Improvement Strategies for Few-Shot Learning in OCT Image Classification of Rare Retinal Diseases

This paper focuses on using few-shot learning to improve the accuracy of classifying OCT diagnosis images with major and rare classes. We used the GAN-based augmentation strategy as a baseline and introduced several novel methods to further enhance our model. The proposed strategy contains U-GAT-IT for improving the generative part and uses the data balance technique to narrow down the skew of accuracy between all categories. The best model obtained was built with CBAM attention mechanism and fine-tuned InceptionV3, and achieved an overall accuracy of 97.85%, representing a significant improvement over the original baseline.

The Hitchhikers Guide to Production-ready Trustworthy Foundation Model powered Software (FMware)

Foundation Models (FMs) such as Large Language Models (LLMs) are reshaping the software industry by enabling FMware, systems that integrate these FMs as core components. In this KDD 2025 tutorial, we present a comprehensive exploration of FMware that combines a curated catalogue of challenges with real-world production concerns. We first discuss the state of research and practice in building FMware. We further examine the difficulties in selecting suitable models, aligning high-quality domain-specific data, engineering robust prompts, and orchestrating autonomous agents. We then address the complex journey from impressive demos to production-ready systems by outlining issues in system testing, optimization, deployment, and integration with legacy software. Drawing on our industrial experience and recent research in the area, we provide actionable insights and a technology roadmap for overcoming these challenges. Attendees will gain practical strategies to enable the creation of trustworthy FMware in the evolving technology landscape.

CLIMB: CLustering-based Iterative Data Mixture Bootstrapping for Language Model Pre-training

Pre-training datasets are typically collected from web content and lack inherent domain divisions. For instance, widely used datasets like Common Crawl do not include explicit domain labels, while manually curating labeled datasets such as The Pile is labor-intensive. Consequently, identifying an optimal pre-training data mixture remains a challenging problem, despite its significant benefits for pre-training performance. To address these challenges, we propose CLustering-based Iterative Data Mixture Bootstrapping (CLIMB), an automated framework that discovers, evaluates, and refines data mixtures in a pre-training setting. Specifically, CLIMB embeds and clusters large-scale datasets in a semantic space and then iteratively searches for optimal mixtures using a smaller proxy model and a predictor. When continuously trained on 400B tokens with this mixture, our 1B model exceeds the state-of-the-art Llama-3.2-1B by 2.0%. Moreover, we observe that optimizing for a specific domain (e.g., Social Sciences) yields a 5% improvement over random sampling. Finally, we introduce ClimbLab, a filtered 1.2-trillion-token corpus with 20 clusters as a research playground, and ClimbMix, a compact yet powerful 400-billion-token dataset designed for efficient pre-training that delivers superior performance under an equal token budget. We analyze the final data mixture, elucidating the characteristics of an optimal data mixture. Our data is available at: https://research.nvidia.com/labs/lpr/climb/

Early-Bird Diffusion: Investigating and Leveraging Timestep-Aware Early-Bird Tickets in Diffusion Models for Efficient Training

Training diffusion models (DMs) requires substantial computational resources due to multiple forward and backward passes across numerous timesteps, motivating research into efficient training techniques. In this paper, we propose EB-Diff-Train, a new efficient DM training approach that is orthogonal to other methods of accelerating DM training, by investigating and leveraging Early-Bird (EB) tickets -- sparse subnetworks that manifest early in the training process and maintain high generation quality. We first investigate the existence of traditional EB tickets in DMs, enabling competitive generation quality without fully training a dense model. Then, we delve into the concept of diffusion-dedicated EB tickets, drawing on insights from varying importance of different timestep regions. These tickets adapt their sparsity levels according to the importance of corresponding timestep regions, allowing for aggressive sparsity during non-critical regions while conserving computational resources for crucial timestep regions. Building on this, we develop an efficient DM training technique that derives timestep-aware EB tickets, trains them in parallel, and combines them during inference for image generation. Extensive experiments validate the existence of both traditional and timestep-aware EB tickets, as well as the effectiveness of our proposed EB-Diff-Train method. This approach can significantly reduce training time both spatially and temporally -- achieving 2.9$\times$ to 5.8$\times$ speedups over training unpruned dense models, and up to 10.3$\times$ faster training compared to standard train-prune-finetune pipelines -- without compromising generative quality. Our code is available at https://github.com/GATECH-EIC/Early-Bird-Diffusion.

Impact of Stain Variation and Color Normalization for Prognostic Predictions in Pathology

In recent years, deep neural networks (DNNs) have demonstrated remarkable performance in pathology applications, potentially even outperforming expert pathologists due to their ability to learn subtle features from large datasets. One complication in preparing digital pathology datasets for DNN tasks is variation in tinctorial qualities. A common way to address this is to perform stain normalization on the images. In this study, we show that a well-trained DNN model trained on one batch of histological slides failed to generalize to another batch prepared at a different time from the same tissue blocks, even when stain normalization methods were applied. This study used sample data from a previously reported DNN that was able to identify patients with early stage non-small cell lung cancer (NSCLC) whose tumors did and did not metastasize, with high accuracy, based on training and then testing of digital images from H&E stained primary tumor tissue sections processed at the same time. In this study we obtained a new series of histologic slides from the adjacent recuts of same tissue blocks processed in the same lab but at a different time. We found that the DNN trained on the either batch of slides/images was unable to generalize and failed to predict progression in the other batch of slides/images (AUC_cross-batch = 0.52 - 0.53 compared to AUC_same-batch = 0.74 - 0.81). The failure to generalize did not improve even when the tinctorial difference correction were made through either traditional color-tuning or stain normalization with the help of a Cycle Generative Adversarial Network (CycleGAN) process. This highlights the need to develop an entirely new way to process and collect consistent microscopy images from histologic slides that can be used to both train and allow for the general application of predictive DNN algorithms.

MG-Verilog: Multi-grained Dataset Towards Enhanced LLM-assisted Verilog Generation

Large Language Models (LLMs) have recently shown promise in streamlining hardware design processes by encapsulating vast amounts of domain-specific data. In addition, they allow users to interact with the design processes through natural language instructions, thus making hardware design more accessible to developers. However, effectively leveraging LLMs in hardware design necessitates providing domain-specific data during inference (e.g., through in-context learning), fine-tuning, or pre-training. Unfortunately, existing publicly available hardware datasets are often limited in size, complexity, or detail, which hinders the effectiveness of LLMs in hardware design tasks. To address this issue, we first propose a set of criteria for creating high-quality hardware datasets that can effectively enhance LLM-assisted hardware design. Based on these criteria, we propose a Multi-Grained-Verilog (MG-Verilog) dataset, which encompasses descriptions at various levels of detail and corresponding code samples. To benefit the broader hardware design community, we have developed an open-source infrastructure that facilitates easy access, integration, and extension of the dataset to meet specific project needs. Furthermore, to fully exploit the potential of the MG-Verilog dataset, which varies in complexity and detail, we introduce a balanced fine-tuning scheme. This scheme serves as a unique use case to leverage the diverse levels of detail provided by the dataset. Extensive experiments demonstrate that the proposed dataset and fine-tuning scheme consistently improve the performance of LLMs in hardware design tasks.

When Linear Attention Meets Autoregressive Decoding: Towards More Effective and Efficient Linearized Large Language Models

Autoregressive Large Language Models (LLMs) have achieved impressive performance in language tasks but face two significant bottlenecks: (1) quadratic complexity in the attention module as the number of tokens increases, and (2) limited efficiency due to the sequential processing nature of autoregressive LLMs during generation. While linear attention and speculative decoding offer potential solutions, their applicability and synergistic potential for enhancing autoregressive LLMs remain uncertain. We conduct the first comprehensive study on the efficacy of existing linear attention methods for autoregressive LLMs, integrating them with speculative decoding. We introduce an augmentation technique for linear attention that ensures compatibility with speculative decoding, enabling more efficient training and serving of LLMs. Extensive experiments and ablation studies involving seven existing linear attention models and five encoder/decoder-based LLMs consistently validate the effectiveness of our augmented linearized LLMs. Notably, our approach achieves up to a 6.67 reduction in perplexity on the LLaMA model and up to a 2$\times$ speedup during generation compared to prior linear attention methods. Codes and models are available at https://github.com/GATECH-EIC/Linearized-LLM.

ShiftAddLLM: Accelerating Pretrained LLMs via Post-Training Multiplication-Less Reparameterization

Large language models (LLMs) have shown impressive performance on language tasks but face challenges when deployed on resource-constrained devices due to their extensive parameters and reliance on dense multiplications, resulting in high memory demands and latency bottlenecks. Shift-and-add reparameterization offers a promising solution by replacing costly multiplications with hardware-friendly primitives in both the attention and multi-layer perceptron (MLP) layers of an LLM. However, current reparameterization techniques require training from scratch or full parameter fine-tuning to restore accuracy, which is resource-intensive for LLMs. To address this, we propose accelerating pretrained LLMs through post-training shift-and-add reparameterization, creating efficient multiplication-free models, dubbed ShiftAddLLM. Specifically, we quantize each weight matrix into binary matrices paired with group-wise scaling factors. The associated multiplications are reparameterized into (1) shifts between activations and scaling factors and (2) queries and adds according to the binary matrices. To reduce accuracy loss, we present a multi-objective optimization method to minimize both weight and output activation reparameterization errors. Additionally, based on varying sensitivity across layers to reparameterization, we develop an automated bit allocation strategy to further reduce memory usage and latency. Experiments on five LLM families and eight tasks consistently validate the effectiveness of ShiftAddLLM, achieving average perplexity improvements of 5.6 and 22.7 points at comparable or lower latency compared to the most competitive quantized LLMs at 3 and 2 bits, respectively, and more than 80% memory and energy reductions over the original LLMs. Codes and models are available at https://github.com/GATECH-EIC/ShiftAddLLM.

Length-scale study in deep learning prediction for non-small cell lung cancer brain metastasis

Deep learning assisted digital pathology has the potential to impact clinical practice in significant ways. In recent studies, deep neural network (DNN) enabled analysis outperforms human pathologists. Increasing sizes and complexity of the DNN architecture generally improves performance at the cost of DNN's explainability. For pathology, this lack of DNN explainability is particularly problematic as it hinders the broader clinical interpretation of the pathology features that may provide physiological disease insights. To better assess the features that DNN uses in developing predictive algorithms to interpret digital microscopic images, we sought to understand the role of resolution and tissue scale and here describe a novel method for studying the predictive feature length-scale that underpins a DNN's predictive power. We applied the method to study a DNN's predictive capability in the case example of brain metastasis prediction from early-stage non-small-cell lung cancer biopsy slides. The study highlights the DNN attention in the brain metastasis prediction targeting both cellular scale (resolution) and tissue scale features on H&E-stained histological whole slide images. At the cellular scale, we see that DNN's predictive power is progressively increased at higher resolution (i.e., lower resolvable feature length) and is largely lost when the resolvable feature length is longer than 5 microns. In addition, DNN uses more macro-scale features (maximal feature length) associated with tissue organization/architecture and is optimized when assessing visual fields larger than 41 microns. This study for the first time demonstrates the length-scale requirements necessary for optimal DNN learning on digital whole slide images.

Improving Cancer Imaging Diagnosis with Bayesian Networks and Deep Learning: A Bayesian Deep Learning Approach

With recent advancements in the development of artificial intelligence applications using theories and algorithms in machine learning, many accurate models can be created to train and predict on given datasets. With the realization of the importance of imaging interpretation in cancer diagnosis, this article aims to investigate the theory behind Deep Learning and Bayesian Network prediction models. Based on the advantages and drawbacks of each model, different approaches will be used to construct a Bayesian Deep Learning Model, combining the strengths while minimizing the weaknesses. Finally, the applications and accuracy of the resulting Bayesian Deep Learning approach in the health industry in classifying images will be analyzed.