Unsupervised Adaptation from FDG to PSMA PET/CT for 3D Lesion Detection under Label Shift

In this work, we propose an unsupervised domain adaptation (UDA) framework for 3D volumetric lesion detection that adapts a detector trained on labeled FDG PET/CT to unlabeled PSMA PET/CT. Beyond covariate shift, cross tracer adaptation also exhibits label shift in both lesion size composition and the number of lesions per subject. We introduce self-training with two mechanisms that explicitly model and compensate for this label shift. First, we adaptively adjust the detection anchor shapes by re-estimating target domain box scales from selected pseudo labels and updating anchors with an exponential moving average. This increases positive anchor coverage for small PSMA lesions and stabilizes box regression. Second, instead of a fixed confidence threshold for pseudo-label selection, we allocate size bin-wise quotas according to the estimated target domain histogram over lesion volumes. The self-training alternates between supervised learning with prior-guided pseudo labeling on PSMA and supervised learning on labeled FDG. On AutoPET 2024, adapting from 501 labeled FDG studies to 369 $^{18}$F-PSMA studies, the proposed method improves both AP and FROC over the source-only baseline and conventional self-training without label-shift mitigation, indicating that modeling target lesion prevalence and size composition is an effective path to robust cross-tracer detection.

GLEAM: A Multimodal Imaging Dataset and HAMM for Glaucoma Classification

We propose glaucoma lesion evaluation and analysis with multimodal imaging (GLEAM), the first publicly available tri-modal glaucoma dataset comprising scanning laser ophthalmoscopy fundus images, circumpapillary OCT images, and visual field pattern deviation maps, annotated with four disease stages, enabling effective exploitation of multimodal complementary information and facilitating accurate diagnosis and treatment across disease stages. To effectively integrate cross-modal information, we propose hierarchical attentive masked modeling (HAMM) for multimodal glaucoma classification. Our framework employs hierarchical attentive encoders and light decoders to focus cross-modal representation learning on the encoder.

DECADE: A Temporally-Consistent Unsupervised Diffusion Model for Enhanced Rb-82 Dynamic Cardiac PET Image Denoising

Rb-82 dynamic cardiac PET imaging is widely used for the clinical diagnosis of coronary artery disease (CAD), but its short half-life results in high noise levels that degrade dynamic frame quality and parametric imaging. The lack of paired clean-noisy training data, rapid tracer kinetics, and frame-dependent noise variations further limit the effectiveness of existing deep learning denoising methods. We propose DECADE (A Temporally-Consistent Unsupervised Diffusion model for Enhanced Rb-82 CArdiac PET DEnoising), an unsupervised diffusion framework that generalizes across early- to late-phase dynamic frames. DECADE incorporates temporal consistency during both training and iterative sampling, using noisy frames as guidance to preserve quantitative accuracy. The method was trained and evaluated on datasets acquired from Siemens Vision 450 and Siemens Biograph Vision Quadra scanners. On the Vision 450 dataset, DECADE consistently produced high-quality dynamic and parametric images with reduced noise while preserving myocardial blood flow (MBF) and myocardial flow reserve (MFR). On the Quadra dataset, using 15%-count images as input and full-count images as reference, DECADE outperformed UNet-based and other diffusion models in image quality and K1/MBF quantification. The proposed framework enables effective unsupervised denoising of Rb-82 dynamic cardiac PET without paired training data, supporting clearer visualization while maintaining quantitative integrity.

Osmosis Distillation: Model Hijacking with the Fewest Samples

Transfer learning is devised to leverage knowledge from pre-trained models to solve new tasks with limited data and computational resources. Meanwhile, dataset distillation has emerged to synthesize a compact dataset that preserves critical information from the original large dataset. Therefore, a combination of transfer learning and dataset distillation offers promising performance in evaluations. However, a non-negligible security threat remains undiscovered in transfer learning using synthetic datasets generated by dataset distillation methods, where an adversary can perform a model hijacking attack with only a few poisoned samples in the synthetic dataset. To reveal this threat, we propose Osmosis Distillation (OD) attack, a novel model hijacking strategy that targets deep learning models using the fewest samples. Comprehensive evaluations on various datasets demonstrate that the OD attack attains high attack success rates in hidden tasks while preserving high model utility in original tasks. Furthermore, the distilled osmosis set enables model hijacking across diverse model architectures, allowing model hijacking in transfer learning with considerable attack performance and model utility. We argue that awareness of using third-party synthetic datasets in transfer learning must be raised.

Adaptive-Boundary-Clipping GRPO: Ensuring Bounded Ratios for Stable and Generalizable Training

Group Relative Policy Optimization (GRPO) has emerged as a popular algorithm for reinforcement learning with large language models (LLMs). However, upon analyzing its clipping mechanism, we argue that it is suboptimal in certain scenarios. With appropriate modifications, GRPO can be significantly enhanced to improve both flexibility and generalization. To this end, we propose Adaptive-Boundary-Clipping GRPO (ABC-GRPO), an asymmetric and adaptive refinement of the original GRPO framework. We demonstrate that ABC-GRPO achieves superior performance over standard GRPO on mathematical reasoning tasks using the Qwen3 LLMs. Moreover, ABC-GRPO maintains substantially higher entropy throughout training, thereby preserving the model's exploration capacity and mitigating premature convergence. The implementation code is available online to ease reproducibility https://github.com/chi2liu/ABC-GRPO.

Fraud Detection Through Large-Scale Graph Clustering with Heterogeneous Link Transformation

Collaborative fraud, where multiple fraudulent accounts coordinate to exploit online payment systems, poses significant challenges due to the formation of complex network structures. Traditional detection methods that rely solely on high-confidence identity links suffer from limited coverage, while approaches using all available linkages often result in fragmented graphs with reduced clustering effectiveness. In this paper, we propose a novel graph-based fraud detection framework that addresses the challenge of large-scale heterogeneous graph clustering through a principled link transformation approach. Our method distinguishes between \emph{hard links} (high-confidence identity relationships such as phone numbers, credit cards, and national IDs) and \emph{soft links} (behavioral associations including device fingerprints, cookies, and IP addresses). We introduce a graph transformation technique that first identifies connected components via hard links, merges them into super-nodes, and then reconstructs a weighted soft-link graph amenable to efficient embedding and clustering. The transformed graph is processed using LINE (Large-scale Information Network Embedding) for representation learning, followed by HDBSCAN (Hierarchical Density-Based Spatial Clustering of Applications with Noise) for density-based cluster discovery. Experiments on a real-world payment platform dataset demonstrate that our approach achieves significant graph size reduction (from 25 million to 7.7 million nodes), doubles the detection coverage compared to hard-link-only baselines, and maintains high precision across identified fraud clusters. Our framework provides a scalable and practical solution for industrial-scale fraud detection systems.

Rethinking Bias in Generative Data Augmentation for Medical AI: a Frequency Recalibration Method

Developing Medical AI relies on large datasets and easily suffers from data scarcity. Generative data augmentation (GDA) using AI generative models offers a solution to synthesize realistic medical images. However, the bias in GDA is often underestimated in medical domains, with concerns about the risk of introducing detrimental features generated by AI and harming downstream tasks. This paper identifies the frequency misalignment between real and synthesized images as one of the key factors underlying unreliable GDA and proposes the Frequency Recalibration (FreRec) method to reduce the frequency distributional discrepancy and thus improve GDA. FreRec involves (1) Statistical High-frequency Replacement (SHR) to roughly align high-frequency components and (2) Reconstructive High-frequency Mapping (RHM) to enhance image quality and reconstruct high-frequency details. Extensive experiments were conducted in various medical datasets, including brain MRIs, chest X-rays, and fundus images. The results show that FreRec significantly improves downstream medical image classification performance compared to uncalibrated AI-synthesized samples. FreRec is a standalone post-processing step that is compatible with any generative model and can integrate seamlessly with common medical GDA pipelines.

Causal Fingerprints of AI Generative Models

AI generative models leave implicit traces in their generated images, which are commonly referred to as model fingerprints and are exploited for source attribution. Prior methods rely on model-specific cues or synthesis artifacts, yielding limited fingerprints that may generalize poorly across different generative models. We argue that a complete model fingerprint should reflect the causality between image provenance and model traces, a direction largely unexplored. To this end, we conceptualize the \emph{causal fingerprint} of generative models, and propose a causality-decoupling framework that disentangles it from image-specific content and style in a semantic-invariant latent space derived from pre-trained diffusion reconstruction residual. We further enhance fingerprint granularity with diverse feature representations. We validate causality by assessing attribution performance across representative GANs and diffusion models and by achieving source anonymization using counterfactual examples generated from causal fingerprints. Experiments show our approach outperforms existing methods in model attribution, indicating strong potential for forgery detection, model copyright tracing, and identity protection.

Fleming-R1: Toward Expert-Level Medical Reasoning via Reinforcement Learning

While large language models show promise in medical applications, achieving expert-level clinical reasoning remains challenging due to the need for both accurate answers and transparent reasoning processes. To address this challenge, we introduce Fleming-R1, a model designed for verifiable medical reasoning through three complementary innovations. First, our Reasoning-Oriented Data Strategy (RODS) combines curated medical QA datasets with knowledge-graph-guided synthesis to improve coverage of underrepresented diseases, drugs, and multi-hop reasoning chains. Second, we employ Chain-of-Thought (CoT) cold start to distill high-quality reasoning trajectories from teacher models, establishing robust inference priors. Third, we implement a two-stage Reinforcement Learning from Verifiable Rewards (RLVR) framework using Group Relative Policy Optimization, which consolidates core reasoning skills while targeting persistent failure modes through adaptive hard-sample mining. Across diverse medical benchmarks, Fleming-R1 delivers substantial parameter-efficient improvements: the 7B variant surpasses much larger baselines, while the 32B model achieves near-parity with GPT-4o and consistently outperforms strong open-source alternatives. These results demonstrate that structured data design, reasoning-oriented initialization, and verifiable reinforcement learning can advance clinical reasoning beyond simple accuracy optimization. We release Fleming-R1 publicly to promote transparent, reproducible, and auditable progress in medical AI, enabling safer deployment in high-stakes clinical environments.

Unleashing the Power of Pre-trained Encoders for Universal Adversarial Attack Detection

Adversarial attacks pose a critical security threat to real-world AI systems by injecting human-imperceptible perturbations into benign samples to induce misclassification in deep learning models. While existing detection methods, such as Bayesian uncertainty estimation and activation pattern analysis, have achieved progress through feature engineering, their reliance on handcrafted feature design and prior knowledge of attack patterns limits generalization capabilities and incurs high engineering costs. To address these limitations, this paper proposes a lightweight adversarial detection framework based on the large-scale pre-trained vision-language model CLIP. Departing from conventional adversarial feature characterization paradigms, we innovatively adopt an anomaly detection perspective. By jointly fine-tuning CLIP's dual visual-text encoders with trainable adapter networks and learnable prompts, we construct a compact representation space tailored for natural images. Notably, our detection architecture achieves substantial improvements in generalization capability across both known and unknown attack patterns compared to traditional methods, while significantly reducing training overhead. This study provides a novel technical pathway for establishing a parameter-efficient and attack-agnostic defense paradigm, markedly enhancing the robustness of vision systems against evolving adversarial threats.