervised segmentation stage is implemented by first training a standard SVM classifier on the learned features with a small fraction of labeled snapshots. The trained SVM is used to predict labels for input snapshots and predicted labels are converted into point-wise label assignments for semantic segmentation of the entire scene using a voting procedure. The experiments are conducted on the Semantic3D dataset and the results have shown that the proposed method is capable of learning effective features from snapshots of complex scene data without any labels. Moreover, the proposed method has shown advantages when comparing to the SOA method on weakly-supervised point cloud semantic segmentation.

A free lunch from ViT:Adaptive Attention Multi-scale Fusion Transformer for Fine-grained Visual Recognition

Learning subtle representation about object parts plays a vital role in fine-grained visual recognition (FGVR) field. The vision transformer (ViT) achieves promising results on computer vision due to its attention mechanism. Nonetheless, with the fixed size of patches in ViT, the class token in deep layer focuses on the global receptive field and cannot generate multi-granularity features for FGVR. To capture region attention without box annotations and compensate for ViT shortcomings in FGVR, we propose a novel method named Adaptive attention multi-scale Fusion Transformer (AFTrans). The Selective Attention Collection Module (SACM) in our approach leverages attention weights in ViT and filters them adaptively to correspond with the relative importance of input patches. The multiple scales (global and local) pipeline is supervised by our weights sharing encoder and can be easily trained end-to-end. Comprehensive experiments demonstrate that AFTrans can achieve SOTA performance on three published fine-grained benchmarks: CUB-200-2011, Stanford Dogs and iNat2017.